JP2001518879A - 薬剤化合物の向上した浸透性のための溶媒システム - Google Patents
薬剤化合物の向上した浸透性のための溶媒システムInfo
- Publication number
- JP2001518879A JP2001518879A JP54163598A JP54163598A JP2001518879A JP 2001518879 A JP2001518879 A JP 2001518879A JP 54163598 A JP54163598 A JP 54163598A JP 54163598 A JP54163598 A JP 54163598A JP 2001518879 A JP2001518879 A JP 2001518879A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- pharmaceutical composition
- composition according
- topical pharmaceutical
- active drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 150000003873 salicylate salts Chemical class 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000002294 steroidal antiinflammatory agent Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical compound C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82909197A | 1997-03-31 | 1997-03-31 | |
| US08/829,091 | 1997-03-31 | ||
| PCT/US1998/004033 WO1998043673A1 (en) | 1997-03-31 | 1998-03-03 | Solvent system for enhanced penetration of pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2001518879A true JP2001518879A (ja) | 2001-10-16 |
Family
ID=25253504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP54163598A Pending JP2001518879A (ja) | 1997-03-31 | 1998-03-03 | 薬剤化合物の向上した浸透性のための溶媒システム |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0971746A1 (es) |
| JP (1) | JP2001518879A (es) |
| KR (1) | KR19980081207A (es) |
| CN (1) | CN1252003A (es) |
| AR (1) | AR012217A1 (es) |
| AU (1) | AU6677698A (es) |
| BR (1) | BR9811458A (es) |
| CA (1) | CA2285368A1 (es) |
| CO (1) | CO5050328A1 (es) |
| HU (1) | HUP0001739A3 (es) |
| IL (1) | IL132096A0 (es) |
| PL (1) | PL335934A1 (es) |
| WO (1) | WO1998043673A1 (es) |
| ZA (1) | ZA982662B (es) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10287588A (ja) * | 1997-04-10 | 1998-10-27 | Roche Consumer Health Worldwide Ltd | 医薬製剤 |
| WO2005002561A1 (ja) * | 2003-07-03 | 2005-01-13 | Taisho Pharmaceutical Co.,Ltd. | 外用抗真菌剤組成物 |
| JP2005036000A (ja) * | 2003-07-03 | 2005-02-10 | Taisho Pharmaceut Co Ltd | 容器への吸着を防止した外用抗真菌組成物 |
| US8492421B2 (en) | 2007-08-27 | 2013-07-23 | Nihon Nohyaku Co., Ltd. | Agent for fungal dermatitis |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000072818A1 (en) * | 1999-05-27 | 2000-12-07 | The Procter & Gamble Company | Topical compositions providing improved treatment of skin or scalp fungal infections |
| GB0103046D0 (en) | 2001-02-07 | 2001-03-21 | Novartis Ag | Organic Compounds |
| IL142037A0 (en) * | 2001-03-15 | 2002-03-10 | Agis Ind 1983 Ltd | Pharmaceutical compositions containing a non-steroidal anti-inflammatory drug |
| MY129350A (en) * | 2001-04-25 | 2007-03-30 | Bristol Myers Squibb Co | Aripiprazole oral solution |
| DE102005059742A1 (de) | 2005-12-13 | 2007-06-14 | Beiersdorf Ag | Transparentes Sonnenschutzmittel |
| US20080032994A1 (en) | 2006-08-03 | 2008-02-07 | Marcel Borgers | Modified azole compounds as antifungal and antibacterial agents |
| WO2009013331A1 (en) * | 2007-07-25 | 2009-01-29 | Ixodes Gmbh | Topical antibiotic composition for the prevention of lyme disease |
| US20090175810A1 (en) | 2008-01-03 | 2009-07-09 | Gareth Winckle | Compositions and methods for treating diseases of the nail |
| US8039494B1 (en) | 2010-07-08 | 2011-10-18 | Dow Pharmaceutical Sciences, Inc. | Compositions and methods for treating diseases of the nail |
| US9839611B2 (en) * | 2013-09-10 | 2017-12-12 | Insys Development Company, Inc. | Sublingual buprenorphine spray |
| MY179756A (en) | 2013-10-03 | 2020-11-12 | Dow Pharmaceutical Sciences | Stabilized efinaconazole formulations |
| CN105848719A (zh) | 2013-11-22 | 2016-08-10 | 道尔医药科学公司 | 抗感染的方法、组合物和装置 |
| CN115745757B (zh) * | 2022-11-07 | 2024-04-26 | 中国人民解放军军事科学院军事医学研究院 | 一种液态多甘醇柱芳烃衍生物的合成及对经皮药效分子缓释的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2051998T3 (es) * | 1988-02-29 | 1994-07-01 | Pfizer | Composiciones aumentadoras del flujo transdermal. |
| GB8827822D0 (en) * | 1988-11-29 | 1988-12-29 | Janssen Pharmaceutica Nv | (1h-azol-1-ylmethyl)substituted quinoline derivatives |
| CN1106259A (zh) * | 1994-02-05 | 1995-08-09 | 日东制药株式会社 | 含有作为有效成分的丙酸类非类固醇性药物的新颖消炎镇痛外用凝胶制剂 |
-
1998
- 1998-03-03 WO PCT/US1998/004033 patent/WO1998043673A1/en not_active Application Discontinuation
- 1998-03-03 HU HU0001739A patent/HUP0001739A3/hu unknown
- 1998-03-03 PL PL98335934A patent/PL335934A1/xx unknown
- 1998-03-03 CA CA002285368A patent/CA2285368A1/en not_active Abandoned
- 1998-03-03 BR BR9811458-1A patent/BR9811458A/pt not_active Application Discontinuation
- 1998-03-03 AU AU66776/98A patent/AU6677698A/en not_active Abandoned
- 1998-03-03 IL IL13209698A patent/IL132096A0/xx unknown
- 1998-03-03 JP JP54163598A patent/JP2001518879A/ja active Pending
- 1998-03-03 EP EP98908843A patent/EP0971746A1/en not_active Withdrawn
- 1998-03-03 CN CN98803908A patent/CN1252003A/zh active Pending
- 1998-03-30 ZA ZA9802662A patent/ZA982662B/xx unknown
- 1998-03-31 CO CO98017937A patent/CO5050328A1/es unknown
- 1998-03-31 AR ARP980101461A patent/AR012217A1/es unknown
- 1998-03-31 KR KR1019980012493A patent/KR19980081207A/ko not_active Application Discontinuation
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10287588A (ja) * | 1997-04-10 | 1998-10-27 | Roche Consumer Health Worldwide Ltd | 医薬製剤 |
| JP4580476B2 (ja) * | 1997-04-10 | 2010-11-10 | ロシュ コンシューマー ヘルス （ワールドワイド） エスエー | 医薬製剤 |
| WO2005002561A1 (ja) * | 2003-07-03 | 2005-01-13 | Taisho Pharmaceutical Co.,Ltd. | 外用抗真菌剤組成物 |
| JP2005036000A (ja) * | 2003-07-03 | 2005-02-10 | Taisho Pharmaceut Co Ltd | 容器への吸着を防止した外用抗真菌組成物 |
| JPWO2005002561A1 (ja) * | 2003-07-03 | 2006-10-19 | 大正製薬株式会社 | 外用抗真菌剤組成物 |
| JP5435836B2 (ja) * | 2003-07-03 | 2014-03-05 | 大正製薬株式会社 | 外用抗真菌剤組成物 |
| US8492421B2 (en) | 2007-08-27 | 2013-07-23 | Nihon Nohyaku Co., Ltd. | Agent for fungal dermatitis |
| JP5313905B2 (ja) * | 2007-08-27 | 2013-10-09 | 日本農薬株式会社 | 真菌性皮膚炎用剤 |
| US8835479B2 (en) | 2007-08-27 | 2014-09-16 | Nihon Nohyaku Co., Ltd. | Agent for fungal dermatitis |
Also Published As
| Publication number | Publication date |
|---|---|
| AR012217A1 (es) | 2000-09-27 |
| CO5050328A1 (es) | 2001-06-27 |
| EP0971746A1 (en) | 2000-01-19 |
| BR9811458A (pt) | 2000-09-19 |
| HUP0001739A3 (en) | 2001-04-28 |
| PL335934A1 (en) | 2000-05-22 |
| IL132096A0 (en) | 2001-03-19 |
| KR19980081207A (ko) | 1998-11-25 |
| AU6677698A (en) | 1998-10-22 |
| ZA982662B (en) | 1999-09-30 |
| HUP0001739A2 (hu) | 2000-12-28 |
| CN1252003A (zh) | 2000-05-03 |
| WO1998043673A1 (en) | 1998-10-08 |
| CA2285368A1 (en) | 1998-10-08 |
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