ITMI20080560A1 - Composizioni preventive-protettive contro l'insorgenza di manifestazioni cutanee fotoallergiche e fototossiche - Google Patents
Composizioni preventive-protettive contro l'insorgenza di manifestazioni cutanee fotoallergiche e fototossiche Download PDFInfo
- Publication number
- ITMI20080560A1 ITMI20080560A1 IT000560A ITMI20080560A ITMI20080560A1 IT MI20080560 A1 ITMI20080560 A1 IT MI20080560A1 IT 000560 A IT000560 A IT 000560A IT MI20080560 A ITMI20080560 A IT MI20080560A IT MI20080560 A1 ITMI20080560 A1 IT MI20080560A1
- Authority
- IT
- Italy
- Prior art keywords
- compositions according
- derivatives
- components
- concentrations
- beta
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 32
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 20
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 18
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 15
- 229920002498 Beta-glucan Polymers 0.000 claims description 11
- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical compound CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 claims description 10
- 235000019154 vitamin C Nutrition 0.000 claims description 10
- 239000011718 vitamin C Substances 0.000 claims description 10
- 239000011787 zinc oxide Substances 0.000 claims description 10
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 9
- -1 alkyl benzoates Chemical class 0.000 claims description 9
- 235000019165 vitamin E Nutrition 0.000 claims description 9
- 239000011709 vitamin E Substances 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 8
- KNUPSOXBESCJLY-UHFFFAOYSA-N 2-methoxy-1-phenylhexan-1-one Chemical compound CCCCC(OC)C(=O)C1=CC=CC=C1 KNUPSOXBESCJLY-UHFFFAOYSA-N 0.000 claims description 7
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 7
- 229930003268 Vitamin C Natural products 0.000 claims description 7
- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 claims description 7
- 229960001630 diethylamino hydroxybenzoyl hexyl benzoate Drugs 0.000 claims description 7
- 231100000760 phototoxic Toxicity 0.000 claims description 7
- 230000000699 topical effect Effects 0.000 claims description 7
- 229930003427 Vitamin E Natural products 0.000 claims description 6
- 229920002000 Xyloglucan Polymers 0.000 claims description 6
- 229940093797 bioflavonoids Drugs 0.000 claims description 6
- 229920002770 condensed tannin Polymers 0.000 claims description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 6
- 239000000419 plant extract Substances 0.000 claims description 6
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 6
- 235000013824 polyphenols Nutrition 0.000 claims description 6
- QFRYQWYZSQDFOS-UHFFFAOYSA-N verbascoside Natural products CC1OC(COC2C(O)C(COC3OC(C(O)C(O)C3O)C(=O)O)OC(Oc4cc(O)cc5OC(=CC(=O)c45)c6ccc(O)c(O)c6)C2O)C(O)C(O)C1O QFRYQWYZSQDFOS-UHFFFAOYSA-N 0.000 claims description 6
- 229940046009 vitamin E Drugs 0.000 claims description 6
- 239000000839 emulsion Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 230000004224 protection Effects 0.000 claims description 4
- 241000736199 Paeonia Species 0.000 claims description 3
- 244000179560 Prunella vulgaris Species 0.000 claims description 3
- 235000010674 Prunella vulgaris Nutrition 0.000 claims description 3
- 235000006468 Thea sinensis Nutrition 0.000 claims description 3
- 241000157352 Uncaria Species 0.000 claims description 3
- 240000006365 Vitis vinifera Species 0.000 claims description 3
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 3
- 235000002532 grape seed extract Nutrition 0.000 claims description 3
- 229930003799 tocopherol Natural products 0.000 claims description 3
- 235000010384 tocopherol Nutrition 0.000 claims description 3
- 229960001295 tocopherol Drugs 0.000 claims description 3
- 239000011732 tocopherol Substances 0.000 claims description 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 3
- 206010040914 Skin reaction Diseases 0.000 claims description 2
- OEWBEINAQKIQLZ-CMRBMDBWSA-N [(2s)-2-[(2r)-3,4-bis(2-hexyldecanoyloxy)-5-oxo-2h-furan-2-yl]-2-(2-hexyldecanoyloxy)ethyl] 2-hexyldecanoate Chemical compound CCCCCCCCC(CCCCCC)C(=O)OC[C@H](OC(=O)C(CCCCCC)CCCCCCCC)[C@H]1OC(=O)C(OC(=O)C(CCCCCC)CCCCCCCC)=C1OC(=O)C(CCCCCC)CCCCCCCC OEWBEINAQKIQLZ-CMRBMDBWSA-N 0.000 claims description 2
- 235000010323 ascorbic acid Nutrition 0.000 claims description 2
- 239000011668 ascorbic acid Substances 0.000 claims description 2
- 229960005070 ascorbic acid Drugs 0.000 claims description 2
- 229940008099 dimethicone Drugs 0.000 claims description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 239000004137 magnesium phosphate Substances 0.000 claims description 2
- 229960002261 magnesium phosphate Drugs 0.000 claims description 2
- 229910000157 magnesium phosphate Inorganic materials 0.000 claims description 2
- 235000010994 magnesium phosphates Nutrition 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 235000010446 mineral oil Nutrition 0.000 claims description 2
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 claims description 2
- 229960000601 octocrylene Drugs 0.000 claims description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 231100000430 skin reaction Toxicity 0.000 claims description 2
- 230000035483 skin reaction Effects 0.000 claims description 2
- YRWWOAFMPXPHEJ-OFBPEYICSA-K sodium L-ascorbic acid 2-phosphate Chemical compound [Na+].[Na+].[Na+].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] YRWWOAFMPXPHEJ-OFBPEYICSA-K 0.000 claims description 2
- 229940048058 sodium ascorbyl phosphate Drugs 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 244000052707 Camellia sinensis Species 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- 208000002440 photoallergic dermatitis Diseases 0.000 description 6
- 230000001120 cytoprotective effect Effects 0.000 description 5
- 230000036542 oxidative stress Effects 0.000 description 5
- 239000003963 antioxidant agent Substances 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 150000003722 vitamin derivatives Chemical class 0.000 description 4
- 208000031709 Skin Manifestations Diseases 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 229920001503 Glucan Polymers 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 2
- CNBGNNVCVSKAQZ-UHFFFAOYSA-N benzydamine Chemical compound C12=CC=CC=C2C(OCCCN(C)C)=NN1CC1=CC=CC=C1 CNBGNNVCVSKAQZ-UHFFFAOYSA-N 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 239000007764 o/w emulsion Substances 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- GUHPRPJDBZHYCJ-SECBINFHSA-N (2s)-2-(5-benzoylthiophen-2-yl)propanoic acid Chemical compound S1C([C@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CC=C1 GUHPRPJDBZHYCJ-SECBINFHSA-N 0.000 description 1
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 1
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 1
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 1
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- ITPDYQOUSLNIHG-UHFFFAOYSA-N Amiodarone hydrochloride Chemical compound [Cl-].CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCC[NH+](CC)CC)C(I)=C1 ITPDYQOUSLNIHG-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108010006654 Bleomycin Proteins 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 description 1
- GDLIGKIOYRNHDA-UHFFFAOYSA-N Clomipramine Chemical compound C1CC2=CC=C(Cl)C=C2N(CCCN(C)C)C2=CC=CC=C21 GDLIGKIOYRNHDA-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 230000005778 DNA damage Effects 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- HCYAFALTSJYZDH-UHFFFAOYSA-N Desimpramine Chemical compound C1CC2=CC=CC=C2N(CCCNC)C2=CC=CC=C21 HCYAFALTSJYZDH-UHFFFAOYSA-N 0.000 description 1
- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- WQXNXVUDBPYKBA-UHFFFAOYSA-N Ectoine Natural products CC1=NCCC(C(O)=O)N1 WQXNXVUDBPYKBA-UHFFFAOYSA-N 0.000 description 1
- 108010061435 Enalapril Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 description 1
- 241000191007 Halorhodospira halochloris Species 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 description 1
- 150000000996 L-ascorbic acids Chemical class 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 description 1
- KYGZCKSPAKDVKC-UHFFFAOYSA-N Oxolinic acid Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC2=C1OCO2 KYGZCKSPAKDVKC-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- KLBQZWRITKRQQV-UHFFFAOYSA-N Thioridazine Chemical compound C12=CC(SC)=CC=C2SC2=CC=CC=C2N1CCC1CCCCN1C KLBQZWRITKRQQV-UHFFFAOYSA-N 0.000 description 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 229960004538 alprazolam Drugs 0.000 description 1
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
- 229960005260 amiodarone Drugs 0.000 description 1
- 229960000836 amitriptyline Drugs 0.000 description 1
- KRMDCWKBEZIMAB-UHFFFAOYSA-N amitriptyline Chemical compound C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KRMDCWKBEZIMAB-UHFFFAOYSA-N 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229960005475 antiinfective agent Drugs 0.000 description 1
- 229960005274 benzocaine Drugs 0.000 description 1
- 229960000333 benzydamine Drugs 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960001561 bleomycin Drugs 0.000 description 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
- 229960000830 captopril Drugs 0.000 description 1
- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 description 1
- 229960000623 carbamazepine Drugs 0.000 description 1
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960004782 chlordiazepoxide Drugs 0.000 description 1
- ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 description 1
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 description 1
- 229960001076 chlorpromazine Drugs 0.000 description 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 1
- 229960003405 ciprofloxacin Drugs 0.000 description 1
- 229960001214 clofibrate Drugs 0.000 description 1
- KNHUKKLJHYUCFP-UHFFFAOYSA-N clofibrate Chemical compound CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 KNHUKKLJHYUCFP-UHFFFAOYSA-N 0.000 description 1
- 229960004606 clomipramine Drugs 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 229960003901 dacarbazine Drugs 0.000 description 1
- 231100000223 dermal penetration Toxicity 0.000 description 1
- 229960003914 desipramine Drugs 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 229960003722 doxycycline Drugs 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 229960000873 enalapril Drugs 0.000 description 1
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
- 229960002297 fenofibrate Drugs 0.000 description 1
- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 229960003883 furosemide Drugs 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 description 1
- 229960002867 griseofulvin Drugs 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229960002003 hydrochlorothiazide Drugs 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 229960004801 imipramine Drugs 0.000 description 1
- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 description 1
- 230000002480 immunoprotective effect Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229960004023 minocycline Drugs 0.000 description 1
- MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 description 1
- 229960000210 nalidixic acid Drugs 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 229960001699 ofloxacin Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229960000321 oxolinic acid Drugs 0.000 description 1
- 229960004236 pefloxacin Drugs 0.000 description 1
- FHFYDNQZQSQIAI-UHFFFAOYSA-N pefloxacin Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCN(C)CC1 FHFYDNQZQSQIAI-UHFFFAOYSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000002165 photosensitisation Effects 0.000 description 1
- 208000017983 photosensitivity disease Diseases 0.000 description 1
- 231100000434 photosensitization Toxicity 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 229960001732 pipemidic acid Drugs 0.000 description 1
- JOHZPMXAZQZXHR-UHFFFAOYSA-N pipemidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCNCC1 JOHZPMXAZQZXHR-UHFFFAOYSA-N 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 229960003910 promethazine Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229940001470 psychoactive drug Drugs 0.000 description 1
- 239000004089 psychotropic agent Substances 0.000 description 1
- 230000000506 psychotropic effect Effects 0.000 description 1
- 229960001404 quinidine Drugs 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000011946 reduction process Methods 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229960005404 sulfamethoxazole Drugs 0.000 description 1
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229960002784 thioridazine Drugs 0.000 description 1
- 229960001312 tiaprofenic acid Drugs 0.000 description 1
- 239000003860 topical agent Substances 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/415—Aminophenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
Descrizione del brevetto per invenzione industriale avente per titolo:
“COMPOSIZIONI PREVENTIVE-PROTETTIVE CONTRO L’INSORGENZA DI MANIFESTAZIONI CUTANEE FOTOALLERGICHE E FOTOTOSSICHE”
La presente invenzione ha per oggetto composizioni di uso topico comprendenti una combinazione di sistemi ad elevata capacità fotoassorbente delle radiazioni ultraviolette A in associazione a derivati vitaminici A e C e a composti con azione citoprotettiva quali derivati del beta glucano e suoi derivati, ectoina ed eventualmente bioflavonoidi, proantocianidine, polifenoli, verbascosidi, xyloglucani o estratti di origine vegetali che li contengono.
Sfondo dell’invenzione
La fotoallergia è una reazione infiammatoria che si manifesta sotto forma di eritema in individui sensibili dopo un’esposizione ad un livello normalmente inoffensivo di radiazioni ultraviolette, principalmente di tipo UV-A.
Il meccanismo di azione della fotoallergia è noto da tempo<1>: l’assorbimento della luce ultravioletta produce uno stato eccitato di farmaco o metabolita, che può seguire alternativamente una delle due vie che alla fine portano a fotosensibilizzazione.
La prima via procede attraverso la generazione di radicali liberi. Seguendo la formazione dei radicali liberi, il fotoprodotto può partecipare al trasferimento elettronico diretto o al legame covalente a componenti cellulari chiave.
La seconda via implica la generazione di un ossigeno singoletto che provoca ossidazione di biomolecole, danneggiando componenti critici cellulari e iniziando il rilascio di mediatori eritrogenici.
La fotoallergia, inoltre, è mediata dal sistema immunitario.
La fotoallergia colpisce innanzitutto soggetti con intolleranze fotodinamiche soggettive: tra queste, la più frequente risulta la dermatite polimorfa alla luce, una forma idiopatica acuta e ricorrente, causata soprattutto dai raggi UV-A (quindi anche dall’esposizione attraverso i vetri), caratterizzata da polimorfismo delle lesioni.
Un’altra causa di fotoallergia è rappresentata dai farmaci, soprattutto quelli che assorbono nella regione UV-A. La fotoallergia può colpire anche soggetti non sottoposti a terapie farmacologiche, ma che vengono a contatto con prodotti sia topici che sistemici in grado di indurre reazioni fototossiche o fotoallergizzanti.
Esempi di farmaci fotosensibilizzanti comprendono:
Anti-infettivi quali dossiciclina, minociclina, tetraciclina, acido nalidissico, flumechina, acido ossolinico, acido pipemidico, pefloxacina, ciprofloxacina, ofloxacina, sulfametossazolo, griseofulvina; anti-infiammatori quali piroxicam, acido tiaprofenico, naproxene, diclofenac, ibuprofene, ketoprofene; anti-tumorali quali bleomicina, dacarbazina, fluorouracile, metotrexate, vinblastina; psicotropi quali imipramina, amitriptilina, desipramina, clomipramina, tioridazina, clorpromazina, carbamazepina, clordiazepossido, alprazolam; farmaci cardiologici quali amiodarone, chinidina, captopril, enalapril, idroclorotiazide, furosemide, fenofibrato, clofibrato e altri ancora, ad esempio benzocaina, prometazina, benzidamina.
Le radiazioni ultraviolette di tipo A sono una componente della radiazione solare caratterizzate da lunghezza d’onda comprese tra 320 a 400 nm e capacità di penetrazione sia epidermica che dermica. Gli UV-A sono pertanto in grado di causare un intenso stress ossidativo.<2, 3 ,4 ,5>
Sostanze quali dietilammino idrossibenzoil esil benzoato, ossido di zinco, butil metossidibenzoilmetano, assorbono nella regione dell’UV-A e sono usate sia singolarmente sia in associazione come filtri anti-UV-A.
Da tempo è poi in atto lo studio di sostanze in grado di garantire un’adeguata protezione del sistema cito-immunologico cutaneo ed in generale la cute dalla stress ossidativo UV indotto.
Tra le varie sostanze studiate, risultano di particolare interesse i glucani, polisaccaridi caratterizzati da un legame 1-3 beta-glucosidico, ottenuti per biofermentazione da lieviti (Saccharomyces cerevisiae) e resi successivamente idrosolubili per carbossimetilazione (carbossimetilbetaglucano). Altri polisaccaridi analoghi sono estratti da funghi.
I glucani<6, 7 , 8, 9, 10, 11>sono in grado di stimolare il sistema immunologico cutaneo e di proteggere dallo stress ossidativo UV-A indotto.
L’ectoina<12, 13, 14, 15, 16>è una sostanza naturale dotata di proprietà citoprotettive ed immunoprotettive presente nei batteri alofili come Ectothiorhodospira halochloris. Tali microrganismi sono in grado di vivere in condizioni estreme (laghi salati, nell’acqua di mare e nei deserti salini esposti ad altissime dosi di radiazioni UV ed IR).
Sono inoltre state studiate le vitamine antiossidanti come agenti topici per la protezione del danno fototossico. È noto ad esempio che la vitamina E
<17, 18, 19, 20 , 21, 22>agisce come “free radical scavenger” definito anche come “chain breaking antioxidant”. La vitamina C<23, 24, 25, 26, 27, 28, 29>agisce (unitamente ad altri agenti riducenti, quali beta-carotene, enzimi come la catalasi e la superossidodismutasi e composti come il glutatione) nei processi di riduzione che minimizzano i danni legati ai fenomeni ossidativi.
Infine, alcune specie vegetali quali Vitis vinifera, Prunella vulgaris, Uncaria tormentosa, Paeonia, Camellia sinensis contengono sostanze ad azione citoprotettiva da danni indotti da radiazioni ultraviolette e da stress ossidativo. Tali piante contengono come ingredienti attivi bioflavonoidi, proantocianidine, polifenoli, verbascosidi e xyloglucani<30, 31, 32>.
Descrizione dell’invenzione
Si è ritrovato che l’associazione di sistemi fotoassorbenti UV-A con antiossidanti quali derivati vitaminici C ed E e citoprotettori quali beta glucani, ectoina ed eventualmente bioflavonoidi, proantocianidine, polifenoli, verbascosidi, xyloglucani o estratti vegetali che li contengono, sono efficaci nel proteggere e prevenire, per via topica, dall’insorgenza di reazioni cutanee fotoallergiche e fototossiche, interagendo fra loro in modo particolarmente vantaggioso e/o sinergico.
L’invenzione fornisce pertanto formulazioni topiche contenenti:
a) sistemi fotoassorbenti UV-A;
b) betaglucano o suoi derivati, e/o ectoina,
c) vitamine C e/o E.
Le composizioni dell’invenzione svolgono una attività di prevenzione e protezione nei confronti di manifestazioni cutanee fotoallergiche o fototossiche mediate da farmaci, prodotti topici e/o alimenti o dovute a predisposizioni soggettive.
Al fine di realizzare sistemi ad elevata capacità fotoassorbente nei confronti delle radiazioni ultraviolette di tipo A, saranno utilizzate diverse tipologia di sostanze fotoassorbenti per via chimica o fisica, sia singolarmente che in associazione.
Secondo la presente invenzione, i componenti fotoassorbenti UV-A saranno caratterizzati da ad elevata capacità fotofiltrante (a lunghezza d’onda critica > 375 nm), e saranno scelti in particolare scelti nel gruppo di dietilammino idrossibenzoil esil benzoato, ossido di zinco, butil metossidibenzoilmetano.
Secondo un aspetto preferito della presente invenzione, i componenti fotoassorbenti saranno presenti nei seguenti intervalli di concentrazione (sul totale dei componenti della composizione):
i) dietilammino idrossibenzoil esil benzoato: da 1 a 5%;
ii) ossido di zinco: da 3 a 10%;
iii) butil metossidibenzoilmetano: da 1 a 5%.
Secondo un aspetto preferito della presente invenzione, il butil metossidibenzoilmetano sarà utilizzato in associazione ad Octocrylene in rapporto 1:1 o 1:1,5, in intervallo di concentrazione da 3 a 10% (sul totale dei componenti della composizione).
Secondo un aspetto preferito della presente invenzione, l’ossido di zinco sarà utilizzato sia in forma libera che micronizzata (tra 20 e 200 micron). Preferibilmente, quando usato in forma micronizzata, l’ossido di zinco sarà in forma di polvere o predisperso in solventi, preferibilmente scelti tra acqua, C12-C15 alchil benzoati, olio minerale, Dimethicone o trigliceridi C8-C12.
Secondo un aspetto preferito della presente invenzione, la somma delle concentrazioni di dietilammino idrossibenzoil esil benzoato e di ossido di zinco sarà compresa in un intervallo da 4 a 8% (sul totale dei componenti della composizione).
Al fine di garantire la massima efficacia all’azione preventiva-protettiva delle composizioni secondo l’invenzione, ai sistemi filtranti UV-A sopra definiti sono stati associati componenti in grado di svolgere una adeguata citoprotezione in termini di stress ossidativi, immunosoppressione e danni al DNA.
Secondo la presente invenzione, i componenti citoprotettivi saranno scelti nel gruppo di betaglucano o i suoi derivati, in particolare carbossimetil betaglucano, ed ectoina.
Secondo un aspetto preferito della presente invenzione, i componenti citoprotettivi saranno presenti nei seguenti intervalli di concentrazione (sul totale dei componenti della composizione):
i) betaglucano o suoi derivati: da 0,01 a 0,2%;
ii) ectoina: da 0,1 a 2%.
Preferibilmente, la somma delle concentrazioni di beta glucano o i suoi derivati, ed ectoina sarà compresa in un intervallo da 0,1 a 1,5% (sul totale dei componenti della composizione).
Secondo la presente invenzione, i componenti vitaminici saranno scelti nel gruppo di vitamina E, vitamina C e loro derivati.
Preferibilmente, la vitamina E sarà utilizzata in forma di tocoferolo naturale, di tocoferolo sintetico di derivati quali tocoferil acetato, e la vitamina C sarà utilizzata sia in forma di acido ascorbico sia come derivati dell’acido ascorbico quali ascorbil magnesio fosfato, ascorbil tetraisopalmitato, sodio ascorbil fosfato.
Secondo un aspetto preferito della presente invenzione, i componenti vitaminici o i loro derivati saranno presenti nei seguenti intervalli di concentrazione (sul totale dei componenti della composizione):
i) Vitamina E: in concentrazioni almeno uguali o superiori a 2%; ii) Vitamina C: in concentrazioni almeno uguali o superiori a 0,3%. Preferibilmente, la somma delle concentrazioni dei componenti vitaminici o i loro derivati sarà almeno superiore al 2% (sul totale dei componenti della composizione) per garantire un’adeguata copertura antiossidante.
Secondo un aspetto preferito, le composizioni della presente invenzione potranno inoltre contenere estratti vegetali quali estratti da Vitis vinifera, Prunella vulgaris, Uncaria tormentosa, Paeonia, Camellia sinensis; e sostanze ad attività complementare o comunque utile, quali bioflavonoidi, proantocianidine, polifenoli, verbascosidi, xyloglucani o estratti vegetali che li contengono.
Le composizioni dell’invenzione saranno utilizzate in medicamenti, presidi, dermocosmetici e dispositivi medici favorenti una azione protettiva e preventiva l’insorgere di manifestazioni cutanee fotoallergiche e fototossiche mediate da farmaci, da sostanze applicate per uso topico o sistemico, intolleranze soggettive in soggetti predisposti, soggetti affetti da dermatiti fotoindotte.
Le composizioni della presente invenzione potranno essere formulate secondo metodi convenzionali ben noti nella tecnica, come quelli descritti in “Remington’s Pharmaceutical Handbook”, Mack Publishing Co., N.Y., USA, in qualsiasi forma destinata all’uso topico, preferibilmente come emulsione a fase estera oleosa od acquosa contenenti polimeri acrilici oltre ad altri eccipienti di uso convenzionale, quali agenti conservanti, umettanti, siliconi; o in forma di gel o di emulgel, utilizzanti opportuni agenti formulativi quali polimeri carbossivinilici e acrilici, cellulose, associazioni di emulsionanti e polimeri.
I seguenti esempi illustrano ulteriormente l’invenzione.
I termini utilizzati seguono le regole ENCI.
ESEMPIO 1 - EMULGEL OLIO-IN-ACQUA
ESEMPIO 2 - EMULSIONE OLIO-IN-ACQUA
ESEMPIO 3 - EMULSIONE OLIO-IN-ACQUA
, , , , , ESEMPIO 4 - EMULSIONE POLIMERICA OLIO-IN-ACQUA
ESEMPIO 5 - EMULSIONE A CRISTALLI LIQUIDI OLIO-IN-ACQUA
ESEMPIO 6 - EMULSIONE IN GEL
Bibliografia
1. J.H. Saurat - E. Grosshans - P. Laugier - J.M. Lachapelle.
Dermatologia e malattie sessualmente trasmesse - Edizioni Masson. 2. Gasparro FP. Environ Health Perspect. 2000;108(suppl 1):71-78.
3. DeBuys HV, Levy SB, Murray JC, et al. Derm Clin. 2000;18:577-590.
4. Lim HW: J Am Acad Dermatol. 2001;44:505-508.
5. Berneburg M, et al. J Biol Chem 1999; 274: 15345.
6. Pillemer L. et al. J. Biol. Chem. 137, 139-142. 1941.
7. Sherwood E. et al. J. Biol. Res. Mod. 6, 358381, 1986.
8. Zulli F. et al., Eurocosmetics, 11, 46-50, 1195.
9. Applegate L.A.,et al., Photochemistry and photobiology. 61, 285-291, 3, 1995.
10. Zulli F.et al. International Journal of Cosmetic Science, 20, 79-86, 998.
11. Elmets C.A., et al., Photoimmunol Photomed 1992; 9; 113-120, 1992.
12. Galinski, E.A.,et al., Comp. Biochem. Physiol., Vol. 117A, No. 3, 357-365, 1997.
13. Galinski, E.A., Compatible solutes of halophilic eubacteria: molecular principles, water-solute interaction, stress protection, Birkhäuser Verlag, 1993.
14. Galinski, E.A. et al., General and Applied Aspects of Halophilic Microorganisms, 1991.
15. Bunger J. et al., IFSCC Magazine vol.4, n° 2, 127-131, 2001.
16. Bunger J. et al., SPFW Journal.
17. Burton G.W. et al., Acc. Chem. Res. 19, 194202, 1986.
18. Ursini F. La Vitamina E in Dermatologia. Cleup University Publisher, Padova, 15-34. 2001.
19. Mc Vean et al., Carcinogenesis, 18, 1617-1622, 1997.
20. Gensler L. et al. Nutr. Cancer, 15, 97107, 1991.
21. Berton T.R. et al., Molec. Carcinogen., 23, 175-184, 1998.
22. Halliday GM et al., Australas J Dermatol 1998 May;39(2):71-5.
23. Padh H Nutr. Rev. 49, 65-70, 1991.
24. Niki E. et al. .: J. Biol. Chem. 259, 4177-4182, 1984.
25. Leung H. W. et al., Biochim. Biophys. Acta 664, 266-272, 1981.
26. Harman D.: The aging process. Proc. Natl. Acad. Sci. USA 78, 7124-7128, 1981.
27. Ames B.N. Free Rad. Res. Commun. 7, 121128, 1989.
28. Halliwell B. and Gutteridge J.M.C.: Free Radicals in Biology and Medicine (Clarendon, Oxford) 2<nd>Ed., 1990.
29. Fraga C.G.,et al.: Ascorbic acid protects against endogenous oxidative.
30. Leung A., Foster S. Encyclopedia of common natural ingredients, 2° edition. A. Wiley Interscience Pubblication 1996.
31. Firenzuoli F. Fitoperapia 3° edition. Edizioni Masson, 2002.
32. Psotova J, et al., J. Photochem Photobiol B. 2006 Sep 1;84(3):167-74. Epub 2006 Apr 21.
Claims (12)
- RIVENDICAZIONI 1. Composizioni topiche contenenti: a) componenti fotoassorbenti UV-A; b) betaglucano o suoi derivati, e/o ectoina; c) vitamine C e/o E e/o loro derivati.
- 2. Composizioni secondo la rivendicazione 1, in cui i componenti fotoassorbenti UV-A sono scelti nel gruppo di dietilammino idrossibenzoil esil benzoato, ossido di zinco, butil metossidibenzoilmetano.
- 3. Composizioni secondo la rivendicazione 2, in cui i componenti fotoassorbenti sono presenti nei seguenti intervalli di concentrazione: i) dietilammino idrossibenzoil esil benzoato: da 1 a 5%; ii) ossido di zinco: da 3 a 10%; iii) butil metossidibenzoilmetano: da 1 a 5%; e la somma delle concentrazioni di dietilammino idrossibenzoil esil benzoato e di ossido di zinco è compresa in un intervallo da 4 a 8%; le concentrazioni essendo intese sul totale dei componenti della composizione.
- 4. Composizioni secondo la rivendicazione 3, in cui il butil metossidibenzoilmetano è utilizzato in associazione ad Octocrylene in rapporto 1:1 o 1:1,5, in intervallo di concentrazione da 3 a 10% (sul totale dei componenti della composizione).
- 5. Composizioni secondo la rivendicazione 1, in cui l’ossido di zinco è utilizzato in forma libera o micronizzata tra 20 e 200 micron, come polvere o predisperso in solventi scelti tra acqua, C12-C15 alchil benzoati, olio minerale, Dimethicone o trigliceridi C8-C12.
- 6. Composizioni secondo la rivendicazione 1, in cui il derivato di betaglucano è il carbossimetil betaglucano.
- 7. Composizioni secondo la rivendicazione 1, in cui la concentrazione di betaglucano o suoi derivati e di ectoina è rispettivamente da 0,01 a 0,2% e da 0,1 a 2%, e la loro somma è compresa in un intervallo da 0,1 a 1,5%; le concentrazioni essendo intese sul totale dei componenti della composizione.
- 8. Composizioni secondo la rivendicazione 1, in cui la vitamina E è presente in forma di tocoferolo naturale, sintetico o di derivati, in concentrazioni almeno uguali o superiori a 2%; e la vitamina C è presente in forma di acido ascorbico o di derivati scelti tra ascorbil magnesio fosfato, ascorbil tetraisopalmitato, sodio ascorbil fosfato, in concentrazioni almeno uguali o superiori a 0,3%; e la somma delle concentrazioni di vitamina E e vitamina C è almeno superiore al 2%, le concentrazioni essendo intese sul totale dei componenti della composizione.
- 9. Composizioni secondo una qualsiasi delle rivendicazioni da 1 a 8, contenenti inoltre estratti vegetali quali estratti da Vitis vinifera, Prunella vulgaris, Uncaria tormentosa, Paeonia, Camellia Sinensis.
- 10. Composizioni secondo una qualsiasi delle rivendicazioni da 1 a 9, contenenti inoltre sostanze quali bioflavonoidi, proantocianidine, polifenoli, verbascosidi, xyloglucani o estratti vegetali che li contengono.
- 11. Composizioni secondo una qualsiasi delle rivendicazioni da 1 a 9, in forma di emulsione a fase estera oleosa od acquosa, o in forma di gel o di emulgel.
- 12. Uso di: a) sistemi fotoassorbenti UV-A; b) betaglucano o suoi derivati, e/o ectoina; c) vitamine C e/o E e/o loro derivati; d) ed eventualmente di bioflavonoidi, proantocianidine, polifenoli, verbascosidi, xyloglucani o estratti vegetali che li contengono; per la preparazione di composizioni topiche per la protezione e la prevenzione di reazioni cutanee fotoallergiche e fototossiche.
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000560A ITMI20080560A1 (it) | 2008-04-01 | 2008-04-01 | Composizioni preventive-protettive contro l'insorgenza di manifestazioni cutanee fotoallergiche e fototossiche |
| DK09734893.2T DK2257266T3 (en) | 2008-04-01 | 2009-03-23 | CONFIGURATIONS DESIGNED TO PREVENT / PROTECT AGAINST PHOTO AND ALLERGIC phototoxic SKIN REACTIONS |
| PCT/EP2009/002122 WO2009129904A2 (en) | 2008-04-01 | 2009-03-23 | Compositions designed to prevent/protect against photoallergic and phototoxic skin reactions |
| EP09734893.2A EP2257266B1 (en) | 2008-04-01 | 2009-03-23 | Compositions designed to prevent/protect against photoallergic and phototoxic skin reactions |
| ES09734893.2T ES2575374T3 (es) | 2008-04-01 | 2009-03-23 | Composiciones concebidas para prevenir/proteger contra las reacciones cutáneas fotoalérgicas y fototóxicas |
| PL09734893T PL2257266T3 (pl) | 2008-04-01 | 2009-03-23 | Kompozycje przeznaczone do zapobiegania i ochrony przed fotoalergicznymi i fototoksycznymi reakcjami skóry |
| HUE09734893A HUE027899T2 (en) | 2008-04-01 | 2009-03-23 | Preparations for preventing or protecting against photo-allergic and phototoxic skin reactions |
| PT09734893T PT2257266E (pt) | 2008-04-01 | 2009-03-23 | Composições concebidas para evitar/proteger contra reações cutâneas fotoalérgicas e fototóxicas |
| SI200931437A SI2257266T1 (sl) | 2008-04-01 | 2009-03-23 | Sestavki, zasnovani za preprečevanje fotoalergijskih in fototoksičnih kožnih reakcij oz. za zaščito pred njimi |
| CY20161100467T CY1117829T1 (el) | 2008-04-01 | 2016-05-30 | Συνθεσεις οι οποιες εχουν σχεδιασθει ωστε να προλαμβανουν/προστατευουν εναντι φωτοαλλεργικων και φωτοτοξικων δερματικων αντιδρασεων |
| HRP20160589TT HRP20160589T1 (hr) | 2008-04-01 | 2016-06-01 | Pripravci dizajnirani za sprječavanje/zaštitu od fotoalergijskih i fototoksičnih reakcija kože |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000560A ITMI20080560A1 (it) | 2008-04-01 | 2008-04-01 | Composizioni preventive-protettive contro l'insorgenza di manifestazioni cutanee fotoallergiche e fototossiche |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITMI20080560A1 true ITMI20080560A1 (it) | 2009-10-02 |
Family
ID=40296828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT000560A ITMI20080560A1 (it) | 2008-04-01 | 2008-04-01 | Composizioni preventive-protettive contro l'insorgenza di manifestazioni cutanee fotoallergiche e fototossiche |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP2257266B1 (it) |
| CY (1) | CY1117829T1 (it) |
| DK (1) | DK2257266T3 (it) |
| ES (1) | ES2575374T3 (it) |
| HR (1) | HRP20160589T1 (it) |
| HU (1) | HUE027899T2 (it) |
| IT (1) | ITMI20080560A1 (it) |
| PL (1) | PL2257266T3 (it) |
| PT (1) | PT2257266E (it) |
| SI (1) | SI2257266T1 (it) |
| WO (1) | WO2009129904A2 (it) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8623506B2 (en) | 2011-06-22 | 2014-01-07 | Empire Technology Development Llc | Non-covalently bonding anti-microbial nanoparticles for water soluble wood treatment |
| EP3624763A1 (en) * | 2017-05-18 | 2020-03-25 | Medena AG | Use of naturally glycosylated polyphenols as protective agents against the effects of ultraviolet irradiation |
| FR3079416B1 (fr) * | 2018-03-27 | 2020-03-06 | Isis Pharma France | Nouvelle composition cosmetique ou dermatologique pour la protection contre les uv |
| WO2024089235A1 (en) * | 2022-10-28 | 2024-05-02 | Dsm Ip Assets B.V. | Sunscreen composition comprising a human milk oligosaccharide |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5827508A (en) * | 1996-09-27 | 1998-10-27 | The Procter & Gamble Company | Stable photoprotective compositions |
| FR2754713B1 (fr) * | 1996-10-22 | 1999-01-08 | Roc Sa | Utilisation de complexes pour la preparation de compositions pour le traitement des peaux sensibles, procede de preparation et compositions hypoallergeniques |
| US6090369A (en) * | 1997-06-04 | 2000-07-18 | Stewart; Ernest Glading | Sunscreen formulation with avobenzone and method for stabilizing sunscreen formulation which contains avobenzone |
| CA2318345C (en) * | 1997-12-24 | 2011-06-07 | Shaklee Corporation | Composition with high efficiency skin protection from damaging effects of ultraviolet light |
| DE19933460A1 (de) * | 1998-07-10 | 2000-01-13 | Beiersdorf Ag | Verwendung von Ectoinen und sulfonierten UV-Filtern |
| DE10002725A1 (de) * | 2000-01-11 | 2001-07-12 | Beiersdorf Ag | Wirkstoffe und Zubereitungen für die Hautaufhellung und zur Verhinderung der Hautbräunung (skin whitening) |
| KR20050007883A (ko) * | 2003-07-12 | 2005-01-21 | (주)현덕비엔티 | 녹차 폴리페놀과, 아스코르빈산 또는 그 유도체를함유하는 피부 광 손상 방지용 조성물 |
| FR2865398B1 (fr) * | 2004-01-23 | 2009-07-03 | Jean Noel Thorel | Compositions destinees a la protection cellulaire vis-a-vis des uva, de la peau, et/ou des phaneres. |
-
2008
- 2008-04-01 IT IT000560A patent/ITMI20080560A1/it unknown
-
2009
- 2009-03-23 PL PL09734893T patent/PL2257266T3/pl unknown
- 2009-03-23 DK DK09734893.2T patent/DK2257266T3/en active
- 2009-03-23 ES ES09734893.2T patent/ES2575374T3/es active Active
- 2009-03-23 EP EP09734893.2A patent/EP2257266B1/en active Active
- 2009-03-23 WO PCT/EP2009/002122 patent/WO2009129904A2/en active Application Filing
- 2009-03-23 PT PT09734893T patent/PT2257266E/pt unknown
- 2009-03-23 HU HUE09734893A patent/HUE027899T2/en unknown
- 2009-03-23 SI SI200931437A patent/SI2257266T1/sl unknown
-
2016
- 2016-05-30 CY CY20161100467T patent/CY1117829T1/el unknown
- 2016-06-01 HR HRP20160589TT patent/HRP20160589T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2575374T3 (es) | 2016-06-28 |
| PT2257266E (pt) | 2016-06-16 |
| HRP20160589T1 (hr) | 2016-07-01 |
| WO2009129904A2 (en) | 2009-10-29 |
| PL2257266T3 (pl) | 2016-08-31 |
| CY1117829T1 (el) | 2017-05-17 |
| WO2009129904A3 (en) | 2010-01-21 |
| WO2009129904A9 (en) | 2010-07-01 |
| HUE027899T2 (en) | 2016-10-28 |
| EP2257266B1 (en) | 2016-03-16 |
| SI2257266T1 (sl) | 2016-06-30 |
| EP2257266A2 (en) | 2010-12-08 |
| DK2257266T3 (en) | 2016-06-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Peres et al. | Ferulic acid photoprotective properties in association with UV filters: Multifunctional sunscreen with improved SPF and UVA-PF | |
| KR102382354B1 (ko) | 자외선차단제를 포함하는 마이크로캡슐 | |
| US20160296438A1 (en) | Protective action of lutein against blue light on human skin cell lines | |
| KR20110036111A (ko) | 산화방지제-기재의 보호 시스템을 갖는 복합물 입자, 및 그를 포함하는 국소용 조성물 | |
| JP6975139B2 (ja) | Ｕｖａ日焼け止め活性薬剤の改良された耐水性を有する日焼け止め組成物 | |
| EP3714865B1 (fr) | Composition cosmetique solaire a haute teneur en filtres solaires derives de triazine | |
| ITMI20080560A1 (it) | Composizioni preventive-protettive contro l'insorgenza di manifestazioni cutanee fotoallergiche e fototossiche | |
| KR20140091690A (ko) | Ｄｇｌａ 및/또는 15-ｈｅｔｒｅ을 포함하는 약제학적 조성물 및 그의 사용 방법 | |
| ES2658363T3 (es) | Composición y asociación de filtros solares para fotoestabilizar el butil metoxidibenzoilmetano (BMDBM) | |
| KR20230005221A (ko) | 비-수성 국소용 제형 | |
| KR101627051B1 (ko) | 비타민 c 함유 천연 리포좀, 그 제조방법 및 이를 포함하는 화장료 조성물 | |
| US20060045858A1 (en) | Composition and method for reducing harmful effects of ultraviolet radiation impinging on the skin | |
| JP7263658B2 (ja) | 青色光による暴露に際しての損傷からヒト皮膚を保護するための方法 | |
| Limsuwan et al. | Effect of grape seed extract in sunscreen lotion on sun protection factor (SPF) determined by in vitro method | |
| KR102012798B1 (ko) | 자외선 유도된 지질 과산화를 감소시키는 상승작용 조성물, 제형 및 방법 | |
| US10550094B2 (en) | Compounds having antioxidant activity against free radicals and anti-inflammatory activity, and corresponding pharmaceutical or cosmetic compositions for skin care | |
| FR3091649A1 (fr) | Composition cosmetique ou pharmaceutique permettant de reduire l’immunosuppression induite par une exposition au rayonnement ultraviolet | |
| Pasuch Gluzezak et al. | Evaluation of the photoprotective and antioxidant potential of an avobenzone derivative | |
| Liyanaarachchi et al. | 8 Photoprotective potential in medicinal plants | |
| Singh et al. | Photoprotective efficacy of Sunset Yellow via inhibition of type‐I and type‐II pathway under exposure of sunlight | |
| Soares et al. | In vitro approaches to antioxidant screening for the development of a sunscreen formulation | |
| ITMI20091190A1 (it) | Composizioni cosmetiche e dermatologiche | |
| ITMI980660A1 (it) | Melatonina e suoi composti idrosolubili in combinazione con sostanze anti-ossidanti per formulazioni cosmetiche e dermatologiche ad | |
| EP2039341A1 (fr) | Utilisation topique de dérivés thiazolidines contre les conséquences du stress oxydatif de la peau |