JP2002128796A5 - - Google Patents

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Publication number
JP2002128796A5
JP2002128796A5 JP2000324030A JP2000324030A JP2002128796A5 JP 2002128796 A5 JP2002128796 A5 JP 2002128796A5 JP 2000324030 A JP2000324030 A JP 2000324030A JP 2000324030 A JP2000324030 A JP 2000324030A JP 2002128796 A5 JP2002128796 A5 JP 2002128796A5
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JP
Japan
Prior art keywords
serum albumin
human serum
yeast
hsa
bacillus subtilis
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JP2000324030A
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English (en)
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JP2002128796A (ja
JP4798833B2 (ja
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Priority claimed from JP2000324030A external-priority patent/JP4798833B2/ja
Priority to JP2000324030A priority Critical patent/JP4798833B2/ja
Priority to DK01978883T priority patent/DK1329462T3/da
Priority to KR1020027008242A priority patent/KR100839937B1/ko
Priority to CNB018056466A priority patent/CN1313493C/zh
Priority to CA2395590A priority patent/CA2395590C/en
Priority to PCT/JP2001/009336 priority patent/WO2002034787A1/ja
Priority to ES01978883T priority patent/ES2272548T3/es
Priority to EP01978883A priority patent/EP1329462B1/en
Priority to AU10936/02A priority patent/AU783638B2/en
Priority to AT01978883T priority patent/ATE348111T1/de
Priority to DE60125218T priority patent/DE60125218T2/de
Publication of JP2002128796A publication Critical patent/JP2002128796A/ja
Priority to US10/175,103 priority patent/US6908749B2/en
Publication of JP2002128796A5 publication Critical patent/JP2002128796A5/ja
Publication of JP4798833B2 publication Critical patent/JP4798833B2/ja
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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従来、ＨＳＡは、ヒト血漿からコーンの低温エタノール分画法あるいは該方法に準じて、ＨＳＡ画分（ＨＳＡは画分Vに分画される）を得た後、更に、種々の精製方法を駆使して製造されている。また近年、原料をヒト血漿に依存しない方法として、遺伝子組換え技術を応用して酵母や大腸菌、枯草菌にヒト血清アルブミンを生産させる技術が開発されている。酵母については、(1) Production of Recombinant Human Serum Albumin from Saccharomyces cerevisiae; Quirk, R. et. al, Biotechnology and Applied Biochemistry 11, 273-287(1989)、(2) Secretory Expression of the Human Serum Albumin Gene in the Yeast, Saccharomyces cerevisiae; Ken. Okabayashi et.al, J. Biochemistry, 110, 103-110 (1991)、(3)Yeast Systems for the Commercial Production of Heterologous Proteins; Richard G. Buckholz and Martin A. G. Gleeson, Bio/Technology 9, 1067-1072(1991)、大腸菌については(4) Construction of DNA sequences and their use for microbial production of proteins, in particular human serum albumin; Lawn, R. M., European Patent Appl. 73,646 (1983)、(5) Synthesis and Purification of mature human serum albumin from E. coli; Latta, L. et. al. Biotechnique 5, 1309-1314 (1987)、枯草菌については(6) Secretion of human serum albumin from Bacillus subtilis; Saunders, C. W. et. al, J. Bacteriol. 169, 2917-2925 (1987)参照。
JP2000324030A 2000-10-24 2000-10-24 加熱処理工程を含むヒト血清アルブミンの製造方法 Expired - Fee Related JP4798833B2 (ja)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP2000324030A JP4798833B2 (ja) 2000-10-24 2000-10-24 加熱処理工程を含むヒト血清アルブミンの製造方法
AU10936/02A AU783638B2 (en) 2000-10-24 2001-10-24 Method of producing human serum albumin involving heating step
DE60125218T DE60125218T2 (de) 2000-10-24 2001-10-24 Verfahren zur herstellung von humanen serumalbumin unter einbeziehen eines erwärmungsschrittes
CNB018056466A CN1313493C (zh) 2000-10-24 2001-10-24 包括加热处理步骤的人血清白蛋白的制造方法
CA2395590A CA2395590C (en) 2000-10-24 2001-10-24 Method of producing human serum albumin involving heating step
PCT/JP2001/009336 WO2002034787A1 (fr) 2000-10-24 2001-10-24 Procede d"elaboration d"albumine de serum d"origine humaine comportant une etape de chauffage
ES01978883T ES2272548T3 (es) 2000-10-24 2001-10-24 Metodo para producir albumina de suero humano que implica un etapa de tratamiento con calor.
EP01978883A EP1329462B1 (en) 2000-10-24 2001-10-24 Method of producing human serum albumin involving heating step
DK01978883T DK1329462T3 (da) 2000-10-24 2001-10-24 Fremgangsmåde til fremstilling af human serumalbumin, som inddrager opvarmningstrin
AT01978883T ATE348111T1 (de) 2000-10-24 2001-10-24 Verfahren zur herstellung von humanem serumalbumin unter verwendung eines aufwarmschrittes
KR1020027008242A KR100839937B1 (ko) 2000-10-24 2001-10-24 가열처리 공정을 포함하는 인체 혈청알부민의 제조방법
US10/175,103 US6908749B2 (en) 2000-10-24 2002-06-20 Method for preparing human serum albumin containing heat-treatment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000324030A JP4798833B2 (ja) 2000-10-24 2000-10-24 加熱処理工程を含むヒト血清アルブミンの製造方法

Publications (3)

Publication Number Publication Date
JP2002128796A JP2002128796A (ja) 2002-05-09
JP2002128796A5 true JP2002128796A5 (ja) 2007-12-06
JP4798833B2 JP4798833B2 (ja) 2011-10-19

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ID=18801621

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000324030A Expired - Fee Related JP4798833B2 (ja) 2000-10-24 2000-10-24 加熱処理工程を含むヒト血清アルブミンの製造方法

Country Status (12)

Country Link
US (1) US6908749B2 (ja)
EP (1) EP1329462B1 (ja)
JP (1) JP4798833B2 (ja)
KR (1) KR100839937B1 (ja)
CN (1) CN1313493C (ja)
AT (1) ATE348111T1 (ja)
AU (1) AU783638B2 (ja)
CA (1) CA2395590C (ja)
DE (1) DE60125218T2 (ja)
DK (1) DK1329462T3 (ja)
ES (1) ES2272548T3 (ja)
WO (1) WO2002034787A1 (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE331735T1 (de) * 2000-10-24 2006-07-15 Chemo Sero Therapeut Res Inst Verfahren zur monomerisierung von humanen serumalbumin-polymeren
ATE382057T1 (de) 2001-06-28 2008-01-15 Novo Nordisk As Stabile formulierung von modifiziertem glp-1
AU2003281982A1 (en) * 2002-11-26 2004-06-18 Novo Nordisk A/S Process for purifying a fermentation-derived product
GB0305989D0 (en) * 2003-03-15 2003-04-23 Delta Biotechnology Ltd Agent
BRPI0410972C1 (pt) 2003-06-03 2021-05-25 Novo Nordisk As método para aumentar a vida de armazenagem de uma composição farmacêutica, composição farmacêutica, e, método para tratamento de hiperglicemia
JP2007524592A (ja) 2003-06-03 2007-08-30 ノボ・ノルデイスク・エー／エス 安定化された薬学的ペプチド組成物
DK1687019T3 (en) 2003-11-20 2018-02-12 Novo Nordisk As Propylene glycol peptide formulations that are optimal for production and use in injection devices
WO2005068489A1 (ja) * 2004-01-20 2005-07-28 Juridical Foundation The Chemo-Sero Therapeutic Research Institute ２価陽イオン存在下加熱処理によるヒト血清アルブミンの製造方法
PL1789434T3 (pl) 2004-08-31 2014-07-31 Novo Nordisk As Zastosowanie tris(hydroksymetylo)aminometanu do stabilizacji peptydów, polipeptydów i białek
BRPI0517341A (pt) 2004-11-12 2008-10-07 Novo Nordisk As composição farmacêutica estável em prateleira, métodos para a preparação de uma composição farmacêutica, para o tratamento de hiperglicemia, para o tratamento de obesidade, deficiência de célula beta, igt ou dislipidemia, para a preparação de uma solução estável de um composto glp-1, para a preparação de um composto glp-1 estável e para a preparação de uma composição farmacêutica estável em prateleira de um composto glp-1, solução estável de um composto glp-1, e, uso de uma solução estável de um composto glp-1
EP1966239A1 (de) 2005-12-22 2008-09-10 CSL Behring GmbH Oktanoatreduziertes human albumin
JP4936272B2 (ja) * 2006-02-13 2012-05-23 独立行政法人科学技術振興機構 バイオナノカプセルの効率的な精製法
EP2170356A1 (en) * 2007-06-25 2010-04-07 Fred Hutchinson Cancer Research Center Methods and compositions regarding polychalcogenide compositions
DK3429345T3 (da) 2016-10-04 2019-11-25 Albumedix Ltd Anvendelser af rekombinant gær-afledt serumalbumin
CN106749623B (zh) * 2016-12-09 2020-04-10 浙江大学 一种基于混合模式的扩张床吸附分离人血白蛋白方法
PL3474820T3 (pl) 2017-08-24 2024-05-13 Novo Nordisk A/S Kompozycje glp-1 i ich zastosowania
EP4069200A1 (en) 2019-12-04 2022-10-12 Albumedix Ltd Methods and compositions produced thereby
KR20220143037A (ko) 2020-02-18 2022-10-24 노보 노르디스크 에이/에스 Glp-1 조성물 및 이의 용도
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5071897A (ja) * 1973-11-07 1975-06-14
US4025500A (en) * 1974-06-06 1977-05-24 Baxter Laboratories, Inc. Preparation of albumin by fractionation of blood plasma or serum
IL66614A (en) 1981-08-28 1985-09-29 Genentech Inc Method of constructing a dna sequence encoding a polypeptide,microbial production of human serum albumin,and pharmaceutical compositions comprising it
US5004688A (en) * 1988-04-15 1991-04-02 Phillips Petroleum Company Purification of hepatitis proteins
JP2926722B2 (ja) 1988-10-20 1999-07-28 吉富製薬株式会社 アルブミン製剤及びその製造方法
JPH0768137B2 (ja) * 1989-06-15 1995-07-26 株式会社ミドリ十字 アルブミン製剤及びその製法
JPH0671434B2 (ja) * 1989-09-18 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法
JPH04234326A (ja) * 1990-12-27 1992-08-24 Green Cross Corp:The アルブミン製剤及びその製法
JPH0671434A (ja) 1991-05-30 1994-03-15 Tadahiro Omi クリーンチャンバーの溶接方法
US5521287A (en) * 1992-05-20 1996-05-28 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
US5440018A (en) * 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
JP3269504B2 (ja) * 1992-07-08 2002-03-25 三菱ウェルファーマ株式会社 ヒト血清アルブミンの製造方法
US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
JPH07126182A (ja) * 1993-10-27 1995-05-16 Green Cross Corp:The 組換えヒト血清アルブミン製剤の滅菌方法
JP3840674B2 (ja) * 1994-08-31 2006-11-01 三菱ウェルファーマ株式会社 遺伝子操作に由来するヒト血清アルブミンの精製方法
WO1998007873A1 (fr) * 1996-08-23 1998-02-26 Kirin Beer Kabushiki Kaisha Vecteurs de levure et procede de production de proteines les utilisant
JP2885212B2 (ja) * 1997-01-06 1999-04-19 吉富製薬株式会社 遺伝子操作由来のヒト血清アルブミンより得られる高純度ヒト血清アルブミン含有組成物

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