JP2001527032A5 - - Google Patents
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- Publication number
- JP2001527032A5 JP2001527032A5 JP2000526199A JP2000526199A JP2001527032A5 JP 2001527032 A5 JP2001527032 A5 JP 2001527032A5 JP 2000526199 A JP2000526199 A JP 2000526199A JP 2000526199 A JP2000526199 A JP 2000526199A JP 2001527032 A5 JP2001527032 A5 JP 2001527032A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- skin
- sunscreen
- vitamin
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 description 336
- 239000000516 sunscreening agent Substances 0.000 description 154
- 230000000475 sunscreen Effects 0.000 description 89
- 239000003963 antioxidant agent Substances 0.000 description 86
- 235000006708 antioxidants Nutrition 0.000 description 85
- 210000003491 Skin Anatomy 0.000 description 78
- 230000003078 antioxidant Effects 0.000 description 49
- -1 pamate O Chemical compound 0.000 description 47
- 238000009472 formulation Methods 0.000 description 45
- 230000000111 anti-oxidant Effects 0.000 description 44
- 239000003995 emulsifying agent Substances 0.000 description 33
- 230000004224 protection Effects 0.000 description 31
- FYGDTMLNYKFZSV-WFYNLLPOSA-N (2S,3R,4S,5S,6R)-2-[(2R,4R,5R,6S)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-WFYNLLPOSA-N 0.000 description 26
- 229920002498 Beta-glucan Polymers 0.000 description 26
- 102000019197 Superoxide Dismutase Human genes 0.000 description 26
- 108010012715 Superoxide Dismutase Proteins 0.000 description 26
- 238000004519 manufacturing process Methods 0.000 description 26
- 229940087603 Grape Seed Extract Drugs 0.000 description 25
- 235000002532 grape seed extract Nutrition 0.000 description 25
- 239000003921 oil Substances 0.000 description 25
- 239000001717 vitis vinifera seed extract Substances 0.000 description 25
- 229930003268 Vitamin C Natural products 0.000 description 23
- 239000000839 emulsion Substances 0.000 description 23
- VYGQUTWHTHXGQB-FFHKNEKCSA-N trans-Retinyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 23
- 235000019154 vitamin C Nutrition 0.000 description 23
- 239000011718 vitamin C Substances 0.000 description 23
- 150000003700 vitamin C derivatives Chemical class 0.000 description 23
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 22
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- 239000011619 pantothenol Substances 0.000 description 22
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 21
- 235000019155 vitamin A Nutrition 0.000 description 21
- 239000011719 vitamin A Substances 0.000 description 21
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- 229940045997 Vitamin A Drugs 0.000 description 19
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- 230000000694 effects Effects 0.000 description 19
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- 238000004113 cell culture Methods 0.000 description 18
- 150000003712 vitamin E derivatives Chemical class 0.000 description 18
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl methoxycinnamate Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 17
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- 239000012071 phase Substances 0.000 description 16
- DXGLGDHPHMLXJC-UHFFFAOYSA-N Oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 15
- 239000004615 ingredient Substances 0.000 description 15
- 150000003839 salts Chemical class 0.000 description 15
- QIQXTHQIDYTFRH-UHFFFAOYSA-N Stearic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 14
- 150000002148 esters Chemical class 0.000 description 14
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- 238000011002 quantification Methods 0.000 description 14
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 14
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-α-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 13
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 13
- 239000002537 cosmetic Substances 0.000 description 12
- 235000019198 oils Nutrition 0.000 description 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 12
- 230000002633 protecting Effects 0.000 description 12
- 239000003642 reactive oxygen metabolite Substances 0.000 description 12
- 235000019172 retinyl palmitate Nutrition 0.000 description 12
- 239000011769 retinyl palmitate Substances 0.000 description 12
- 229950004578 vitamin A palmitate Drugs 0.000 description 12
- XLOMVQKBTHCTTD-UHFFFAOYSA-N zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 12
- IPCSVZSSVZVIGE-UHFFFAOYSA-N Palmitic acid Chemical class CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 11
- 229960001452 alpha-Tocopherol Acetate Drugs 0.000 description 11
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N Oleic acid Chemical class CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 10
- 239000004166 Lanolin Substances 0.000 description 9
- 235000019441 ethanol Nutrition 0.000 description 9
- 150000004665 fatty acids Chemical class 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 235000019388 lanolin Nutrition 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
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- 230000001681 protective Effects 0.000 description 9
- MEZZCSHVIGVWFI-UHFFFAOYSA-N Dioxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1O MEZZCSHVIGVWFI-UHFFFAOYSA-N 0.000 description 8
- WSSJONWNBBTCMG-UHFFFAOYSA-N Homosalate Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 8
- 229960004881 Homosalate Drugs 0.000 description 8
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- 239000004205 dimethyl polysiloxane Substances 0.000 description 8
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 8
- 239000003974 emollient agent Substances 0.000 description 8
- 206010022114 Injury Diseases 0.000 description 7
- 229940078752 MAGNESIUM ASCORBYL PHOSPHATE Drugs 0.000 description 7
- 235000021355 Stearic acid Nutrition 0.000 description 7
- 210000004027 cells Anatomy 0.000 description 7
- 229940008099 dimethicone Drugs 0.000 description 7
- CMBYOWLFQAFZCP-UHFFFAOYSA-N hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 7
- 229940100463 hexyl laurate Drugs 0.000 description 7
- 239000006210 lotion Substances 0.000 description 7
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 235000010215 titanium dioxide Nutrition 0.000 description 7
- 238000004078 waterproofing Methods 0.000 description 7
- 229940068171 ETHYL HEXYL SALICYLATE Drugs 0.000 description 6
- 235000021360 Myristic acid Nutrition 0.000 description 6
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Octyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 description 6
- 235000021314 Palmitic acid Nutrition 0.000 description 6
- 229960004838 Phosphoric acid Drugs 0.000 description 6
- CXQXSVUQTKDNFP-UHFFFAOYSA-N Simethicone Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 6
- 238000000692 Student's t-test Methods 0.000 description 6
- UEVAMYPIMMOEFW-UHFFFAOYSA-N Trolamine salicylate Chemical compound OCCN(CCO)CCO.OC(=O)C1=CC=CC=C1O UEVAMYPIMMOEFW-UHFFFAOYSA-N 0.000 description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 6
- 229960004960 dioxybenzone Drugs 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
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- 150000002191 fatty alcohols Chemical class 0.000 description 6
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- 235000011007 phosphoric acid Nutrition 0.000 description 6
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- 230000000699 topical Effects 0.000 description 6
- 239000001993 wax Substances 0.000 description 6
- 239000011787 zinc oxide Substances 0.000 description 6
- XNEFYCZVKIDDMS-UHFFFAOYSA-N Avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 description 5
- 206010015150 Erythema Diseases 0.000 description 5
- FMJSMJQBSVNSBF-UHFFFAOYSA-N Octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 description 5
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- UKMSUNONTOPOIO-UHFFFAOYSA-N Behenic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 4
- 239000005639 Lauric acid Chemical class 0.000 description 4
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- 239000005642 Oleic acid Chemical class 0.000 description 4
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000002757 inflammatory Effects 0.000 description 4
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- WCJLCOAEJIHPCW-UHFFFAOYSA-N octyl 2-hydroxybenzoate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1O WCJLCOAEJIHPCW-UHFFFAOYSA-N 0.000 description 4
- 239000002304 perfume Substances 0.000 description 4
- 159000000001 potassium salts Chemical class 0.000 description 4
- 125000005373 siloxane group Chemical group [SiH2](O*)* 0.000 description 4
- 239000003009 skin protective agent Substances 0.000 description 4
- 159000000000 sodium salts Chemical class 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N Cetyl alcohol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 3
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
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- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
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| US09/113,815 US6015548A (en) | 1998-07-10 | 1998-07-10 | High efficiency skin protection formulation with sunscreen agents and antioxidants |
| PCT/US1998/027433 WO1999033439A1 (en) | 1997-12-24 | 1998-12-22 | Composition with high efficiency skin protection from damaging effects of ultraviolet light |
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| BR9803936A (pt) | 1998-09-08 | 2000-04-04 | Cosmeticos Natural Ind Com | Processo e composição para aumentar a ação de vitamina a na atividade celular de um indivìduo e uso de vitamina c. |
| BRPI0003166B1 (pt) * | 1999-07-16 | 2015-08-25 | Natura Cosmeticos Sa | Processo para estabilização de compostos antioxidantes, e composições aquosas |
| BR9902972B1 (pt) * | 1999-07-16 | 2012-02-22 | composição bifásica de uso cosmético ou farmacêutico. | |
| ES2161161B1 (es) * | 1999-08-30 | 2002-07-01 | Consejo Superior Investigacion | Extracto de uva para proteccion solar. |
| GB9921238D0 (en) * | 1999-09-09 | 1999-11-10 | Boots Co Plc | Skincare composition |
| US6358517B1 (en) * | 1999-10-22 | 2002-03-19 | Unilever Home & Personal Care Usa, Division Of Conopco | Cosmetic compositions containing resveratrol and retinoids |
| CN1111068C (zh) * | 2000-07-27 | 2003-06-11 | 上海北医大生物科技有限公司 | 一种葡萄籽提取物opc强抗氧化复合胶囊及其制造方法 |
| FR2812190B1 (fr) * | 2000-07-28 | 2003-01-31 | Oreal | Utilisation d'agonistes non prostanoiques des recepteurs des prostaglandines ep-2 et/ou ep-4 comme agent cosmetique permettant d'attenuer, de diminuer ou d'arreter la chute des cheveux et des poils |
| FR2812192B1 (fr) * | 2000-07-28 | 2003-01-31 | Oreal | Utilisation d'antagonistes de recepteur des prostaglandines ep-3 comme agent cosmetique permettant d'attenuer, de diminuer ou d'arreter la chute des cheveux et des poils |
| JP2002204687A (ja) * | 2000-11-09 | 2002-07-23 | Onaka Yasushi | β−１．３−１．６グルカン（アウレオバシジウム培養液）の医療、保健、福祉、食品および各種産業分野での応用 |
| JP4824181B2 (ja) * | 2001-02-13 | 2011-11-30 | 日本メナード化粧品株式会社 | 皮膚外用剤 |
| US6436378B1 (en) * | 2001-02-28 | 2002-08-20 | Colgate-Palmolive Company | Composition |
| EP1398019A1 (de) * | 2002-09-13 | 2004-03-17 | Cognis France S.A. | Verfahren zum Schutz und zur Modulation von Dermal Epidermal Junctions |
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| KR100673044B1 (ko) * | 2003-05-16 | 2007-01-22 | 로터스 파마세티컬 리미티드 컴퍼니 | 경피 투여용 국소 조성물 |
| ITMI20040402A1 (it) | 2004-03-03 | 2004-06-03 | Isagro Spa | Miscele e metodo per l'induzione di resistenza nella pianta |
| BRPI0516174B1 (pt) * | 2004-09-29 | 2015-06-16 | Ciba Sc Holding Ag | Usos de agentes estabilizantes |
| US7348034B2 (en) * | 2005-03-07 | 2008-03-25 | Access Business Group International Llc | Plant based formulations for improving skin moisture, texture, and appearance |
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| KR20090009513A (ko) * | 2007-07-20 | 2009-01-23 | 한국원자력연구원 | 방사선 조사에 의한 저 분자량의 베타글루칸의 제조 방법및 방사선 조사에 의하여 제조된 저 분자량의 베타글루칸 |
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| EP2229180A1 (en) * | 2007-12-27 | 2010-09-22 | D.M.G. Italia Srl | Composition comprising superoxide dismutase and carboxv methyl beta-1,3 glucan |
| EP2247949B1 (en) | 2008-01-25 | 2017-05-24 | Bayer Consumer Care AG | Method of selecting antioxidants for use in topically applied compositions |
| EP2284281A4 (en) | 2008-03-28 | 2011-08-10 | Sysmex Corp | REAGENT COMPRISING A PRIMER FOR THE DETECTION OF MRM FOR CYTOKERATIN-7 |
| ITMI20080560A1 (it) * | 2008-04-01 | 2009-10-02 | Lodovico Gianluca Braguti | Composizioni preventive-protettive contro l'insorgenza di manifestazioni cutanee fotoallergiche e fototossiche |
| EP2135598B1 (en) * | 2008-06-16 | 2011-08-03 | Rohm and Haas Company | Particle Containing Ultraviolet Absorber |
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| DK2355793T3 (en) * | 2008-11-12 | 2019-01-07 | June Jacobs Laboratories Llc | ANTIOXIDAN COMPOSITIONS FOR CLEANING AND CONDITIONING SKIN |
| EP2263481A1 (en) * | 2009-05-29 | 2010-12-22 | Nestec S.A. | Green tea extracts of improved bioavailability |
| CA2839507A1 (en) * | 2011-06-24 | 2012-12-27 | Epitogenesis Inc. | Pharmaceutical compositions, comprising a combination of select carriers, vitamins, tannins and flavonoids as antigen-specific immuno-modulators |
| CN102793642B (zh) * | 2012-08-28 | 2014-01-15 | 广州丹奇日用化工厂有限公司 | 一种护肤品组合物 |
| JP2014162756A (ja) * | 2013-02-26 | 2014-09-08 | Kowa Company Ltd | パンテノール類を含有する含水組成物 |
| CN103520058B (zh) * | 2013-10-18 | 2015-03-25 | 山东省农业科学院农产品研究所 | 一种蚕蛹活性多肽晒后修复凝露及其制备方法 |
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| US5486352A (en) * | 1995-01-03 | 1996-01-23 | Elizabeth Arden Company | Sunscreen compositions |
| AUPN166195A0 (en) * | 1995-03-13 | 1995-04-06 | Norvet Research Pty Limited | Process for glucan extraction |
| US5609854A (en) * | 1995-06-06 | 1997-03-11 | Elizabeth Arden Company, Division Of Conopco, Inc. | Thickened and stabilized cosmetic emulsion compositions |
| EP0897264A4 (en) * | 1996-04-22 | 1999-09-08 | Henkel Corp | NATURAL ANTIOXIDANT COMPOSITION |
-
1998
- 1998-12-22 AU AU19445/99A patent/AU1944599A/en not_active Abandoned
- 1998-12-22 CA CA2318345A patent/CA2318345C/en not_active Expired - Lifetime
- 1998-12-22 EP EP98964275A patent/EP1047392A4/en not_active Withdrawn
- 1998-12-22 JP JP2000526199A patent/JP4150501B2/ja not_active Expired - Lifetime
- 1998-12-22 WO PCT/US1998/027433 patent/WO1999033439A1/en active Application Filing
-
2007
- 2007-12-25 JP JP2007332328A patent/JP2008088188A/ja active Pending
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