JP2002145731A - Cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cosmetic that has antioxidative effect, antimutagenic effect, antiinflammatory effect, antiallergic effect and humectant effect, thus is useful as a cosmetic in addition to the use as medicine, quasi-drug and the like. SOLUTION: The objective cosmetic includes an extract from a plant, plantain belong to Sapindaceae.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a cosmetic comprising a psyllium extract,
The field of application is, for example, cosmetics (various preparations used for humans and other animals), pharmaceuticals, quasi-drugs, and the like.

[0002]

BACKGROUND ART Plantain is a plant belonging to the plantain family.
The scientific name is PLANTAGO ASIATICA L.
In Japan, it is also known as a car foreflower and is used as a folk medicine because of its antitussive and diuretic properties. It is also known to be effective for adult diseases such as diabetes and arteriosclerosis, and for dieting.

[0003]

DISCLOSURE OF THE INVENTION The present inventors have conducted intensive studies with the aim of finding a unique novel function of psyllium and finding a useful method of using it.

[0004]

Means for Solving the Problems The inventors of the present invention have studied and pursued a useful use method and action of psyllium to achieve the above-mentioned object. It has sexual, anti-inflammatory, anti-allergic, and moisturizing effects, and has been found to be very effective for application to cosmetics, and has completed the present invention.

That is, the present invention relates to a cosmetic composition containing psyllium extract, which has functions as an antioxidant, an anti-mutagenic substance, an anti-inflammatory agent, an anti-allergic agent, and a humectant. It is. Psyllium used in the present invention may be any plant belonging to the Psyllium family, but is preferably Psyllium psyllium, Psyllium psyllium, Psyllium psyllium, Psyllium psyllium, Tubo psyllium, and Psyllium psyllium. As the site to be used, leaves, stems, roots, seeds, petals and the like can be used.

The psyllium extract used in the present invention can be prepared by extracting psyllium with water, an alcohol, a polyhydric alcohol or a mixture thereof, and using them in solution. However, powdery products obtained by drying these solutions can also be used in cosmetics. In extracting psyllium, a buffer, a dilute acid and a dilute alkali can be used instead of water.

It is desirable that the psyllium extract of the present invention be extracted after the psyllium is dried and the impurities are sufficiently washed with water. Psyllium from which impurities have been removed can be extracted as it is, but can also be pulverized before being subjected to extraction. The psyllium extract is obtained by washing the washed psyllium with natural alcohols such as water, methanol, ethanol, isopropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, 2-hexyldecanol, isostearyl alcohol, -Synthetic alcohols such as octyldodecanol, ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether,
Diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, polyhydric alcohols such as mannitol, ketones such as acetone, diethyl ether, dioxane, Acetonitrile, ethyl acetate, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate,
Esters such as cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, aluminum stearate, magnesium stearate, zinc stearate, Metal soaps such as calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, organic solvents such as pyridine, chloroform, benzene, toluene, xylene, cyclohexane and hexane, avocado oil, almond oil, fennel oil , Perilla oil, olive oil, orange oil, orange raffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut , Safflower oil, shea butter oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, Fats and oils such as mokuro, coconut oil, beef tallow, lard, and hydrogenated products of these fats and oils (hardened oil, etc.), beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin,
Waxes such as hard lanolin, candelilla wax, montan wax and shellac wax, liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax, squalene, squalane, pristane, and other mineral oils, lauric acid, myristic acid, palmitic acid,
Stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acids, isononanoic acid, caproic acid,
Synthetic fatty acids such as 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, and isopentanoic acid; buffers such as citrate buffer, phosphate buffer, borate buffer, and Tris-HCl buffer; Rare caustic soda,
Dilute alkali such as potassium hydroxide, sodium carbonate, and ammonia, dilute acid such as dilute hydrochloric acid, dilute citric acid, dilute acetic acid, dilute lactic acid, or a mixture thereof, and stirring at 0 to 110 ° C. for 1 hour to 2 months. Can be obtained.

Although the extracted psyllium extract can be used as it is, it is preferable to further purify it by a process such as filtration and centrifugation. In many cases, it can be used as is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected.
An activated carbon column or the like may be used as a purification treatment means such as deodorization and decolorization, and any ordinary means generally applied to the extracted substance may be selected. Further, the obtained plantain extract can be obtained as a dried product by a heat drying method such as a freeze drying method and a spray drying method.

[0009] Cosmetics to which the psyllium extract of the present invention is blended include face lotions, lotions, serums, general creams, cleansing creams, and the like, packs, shaving creams, tanning creams, sunscreens, and suntans. Stop lotion, suntan lotion, toilet soap, foundation, whitening, powder, lipstick, lip balm, eyeliner, eye cream, eyeshadow, mascara, bath cosmetics, shampoo, rinse, hair dye, hair cosmetics, etc. It is possible. The amount may be 0.001 to 100%, preferably 0.001 to 10%, and more preferably 0.01 to 5% in the cosmetic composition.

The cosmetic of the present invention is manufactured by arbitrarily selecting and using, in combination, any of the various components and additives usually used in cosmetics such as cosmetics as shown below. be able to.

[0011] For example, avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukuinut oil,
Safflower oil, shea butter, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, mocro , Coconut oil, beef tallow, lard, and the like, or hydrogenated products of these fats and oils (hardened oil, etc.).

Waxes such as beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax and shellac wax. Mineral oils such as liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax, squalene, squalane, and pristane. Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid,
Natural fatty acids such as undecylenic acid, tall oil, and lanolin fatty acids. Synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, and isopentanoic acid. Ethanol, isopropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol,
Natural alcohols such as lanolin alcohol, cholesterol, phytosterols.

Synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol and 2-octyldodecanol. Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol And polyhydric alcohols such as glycerin, pentaerythritol, sorbitol and mannitol.

Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl phthalate, phthalate Esters such as diethyl, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, and propylene glycol dioleate.

Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate,
Metal soaps such as zinc laurate and zinc undecylenate.

Gum arabic, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose and its esters, trehalose and its derivatives, dextrin, gelatin, pectin , Starch, carrageenan, succinyl chitosan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan added with alkylene (C2-C4) oxide such as ethylene oxide, low molecular weight chitin or chitosan, chitosan salt,
Sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid and its salts, hyaluronic acid and its salts, chondroitin sulfate and its salts, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxyethylcellulose, carboxyethylcellulose sodium, hydroxyethylcellulose, hydroxypropyl Cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, polyethyleneimine, etc. Gums, sugars and water-soluble polymer compounds

Anionic surfactants (alkyl carboxylate, alkyl sulfonate, alkyl sulfate,
Alkyl phosphate salts), cationic surfactants (alkyl amine salts, alkyl quaternary ammonium salts), amphoteric surfactants: carboxylic acid type amphoteric surfactants (amino type,
Betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant, ether ester type nonionic surfactant) Agents, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants, protein hydrolyzate derivatives, polymer interfaces) Surfactants such as surfactants, surfactants containing titanium and silicon, and fluorocarbon surfactants).

Retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folate , Nicotinic acids, pantothenic acids, biotins, choline, inositols,
Ascorbic acid and its derivatives, ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydrotaxerol, tocopherol and its derivatives, ubiquinones, phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3) ), Menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamins such as vitamin U.

Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, Ornithine,
Amino acids such as histidine and their sulfates, phosphates, nitrates and citrates; and amino acid derivatives such as pyrrolidone carboxylic acid. Microbial culture metabolites such as yeast metabolites, yeast extract, rice ferment extract, rice bran extract, euglena extract, trehalose or derivatives thereof.

Α-hydroxy acids such as glycolic acid, citric acid, malic acid, tartaric acid and lactic acid. Silicic anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide Inorganic pigments, such as limestone, chromium oxide, chromium hydroxide, carbon black, and calamine.

P-aminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, UV absorption of nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, benzophenones, oxybenzone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, urocanic acid derivatives, escalol, zinc oxide, talc, kaolin, etc. A blocking agent.

P-aminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin,
Whitening agents such as baicalin, baicalein, and berberine.

Ascorbic acid and its derivatives, hydroquinone and its glycosides, kojic acid and its derivatives, placenta extract, silk peptide, plant extracts (mulberry, corn,
Waremokou, mugwort, honeysuckle, yellowfin, prickle,
Matsuhod, Adlay, Pompidium, Hawthorn, Eucalyptus, Achillea millefolium, Altea, Keihi, Mankeishi, Hamamelis, Yamaguwa, Extended life grass, Bellflower, Toshishi,
Zuisonko, Sun-dried, Mao, Senkyu, Dokkatsu, Psycho,
Boufu, Hamabofu, Ogon, Peony, Gennoshoco, Licorice, Fivefold child, Aloe, Ginger, Safflower,
Tyrosinase activity inhibitors such as Asenyaku.

Melanin pigment reducing / decomposing agents such as hydroquinone monobenzyl ether, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, aqueous hydrogen peroxide and zinc peroxide. Hydroquinone, lactic acid bacteria extract, placenta extract, ganoderma extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe, ogon, horsetail, kentiana, burdock, sicon, carrot, Turnover-promoting / cell activators, such as hamamelis, hops, yokuinin, edulis, assembly, touki, balsam, amacha, hypericum, cucumber, scorpion, rosemary and parsley.

Astringents such as succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compounds). Active oxygen scavengers such as SOD, catalase and glutathione peroxidase. Ascorbic acid and its salts,
Such as stearic acid ester, tocopherol and its ester derivative, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamoline, gossypol Antioxidants.

Β-carotene, plant extract (cultured sesame cells, amacha, hypericum, hamamelis, clove,
Lipid peroxide production inhibitors such as melissa, emicou, birch, sage, rosemary, Minami Tenmi, kina, age, ginkgo). Icutamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, difenvidramine hydrochloride, d or dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid and its salts, glycyrrhetinic acid and Anti-inflammatory agents such as salt, licorice extract component, sicon extract, age extract.

Acrinol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, isopropylmethylphenol, Disinfectants for disinfectants such as triclosan and kujin.

Glycerin, propylene glycol, 1,
Humectants such as 3-butylene glycol, hyaluronic acid and its salts, polyethylene glycol, chondroitin sulfate and its salts, water-soluble chitin or chitosan derivatives, pyrrolidone carboxylic acid and its salts, sodium lactate, and mini-sasanashiki extract.

Selenium disulfide, alkyl isoquinolinium bromide, zinc pyrithione, biphenamine, thiantole, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, sodium bromate, thioglycolic acid, etc. For hair.

Antiandrogens such as estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrone and the like. Vitamin E and its derivatives, assembly extract, garlic extract,
Peripheral vascular blood flow enhancers such as ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride and minoxidil.

Topical stimulants such as pepper tincture, nonylate tinilamide, cantaris tincture, ginger tincture, peppermint oil, l-menthol, camphor and benzyl nicotinate. Metabolic activators such as photosensitizer 301, hinokitiol, pantothenic acid and derivatives thereof, allantoin, placental extract, biotin, and glyceride pentadecanoate. Antiseborrheic agents such as pyridoxine and its derivatives, sulfur and vitamin B6.

Keratolytic agents such as resorcin, salicylic acid and lactic acid. Aqueous hydrogen peroxide, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate And oxidizing agents such as sodium hydrogen silicate peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, and mushroom extract.

Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide and calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, thioglycolate) Hair remover such as strontium acid). Hair swelling agents such as ethanolamine, urea, and guanidine.

5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4 hydrochloride -Diaminophenoxyethanol, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, acetic acid N-phenylparaphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5
-Dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium piclamate, N, N'-bis (4-aminophenyl)-
2,5-diamino-1,4-quinonediimine, 5- (2
-Hydroxyethylamino) -2-methylphenol,
N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, sulfuric acid 4,4'- Diaminodiphenylamine, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, sulfuric acid Paramethylaminophenol, metaaminophenol sulfate,
Metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy-5-nitro-2 ′, 4′-diaminoazobenzozen-5 ′ Dyestuffs such as sodium sulfonate, hematein and the like;

Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil,
Cardamom essential oil, guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, cedar wood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Greater Fengxiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batchy essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petitgren essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil,
Plant flavors such as rosemary essential oil and Japanese peppermint essential oil,
Other fragrances such as synthetic fragrances.

Red cabbage pigment, red rice pigment, madder pigment,
Anato color, squid color, turmeric color, orange color, krill color, persimmon color, caramel, gold, silver, gardenia color, corn color, onion color, tamarind color,
Pigments and coloring agents such as spirulina pigment, buckwheat whole plant pigment, cherry pigment, nori pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment and rutin.

Also, almonds (red peaches), eyes (blue leaves), blue vegetation (Seifu Fuji), blue vegetation (Kibo), blue-green agave, blue-green agave, red grape, red grape, akaminoshiwa (logwood) Red buds, Akane (Akane grass roots), Akajiojiu Jiou (Jihuang), Agi (Awei), Akinire (Royu skin), Akebi (Kidori), Asa (Asakojin), Malva asagao or Asagao (Toshiko), Ashitaba (Asuka), Azuki (red azuki), Acerola, Asenyaku (Asenyaku), Anise, Abemaki fruit, Avocado,
Ama, Amacha (Amacha), Amachaworu, Amadokoro (Tamatake), Amigasa lily (Shellfish), Altea, Arnica, Aloe (Lugu), Aloe vera, Angelica, Anzu Honganzu (Anjin), Ansokkou (Azuka), Igakozolina (Earth) Bile head), knotweed (tiger root), strawberry, fig (apricot) or its leaves, strawberry (winter aoiko), ichiyakusou, ginkgo (ginko leaves, ginkgo), Itohimehagi (enshi), carob, rice seed or seed coat,
Inondo seeds, Ibuki gypsophila, nettle, ylang-ylang, fennel (fenka), ukiyagara (sanryo), guisukagura fruit, himeuikyo, turmeric (depression),
Usubasaishin Keirinsaishin (spicy), Usbenioioi, Usbeniitaoioi, Utsubogusa (summer hay),
Udo or Shishudo (Qanggai, Independent, Tang Deng), Plum (Ume) or its pulp, Vladimir, Oolong tea, Uwaurushi (Kusaco peach), Unshu mandarin (Chen skin),
Estragon, Ezokogi (Ezo Goka), Ezoki strawberry, Echinashi (Hosobamurasakibarengiku), Enishida, Enokitake (Enokitake), Ebisugusa (Keiko), Elderberry fruit, Elemi, Eringyi (pre-lotus erinji), Enduyu (pre-flower) (Rice blossom), ogi / kibanaogi (radix astragali), uren (orange), giant crow squirrel (karonin), ootsu-la-fuji (self-defense), psyllium (vegetative child, vegetative grass), tou-habami (haruko), eucalyptus okaera (white jujitsu) ), Obanaya shabushi fruit, O hawthorn hawthorn (Yamako), Oohisasanoyuki, Sasanoyuki, Barley (barley), Ogurma (turning), Okra fruit, Panax ginseng Tochibanjin (Ginseng), Ogirisou Kogomebayotoyosougi grass Odrico C (continued cross-sectional), cocklebur (Aoimimiko), Juglans, Gastrodia elata (Tian Ma), Tiger -
Sasayuri Hakatayuri (Yuri), Halibut (Hihayu),
Ominaeshi (defeated soybean), Dutch strawberry, Dutch mustard (Watercress), Dutch jelly, Dutch honeysuckle, olive, oregano, orange fruit or pericarp, silkworm (ripened yellow), cacao seed, oyster or its leaves (persimmon), (Katsuo Choto), Cassia, Cassinaki fruit (Kozou), Gajutsu (Shazajutsu), Kashiwa (Shakiju, Sakuraha),
Cascarilla, Kanixa (Kinosato), Valerian (Kisosone), Birch or Weeping birch (White birch), Pumpkin, Capoknoki seed, Kahoku Sansho (Shupper), Gama (Gambah), Chamomile roman chamomile, Kamiyatsude (Tsou grass), Kam Kam / Duck, duckweed (gold melon),
Crow squirrel (midsummer), oats, guarana seeds, karahoo (thick), karaya, karin (gourd), garcinia, kawayanagi, kawaratake, kawamuragi (inchinko), kansui (successful), licorice (licorice), kantarasa, Candelilla, canto, canna, raspberry, kiwi fruit, kikarasuuri (urorone), kikyo (bellflower, bellflower), chrysanthemum (chrysanthemum), catalpa (azumi), sagebrush (yotei), pheasant (komi), kizuta , Kidachi aloe,
Mint, quince, linden (shincona, red linden), yellowfin (yellow), gymnema sylvestre, cabbage, cabbage immature fruit, cucumber, kiraja saponaria, kiraya, kumquat fruit, betel, quince, guava fruit, guayule, Quercus Infectria (Gallery), Kukui Nuts, Wolfberry (Gugi, Gyugia, Gyugi Leaves, Skeletal Bark), Quercus spp. (Tenmen Winter),
Camphor tree, gooseberry fruit, gardenia, gardenia, kunugi (bokusou), kumazasa, black pine (horse whip), clara (bitan), cranberry fruit, chestnut or its skin, curculigo latifolia fruit, grapefruit, buckthorn, black squirrel Rescue), Kurobana Hiokikoshi, Clove (cloves, cloves), Kaigai (codling, codling spikes), Celosia (corolla, cotyledon), bay laurel (laurel), kenashisarutoribara (tokubukuryo, mountain return), gentian, gennoshoko (old) Kouzi / Tachibana / Obenimikan / Ponkan / Santara (Tachibana skin), Koushinbara (Monthly flower), Kouzui mint, Kozo fruit, Koucha (tea), Kouhone (river bone), Koufon (straw book, Kara straw book), Koulyang, cilantro fruit, koganebana (yellow gon), Kemomo (Koshibachi), Coconut fruit, Goshuyu (Gusyuyu), Goshoichigo (Ubonboshi), Pepper (Hushu), Copaiba balsam, Coffee beans, Kobushi magnolia (Spicy), Burdock (burdock, Burdock), Kobotur, Sesame seeds (sesame), sesame seeds (ginseng), garnish (gomiko), Sanekazura binankazura Matsubusa,
Wheat (wheat), rice, rice bran (red bran, white bran), rice oil, cola acuminata seeds, cola vera seeds, fenugreek fruit, colombo, conzulango, kelp, konjac, comfrey (finnari grass), sisal, sisal asa , Sakisima buttonpul (weird sen), sakura (Oshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura,
Leaves, flowers, fruits, bark (cherry bark), cherries, pomegranate, sasa, sasanqua, sardine, sweet potato, sugar cane, sugar beet, Jujube jujube (acid jujube), saffron (banana safflower, western safflower), pomelo fruit, sabonso, salmon berry fruit, sarashinasho (masuma), salvia (sage), sawagikyo (yamachona), sawagurumi (yamawomo), sanshichi Carrot (37 ginseng), sanshuyu (sanshuyu), sansho (sansho),
Sandscon (Yamazone), Shea (Karite), Cyanoki fruit, Shiitake (Shiitake), Shion (Shion), Dikitaris,
Sikunshi (Kimiko), Shiso Aojiso Chirimenjiso
Katamenjiso (perilla leaves, perilla), rosewood, linden,
Pterodactyla, Lynchium japonicus (serial forsythia), Shimakangiku (chrysanthemum flower), Shimeji (Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiiroshimeji, Bunashimeji, Shirotamogitake), Shimotsukesou, Potato, Paeonia ), Jujudama, Palm fruit, Ginger (ginger), Shobu (Iris, Iris root), Shozuku fruit, Shirakashi seed, Shirogoshi butterfly seed, Shirobanatsuta flower, Shirominanten (Minami Tenmi), Cinchona saxilbra, Cinnamon, Watermelon ( Watermelon), honeysuckle (gold and silver flowers, Shinobi winter), sorrel (acid model),
Swimberry fruit, Stevia, Strawberry fruit, Horsetail (Thorn), Stevia, Plum fruit, Scots pine cone, Larch of Europe, Scotch vine, Scotch pine walnut, Atlantic hawthorn, European dandelion, Horse chestnut (Maloney), Atlantic pear fruit, Atlantic snowfruit, Western elderberry (Elder), Atlantic shrew (Juniper / Morimatsu), Achillea millefolium (Milfoil), Atlantic rose, European cornflower, European mistletoe, Atlantic lipstick, Japanese horseradish, Japanese horseradish , Hirohasenega, senega, seri, celery, senkyu (river kyu), sendan, senburi (drug), senna fruit or leaves, senninsou (large tate), souka (grass), buckwheat seeds, sui Monoimo, rhubarb (daioh), radish, soybean, rhubarb (orange, kikomi), takatodai (daigo), takawarabi (dog sparrow), dark sweet cherry fruit, hollyhock, scotch thyme (thyme, Hyakurika), shiroyanagi, tamarind seeds , Onion, tamshiba (hot spring), arachis or its root bark, tanjin (dansin), dandelion (gakkohide) or shirobana dandelion, moko dandelion, dammar, cherry fruit, tigaya or its root (chinese ginseng), chikusetsujin (bamboo ginseng) , Chicory, ginseng (Gomiko), ginseng (daiko), ginseng (Wuyi), ginseng (carrot), ginseng (Ginseng), artemisia (Aoba), choreimaitake (Irei), Tsukimiso (mushroom), camellia , Spiderweeds, clovers , Tsuyukusa (Dark primrose), Tsuruazuki (red azuki bean), Tsurudukami (Hanshu crow), Tsuruna (Banju), Tsuruninjin (Four leaf ginseng), Tsuwabuki, Deiko, Teuchigurumi, Duberry fruit, Tengusa, Tencha, Tendaiyaku ), Pepper (Furry), Pepper (Pepper), Touki (Toki), Calendula (Marigold), Maize or Maize Hair (Nanban Hair), Toad Mizuchi (Female Sadako), Torindo (Dragon Bile), Dokudami (10 medicines), Tokon (sore root), Toshishi, Mamedaoshi, Nashikazura, Eucommia (Tonaka, Tonaka leaf), Tomato, Traganto, Triacanthus seed, Tormentilla, Dronoki, Troloaoi, Niseria berry fruit, Yam yam (Yamayaku) , Nagikadada (Butcher Bloom), Naginata Kouju, Na Zuna, rapeseed, jujube, jujube (daijuju), nanawaibara (gold cherry blossom), nameko, narco lily (yellow), peanut (peanut), nanten (minamitenmi), nigaki (makinoki), nigarimogi (bitumen), nikuzuku, Fruits, flowers or foliage of Kei Nikkei (Kihi bark) / Keishi (Keishi), Chinese chive (Nirako), Elderberry (bone-bonded tree),
Garlic (garlic), nurde (five times), green onion, thistle (daiji), wild rose (fruit), sawwood, sawdust (maehu), nobara, peach, palm, pineapple fruit, hibiscus (bussouge, hurinbussouge,
Roselle, Hakayamauraboshi (Bone Crushing), Hakusen (Rinosaur), Huckleberry Fruit, Hakobe (Regular), Hazel (Haruko), Hashiridoro (Roto Root), Basil, Lotus (Lotus, Lotus, Lotus), Parsley ( Dutch jelly), naked mussels, batata, hachiku madake (bamboo-boiled), patchouli,
Mentha (light load, light leaves), Adlay (Yokuinin), Hanasuge (Chimo), banana, Hanamint, vanilla bins,
Papaya, hakogusa (rat koji), hub grass, paprika,
Hamago / Mitsubahamago (vine thorn), Hamasuge (Katsukishi), Hamabishi (Situriko), Hamanas (maikai flower), Hamaboufu (beach storm), Hamamelis, rose (rose), agarita (haratake, white-faced agaricus) , Parietaria, Harunire (yu bark, yu white bark, yuba), breadfruit, lizard carrot (party),
Pecan nuts, Amaryllidaceae (silver, vinegar), Hiokikoshi (extended life grass), Hishi (Ryomi), pistachio, beet, Aitsuba (stone reed), Hinata Kozuchi (cow knee), Cypress, Hiba, Castor, Sunflower , Bell pepper, Peanut seed coat, Himegama (incense blossom), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta fruit, Juniperus, Biancucu, Hiyu fruit, Belowudo oyster, Hiroha okinagusa (Hakuto-oka), Loquat (Loquat, Loquat leaf), Betel Peel, betel root), spruce buds (southern rattan), butterflies, coltsfoots (winter flowers, winter leaves), fujibakama (orchid grass), wisteria beans (flat beans), grape berries or pericarp, seeds and leaves, beech, fuyumushinatsukustake ), Brazilian Licorice, Black Currant Fruit, Blackberry, Plum Fruit, Flucellaria, Roux berry (Prunus avium), prune, blond psyllium, bundo (green bean), loofah, safflower (safflower), henneken, belladonna, berry fruit, perbianberg, boysenberry fruit, boufu (windproof), spinach, physalis (Torone) , Japanese cypress (Japanese magnolia, Park), Bokeh (Gourd), Hosovanaokera (Aojutsu), Hosobabarengiku, Bodaiju (Bodaiju), Button (peony, Peony bark), Jojoba, Whiteberry fruit, Hongshimeji, Meisurutennanshaw ( (Tennan star), Maitake (Maitake), Ephedra (Mahuang), Macadamia nuts, Macri (Martian grass), Magwa (Mulberry white skin, Mulberry leaf), Magnolia splengeri, Matatabi (Kiten Tate), Matsukasa, Matsuba, Matsuhodo Bukuryo), Mayorum (Hanahakka), Malvanojazine (Difficult), Malbe -Fruits, quince, mango, mangosteen, manshu walnut, mandarin fruit, mannentake (reishi), citrus plant fruit (kokomi), mishima maiko (saiko), mizokoshi (half-side lotus), misohagi (senshu greens), mitsugashiwa ,
Mitsuba, green peppermint, mimosa, mioga, miracle fruit fruit, myrrh, mirobaran, mukuge (mokugei), mukunoki, mukuroji, murasaki (purple root), murasaki maize, mehajiki (masugi), mebogi, melaloka,
Melissa, melilot, melon fruit, sagebrush, moso bamboo, mokkou (wood incense), maple blossom, peach leaves (peach leaves), fruits and seeds (peach seeds), bean sprouts, morello cherry fruits, morroheiya (yellow), yakawamurasakiimo , Yakuchi (Masuchi), Knapweed (Knapweed),
Cornflower, yashabushi (arrow wheel), yachiyanagi, yatsude (octagonal gilding), mistletoe (willow parasitism), willow tree leaf, yabugarashi, yabukouji (purple gold beef), pokeweed (land), yamahanoki (yamaharu), yamamomo (yangmei) Skin), sagebrush, eucalyptus, saxifrage (tiger ear grass),
Yucca flevifolia, Yuzu fruit, lily, yogurtsa, European strawberry, mugwort (Aiba leaf), lime fruit, rye, lacanca fruit, raspberry leaf and fruit, lavender, rambutan seed, ryocha (green tea), apple fruit, gentian, rubas Suavisimus,
Lettuce, red currant fruit, lemon fruit, lemongrass, forsythia (forsythia), astragalus, coconut palm, lokon (reed: Root) loganberry fruit, rosemary (mannen wax), rosehip (nobara), longan seed, wasabi, Plants such as Waremoko (Jiyu), Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella
Green algae such as Ellipsoidia, Aonori (Usubaaonori, Sujiaonori, Hiraaonori, Bowaonori, Hosoedaaonori), and kelp (Macombs, Lysicum, Hosomekombu, Mitsuikonbu), Wakame, Hirome, Aowakaferi, Macrosis Pili Brown algae such as Tis Integrifolia, Neocitys Luetokeana), Hijiki and Hibamata, and Hijirimen, Maxa (Tengusa),
Hirakusa, Omikusa, Obakusa, Katao Bakusa, Yatabegusa, Yuikiri, Shimanegusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Zyakushinkirinsai, Tsunomata, Obatsunomata, Tochaka , Ibotsunomata, Yaleus Banori, Kagius Banori,
Seaweed and Chlamydomonas represented by red algae such as Sujiusbanori, Hiusbanori, Akamominori, Akayukimo, Dunaliella, Chlorococcus, Kwanomimo, Ohigemawari, Volvox, Palmera, Hizaori, Aomidro, Tsurugimidro, Hibimidro, Anaaosa, Amiosa, Amiosa, Amiosa, Amiasa, Amiosa, Amiosa, Amiosa Duckweed, Asamidorigusa, Kawaguogusa, Marimo,
Tamago Baronia, Tamama Baronia, Magamamamo, Husaiwata, Srikkogita, Helaiwata, Kurokita, Hanemo, Mill, Kromil, Sakibuchimil, Nagamir, Hiramil, Casanori, Futjuzmo, Tamazumi, Mizojuzmo, Mizuzumi, Kotogumi, Kotogoma, Kotogomi Green algae such as Himegusa, Motsukihitoe, Sayamidoro, Sunflower, Sumiremo, Hoshimidoro, Fushinashimidoro, etc., Suizenjinori, Aoko, Kawatake, Ishikurage, Hassai,
Blue-green algae such as Euremo, Spirulina, Trichodesmium, Pyraella, Nagamiushimidoro, Isogrape, Isogawara, Gunsenkurogashira, Kashirazaki, Muchimo, Hiramuchimo, Kebelligsa, Amidigusa, Sakibiroamiji, Sanadagusa, Sakuragusa, Lagopodium japonica, Lagerstrophy , Sea urchin,
Konamiumiuchiwa, Akabaumiuchiwa, Hirnamimakula,
Somewagekusa, Nabarimo, Motukichasoumen, Matsumo, Nagamatsumo, Okinawamozuku, Niseftmozuku, Futomozuku, Ishimozuku, Chromo, Nisemozuku, Mozuku,
Ishige, Iloro, Ichimegasa, Keyari, Umibosu, Urushigusa, Keurusigusa, Tobacco grass, Kombmodoki,
Habaromodoki, Habanori, Hiranobori, Common Bukuro, Ezobukuro, Fukuronori, Watamo, Chishima Fukuronori, Kagomenori, Murachidori, Shark's grass, Iwage,
Bivalve seaweed, scallop, fennel, turmo, swordfish, linehead, squirrel, swordfish, swordfish, swordfish, oni kelp, gohei kelp, naga kelp, peas, scutellaria, trolocum, squirrel, swordfish
Kurome, Kikuishi kelp, Twisted kelp, Kuroshiome,
Nekoshikambu, Alame, Ainu-Wakame, Chigaiso, Ezoishige, Yabanemoku, Rapamoku, Uganomok, Jiromoku, Hiemoku, Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Hondawara, Nejimoku, Narakumo, Makuomurata , Tomomoku, Yolemoku, Sawtoothed Moku, Obanokotoyokumoku,
Brown algae such as Sugimoku, Ouukimo, Buruukimo, Kayamonori and ox kenori, Funori no moss, Asakusanori,
Susabinori, Uppluinori, Onimanori, Tasa, Filitasa, Benitasa, Milnoveni, Akebonomozuku, Haikonahada, Yogorekonahada, Aokonahada, Umizoumen, Tsukumonori, Kamogashiranori, Benimozoku, Hosobenomizugaku, Hosobenimosuganoカ, Etsuki Iwanokawa, Kinokawa, Kaninote, San Moss, centipede, sujikade, katanori, hiramukade, kyonohimo, sakuranori, nikumukade, tambanori, tsurutsuru, nurakusa, kuronurakusa, giant cadenoli, hirakintoki, matabo, chabokintoki, kintoki, matsunori, komatsuenotori, komeonotorito )
Kikagenot, Usuginu, Nikuhonoo, Venice Nago,
Susukubebeni, Yamadakusa, Mirin, Hosobamilin, Kikutosaka, Ezonameshi, Isomoka, Yukari, Hosoyukari, Ibaranori, Saidaibara, Tachiibara, Kagiibaranori, Kijinooo, Isodantsuu, Atsubanori, Ogonori, Tsurugiramo, Shiramo, Oomoriogino, Shiramo, Omoogino , Namiiwatake, Spongeweed, Giant squirrel, Itanigusa, Saimi, Harigane, Lotus jigsaw, Ikanoashi, Hosoibonori, Nobonori, Kurohaginnansou, Akabaginnansou, Hishibukuro, Togemadara, Echimadara,
Taogirisou, Hanasakura, Swordfish, Sujikonori, Hananoeda, Hiratagoat, Duls, Masagoshibari, Anadarus, Uebagsa, Benifukuronori, Fushitsunagi, Himefushitsunagi, Kurohafushinagi, Hirakusanagisugi, Osubaisagigi Saeda, Chile maple, Habutaenori, Konohanori,
Suzushironori, Usveni, Hasujiginu, Nagakonohanori, Suzuginu, Atubasuginu, Kagiusbanori, Yaleusbanori, Sujiusbanori, Hyusbanori, Usvanorimodoki, Ayanishiki, Ayaginu, Enashidajia, Isohagigi, Shimogana, Shimogana Moss, moss willow, sasabayanaginori, kurozozo, kobusozo, hanesozo, sozonohana, hanegusa, kehanegusa, kozanemo, isomurasaki, hosokozanemo, himegoke, kurohimegoke, kikuhiodoshi, shirobushi, suzukigashi, suzukigashi, suzukigashio Aokawa Mozuku, Himekawa Mozuku, Ide Yugogome, Okichimo Red algae such as cucumbers, chinorimo, chisinori, and other algae and cockscomb extracts represented by yellow algae such as red algae such as shajikumo, shiratamamo, hossiturimo, rikunotanusu, himejirasamomo, chabosurasomo, tripella, and yellowfin algae, Bovine / human placenta extract, swine / cow stomach, duodenum or intestine extract or its decomposed product, swine / cow spleen extract or its decomposed product, swine / cow brain tissue extract, water soluble Collagen, collagen derivatives such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its degradation products or their derivatives, silk protein and its degradation products or their derivatives, Bovine blood cell digest (globin peptide),
Porcine and bovine hemoglobin degradation products (hemin, hematin, heme,
Materials derived from animal sources such as protoheme, heme iron), milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components and fish meat decomposition products The processing is carried out in a conventional manner according to the product type and form to be added (for example, grinding, milling, washing, hydrolysis, fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powdering, Granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. may be arbitrarily selected and combined), and any of various materials may be selected and provided.

The solvent to be used for the extraction may be selected in consideration of the processing to be performed later, but usually, water or a water-soluble organic solvent (eg, ethanol, propylene glycol, 1,3-butylene) is used. Glycol or the like), and it is desirable to use one or a mixture of two or more selected from among the above. However, when the content of the organic solvent is not preferable depending on the use, water alone may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary liquid mixture with water.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, cooling agents, stabilizing agents, emulsifiers, animal and plant proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and anti-allergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral agents, deodorants / deodorants, bitters, enzymes, and the like are listed, and when used in combination therewith, various additive and synergistic effects can be expected.

[0040]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described with reference to examples, but the present invention is not limited to the examples. Production Example 1 Dried plantain was pulverized, 10 g of the dried plantain was immersed in 100 mL of water, and extracted at 60 ° C. for 24 hours. The precipitate is centrifuged (1
(0000G, 10 minutes), and then filtered to obtain a light brown clear psyllium extract.

Production Example 2 The psyllium extract obtained in Production Example 1 was freeze-dried in vacuum to obtain a freeze-dried powder of the psyllium extract.

Production Example 3 Dried plantain was pulverized, and 10 g of the dried plantain was immersed in 100 mL of a 50% aqueous ethanol solution and extracted at 60 ° C. for 24 hours.
The precipitate was centrifuged (10000 G, 10 minutes) and then filtered to obtain a light brown clear psyllium extract.

Production Example 4 Dried plantain was pulverized and 10 g of ethanol
and extracted at 60 ° C. for 24 hours. The precipitate was centrifuged (10000 G, 10 minutes) and then filtered to obtain a light brown clear psyllium extract.

Production Example 5 Dried psyllium was crushed, and 10 g of the dried psyllium was immersed in 100 mL of a 20% aqueous 1,3-butylene glycol solution.
Extracted for 4 hours. The precipitate is centrifuged (10000 G, 1
After 0 min), the mixture was filtered to obtain a light brown clear psyllium extract.

Production Example 6 Dried plantain was pulverized, and 10 g of the dried plantain was immersed in 100 mL of 1,3-butylene glycol and extracted at 60 ° C. for 24 hours. The precipitate was centrifuged (10000 G, 10 minutes) and then filtered to obtain a light brown clear psyllium extract.

Example 1 <Antioxidant Action> The freeze-dried powder of the psyllium extract prepared in Production Example 2 was subjected to 100 pp using a 50% aqueous ethanol solution.
Sample solutions of m and 500 ppm were prepared. Reaction indicator (800 μmol-DPPH 12 mL, 400 mM
MES Buffer 12mL, 24m ethanol
L) Dispense 0.9 mL into a test tube, and add (300-a) μL of a 50% aqueous ethanol solution. AμL of sample 30
In addition to mixing every second, vortex mixer,
After 20 minutes, the absorbance at 520 nm was measured. a = 0,
The volume was 30, 60, 120, 180, 240 μL. As a control, a freeze-dried powder of tea extract prepared in the same manner as in Production Example 2 was used. The results are shown in FIG. As is clear from FIG. 1, a high antioxidant activity was observed in the psyllium extract.

Example 2 <Anti-mutagenic effect> 100 μL of Trp-
A P2 solution (μg / mL DMSO), 100 μL of the psyllium extract prepared in Production Example 1, and 600 μL of a 0.1 M phosphate buffer (pH 7.0) were dispensed. In addition, 100
μL of S-9 Mix was dispensed and mixed. 100 μL of TA98 strain solution (2 × 10 ⁹ / mL) was added, and the mixture was mixed at 37 ° C.
For 20 minutes. 2 mL of top agar was added and plated on a minimal glucose agar plate. 3
After culturing at 7 ° C. for 48 hours, the number of histidine non-requiring colonies that grew was counted. Antimutagenicity (%) was calculated using the following formula. The antimutagenicity obtained by the formula was 88.2%, and it was clearly confirmed that the psyllium extract had a high antimutagenic effect.

(Equation 1)

A: Number of colonies when sample and Trp-P2 were added B: Number of colonies when only sample was added C: Number of colonies when Trp-P2 was added D: Number of colonies without addition

Example 3 <Anti-inflammatory activity> The lyophilized powder of psyllium extract prepared in Production Example 1 was used in an acetate buffer at 1%, 0.1%, 0.1% and 0.1%.
It was adjusted to 01% and used as a test solution. 0.2 mL of each of a 1% and 0.1% solution was added to 0.1 mL of the hyaluronidase solution (330 units / mL), and the mixture was incubated at 37 ° C. for 20 minutes. Furthermore, an enzyme activity solution (2.5 mM C
aCl ₂ .2H ₂ O) at 37 ° C.
After incubating for 0.5 min, 0.5 mL of a 0.08% hyaluronic acid solution was added, and the temperature was kept constant for exactly 40 min.
Enzyme activity was measured by the Morgan-Elson method.
That is, 0.1 mL of 0.4N NaOH was added to the reaction sample.
Was added to stop the reaction, and then the potassium borate solution was added.
One mL was added and heated in a boiling water bath for 3 minutes. After cooling with running water, p-dimethylaminobenzaldehyde solution 3m
L was added thereto, stirred well, and reacted at 37 ° C. for exactly 20 minutes. The absorbance (OD [S]) was measured at 585 nm.
The hyaluronidase activity inhibition rate was calculated using the following equation.

(Equation 2)

OD [C]: Absorbance of a solution similarly operated using a buffer instead of a test solution OD [B]: Absorbance of a solution similarly operated using a buffer instead of an enzyme solution Absorbance OD [T]: Absorbance of a solution that was similarly operated using a buffer instead of a hyaluronic acid solution

FIG. 2 shows the results. As is clear from FIG. 2, the psyllium extract showed strong hyaluronidase inhibitory activity. Hyaluronidase, which is activated during inflammation as a result of a series of inflammatory reactions, is thought to play a role in destroying the matrix of connective tissue and increasing the permeability of inflammatory cells, thus significantly inhibiting this enzyme. It has been found that the psyllium extract having the effect of reducing odor has a strong anti-inflammatory effect.

Example 4 <Anti-allergic action> IgE was added to mouse mast cells (MC / 9) adjusted to 2 × 10 ⁶ cells / mL in an amount of 0.5%.
μg / mL and sens overnight in the incubator
It was done. The cells are washed twice with PBS and
Adjust to 1 × 10 ⁷ cells / mL with de
Dispense 0 μL each into a sterile eppen tube, add 12.5 μL each of the psyllium extract prepared in Example 1, and add
The mixture was incubated in a constant temperature bath at 7 ° C for 10 minutes. Next, 1
After adding 7.5 μL of the mM DNP-HSA solution and incubating for another 20 minutes, 10 μL of 4 mM EDTA was added.
Immediately after adding the added Tyrode reagent, the mixture was transferred to ice.
After 10 minutes, centrifugation (4 ° C., 15,000 rpm × 5)
Min), collect the supernatant, add an equal volume of 0.1N HCl and add HPLC (column: ODP-50, eluent: 1 mM)
The sample was tested in o-phthalaldehyde / 1 mM N-acetylcysteine / 12% acetonitrile / sodium tetraborate solution (pH 9.5). Azeptin (100 ng /
mL) was used as a positive control.

FIG. 3 shows the results. Relative histamine release (%) was expressed as a ratio using the amount of histamine released when no sample was added as a control. As is clear from FIG. 3, the psyllium extract exhibited an antiallergic effect comparable to that of a commercially available antiallergic agent.

Example 5 <Production of lotion> According to the formulation shown in Table 1, (1) to (1)
0) was stirred and dissolved to produce a lotion. Each of the obtained lotions was stable at 40 ° C. and RH 75% for three months.

[Table 1]

A sensory test was conducted by 10 expert panelists. For the evaluation, the following items were evaluated on a 5-point scale. (1) Skin moistness 1. Be bulky. 2. Slightly soft. Normal 4. 4. Slightly moist. Moist

(2) Skin smoothness It is rough 2. Somewhat rough 3. Normal 4. Somewhat smooth 5. Smooth

(3) Sticky skin 1. Sticky 2. Slightly sticky Normal 4. Slightly refreshing 5. Table 2 shows the average of the scores of 10 panelists. As is clear from Table 2, the product of Example 4 in which the psyllium extract was blended exhibited better moisture retention and skin smoothness than the product of Comparative Example 1 in which the psyllium extract was not blended.

[Table 2]

Example 6 <Production of shampoo> According to the formulation shown in Table 3, (1) to
(4), (6) to (8) were mixed and stirred at 70 ° C.
After cooling, (5) was added and mixed and stirred to obtain a shampoo. When the hair was washed using the obtained product, the feel of the hair was smooth and the hair was moisturized.

[Table 3]

Example 7 <Preparation of cream> According to the formulation shown in Table 4, (1) to
(7) was mixed and stirred at 80 ° C., and then separately (8) and (1).
A mixture obtained by mixing and stirring 0) and (11) at 80 ° C. was added, and the mixture was homogenized and cooled to 30 ° C. while stirring.
Was further added and mixed and stirred to produce a cream. The obtained product was not sticky during use and moisturized the skin.

[Table 4]

Example 8 <Production of body gel> According to the formulation shown in Table 5, (1)
(8) was mixed and stirred at 80 ° C. to obtain a body gel agent. The obtained product was not sticky during use and moisturized the skin.

[Table 5]

Example 9 <Production of Hair Pack> According to the formulation shown in Table 6, (1) to
(2) was mixed and stirred at 80 ° C, and (3) to
The mixture obtained by mixing and stirring (13) at 80 ° C was added, and while mixing and stirring at 80 ° C, (14) and (15) were further added and mixed and stirred to obtain a hair pack agent. When hair treatment was performed using the obtained product, the feel of the hair was smooth and the hair was moisturized.

[Table 6]

[0062]

The extract obtained from psyllium according to the present invention has a remarkable antioxidant action, anti-mutagenic action, anti-inflammatory action, anti-allergic action and moisturizing action. Therefore, a great effect is brought about by containing the psyllium extract of the present invention in a cosmetic. In other fields of use, it can be used as an external preparation for pharmaceuticals, quasi-drugs, cosmetics, and the like.

[Brief description of the drawings]

FIG. 1 shows antioxidant activity.

FIG. 2 is a view showing a hyaluronidase inhibitory activity.

FIG. 3 shows antiallergic activity.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 35/78 A61K 35/78 C A61P 17/16 A61P 17/16 29/00 29/00 37/08 37 / 08 39/00 39/00 39/06 39/06 F term (reference) 4C083 AA111 AA112 AB442 AC022 AC072 AC102 AC122 AC182 AC352 AC422 AC432 AC482 AC642 AC712 AC782 AD042 AD202 AD322 AD352 AD442 AD512 CC01 CC04 CC05 CC23 CC38 DD23 DD27 DD31 DD41 EE06 EE12 EE13 4C088 AB22 AC03 AC04 AC05 AC11 CA03 MA63 NA14 ZA89 ZB11 ZB13 ZC21

Claims (6)

[Claims] 1. A cosmetic comprising a plantain extract. 2. The cosmetic according to claim 1, wherein the psyllium extract is blended as an antioxidant. 3. The cosmetic according to claim 1, wherein the psyllium extract is blended as an anti-mutagenic substance. 4. The cosmetic according to claim 1, wherein the psyllium extract is blended as an anti-inflammatory agent. 5. The cosmetic according to claim 1, wherein the psyllium extract is blended as an antiallergic agent. 6. The cosmetic according to claim 1, wherein the psyllium extract is blended as a humectant.