JP2001516567A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2001516567A5 JP2001516567A5 JP2000511524A JP2000511524A JP2001516567A5 JP 2001516567 A5 JP2001516567 A5 JP 2001516567A5 JP 2000511524 A JP2000511524 A JP 2000511524A JP 2000511524 A JP2000511524 A JP 2000511524A JP 2001516567 A5 JP2001516567 A5 JP 2001516567A5
- Authority
- JP
- Japan
- Prior art keywords
- kit
- hapten
- linked
- peptide
- peptidomimetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 12
- 238000000034 method Methods 0.000 description 11
- 239000000816 peptidomimetic Substances 0.000 description 9
- 102000014914 Carrier Proteins Human genes 0.000 description 7
- 108010078791 Carrier Proteins Proteins 0.000 description 7
- 125000006850 spacer group Chemical group 0.000 description 6
- 230000003053 immunization Effects 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 230000002163 immunogen Effects 0.000 description 3
- UIKROCXWUNQSPJ-VIFPVBQESA-N (-)-cotinine Chemical compound C1CC(=O)N(C)[C@@H]1C1=CC=CN=C1 UIKROCXWUNQSPJ-VIFPVBQESA-N 0.000 description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
- 239000004473 Threonine Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 102000035122 glycosylated proteins Human genes 0.000 description 2
- 108091005608 glycosylated proteins Proteins 0.000 description 2
- 125000000487 histidyl group Chemical class [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 150000003588 threonines Chemical class 0.000 description 2
- -1 2-amino-3-furylpropionyl Chemical group 0.000 description 1
- UIKROCXWUNQSPJ-UHFFFAOYSA-N Cotinine Natural products C1CC(=O)N(C)C1C1=CC=CN=C1 UIKROCXWUNQSPJ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 229950006073 cotinine Drugs 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 150000002614 leucines Chemical class 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5937897P | 1997-09-19 | 1997-09-19 | |
| US60/059,378 | 1997-09-19 | ||
| US9045898P | 1998-06-24 | 1998-06-24 | |
| US60/090,458 | 1998-06-24 | ||
| PCT/US1998/019660 WO1999013907A2 (en) | 1997-09-19 | 1998-09-18 | Methods to improve immunogenicity of antigens and specificity of antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001516567A JP2001516567A (ja) | 2001-10-02 |
| JP2001516567A5 true JP2001516567A5 (enExample) | 2006-01-05 |
Family
ID=26738686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000511524A Pending JP2001516567A (ja) | 1997-09-19 | 1998-09-18 | 抗原の免疫原性および抗体の特異性を改善する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US6455047B1 (enExample) |
| EP (1) | EP1015028A2 (enExample) |
| JP (1) | JP2001516567A (enExample) |
| AU (1) | AU749305B2 (enExample) |
| CA (1) | CA2303775A1 (enExample) |
| WO (1) | WO1999013907A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6232082B1 (en) * | 1998-12-01 | 2001-05-15 | Nabi | Hapten-carrier conjugates for treating and preventing nicotine addiction |
| US6710190B1 (en) | 1999-05-28 | 2004-03-23 | Warner-Lambert Company | 3-heteroarylalkyl substituted gaba analogs |
| AU4673200A (en) * | 1999-05-28 | 2000-12-18 | Warner-Lambert Company | 3-heteroarylalkyl substituted gaba analogs |
| GB0031079D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Vaccine |
| FR2877668B1 (fr) * | 2004-11-10 | 2007-07-06 | Gemac Sa | Procede de couplage de molecules non immunogenes, compose intermediaire, produit final obtenu et utilisations |
| WO2009120954A2 (en) * | 2008-03-27 | 2009-10-01 | The Scripps Research Institute | Nicotine immunoconjugates |
| US8603828B2 (en) * | 2009-11-18 | 2013-12-10 | Bio-Rad Laboratories, Inc. | Multiplex immunoassays for hemoglobin, hemoglobin variants, and glycated forms |
| US20160116489A1 (en) * | 2014-10-23 | 2016-04-28 | Biomedomics, Inc. | Lateral flow immunoassay method of simultaneously detecting hemoglobin s, hemoglobin c, and hemoglobin a in newborns, infants, children, and adults |
| CN106053788A (zh) * | 2016-07-21 | 2016-10-26 | 苏州博源医疗科技有限公司 | 一种可替宁均相酶免疫检测试剂及其制备和检测方法 |
| EP3568157A4 (en) * | 2017-01-13 | 2021-01-06 | National Research Council of Canada | PROCESS FOR THE OPTIMIZATION OF PEPTIDIC IMMUNO-EPITOPE BY GLYCOSYLATION, ASSOCIATED OPTIMIZED PEPTIDE AND ITS USE FOR CONJUGATE VACCINES |
| EP3574326B1 (en) | 2017-05-19 | 2025-03-19 | Philip Morris Products S.A. | Diagnostic test for distinguishing the smoking status of a subject |
| US20210106677A1 (en) * | 2017-11-13 | 2021-04-15 | Matsfide, Inc. | Vaccine development methodology based on an adhesion molecule |
| CN113825765A (zh) * | 2019-03-14 | 2021-12-21 | 詹森生物科技公司 | 用于制备抗il12/il23抗体组合物的制造方法 |
| CN110642743B (zh) * | 2019-10-18 | 2021-01-01 | 中国农业大学 | 硝呋酚酰肼半抗原和人工抗原及其制备方法与应用 |
| CN110724671A (zh) * | 2019-10-31 | 2020-01-24 | 浙江蓝盾药业有限公司 | 杂交瘤细胞株1g8、抗体及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4727036A (en) | 1985-08-08 | 1988-02-23 | Molecular Diagnostics, Inc. | Antibodies for use in determining hemoglobin A1c |
| US4647654A (en) | 1984-10-29 | 1987-03-03 | Molecular Diagnostics, Inc. | Peptides useful in preparing hemoglobin A1c immunogens |
| CA1339952C (en) * | 1984-10-29 | 1998-07-14 | William J. Knowles | Immunoassays for denatured protein analytes, particularly hb alc, and monoclonal antibodies thereto |
| DE3806198A1 (de) * | 1988-02-04 | 1989-08-17 | Boehringer Mannheim Gmbh | Immunogen und seine verwendung zur gewinnung von antikoerpern gegen hba(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)c(pfeil abwaerts) |
| US5045480A (en) * | 1989-02-09 | 1991-09-03 | Miles Inc. | Gel particles having hapten moieties bound thereto as immunoassay reagent |
| US5484735A (en) | 1989-08-23 | 1996-01-16 | Northwestern University | Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids |
| US5164504A (en) | 1991-01-16 | 1992-11-17 | Abbott Laboratories | Haptens, tracers, immunogens and antibodies for immunoassays for cotinine derivatives |
| AU661207B2 (en) * | 1992-11-17 | 1995-07-13 | Boehringer Mannheim Gmbh | Simultaneous determination of HbA1c and haemoglobin variants with a glycation analogus to HbA1c |
| US5876727A (en) * | 1995-03-31 | 1999-03-02 | Immulogic Pharmaceutical Corporation | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
| CA2175862A1 (en) | 1995-05-19 | 1996-11-20 | Roberto Sundoro Wu | Propoxyphene derivatives for immunoassay reagents |
| US5929237A (en) | 1995-10-27 | 1999-07-27 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US5955582A (en) * | 1997-09-26 | 1999-09-21 | Beckman Coulter, Inc. | Antibody against a 3-aminophenylboronic-glycated protein complex and its use in an immunoassay |
-
1998
- 1998-09-18 EP EP98948385A patent/EP1015028A2/en not_active Withdrawn
- 1998-09-18 US US09/156,864 patent/US6455047B1/en not_active Expired - Lifetime
- 1998-09-18 AU AU94969/98A patent/AU749305B2/en not_active Ceased
- 1998-09-18 WO PCT/US1998/019660 patent/WO1999013907A2/en not_active Ceased
- 1998-09-18 CA CA002303775A patent/CA2303775A1/en not_active Abandoned
- 1998-09-18 JP JP2000511524A patent/JP2001516567A/ja active Pending
-
2002
- 2002-08-21 US US10/224,758 patent/US7303750B2/en not_active Expired - Lifetime
- 2002-08-21 US US10/224,800 patent/US7147858B2/en not_active Expired - Fee Related
- 2002-08-21 US US10/224,772 patent/US7335516B2/en not_active Expired - Fee Related
- 2002-08-21 US US10/225,227 patent/US20030077287A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2001516567A5 (enExample) | ||
| US4478823A (en) | Immunological preparations containing purified MHC antigens bonded to other antigens | |
| WO2006076410A3 (en) | Li-key/antigenic epitope hybrid peptide vaccines | |
| KR950702839A (ko) | 레트로, 인버소-, 및 레트로- 인버소 합성 펩티드 유사체(retro-, inverso-, and retro-inverso synthetic peptide analogues) | |
| JP2858848B2 (ja) | Ｂ型肝炎ウイルスコア抗原粒子 | |
| US6048529A (en) | PVA or PEG conjugates of peptides for epitope-specific immunosuppression | |
| ATE468127T1 (de) | Ii-key/antigene epitop-hybrid-peptid-vakzine | |
| JPH09505056A (ja) | ヒトガストリン１７に対する改良された免疫原性組成物 | |
| Johnsen et al. | Antigenic and allergenic determinants of ovalbumin—III. MHC Ia-binding peptide (OA 323–339) interacts with human and rabbit specific antibodies | |
| WO1991008220A1 (en) | A method for the stepwise, controlled synthesis of chemical species, particularly peptides, coupled products obtained by the method and the use of these coupled products, e.g. as vaccines | |
| Dalum et al. | Induction of cross-reactive antibodies against a self protein by immunization with a modified self protein containing a foreign T helper epitope | |
| AU610526B2 (en) | Improvements in or relating to hormones | |
| Elsayed et al. | Synthetic allergenic epitopes from the amino-terminal regions of the major allergens of hazel and birch pollen | |
| WO2002008716A3 (fr) | Procede de criblage de peptides utilisables en immunotherapie | |
| US6455047B1 (en) | Methods to improve immunogenicity of antigens and specificity of antibodies | |
| JP2006515744A5 (enExample) | ||
| JP2002536384A (ja) | Ｔヘルパー細胞エピトープ | |
| HUT52787A (en) | Process for production of biologically active peptides | |
| IE911527A1 (en) | Improved vaccine compositions | |
| JPS63258895A (ja) | ヒンジペプチド、その製造法及びその合成免疫原製造への使用 | |
| Park et al. | Targeted destruction of the polymerized human serum albumin binding site within the preS2 region of the HBV surface antigen while retaining full immunogenicity for this epitope | |
| Morrison et al. | Computer‐aided design and physiological testing of a luteinising hormone‐releasing hormone analogue for ‘adjuvant‐free’immunocastration | |
| AU629179B2 (en) | Biologically active segments of several growth hormones | |
| DE69008701T2 (de) | Ein b-epitop des hüllglykoproteins eines retrovirus und ein t-epitop eines anderen proteins dieses retrovirus enthaltende zusammensetzung. | |
| KR940005665A (ko) | 분리된 폴리펩티드, 이를 암호하는 핵산 분자, 상기 폴리펩티드를 포함하는 조성물 및 이를 사용하는 방법 |