JP2001527558A5 - - Google Patents
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- JP2001527558A5 JP2001527558A5 JP1998549339A JP54933998A JP2001527558A5 JP 2001527558 A5 JP2001527558 A5 JP 2001527558A5 JP 1998549339 A JP1998549339 A JP 1998549339A JP 54933998 A JP54933998 A JP 54933998A JP 2001527558 A5 JP2001527558 A5 JP 2001527558A5
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Description
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/857,007 US5910403A (en) | 1997-05-15 | 1997-05-15 | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
US08/857,007 | 1997-05-15 | ||
PCT/US1998/009479 WO1998051820A1 (en) | 1997-05-15 | 1998-05-08 | METHODS FOR MEASURING CELLULAR PROLIFERATION AND DESTRUCTION RATES IN VITRO AND $i(IN VIVO) |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2001527558A JP2001527558A (ja) | 2001-12-25 |
JP2001527558A5 true JP2001527558A5 (ja) | 2005-12-02 |
JP4510942B2 JP4510942B2 (ja) | 2010-07-28 |
Family
ID=25324953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54933998A Expired - Lifetime JP4510942B2 (ja) | 1997-05-15 | 1998-05-08 | in vitro及びin vivoで細胞増殖速度及び分解速度を測定するための方法 |
Country Status (10)
Country | Link |
---|---|
US (6) | US5910403A (ja) |
EP (1) | EP0980441B1 (ja) |
JP (1) | JP4510942B2 (ja) |
AT (1) | ATE359375T1 (ja) |
AU (1) | AU737119B2 (ja) |
CA (1) | CA2287781C (ja) |
DE (1) | DE69837537T2 (ja) |
DK (1) | DK0980441T3 (ja) |
HK (1) | HK1026004A1 (ja) |
WO (1) | WO1998051820A1 (ja) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002505737A (ja) | 1997-02-14 | 2002-02-19 | ジョージワシントン大学 | Dna合成速度測定のための分析 |
US5910403A (en) * | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
US6653076B1 (en) * | 1998-08-31 | 2003-11-25 | The Regents Of The University Of Washington | Stable isotope metabolic labeling for analysis of biopolymers |
US6764817B1 (en) | 1999-04-20 | 2004-07-20 | Target Discovery, Inc. | Methods for conducting metabolic analyses |
JP4723725B2 (ja) | 1999-04-20 | 2011-07-13 | ターゲット ディスカバリー, インコーポレイテッド | 代謝経路を分析するための方法 |
US7541184B2 (en) * | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
EP1305595A2 (en) | 2000-06-22 | 2003-05-02 | Clinomics Laboratories, Inc. | Frozen tissue microarrays and methods for using the same |
US20020090652A1 (en) * | 2000-12-22 | 2002-07-11 | Fu Emil Wei-Ming | Inverse labeling method for the rapid identification of marker/target proteins |
EP1383929A4 (en) * | 2001-04-04 | 2006-06-07 | Neurome Inc | GENES EXPRESSED IN DARMEPITHELIAL CELLS AND PEYERS 'PATCH M-CELLS |
US7256047B2 (en) * | 2001-05-01 | 2007-08-14 | Board Of Regents, The University Of Texas System | Measurement of gluconeogenesis and intermediary metabolism using stable isotopes |
WO2003015871A2 (en) * | 2001-07-25 | 2003-02-27 | University Of North Carolina At Chapel Hill | Method and apparatus for rapid determination of ligand-protein binding using charcoal adsorption |
US20030077572A1 (en) * | 2001-10-11 | 2003-04-24 | Abramson Fred P. | Quantitative differential display using isotope ratio monitoring |
AU2002365268B2 (en) * | 2001-10-24 | 2008-02-28 | The Regents Of The University Of California | Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water |
JP2005517904A (ja) * | 2002-02-12 | 2005-06-16 | ザ リージェント オブ ザ ユニバーシティ オブ カリフォルニア | 標識取り込みにより生物学的分子の生合成の割合を測定する非侵襲性の方法 |
US20030180800A1 (en) * | 2002-03-22 | 2003-09-25 | Lee Wai-Nang Paul | Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development |
CA2503681A1 (en) * | 2002-04-05 | 2003-10-23 | Marc K. Hellerstein | Method for isolating and measuring proliferation of long-term label retaining cells and stem cells |
US20040151704A1 (en) * | 2002-06-28 | 2004-08-05 | Xcyte Therapies, Inc. | Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
US20040175373A1 (en) * | 2002-06-28 | 2004-09-09 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
US20050084967A1 (en) * | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
US20060094057A1 (en) | 2002-07-30 | 2006-05-04 | Maro K. Hellerstein | Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry |
DE20211783U1 (de) * | 2002-07-31 | 2002-11-07 | Fa. Hermann Heye i.Ins., 31683 Obernkirchen | Pressstempelmechanismus einer Glasformmaschine |
US20040235000A1 (en) * | 2002-09-03 | 2004-11-25 | Kirsty Spalding | Method for retrospective birth dating of biomolecules, cells, tissues, organs and organisms |
AU2003268416A1 (en) * | 2002-09-04 | 2004-03-29 | The Regents Of The University Of California | Methods for measuring rates of replication and death of nfectious microbial agents in an infected host organism |
WO2004025270A2 (en) * | 2002-09-13 | 2004-03-25 | The Regents Of The University Of California | Methods for measuring rates of reserve cholesterol transport in vivo, as an index of anti-atherogenesis |
US20070248540A1 (en) * | 2002-09-16 | 2007-10-25 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
US20040081994A1 (en) * | 2002-09-16 | 2004-04-29 | Hellerstein Marc K. | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
WO2004042360A2 (en) * | 2002-11-04 | 2004-05-21 | The Regents Of The Univeristy Of California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
US7262020B2 (en) * | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
US20050202406A1 (en) * | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
TW200538738A (en) * | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
EP1723252A4 (en) * | 2004-03-11 | 2009-07-29 | Univ California | TIMELY AND SPATIAL CHARACTERIZATION OF BIOSYNTHETIC EVENTS IN LIVING ORGANISMS THROUGH ISOTOPEN FINGERPRINTING UNDER CONDITIONS OF IMPROPER ISOTOPE GRADIENTS |
US20050238577A1 (en) * | 2004-03-29 | 2005-10-27 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
WO2005098024A1 (en) * | 2004-03-30 | 2005-10-20 | Kinemed, Inc. | In vivo measurement of the relative fluxes through ribonucleotide reductase vs. deoxyribonucleoside pathways using isotopes |
US20100092962A1 (en) * | 2004-07-07 | 2010-04-15 | Alexandre Loktionov | Method of Detecting Colorectal Cancer |
WO2006050130A2 (en) * | 2004-10-29 | 2006-05-11 | Target Discovery, Inc. | Glycan analysis using deuterated glucose |
JP4118918B2 (ja) * | 2005-02-28 | 2008-07-16 | シャープ株式会社 | 信号品質評価装置、情報記録再生装置、信号品質評価方法、記録条件決定方法、信号品質評価プログラム、信号品質評価プログラムを記録したコンピュータ読み取り可能な記録媒体 |
US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
TW200711660A (en) | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
WO2007030523A2 (en) * | 2005-09-06 | 2007-03-15 | Kinemed, Inc. | Kinetic biomarker for quantification of lymphoproliferation, clonal expansion, recruitment and trafficking in lymphoid tissues and of the in vivo actions of antigens and modulating agents thereon |
US20070156345A1 (en) * | 2005-12-30 | 2007-07-05 | Hyde Roderick A | Modulating a biological recording with another biological recording |
US20070156347A1 (en) * | 2005-12-30 | 2007-07-05 | Searete Llc | Using a biological recording to obtain time values |
US8150628B2 (en) * | 2005-12-30 | 2012-04-03 | The Invention Science Fund I, Llc | Establishing a biological recording timeline by artificial marking |
US20110076236A1 (en) | 2008-05-21 | 2011-03-31 | Kinemed, Inc. | Compositions and methods of treatment using modulators of motoneuron diseases |
WO2013036885A1 (en) | 2011-09-08 | 2013-03-14 | The Regents Of The University Of California | Metabolic flux measurement, imaging and microscopy |
ES2668678T3 (es) | 2011-12-07 | 2018-05-21 | Glaxosmithkline Llc | Procedimiento de determinación de la masa muscular esquelética corporal total |
EP2912161A4 (en) * | 2012-10-25 | 2016-08-24 | Run Them Sweet Llc | METHODS AND SYSTEMS FOR ESTIMATING NUTRITIONAL NEEDS OF HUMAN PATIENTS AND OTHER PATIENTS AND FOR MANAGING SUCH NUTRITIONAL NEEDS |
US9557334B2 (en) | 2012-10-25 | 2017-01-31 | Run Them Sweet Llc | Formulations and methods to provide nutrition to human and other patients |
JP2016516202A (ja) | 2013-03-15 | 2016-06-02 | キネメッド, インコーポレイテッド | バイオマーカー |
US9134319B2 (en) | 2013-03-15 | 2015-09-15 | The Regents Of The University Of California | Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo |
US9883524B2 (en) * | 2015-11-04 | 2018-01-30 | Huawei Technologies Co., Ltd. | Systems and methods for configuring air interfaces with low overhead |
CN111239353A (zh) * | 2020-01-19 | 2020-06-05 | 辉源生物科技(上海)有限公司 | 一种人源柠檬酸转运蛋白抑制剂化合物的筛选方法 |
Family Cites Families (55)
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US4065552A (en) * | 1975-05-05 | 1977-12-27 | Giovanni Giacomo Costa | Method of detecting malignant neoplasms |
US4332784A (en) * | 1979-02-06 | 1982-06-01 | The Radiochemical Centre Limited | Dual isotope assays |
US5317098A (en) * | 1986-03-17 | 1994-05-31 | Hiroaki Shizuya | Non-radioisotope tagging of fragments |
DE3667103D1 (en) * | 1986-06-09 | 1989-12-28 | Bruker Analytische Messtechnik | Method for determining the turnover of organic material in living tissue and nmr spectrometer for performing this method |
US4940658A (en) * | 1986-11-20 | 1990-07-10 | University Patents, Inc. | Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency |
US5042488A (en) * | 1987-09-29 | 1991-08-27 | The Washington University | Methods employing deuterium for obtaining direct, observable deuterium magnetic resonance images in vivo and in situ |
US6004781A (en) * | 1988-01-22 | 1999-12-21 | The General Hospital Corporation | Nucleic acid encoding Ig-CD4 fusion proteins |
JPH04504049A (ja) * | 1989-03-20 | 1992-07-23 | アンティキャンサー インコーポレイテッド | インビトロにおける組織の生存能力及び増殖能力を測定する、自生状態法及びシステム |
GB2229718B (en) * | 1989-03-22 | 1993-01-06 | Inst Molekularnoi Genetik | Method for preparing hydrogen-isotape labelled biologically active organic compounds |
US5217903A (en) * | 1990-05-15 | 1993-06-08 | Trustees Of Boston University | Measuring connective tissue breakdown products in body fluids |
CA2027714C (en) * | 1990-07-13 | 2003-01-28 | Kenneth W. Turtletaub | Method of measurement in biological systems |
US5209919A (en) * | 1990-07-13 | 1993-05-11 | Regents Of The University Of California | Method of measurement in biological systems |
US5597548A (en) * | 1990-07-18 | 1997-01-28 | Board Of Regents, The University Of Texas System | 13 C Isotopomer analyses in intact tissue using (13 C) homonuclear decoupling |
US5394236A (en) * | 1992-02-03 | 1995-02-28 | Rutgers, The State University | Methods and apparatus for isotopic analysis |
US5338686A (en) * | 1992-04-29 | 1994-08-16 | Hellerstein Marc K | Method for measuring in vivo synthesis of biopolymers |
JP2960832B2 (ja) * | 1992-05-08 | 1999-10-12 | ペルマテック テクノロジー アクチェンゲゼルシャフト | エストラジオールの投与システム |
US5366885A (en) * | 1992-06-09 | 1994-11-22 | Barranco Iii Sam C | Method and kit for testing tumors for drug sensitivity |
US5506147A (en) * | 1993-04-15 | 1996-04-09 | Kolhouse; J. Fred | Non-invasive evaluation of maldigestion and malaborption |
US5665562A (en) * | 1993-05-17 | 1997-09-09 | Amersham International Plc | Devices and methods for the measurement of cellular biochemical processes |
US5439803A (en) * | 1993-08-13 | 1995-08-08 | The Regents Of The University Of Michigan | Isotope and assay for glycolysis and the pentose phosphate pathway |
US5910403A (en) | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
US5961470A (en) * | 1997-07-09 | 1999-10-05 | Wagner; David A. | Breath test for assessing hepatic function |
US6461870B2 (en) * | 1998-05-06 | 2002-10-08 | Isotechnika Inc. | 13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control |
DE1075286T1 (de) * | 1998-05-06 | 2002-05-23 | Isotechnika,Inc. | 13C-Glukose-Atemtest zur Diagnose von Diabetes-Indikationen und Überwachung der glykämischen Kontrolle |
US6284219B1 (en) * | 1998-06-30 | 2001-09-04 | Phenome Sciences Inc. | In vivo determination of metabolic function for use in therapy management |
US6625547B1 (en) * | 1998-08-05 | 2003-09-23 | Washington State University Research Foundation | Relative rates of cytochrome p450 metabolism |
DE19839491A1 (de) * | 1998-08-29 | 2000-03-02 | Hermann Heumann | Verfahren zur Markierung von Biopolymeren mit Isotopen |
US6653076B1 (en) * | 1998-08-31 | 2003-11-25 | The Regents Of The University Of Washington | Stable isotope metabolic labeling for analysis of biopolymers |
US6887712B1 (en) * | 1998-11-09 | 2005-05-03 | Atherogenics, Inc. | Methods and compositions to lower plasma cholesterol levels |
US6764817B1 (en) * | 1999-04-20 | 2004-07-20 | Target Discovery, Inc. | Methods for conducting metabolic analyses |
US6653090B1 (en) * | 1999-11-05 | 2003-11-25 | University Of Alberta | Methods for measuring the metabolism of and screening for drugs in isolated hearts |
AU2001259470A1 (en) * | 2000-05-05 | 2001-11-20 | Purdue Research Foundation | Affinity selected signature peptides for protein identification and quantification |
GB0106923D0 (en) * | 2001-03-20 | 2001-05-09 | Univ Dundee | Liver function test |
US7256047B2 (en) * | 2001-05-01 | 2007-08-14 | Board Of Regents, The University Of Texas System | Measurement of gluconeogenesis and intermediary metabolism using stable isotopes |
US20040253647A1 (en) * | 2001-06-26 | 2004-12-16 | Mathews Paul M. | Cell-based high-throughput screening methods |
AU2002365268B2 (en) | 2001-10-24 | 2008-02-28 | The Regents Of The University Of California | Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water |
JP2005517904A (ja) | 2002-02-12 | 2005-06-16 | ザ リージェント オブ ザ ユニバーシティ オブ カリフォルニア | 標識取り込みにより生物学的分子の生合成の割合を測定する非侵襲性の方法 |
US20030180710A1 (en) * | 2002-03-22 | 2003-09-25 | Lee Wai-Nang Paul | Method of enhancing the efficiency of a pharmaceutical business |
US20030180800A1 (en) * | 2002-03-22 | 2003-09-25 | Lee Wai-Nang Paul | Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development |
CA2503681A1 (en) | 2002-04-05 | 2003-10-23 | Marc K. Hellerstein | Method for isolating and measuring proliferation of long-term label retaining cells and stem cells |
AU2003253702A1 (en) | 2002-06-26 | 2004-01-19 | The Regents Of The University Of California | Methods and kits for determining energy expenditure in living organisms by metabolic water production |
US20060094057A1 (en) * | 2002-07-30 | 2006-05-04 | Maro K. Hellerstein | Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry |
AU2003268416A1 (en) | 2002-09-04 | 2004-03-29 | The Regents Of The University Of California | Methods for measuring rates of replication and death of nfectious microbial agents in an infected host organism |
WO2004025270A2 (en) | 2002-09-13 | 2004-03-25 | The Regents Of The University Of California | Methods for measuring rates of reserve cholesterol transport in vivo, as an index of anti-atherogenesis |
US20040081994A1 (en) * | 2002-09-16 | 2004-04-29 | Hellerstein Marc K. | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
WO2004042360A2 (en) | 2002-11-04 | 2004-05-21 | The Regents Of The Univeristy Of California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
US7262020B2 (en) * | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
WO2005009597A2 (en) | 2003-07-03 | 2005-02-03 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
US20050202406A1 (en) * | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
TW200538738A (en) * | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
EP1723252A4 (en) * | 2004-03-11 | 2009-07-29 | Univ California | TIMELY AND SPATIAL CHARACTERIZATION OF BIOSYNTHETIC EVENTS IN LIVING ORGANISMS THROUGH ISOTOPEN FINGERPRINTING UNDER CONDITIONS OF IMPROPER ISOTOPE GRADIENTS |
US20050238577A1 (en) * | 2004-03-29 | 2005-10-27 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
WO2005098024A1 (en) * | 2004-03-30 | 2005-10-20 | Kinemed, Inc. | In vivo measurement of the relative fluxes through ribonucleotide reductase vs. deoxyribonucleoside pathways using isotopes |
US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
TW200711660A (en) * | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
-
1997
- 1997-05-15 US US08/857,007 patent/US5910403A/en not_active Expired - Lifetime
-
1998
- 1998-05-08 US US09/075,309 patent/US6010846A/en not_active Expired - Lifetime
- 1998-05-08 EP EP98921082A patent/EP0980441B1/en not_active Expired - Lifetime
- 1998-05-08 AU AU73767/98A patent/AU737119B2/en not_active Expired
- 1998-05-08 WO PCT/US1998/009479 patent/WO1998051820A1/en active IP Right Grant
- 1998-05-08 AT AT98921082T patent/ATE359375T1/de not_active IP Right Cessation
- 1998-05-08 DK DK98921082T patent/DK0980441T3/da active
- 1998-05-08 CA CA002287781A patent/CA2287781C/en not_active Expired - Lifetime
- 1998-05-08 JP JP54933998A patent/JP4510942B2/ja not_active Expired - Lifetime
- 1998-05-08 DE DE69837537T patent/DE69837537T2/de not_active Expired - Lifetime
-
1999
- 1999-11-15 US US09/440,596 patent/US6461806B1/en not_active Expired - Lifetime
-
2000
- 2000-08-23 HK HK00105293A patent/HK1026004A1/xx not_active IP Right Cessation
-
2002
- 2002-05-24 US US10/155,536 patent/US6808875B2/en not_active Expired - Lifetime
-
2004
- 2004-09-16 US US10/944,154 patent/US7022834B2/en not_active Expired - Lifetime
-
2005
- 2005-07-19 US US11/185,610 patent/US20060008796A1/en not_active Abandoned