JP2001521490A - 長鎖アルコール類、アルカン類、脂肪酸類およびアミド類によるウイルスの阻害 - Google Patents
長鎖アルコール類、アルカン類、脂肪酸類およびアミド類によるウイルスの阻害Info
- Publication number
- JP2001521490A JP2001521490A JP51473498A JP51473498A JP2001521490A JP 2001521490 A JP2001521490 A JP 2001521490A JP 51473498 A JP51473498 A JP 51473498A JP 51473498 A JP51473498 A JP 51473498A JP 2001521490 A JP2001521490 A JP 2001521490A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- alcohol
- docosanol
- suspension
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Biotechnology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Fats And Perfumes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.製薬的に許容される希釈剤または担体中、約1:1(W:W)から約10: 1(W:W)の非イオン界面活性剤と有効成分の混合物を含み、前記非イオン界 面活性剤は、約1,000から約25,000の分子量を有するブロックポリマ ー、オクトキシノールまたはデオキシコレートであり、前記有効成分は、ステア リルアルコール、エルシルアルコール、ブラシジルアルコール、アラキジルアル コール、n−ドコサノール、n−ドコサン、n−ドコサン酸、エルカミド、ステ アリン酸またはそれらの組合わせである、組成物。 2.前記混合物が、約5:1(W:W)から約10:1(W:W)の割合で前記 非イオン界面活性剤および前記有効成分を含む、請求項1に記載の組成物。 3.前記混合物が、約4:1(W:W)から約10:1(W:W)の割合で前記 非イオン界面活性剤およびn−ドコサノールを含む、請求項1に記載の組成物。 4.前記混合物が、約4:1(W:W)から約10:1(W:W)の割合で前記 非イオン界面活性剤およびステアリン酸を含む、請求項1に記載の組成物。 5.前記ブロックポリマーが、プロピレングリコールのポリオキシアルキレン誘 導体からなり、かつ約25,000の分子量を有する、請求項1に記載の組成物 。 6.前記ブロックポリマーが、エチレンオキシドおよびプロピレンオキシドから なり、かつ約8,400の分子量を有する、請求項1に記載の組成物。 7.前記非イオン界面活性剤が、オクトキシノール−9、オクトキノール−10 またはそれらの組合せである、請求項1に記載の組成物。 8.前記混合物が、約5:1(W:W)の割合で、エチレンオキシドおよびプロ ピレンオキシドからなるブロックポリマーとn−ドコサノールとを含み、前記ブ ロックポリマーは約8,400の分子量を有する、請求項1に記載の組成物。 9.前記混合物が、約5:1(W:W)の割合で、プロピレングリコールのポリ オキシアルキレン誘導体のブロックポリマーとn−ドコサノールとを含み、前記 ブロックポリマーは約25,0000の分子量を有する、請求項1に記載の組成 物。 10.前記混合物が、約5:1(W:W)の割合で、エチレンオキシドおよびプ ロピレンオキシドからなるブロックポリマーとn−ドコサン酸とを含み、前記ブ ロックポリマーは約8,400の分子量を有する、請求項1に記載の組成物。 11.前記混合物が、約5%から約20%(W/W)のステアリン酸を含み、さ らに糖ベースステアレートを含む、請求項1に記載の組成物。 12.前記混合物が、約10%から約12%(W/W)のn−ドコサノールを含 み、さらに糖ベースステアレートを含む、請求項1に記載の組成物。 13.前記混合物が、製薬的に許容される希釈剤または担体中の非イオン界面活 性剤およびステアリン酸の懸濁物から本質的になる、請求項1に記載の組成物。 14.前記非イオン界面活性剤が、オクトキシノール、デオキシコレートまたは プロピレングリコールのポリオキシアルキレン誘導体のブロックポリマーであり 、前記ポリマは約25,000の分子量を有する、請求項13に記載の組成物。 15.細胞の成長または増殖を阻害するための、請求項1から13のいずれかに 記載の混合物を含む組成物の使用。 16.ウイルス感染症の予防または治療のための、請求項1から13のいずれか に記載の混合物を含む組成物の使用。 17.前記ウイルス感染症が、単純ヘルペスウイルス、サイトメガロウイルス、 エプスタイン・バーウイルス、水痘帯状ヘルペスウイルス、インフルエンザウイ ルス、ヒトリンパ球ウイルス、ヒト免疫不全ウイルス、乳頭腫ウイルスまたは呼 吸シンシチアルウイルスによって引起こされるものである、請求項16に記載の 組成物の使用。 18.皮膚または膜の炎症を緩和するための、請求項1から13のいずれかに記 載の混合物を含む組成物の使用。 19.局所適用、経膜的適用または非経口的適用に適する薬剤を調製するための 、請求項1から13のいずれかに記載の混合物を含む組成物の使用。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71500996A | 1996-09-17 | 1996-09-17 | |
US08/715,009 | 1996-09-17 | ||
US08/916,624 US5952392A (en) | 1996-09-17 | 1997-08-22 | Long-chain alcohols, alkanes, fatty acids and amides in the treatment of burns and viral inhibition |
US08/916,624 | 1997-08-22 | ||
PCT/US1997/016007 WO1998011887A2 (en) | 1996-09-17 | 1997-09-10 | Viral inhibition by long-chain alcohols, alkanes, fatty acids and amides |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001521490A true JP2001521490A (ja) | 2001-11-06 |
JP3739098B2 JP3739098B2 (ja) | 2006-01-25 |
Family
ID=27109257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51473498A Expired - Fee Related JP3739098B2 (ja) | 1996-09-17 | 1997-09-10 | 長鎖アルコール類、アルカン類、脂肪酸類およびアミド類によるウイルスの阻害 |
Country Status (16)
Country | Link |
---|---|
EP (2) | EP1557167A1 (ja) |
JP (1) | JP3739098B2 (ja) |
KR (2) | KR100528816B1 (ja) |
CN (1) | CN1213748C (ja) |
AT (1) | ATE299700T1 (ja) |
AU (1) | AU742929B2 (ja) |
BR (1) | BR9711501A (ja) |
CA (1) | CA2273960C (ja) |
DE (1) | DE69733778T2 (ja) |
DK (1) | DK1001759T3 (ja) |
ES (1) | ES2245004T3 (ja) |
IL (2) | IL129033A0 (ja) |
MX (1) | MXPA99002575A (ja) |
PL (1) | PL189618B1 (ja) |
PT (1) | PT1001759E (ja) |
WO (1) | WO1998011887A2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015063474A (ja) * | 2013-09-24 | 2015-04-09 | 株式会社デンソー | 抗ウイルス剤 |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6440980B1 (en) * | 1996-09-17 | 2002-08-27 | Avanir Pharmaceuticals | Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs |
DE69739583D1 (de) | 1996-11-14 | 2009-10-29 | Lipomedica Ehf | Topische zusammensetzungen enthaltend als therapeutisch aktiven wirkstoff ein monoglycerid zur behandlung von schleimhautinfektionen |
AU7928698A (en) | 1997-06-20 | 1999-01-04 | James Clair | A skin-protective composition |
IL142535A0 (en) * | 2001-04-11 | 2002-03-10 | Yeda Res & Dev | Pharmaceutical compositions for the treatment of inflammation |
SE0102289D0 (sv) * | 2001-06-27 | 2001-06-27 | Anders Hamberger | New use of compound |
BR0213323A (pt) * | 2001-10-16 | 2005-01-25 | Avanir Pharmaceuticals | Inibição viral por n-docosanol |
WO2004032824A2 (en) | 2002-10-10 | 2004-04-22 | Yeda Research And Development Co. Ltd. | Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents |
KR200449517Y1 (ko) * | 2008-01-23 | 2010-07-15 | 김영중 | 선박의 조향장치용 헬름 |
KR100971276B1 (ko) * | 2008-05-29 | 2010-07-20 | 김영중 | 조향장치 |
US9242923B2 (en) | 2010-03-11 | 2016-01-26 | Chemic Laboratories Inc. | Compositons and methods |
CN102702061B (zh) * | 2012-06-07 | 2013-04-24 | 浙江维康药业有限公司 | 一种盐酸水苏碱化合物及含有该化合物的药物组合物 |
FR3080038B1 (fr) | 2018-04-16 | 2020-10-09 | Oreal | Composition cosmetique pour fibres keratiniques |
FR3080034B1 (fr) * | 2018-04-16 | 2020-04-24 | L'oreal | Composition cosmetique pour fibres keratiniques |
KR102611242B1 (ko) * | 2021-05-17 | 2023-12-08 | 충남대학교 산학협력단 | 알케인을 유효성분으로 함유하는 항바이러스용 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3421468A1 (de) * | 1984-06-08 | 1985-12-19 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung |
US5208257A (en) * | 1986-04-21 | 1993-05-04 | Kabara Jon J | Topical antimicrobial pharmaceutical compositions and methods |
US5194451A (en) * | 1989-11-02 | 1993-03-16 | Katz David H | Systemic anti-inflammatory treatment |
US5250236A (en) * | 1991-08-05 | 1993-10-05 | Gasco Maria R | Method for producing solid lipid microspheres having a narrow size distribution |
WO1994016061A1 (en) * | 1993-01-15 | 1994-07-21 | Micro Vesicular Systems, Inc. | Method of inhibiting viral reproduction |
SG43833A1 (en) * | 1993-12-13 | 1997-11-14 | Lidak Pharmaceuticals | Sucrose ester-c20 to c25 alcohol formulations |
-
1997
- 1997-09-10 AU AU43397/97A patent/AU742929B2/en not_active Ceased
- 1997-09-10 PL PL97332455A patent/PL189618B1/pl unknown
- 1997-09-10 MX MXPA99002575A patent/MXPA99002575A/es unknown
- 1997-09-10 IL IL12903397A patent/IL129033A0/xx not_active IP Right Cessation
- 1997-09-10 KR KR10-2002-7011861A patent/KR100528816B1/ko not_active IP Right Cessation
- 1997-09-10 IL IL16386597A patent/IL163865A0/xx unknown
- 1997-09-10 DE DE69733778T patent/DE69733778T2/de not_active Expired - Lifetime
- 1997-09-10 CN CNB971998051A patent/CN1213748C/zh not_active Expired - Fee Related
- 1997-09-10 EP EP05075320A patent/EP1557167A1/en not_active Withdrawn
- 1997-09-10 CA CA002273960A patent/CA2273960C/en not_active Expired - Lifetime
- 1997-09-10 ES ES97941503T patent/ES2245004T3/es not_active Expired - Lifetime
- 1997-09-10 WO PCT/US1997/016007 patent/WO1998011887A2/en active IP Right Grant
- 1997-09-10 PT PT97941503T patent/PT1001759E/pt unknown
- 1997-09-10 EP EP97941503A patent/EP1001759B1/en not_active Expired - Lifetime
- 1997-09-10 KR KR10-1999-7002271A patent/KR100528815B1/ko not_active IP Right Cessation
- 1997-09-10 JP JP51473498A patent/JP3739098B2/ja not_active Expired - Fee Related
- 1997-09-10 AT AT97941503T patent/ATE299700T1/de active
- 1997-09-10 DK DK97941503T patent/DK1001759T3/da active
- 1997-09-10 BR BR9711501-0A patent/BR9711501A/pt not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015063474A (ja) * | 2013-09-24 | 2015-04-09 | 株式会社デンソー | 抗ウイルス剤 |
Also Published As
Publication number | Publication date |
---|---|
EP1001759B1 (en) | 2005-07-20 |
ES2245004T3 (es) | 2005-12-16 |
DK1001759T3 (da) | 2005-10-10 |
KR20030097605A (ko) | 2003-12-31 |
CA2273960C (en) | 2003-12-30 |
JP3739098B2 (ja) | 2006-01-25 |
CN1244121A (zh) | 2000-02-09 |
EP1557167A1 (en) | 2005-07-27 |
AU4339797A (en) | 1998-04-14 |
WO1998011887A2 (en) | 1998-03-26 |
BR9711501A (pt) | 2004-05-25 |
MXPA99002575A (es) | 2004-07-29 |
PL189618B1 (pl) | 2005-08-31 |
PT1001759E (pt) | 2005-10-31 |
WO1998011887A3 (en) | 1998-06-25 |
PL332455A1 (en) | 1999-09-13 |
DE69733778T2 (de) | 2006-04-20 |
AU742929B2 (en) | 2002-01-17 |
KR100528816B1 (ko) | 2005-11-16 |
IL129033A0 (en) | 2000-02-17 |
DE69733778D1 (de) | 2005-08-25 |
KR20000036210A (ko) | 2000-06-26 |
CN1213748C (zh) | 2005-08-10 |
EP1001759A2 (en) | 2000-05-24 |
KR100528815B1 (ko) | 2005-11-16 |
ATE299700T1 (de) | 2005-08-15 |
IL163865A0 (en) | 2005-12-18 |
CA2273960A1 (en) | 1998-03-26 |
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LAPS | Cancellation because of no payment of annual fees |