JP2001527558A5 - - Google Patents
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- JP2001527558A5 JP2001527558A5 JP1998549339A JP54933998A JP2001527558A5 JP 2001527558 A5 JP2001527558 A5 JP 2001527558A5 JP 1998549339 A JP1998549339 A JP 1998549339A JP 54933998 A JP54933998 A JP 54933998A JP 2001527558 A5 JP2001527558 A5 JP 2001527558A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/857,007 | 1997-05-15 | ||
| US08/857,007 US5910403A (en) | 1997-05-15 | 1997-05-15 | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
| PCT/US1998/009479 WO1998051820A1 (en) | 1997-05-15 | 1998-05-08 | METHODS FOR MEASURING CELLULAR PROLIFERATION AND DESTRUCTION RATES IN VITRO AND $i(IN VIVO) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001527558A JP2001527558A (ja) | 2001-12-25 |
| JP2001527558A5 true JP2001527558A5 (enExample) | 2005-12-02 |
| JP4510942B2 JP4510942B2 (ja) | 2010-07-28 |
Family
ID=25324953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54933998A Expired - Lifetime JP4510942B2 (ja) | 1997-05-15 | 1998-05-08 | in vitro及びin vivoで細胞増殖速度及び分解速度を測定するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US5910403A (enExample) |
| EP (1) | EP0980441B1 (enExample) |
| JP (1) | JP4510942B2 (enExample) |
| AT (1) | ATE359375T1 (enExample) |
| AU (1) | AU737119B2 (enExample) |
| CA (1) | CA2287781C (enExample) |
| DE (1) | DE69837537T2 (enExample) |
| DK (1) | DK0980441T3 (enExample) |
| WO (1) | WO1998051820A1 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002505737A (ja) | 1997-02-14 | 2002-02-19 | ジョージワシントン大学 | Dna合成速度測定のための分析 |
| US5910403A (en) * | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
| JP2002523114A (ja) * | 1998-08-31 | 2002-07-30 | ユニバーシテイ オブ ワシントン | バイオポリマーの分析のための安定なアイソトープ代謝性ラベリング |
| US6764817B1 (en) * | 1999-04-20 | 2004-07-20 | Target Discovery, Inc. | Methods for conducting metabolic analyses |
| IL146093A0 (en) | 1999-04-20 | 2002-07-25 | Target Discovery Inc | Method of separating a polypeptide or protein from a solution containing a plurality thereof |
| US7541184B2 (en) * | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US8278034B2 (en) | 2000-06-22 | 2012-10-02 | Nuclea Biotechnologies, Inc. | Methods of making frozen tissue microarrays |
| US20020090652A1 (en) * | 2000-12-22 | 2002-07-11 | Fu Emil Wei-Ming | Inverse labeling method for the rapid identification of marker/target proteins |
| WO2002080852A2 (en) * | 2001-04-04 | 2002-10-17 | Digital Gene Technologies, Inc. | Genes expressed in intestinal epithelium and peyer's patch m cells |
| US7256047B2 (en) * | 2001-05-01 | 2007-08-14 | Board Of Regents, The University Of Texas System | Measurement of gluconeogenesis and intermediary metabolism using stable isotopes |
| CA2455793A1 (en) * | 2001-07-25 | 2003-02-27 | University Of North Carolina At Chapel Hill | Method and apparatus for rapid determination of ligand-protein binding using charcoal adsorption |
| US20030077572A1 (en) * | 2001-10-11 | 2003-04-24 | Abramson Fred P. | Quantitative differential display using isotope ratio monitoring |
| IL161498A0 (en) * | 2001-10-24 | 2004-09-27 | Univ California | Measurement of protein synthesis rates in humans and experimental system by use of isotopically labeled water |
| US7449171B2 (en) * | 2002-02-12 | 2008-11-11 | The Regents Of The University Of California | Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, by label incorporation into metabolic derivatives and catabolic products |
| US20030180800A1 (en) * | 2002-03-22 | 2003-09-25 | Lee Wai-Nang Paul | Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development |
| AU2003234688A1 (en) * | 2002-04-05 | 2003-10-27 | The Regents Of The University Of California | Method for isolating and measuring proliferation of long-term label retaining cells and stem cells |
| US20050084967A1 (en) * | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| US20040175373A1 (en) * | 2002-06-28 | 2004-09-09 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| AU2003253684A1 (en) * | 2002-06-28 | 2004-01-19 | Xcyte Therapies, Inc. | Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| EP1546364A4 (en) | 2002-07-30 | 2006-09-06 | Univ California | METHOD FOR THE AUTOMATIC MEASUREMENT OF THE MOLECULAR FLOW RATE SPEED OF THE PROTEOM OR ORGANOMA BY MEANS OF MASS SPECTROMETRY |
| DE20211783U1 (de) * | 2002-07-31 | 2002-11-07 | Fa. Hermann Heye i.Ins., 31683 Obernkirchen | Pressstempelmechanismus einer Glasformmaschine |
| JP2005537490A (ja) * | 2002-09-03 | 2005-12-08 | ニューロノバ エービー | 生体分子、細胞、組織、器官および生物体の逆算的な、誕生齢決定のための方法 |
| US20060105339A1 (en) * | 2002-09-04 | 2006-05-18 | Marc Hellerstein | Methods for measuring the rates of replication and death of microbial infectious agents in an infected |
| AU2003267283B2 (en) * | 2002-09-13 | 2009-09-03 | The Regents Of The University Of California | Methods for measuring rates of reserve cholesterol transport in vivo, as an index of anti-atherogenesis |
| EP1545628A4 (en) * | 2002-09-16 | 2010-07-28 | Univ California | BIOCHEMICAL METHOD FOR MEASURING THE METABOLIC FITNESS OF WOVEN OR THE WHOLE ORGANISM |
| US20070248540A1 (en) * | 2002-09-16 | 2007-10-25 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
| WO2004042360A2 (en) * | 2002-11-04 | 2004-05-21 | The Regents Of The Univeristy Of California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
| US7262020B2 (en) * | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
| US20050202406A1 (en) * | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
| TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
| US20050201937A1 (en) * | 2004-03-11 | 2005-09-15 | The Regents Of The University Of California | Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients |
| WO2005094327A2 (en) * | 2004-03-29 | 2005-10-13 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
| WO2005098024A1 (en) * | 2004-03-30 | 2005-10-20 | Kinemed, Inc. | In vivo measurement of the relative fluxes through ribonucleotide reductase vs. deoxyribonucleoside pathways using isotopes |
| US20100092962A1 (en) * | 2004-07-07 | 2010-04-15 | Alexandre Loktionov | Method of Detecting Colorectal Cancer |
| JP2008519261A (ja) * | 2004-10-29 | 2008-06-05 | ターゲット ディスカバリー インク. | 重水素化グルコースを用いたグリカン分析 |
| JP4118918B2 (ja) * | 2005-02-28 | 2008-07-16 | シャープ株式会社 | 信号品質評価装置、情報記録再生装置、信号品質評価方法、記録条件決定方法、信号品質評価プログラム、信号品質評価プログラムを記録したコンピュータ読み取り可能な記録媒体 |
| US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
| TW200711660A (en) | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
| JP2009506789A (ja) * | 2005-09-06 | 2009-02-19 | キナメッド・インコーポレイテッド | リンパ組織におけるリンパ増殖、クローン拡大、動員および輸送ならびにそれらに対する抗原および調整剤のインビボ作用を定量するためのキネティックバイオマーカー |
| US8150628B2 (en) * | 2005-12-30 | 2012-04-03 | The Invention Science Fund I, Llc | Establishing a biological recording timeline by artificial marking |
| US20070156347A1 (en) * | 2005-12-30 | 2007-07-05 | Searete Llc | Using a biological recording to obtain time values |
| US20070156345A1 (en) * | 2005-12-30 | 2007-07-05 | Hyde Roderick A | Modulating a biological recording with another biological recording |
| CA2725138A1 (en) | 2008-05-21 | 2009-11-26 | Kinemed, Inc. | Compositions and methods of treatment using modulators of motoneuron diseases |
| EP2753707A4 (en) | 2011-09-08 | 2015-03-04 | Univ California | METABOLIC FLOW MEASUREMENT, IMAGING AND MICROSCOPY |
| ES2668678T3 (es) | 2011-12-07 | 2018-05-21 | Glaxosmithkline Llc | Procedimiento de determinación de la masa muscular esquelética corporal total |
| KR102172971B1 (ko) * | 2012-10-25 | 2020-11-03 | 런 뎀 스위트, 엘엘씨 | 인간과 환자의 영양 요구를 측정, 평가하고 그 영양 요구의 충족을 돕는 방법 및 시스템 |
| US9500657B2 (en) | 2012-10-25 | 2016-11-22 | Run Them Sweet Llc | Formulations containing labels for medical diagnostics |
| US9134319B2 (en) | 2013-03-15 | 2015-09-15 | The Regents Of The University Of California | Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo |
| EP2972329A2 (en) | 2013-03-15 | 2016-01-20 | Kinemed, Inc. | Biomarkers |
| US9883524B2 (en) * | 2015-11-04 | 2018-01-30 | Huawei Technologies Co., Ltd. | Systems and methods for configuring air interfaces with low overhead |
| CN111239353A (zh) * | 2020-01-19 | 2020-06-05 | 辉源生物科技(上海)有限公司 | 一种人源柠檬酸转运蛋白抑制剂化合物的筛选方法 |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4065552A (en) * | 1975-05-05 | 1977-12-27 | Giovanni Giacomo Costa | Method of detecting malignant neoplasms |
| US4332784A (en) * | 1979-02-06 | 1982-06-01 | The Radiochemical Centre Limited | Dual isotope assays |
| US5317098A (en) * | 1986-03-17 | 1994-05-31 | Hiroaki Shizuya | Non-radioisotope tagging of fragments |
| DE3667103D1 (en) * | 1986-06-09 | 1989-12-28 | Bruker Analytische Messtechnik | Method for determining the turnover of organic material in living tissue and nmr spectrometer for performing this method |
| US4940658A (en) * | 1986-11-20 | 1990-07-10 | University Patents, Inc. | Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency |
| US5042488A (en) * | 1987-09-29 | 1991-08-27 | The Washington University | Methods employing deuterium for obtaining direct, observable deuterium magnetic resonance images in vivo and in situ |
| US6004781A (en) * | 1988-01-22 | 1999-12-21 | The General Hospital Corporation | Nucleic acid encoding Ig-CD4 fusion proteins |
| JPH04504049A (ja) * | 1989-03-20 | 1992-07-23 | アンティキャンサー インコーポレイテッド | インビトロにおける組織の生存能力及び増殖能力を測定する、自生状態法及びシステム |
| US5026909A (en) * | 1989-03-22 | 1991-06-25 | Zolotarev Jury A | Method for preparing biologically active organic compound labelled with hydrogen isotope |
| US5217903A (en) * | 1990-05-15 | 1993-06-08 | Trustees Of Boston University | Measuring connective tissue breakdown products in body fluids |
| CA2027714C (en) * | 1990-07-13 | 2003-01-28 | Kenneth W. Turtletaub | Method of measurement in biological systems |
| US5209919A (en) * | 1990-07-13 | 1993-05-11 | Regents Of The University Of California | Method of measurement in biological systems |
| US5597548A (en) * | 1990-07-18 | 1997-01-28 | Board Of Regents, The University Of Texas System | 13 C Isotopomer analyses in intact tissue using (13 C) homonuclear decoupling |
| US5394236A (en) * | 1992-02-03 | 1995-02-28 | Rutgers, The State University | Methods and apparatus for isotopic analysis |
| US5338686A (en) * | 1992-04-29 | 1994-08-16 | Hellerstein Marc K | Method for measuring in vivo synthesis of biopolymers |
| JP2960832B2 (ja) * | 1992-05-08 | 1999-10-12 | ペルマテック テクノロジー アクチェンゲゼルシャフト | エストラジオールの投与システム |
| US5366885A (en) * | 1992-06-09 | 1994-11-22 | Barranco Iii Sam C | Method and kit for testing tumors for drug sensitivity |
| US5506147A (en) * | 1993-04-15 | 1996-04-09 | Kolhouse; J. Fred | Non-invasive evaluation of maldigestion and malaborption |
| JP3152933B2 (ja) * | 1993-05-17 | 2001-04-03 | アマーシャム・インターナショナル・ピーエルシー | 細胞生化学プロセスを測定するための装置および方法 |
| US5439803A (en) * | 1993-08-13 | 1995-08-08 | The Regents Of The University Of Michigan | Isotope and assay for glycolysis and the pentose phosphate pathway |
| US5910403A (en) * | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
| US5961470A (en) | 1997-07-09 | 1999-10-05 | Wagner; David A. | Breath test for assessing hepatic function |
| US6461870B2 (en) | 1998-05-06 | 2002-10-08 | Isotechnika Inc. | 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control |
| CA2331812C (en) | 1998-05-06 | 2006-08-22 | Randall W. Yatscoff | 13c glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control |
| US6284219B1 (en) * | 1998-06-30 | 2001-09-04 | Phenome Sciences Inc. | In vivo determination of metabolic function for use in therapy management |
| US6625547B1 (en) * | 1998-08-05 | 2003-09-23 | Washington State University Research Foundation | Relative rates of cytochrome p450 metabolism |
| DE19839491A1 (de) * | 1998-08-29 | 2000-03-02 | Hermann Heumann | Verfahren zur Markierung von Biopolymeren mit Isotopen |
| JP2002523114A (ja) * | 1998-08-31 | 2002-07-30 | ユニバーシテイ オブ ワシントン | バイオポリマーの分析のための安定なアイソトープ代謝性ラベリング |
| US6887712B1 (en) * | 1998-11-09 | 2005-05-03 | Atherogenics, Inc. | Methods and compositions to lower plasma cholesterol levels |
| US6764817B1 (en) * | 1999-04-20 | 2004-07-20 | Target Discovery, Inc. | Methods for conducting metabolic analyses |
| US6653090B1 (en) | 1999-11-05 | 2003-11-25 | University Of Alberta | Methods for measuring the metabolism of and screening for drugs in isolated hearts |
| IL152620A (en) * | 2000-05-05 | 2010-05-17 | Purdue Research Foundation | Affinity selected signature peptides for protein identification and quantification |
| GB0106923D0 (en) | 2001-03-20 | 2001-05-09 | Univ Dundee | Liver function test |
| US7256047B2 (en) | 2001-05-01 | 2007-08-14 | Board Of Regents, The University Of Texas System | Measurement of gluconeogenesis and intermediary metabolism using stable isotopes |
| US20040253647A1 (en) | 2001-06-26 | 2004-12-16 | Mathews Paul M. | Cell-based high-throughput screening methods |
| IL161498A0 (en) * | 2001-10-24 | 2004-09-27 | Univ California | Measurement of protein synthesis rates in humans and experimental system by use of isotopically labeled water |
| US7449171B2 (en) | 2002-02-12 | 2008-11-11 | The Regents Of The University Of California | Measurement of biosynthesis and breakdown rates of biological molecules that are inaccessible or not easily accessible to direct sampling, non-invasively, by label incorporation into metabolic derivatives and catabolic products |
| US20030180710A1 (en) | 2002-03-22 | 2003-09-25 | Lee Wai-Nang Paul | Method of enhancing the efficiency of a pharmaceutical business |
| US20030180800A1 (en) | 2002-03-22 | 2003-09-25 | Lee Wai-Nang Paul | Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development |
| AU2003234688A1 (en) | 2002-04-05 | 2003-10-27 | The Regents Of The University Of California | Method for isolating and measuring proliferation of long-term label retaining cells and stem cells |
| WO2004003493A2 (en) | 2002-06-26 | 2004-01-08 | The Regents Of The University Of California | Methods and kits for determining energy expenditure in living organisms by metabolic water production |
| EP1546364A4 (en) * | 2002-07-30 | 2006-09-06 | Univ California | METHOD FOR THE AUTOMATIC MEASUREMENT OF THE MOLECULAR FLOW RATE SPEED OF THE PROTEOM OR ORGANOMA BY MEANS OF MASS SPECTROMETRY |
| US20060105339A1 (en) * | 2002-09-04 | 2006-05-18 | Marc Hellerstein | Methods for measuring the rates of replication and death of microbial infectious agents in an infected |
| AU2003267283B2 (en) * | 2002-09-13 | 2009-09-03 | The Regents Of The University Of California | Methods for measuring rates of reserve cholesterol transport in vivo, as an index of anti-atherogenesis |
| EP1545628A4 (en) | 2002-09-16 | 2010-07-28 | Univ California | BIOCHEMICAL METHOD FOR MEASURING THE METABOLIC FITNESS OF WOVEN OR THE WHOLE ORGANISM |
| WO2004042360A2 (en) | 2002-11-04 | 2004-05-21 | The Regents Of The Univeristy Of California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
| WO2005009597A2 (en) | 2003-07-03 | 2005-02-03 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
| US7262020B2 (en) | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
| US20050202406A1 (en) * | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
| TW200538738A (en) * | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
| US20050201937A1 (en) * | 2004-03-11 | 2005-09-15 | The Regents Of The University Of California | Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients |
| WO2005094327A2 (en) * | 2004-03-29 | 2005-10-13 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
| WO2005098024A1 (en) * | 2004-03-30 | 2005-10-20 | Kinemed, Inc. | In vivo measurement of the relative fluxes through ribonucleotide reductase vs. deoxyribonucleoside pathways using isotopes |
| US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
| TW200711660A (en) * | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
-
1997
- 1997-05-15 US US08/857,007 patent/US5910403A/en not_active Expired - Lifetime
-
1998
- 1998-05-08 AU AU73767/98A patent/AU737119B2/en not_active Expired
- 1998-05-08 US US09/075,309 patent/US6010846A/en not_active Expired - Lifetime
- 1998-05-08 CA CA002287781A patent/CA2287781C/en not_active Expired - Lifetime
- 1998-05-08 AT AT98921082T patent/ATE359375T1/de not_active IP Right Cessation
- 1998-05-08 EP EP98921082A patent/EP0980441B1/en not_active Expired - Lifetime
- 1998-05-08 JP JP54933998A patent/JP4510942B2/ja not_active Expired - Lifetime
- 1998-05-08 DK DK98921082T patent/DK0980441T3/da active
- 1998-05-08 WO PCT/US1998/009479 patent/WO1998051820A1/en not_active Ceased
- 1998-05-08 DE DE69837537T patent/DE69837537T2/de not_active Expired - Lifetime
-
1999
- 1999-11-15 US US09/440,596 patent/US6461806B1/en not_active Expired - Lifetime
-
2002
- 2002-05-24 US US10/155,536 patent/US6808875B2/en not_active Expired - Lifetime
-
2004
- 2004-09-16 US US10/944,154 patent/US7022834B2/en not_active Expired - Lifetime
-
2005
- 2005-07-19 US US11/185,610 patent/US20060008796A1/en not_active Abandoned