JP2001518523A - インターベンショナル療法をモニタリングするためのコントラスト増強型診断的画像化方法 - Google Patents

インターベンショナル療法をモニタリングするためのコントラスト増強型診断的画像化方法

Info

Publication number
JP2001518523A
JP2001518523A JP2000514677A JP2000514677A JP2001518523A JP 2001518523 A JP2001518523 A JP 2001518523A JP 2000514677 A JP2000514677 A JP 2000514677A JP 2000514677 A JP2000514677 A JP 2000514677A JP 2001518523 A JP2001518523 A JP 2001518523A
Authority
JP
Japan
Prior art keywords
tissue
contrast agent
state
contrast
bound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000514677A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001518523A5 (https=
Inventor
ランドール ビー． ラファー，
ステファン オー． ダナム，
Original Assignee
エピックス メディカル， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エピックス メディカル， インコーポレイテッド filed Critical エピックス メディカル， インコーポレイテッド
Publication of JP2001518523A publication Critical patent/JP2001518523A/ja
Publication of JP2001518523A5 publication Critical patent/JP2001518523A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Transforming Light Signals Into Electric Signals (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
JP2000514677A 1997-10-02 1998-09-24 インターベンショナル療法をモニタリングするためのコントラスト増強型診断的画像化方法 Pending JP2001518523A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94298997A 1997-10-02 1997-10-02
US08/942,989 1997-10-02
PCT/US1998/020182 WO1999017809A2 (en) 1997-10-02 1998-09-24 Contrast-enhanced diagnostic imaging method for monitoring interventional therapies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005276942A Division JP2006077020A (ja) 1997-10-02 2005-09-22 インターベンショナル療法をモニタリングするためのコントラスト増強型診断的画像化方法

Publications (2)

Publication Number Publication Date
JP2001518523A true JP2001518523A (ja) 2001-10-16
JP2001518523A5 JP2001518523A5 (https=) 2006-01-05

Family

ID=25478927

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000514677A Pending JP2001518523A (ja) 1997-10-02 1998-09-24 インターベンショナル療法をモニタリングするためのコントラスト増強型診断的画像化方法
JP2005276942A Pending JP2006077020A (ja) 1997-10-02 2005-09-22 インターベンショナル療法をモニタリングするためのコントラスト増強型診断的画像化方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2005276942A Pending JP2006077020A (ja) 1997-10-02 2005-09-22 インターベンショナル療法をモニタリングするためのコントラスト増強型診断的画像化方法

Country Status (19)

Country Link
US (2) US6861045B1 (https=)
EP (1) EP1019094B1 (https=)
JP (2) JP2001518523A (https=)
KR (1) KR20010030854A (https=)
AT (1) ATE254479T1 (https=)
AU (1) AU742438C (https=)
BR (1) BR9812716A (https=)
CA (1) CA2303426C (https=)
DE (1) DE69819925T2 (https=)
DK (1) DK1019094T3 (https=)
ES (1) ES2206996T3 (https=)
HU (1) HUP0101245A3 (https=)
IL (1) IL134985A0 (https=)
IS (1) IS2041B (https=)
NO (1) NO321966B1 (https=)
NZ (1) NZ503402A (https=)
PT (1) PT1019094E (https=)
SK (1) SK4842000A3 (https=)
WO (1) WO1999017809A2 (https=)

Cited By (3)

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JP2009517118A (ja) * 2005-11-29 2009-04-30 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 磁気共鳴を使用して結合している及び結合していない造影剤を識別する方法
JP2010501009A (ja) * 2006-08-17 2010-01-14 エピックス ファーマシューティカルズ，インコーポレイテッド リンパ系撮像方法
JP2016514151A (ja) * 2013-03-13 2016-05-19 ランセウス メディカル イメージング， インコーポレイテッド ガドフォスベセット三ナトリウム一水和物の製造方法

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JP2004537580A (ja) * 2001-08-10 2004-12-16 エピックス メディカル， インコーポレイテッド 延長された循環半減期を有するポリペプチド結合体
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
CA2666005C (en) 2002-03-01 2016-01-19 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
PT2949658T (pt) 2003-03-03 2018-10-18 Bracco Suisse Sa Péptidos que ligam especificamente o recetor de hgf (cmet) e utilizações dos mesmos
US20050064045A1 (en) * 2003-09-18 2005-03-24 Sheng-Ping Zhong Injectable therapeutic formulations
WO2005110495A1 (en) * 2004-05-18 2005-11-24 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy control in radiation therapy with proton or ion beams
US7585492B2 (en) 2004-05-18 2009-09-08 Siemens Aktiengesellschaft Biomolecular contrast agents for therapy success and dose monitoring in radiation therapy with proton or ion beams
JP2006248978A (ja) * 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
WO2007073792A1 (de) * 2005-12-19 2007-07-05 Bayer Schering Pharma Aktiengesellschaft Verfahren zur herstellung von 4,4-diphenylcyclohexanol
DE102006049821A1 (de) 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
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US11160454B2 (en) * 2013-04-08 2021-11-02 Sunnybrook Research Institute System and method for imaging biomarkers indicative of cardiac thermal ablation lesions
JP2015087167A (ja) * 2013-10-29 2015-05-07 キヤノン株式会社 画像処理方法、画像処理システム
US10314648B2 (en) 2013-12-13 2019-06-11 The Trustees of the Universoty of Pennsylvania Coaxial ablation probe and method and system for real-time monitoring of ablation therapy
WO2015171543A1 (en) 2014-05-05 2015-11-12 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
WO2015196208A2 (en) 2014-06-20 2015-12-23 The General Hospital Corporation Collagen targeted imaging probes
EP3270951B1 (en) 2015-03-16 2020-09-09 California Institute of Technology Botulinum neurotoxin-specific capture agents, compositions, and methods of using and making
CN115112898B (zh) 2015-07-15 2026-03-24 加州理工学院 Il-17f-特异性捕获剂、组合物以及使用和制造的方法
US10383590B2 (en) 2015-09-28 2019-08-20 General Electric Company Methods and systems for adaptive scan control
CN115109120A (zh) 2016-04-04 2022-09-27 英蒂分子公司 Cd8-特异性捕获剂、组合物及使用和制备方法
US11884707B2 (en) 2016-09-29 2024-01-30 Regeneron Pharmaceuticals, Inc. Compositions for detection, inhibition and imaging of indoleamine 2, 3-dioxygenase 1 (IDO1) and methods of making and using same
EP3535278A4 (en) 2016-11-01 2020-06-24 Ohio State Innovation Foundation METHOD FOR IODING BIOMOLECULES
EP3638687A1 (en) 2017-06-15 2020-04-22 Indi Molecular, Inc. Il-17f and il-17a-specific capture agents, compositions, and methods of using and making
US20190370956A1 (en) 2018-05-30 2019-12-05 General Electric Company Contrast imaging system and method
WO2020093055A2 (en) 2018-11-02 2020-05-07 Indi Molecular, Inc. Peptide libraries with non-canonical amino acids
US11638764B2 (en) 2018-11-08 2023-05-02 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
US12201679B2 (en) 2019-04-05 2025-01-21 Institute For Systems Biology Epitope-targeted peptide immunostimulants
WO2020236969A1 (en) 2019-05-20 2020-11-26 Indi Molecular, Inc. Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1)
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
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US12209142B2 (en) 2020-05-29 2025-01-28 Institute For Systems Biology SARS-CoV-2 epitope-targeted peptide immunostimulants
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009517118A (ja) * 2005-11-29 2009-04-30 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 磁気共鳴を使用して結合している及び結合していない造影剤を識別する方法
JP2010501009A (ja) * 2006-08-17 2010-01-14 エピックス ファーマシューティカルズ，インコーポレイテッド リンパ系撮像方法
JP2016514151A (ja) * 2013-03-13 2016-05-19 ランセウス メディカル イメージング， インコーポレイテッド ガドフォスベセット三ナトリウム一水和物の製造方法

Also Published As

Publication number Publication date
IS5399A (is) 2000-03-10
IL134985A0 (en) 2001-05-20
DE69819925T2 (de) 2004-09-02
US7175829B2 (en) 2007-02-13
US6861045B1 (en) 2005-03-01
BR9812716A (pt) 2000-08-22
KR20010030854A (ko) 2001-04-16
HK1030744A1 (en) 2001-05-18
AU742438C (en) 2003-05-22
ATE254479T1 (de) 2003-12-15
NZ503402A (en) 2002-03-01
NO20001707L (no) 2000-05-31
SK4842000A3 (en) 2000-11-07
EP1019094B1 (en) 2003-11-19
NO321966B1 (no) 2006-07-31
ES2206996T3 (es) 2004-05-16
JP2006077020A (ja) 2006-03-23
DK1019094T3 (da) 2004-02-16
IS2041B (is) 2005-09-15
AU742438B2 (en) 2002-01-03
CA2303426C (en) 2008-09-23
AU9668698A (en) 1999-04-27
NO20001707D0 (no) 2000-04-03
EP1019094A2 (en) 2000-07-19
HUP0101245A2 (hu) 2001-08-28
CA2303426A1 (en) 1999-04-15
HUP0101245A3 (en) 2003-10-28
US20050118103A1 (en) 2005-06-02
WO1999017809A2 (en) 1999-04-15
DE69819925D1 (de) 2003-12-24
PT1019094E (pt) 2004-03-31
WO1999017809A3 (en) 1999-05-20

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