CA2287781C - Methods for measuring cellular proliferation and destruction rates in vitro and in vivo - Google Patents
Methods for measuring cellular proliferation and destruction rates in vitro and in vivo Download PDFInfo
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- CA2287781C CA2287781C CA002287781A CA2287781A CA2287781C CA 2287781 C CA2287781 C CA 2287781C CA 002287781 A CA002287781 A CA 002287781A CA 2287781 A CA2287781 A CA 2287781A CA 2287781 C CA2287781 C CA 2287781C
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
Landscapes
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- Zoology (AREA)
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US08/857,007 | 1997-05-15 | ||
| US08/857,007 US5910403A (en) | 1997-05-15 | 1997-05-15 | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
| PCT/US1998/009479 WO1998051820A1 (en) | 1997-05-15 | 1998-05-08 | METHODS FOR MEASURING CELLULAR PROLIFERATION AND DESTRUCTION RATES IN VITRO AND $i(IN VIVO) |
Publications (2)
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| CA2287781A1 CA2287781A1 (en) | 1998-11-19 |
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| AU (1) | AU737119B2 (enExample) |
| CA (1) | CA2287781C (enExample) |
| DE (1) | DE69837537T2 (enExample) |
| DK (1) | DK0980441T3 (enExample) |
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| JP2002505737A (ja) | 1997-02-14 | 2002-02-19 | ジョージワシントン大学 | Ｄｎａ合成速度測定のための分析 |
| US5910403A (en) * | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
| JP2002523114A (ja) * | 1998-08-31 | 2002-07-30 | ユニバーシテイ オブ ワシントン | バイオポリマーの分析のための安定なアイソトープ代謝性ラベリング |
| US6764817B1 (en) * | 1999-04-20 | 2004-07-20 | Target Discovery, Inc. | Methods for conducting metabolic analyses |
| IL146093A0 (en) | 1999-04-20 | 2002-07-25 | Target Discovery Inc | Method of separating a polypeptide or protein from a solution containing a plurality thereof |
| US7541184B2 (en) * | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US8278034B2 (en) | 2000-06-22 | 2012-10-02 | Nuclea Biotechnologies, Inc. | Methods of making frozen tissue microarrays |
| US20020090652A1 (en) * | 2000-12-22 | 2002-07-11 | Fu Emil Wei-Ming | Inverse labeling method for the rapid identification of marker/target proteins |
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| US20030077572A1 (en) * | 2001-10-11 | 2003-04-24 | Abramson Fred P. | Quantitative differential display using isotope ratio monitoring |
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| US20030180800A1 (en) * | 2002-03-22 | 2003-09-25 | Lee Wai-Nang Paul | Stable isotope based dynamic metabolic profiling of living organisms for characterization of metabolic diseases, drug testing and drug development |
| AU2003234688A1 (en) * | 2002-04-05 | 2003-10-27 | The Regents Of The University Of California | Method for isolating and measuring proliferation of long-term label retaining cells and stem cells |
| US20050084967A1 (en) * | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
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| US20060105339A1 (en) * | 2002-09-04 | 2006-05-18 | Marc Hellerstein | Methods for measuring the rates of replication and death of microbial infectious agents in an infected |
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| EP1545628A4 (en) * | 2002-09-16 | 2010-07-28 | Univ California | BIOCHEMICAL METHOD FOR MEASURING THE METABOLIC FITNESS OF WOVEN OR THE WHOLE ORGANISM |
| US20070248540A1 (en) * | 2002-09-16 | 2007-10-25 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
| WO2004042360A2 (en) * | 2002-11-04 | 2004-05-21 | The Regents Of The Univeristy Of California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
| US7262020B2 (en) * | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
| US20050202406A1 (en) * | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
| TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
| US20050201937A1 (en) * | 2004-03-11 | 2005-09-15 | The Regents Of The University Of California | Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients |
| WO2005094327A2 (en) * | 2004-03-29 | 2005-10-13 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
| WO2005098024A1 (en) * | 2004-03-30 | 2005-10-20 | Kinemed, Inc. | In vivo measurement of the relative fluxes through ribonucleotide reductase vs. deoxyribonucleoside pathways using isotopes |
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| TW200711660A (en) | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
| JP2009506789A (ja) * | 2005-09-06 | 2009-02-19 | キナメッド・インコーポレイテッド | リンパ組織におけるリンパ増殖、クローン拡大、動員および輸送ならびにそれらに対する抗原および調整剤のインビボ作用を定量するためのキネティックバイオマーカー |
| US8150628B2 (en) * | 2005-12-30 | 2012-04-03 | The Invention Science Fund I, Llc | Establishing a biological recording timeline by artificial marking |
| US20070156347A1 (en) * | 2005-12-30 | 2007-07-05 | Searete Llc | Using a biological recording to obtain time values |
| US20070156345A1 (en) * | 2005-12-30 | 2007-07-05 | Hyde Roderick A | Modulating a biological recording with another biological recording |
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| EP2753707A4 (en) | 2011-09-08 | 2015-03-04 | Univ California | METABOLIC FLOW MEASUREMENT, IMAGING AND MICROSCOPY |
| ES2668678T3 (es) | 2011-12-07 | 2018-05-21 | Glaxosmithkline Llc | Procedimiento de determinación de la masa muscular esquelética corporal total |
| KR102172971B1 (ko) * | 2012-10-25 | 2020-11-03 | 런 뎀 스위트, 엘엘씨 | 인간과 환자의 영양 요구를 측정, 평가하고 그 영양 요구의 충족을 돕는 방법 및 시스템 |
| US9500657B2 (en) | 2012-10-25 | 2016-11-22 | Run Them Sweet Llc | Formulations containing labels for medical diagnostics |
| US9134319B2 (en) | 2013-03-15 | 2015-09-15 | The Regents Of The University Of California | Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo |
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-
1997
- 1997-05-15 US US08/857,007 patent/US5910403A/en not_active Expired - Lifetime
-
1998
- 1998-05-08 AU AU73767/98A patent/AU737119B2/en not_active Expired
- 1998-05-08 US US09/075,309 patent/US6010846A/en not_active Expired - Lifetime
- 1998-05-08 CA CA002287781A patent/CA2287781C/en not_active Expired - Lifetime
- 1998-05-08 AT AT98921082T patent/ATE359375T1/de not_active IP Right Cessation
- 1998-05-08 EP EP98921082A patent/EP0980441B1/en not_active Expired - Lifetime
- 1998-05-08 JP JP54933998A patent/JP4510942B2/ja not_active Expired - Lifetime
- 1998-05-08 DK DK98921082T patent/DK0980441T3/da active
- 1998-05-08 WO PCT/US1998/009479 patent/WO1998051820A1/en not_active Ceased
- 1998-05-08 DE DE69837537T patent/DE69837537T2/de not_active Expired - Lifetime
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1999
- 1999-11-15 US US09/440,596 patent/US6461806B1/en not_active Expired - Lifetime
-
2002
- 2002-05-24 US US10/155,536 patent/US6808875B2/en not_active Expired - Lifetime
-
2004
- 2004-09-16 US US10/944,154 patent/US7022834B2/en not_active Expired - Lifetime
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2005
- 2005-07-19 US US11/185,610 patent/US20060008796A1/en not_active Abandoned
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| Publication number | Publication date |
|---|---|
| US20050053992A1 (en) | 2005-03-10 |
| US20030068634A1 (en) | 2003-04-10 |
| ATE359375T1 (de) | 2007-05-15 |
| US6461806B1 (en) | 2002-10-08 |
| JP2001527558A (ja) | 2001-12-25 |
| US6010846A (en) | 2000-01-04 |
| US6808875B2 (en) | 2004-10-26 |
| AU7376798A (en) | 1998-12-08 |
| DK0980441T3 (da) | 2007-09-03 |
| DE69837537T2 (de) | 2007-12-20 |
| DE69837537D1 (de) | 2007-05-24 |
| EP0980441B1 (en) | 2007-04-11 |
| JP4510942B2 (ja) | 2010-07-28 |
| WO1998051820A1 (en) | 1998-11-19 |
| EP0980441A1 (en) | 2000-02-23 |
| HK1026004A1 (en) | 2000-12-01 |
| CA2287781A1 (en) | 1998-11-19 |
| US5910403A (en) | 1999-06-08 |
| US20060008796A1 (en) | 2006-01-12 |
| AU737119B2 (en) | 2001-08-09 |
| US7022834B2 (en) | 2006-04-04 |
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