AU749305B2 - Methods to improve immunogenicity of antigens and specificity of antibodies - Google Patents
Methods to improve immunogenicity of antigens and specificity of antibodies Download PDFInfo
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- AU749305B2 AU749305B2 AU94969/98A AU9496998A AU749305B2 AU 749305 B2 AU749305 B2 AU 749305B2 AU 94969/98 A AU94969/98 A AU 94969/98A AU 9496998 A AU9496998 A AU 9496998A AU 749305 B2 AU749305 B2 AU 749305B2
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- peptide
- hapten
- antibody
- cotinine
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- 239000010432 diamond Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
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- 230000000694 effects Effects 0.000 description 1
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- 108091005608 glycosylated proteins Proteins 0.000 description 1
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- 150000003278 haem Chemical class 0.000 description 1
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- 108060003552 hemocyanin Proteins 0.000 description 1
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- 239000010410 layer Substances 0.000 description 1
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- 239000007791 liquid phase Substances 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
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- FJLBFSROUSIWMA-UHFFFAOYSA-N metyrapone Chemical compound C=1C=CN=CC=1C(C)(C)C(=O)C1=CC=CN=C1 FJLBFSROUSIWMA-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/16—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5937897P | 1997-09-19 | 1997-09-19 | |
| US60/059378 | 1997-09-19 | ||
| US9045898P | 1998-06-24 | 1998-06-24 | |
| US60/090458 | 1998-06-24 | ||
| PCT/US1998/019660 WO1999013907A2 (en) | 1997-09-19 | 1998-09-18 | Methods to improve immunogenicity of antigens and specificity of antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU9496998A AU9496998A (en) | 1999-04-05 |
| AU749305B2 true AU749305B2 (en) | 2002-06-20 |
Family
ID=26738686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU94969/98A Ceased AU749305B2 (en) | 1997-09-19 | 1998-09-18 | Methods to improve immunogenicity of antigens and specificity of antibodies |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US6455047B1 (enExample) |
| EP (1) | EP1015028A2 (enExample) |
| JP (1) | JP2001516567A (enExample) |
| AU (1) | AU749305B2 (enExample) |
| CA (1) | CA2303775A1 (enExample) |
| WO (1) | WO1999013907A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6232082B1 (en) * | 1998-12-01 | 2001-05-15 | Nabi | Hapten-carrier conjugates for treating and preventing nicotine addiction |
| US6710190B1 (en) | 1999-05-28 | 2004-03-23 | Warner-Lambert Company | 3-heteroarylalkyl substituted gaba analogs |
| AU4673200A (en) * | 1999-05-28 | 2000-12-18 | Warner-Lambert Company | 3-heteroarylalkyl substituted gaba analogs |
| GB0031079D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Vaccine |
| FR2877668B1 (fr) * | 2004-11-10 | 2007-07-06 | Gemac Sa | Procede de couplage de molecules non immunogenes, compose intermediaire, produit final obtenu et utilisations |
| WO2009120954A2 (en) * | 2008-03-27 | 2009-10-01 | The Scripps Research Institute | Nicotine immunoconjugates |
| US8603828B2 (en) * | 2009-11-18 | 2013-12-10 | Bio-Rad Laboratories, Inc. | Multiplex immunoassays for hemoglobin, hemoglobin variants, and glycated forms |
| US20160116489A1 (en) * | 2014-10-23 | 2016-04-28 | Biomedomics, Inc. | Lateral flow immunoassay method of simultaneously detecting hemoglobin s, hemoglobin c, and hemoglobin a in newborns, infants, children, and adults |
| CN106053788A (zh) * | 2016-07-21 | 2016-10-26 | 苏州博源医疗科技有限公司 | 一种可替宁均相酶免疫检测试剂及其制备和检测方法 |
| EP3568157A4 (en) * | 2017-01-13 | 2021-01-06 | National Research Council of Canada | PROCESS FOR THE OPTIMIZATION OF PEPTIDIC IMMUNO-EPITOPE BY GLYCOSYLATION, ASSOCIATED OPTIMIZED PEPTIDE AND ITS USE FOR CONJUGATE VACCINES |
| EP3574326B1 (en) | 2017-05-19 | 2025-03-19 | Philip Morris Products S.A. | Diagnostic test for distinguishing the smoking status of a subject |
| US20210106677A1 (en) * | 2017-11-13 | 2021-04-15 | Matsfide, Inc. | Vaccine development methodology based on an adhesion molecule |
| CN113825765A (zh) * | 2019-03-14 | 2021-12-21 | 詹森生物科技公司 | 用于制备抗il12/il23抗体组合物的制造方法 |
| CN110642743B (zh) * | 2019-10-18 | 2021-01-01 | 中国农业大学 | 硝呋酚酰肼半抗原和人工抗原及其制备方法与应用 |
| CN110724671A (zh) * | 2019-10-31 | 2020-01-24 | 浙江蓝盾药业有限公司 | 杂交瘤细胞株1g8、抗体及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0185870A2 (en) * | 1984-10-29 | 1986-07-02 | Bayer Corporation | Immunoassays for denatured protein analytes, particularly HB Alc, and monoclonal antibodies thereto |
| WO1992012975A1 (en) * | 1991-01-16 | 1992-08-06 | Abbott Laboratories | Haptens, tracers, immunogens and antibodies for immunoassays for cotinine |
| US5646255A (en) * | 1988-02-04 | 1997-07-08 | Boehringer Mannheim Gmbh | Immunogens and the use thereof for obtaining antibodies against HBA1C |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4727036A (en) | 1985-08-08 | 1988-02-23 | Molecular Diagnostics, Inc. | Antibodies for use in determining hemoglobin A1c |
| US4647654A (en) | 1984-10-29 | 1987-03-03 | Molecular Diagnostics, Inc. | Peptides useful in preparing hemoglobin A1c immunogens |
| US5045480A (en) * | 1989-02-09 | 1991-09-03 | Miles Inc. | Gel particles having hapten moieties bound thereto as immunoassay reagent |
| US5484735A (en) | 1989-08-23 | 1996-01-16 | Northwestern University | Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids |
| AU661207B2 (en) * | 1992-11-17 | 1995-07-13 | Boehringer Mannheim Gmbh | Simultaneous determination of HbA1c and haemoglobin variants with a glycation analogus to HbA1c |
| US5876727A (en) * | 1995-03-31 | 1999-03-02 | Immulogic Pharmaceutical Corporation | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same |
| CA2175862A1 (en) | 1995-05-19 | 1996-11-20 | Roberto Sundoro Wu | Propoxyphene derivatives for immunoassay reagents |
| US5929237A (en) | 1995-10-27 | 1999-07-27 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US5955582A (en) * | 1997-09-26 | 1999-09-21 | Beckman Coulter, Inc. | Antibody against a 3-aminophenylboronic-glycated protein complex and its use in an immunoassay |
-
1998
- 1998-09-18 EP EP98948385A patent/EP1015028A2/en not_active Withdrawn
- 1998-09-18 US US09/156,864 patent/US6455047B1/en not_active Expired - Lifetime
- 1998-09-18 AU AU94969/98A patent/AU749305B2/en not_active Ceased
- 1998-09-18 WO PCT/US1998/019660 patent/WO1999013907A2/en not_active Ceased
- 1998-09-18 CA CA002303775A patent/CA2303775A1/en not_active Abandoned
- 1998-09-18 JP JP2000511524A patent/JP2001516567A/ja active Pending
-
2002
- 2002-08-21 US US10/224,758 patent/US7303750B2/en not_active Expired - Lifetime
- 2002-08-21 US US10/224,800 patent/US7147858B2/en not_active Expired - Fee Related
- 2002-08-21 US US10/224,772 patent/US7335516B2/en not_active Expired - Fee Related
- 2002-08-21 US US10/225,227 patent/US20030077287A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0185870A2 (en) * | 1984-10-29 | 1986-07-02 | Bayer Corporation | Immunoassays for denatured protein analytes, particularly HB Alc, and monoclonal antibodies thereto |
| US5646255A (en) * | 1988-02-04 | 1997-07-08 | Boehringer Mannheim Gmbh | Immunogens and the use thereof for obtaining antibodies against HBA1C |
| WO1992012975A1 (en) * | 1991-01-16 | 1992-08-06 | Abbott Laboratories | Haptens, tracers, immunogens and antibodies for immunoassays for cotinine |
Also Published As
| Publication number | Publication date |
|---|---|
| US20030086939A1 (en) | 2003-05-08 |
| US20030095976A1 (en) | 2003-05-22 |
| US20030077287A1 (en) | 2003-04-24 |
| US20030113339A1 (en) | 2003-06-19 |
| US7335516B2 (en) | 2008-02-26 |
| CA2303775A1 (en) | 1999-03-25 |
| AU9496998A (en) | 1999-04-05 |
| JP2001516567A (ja) | 2001-10-02 |
| US7303750B2 (en) | 2007-12-04 |
| WO1999013907A2 (en) | 1999-03-25 |
| EP1015028A2 (en) | 2000-07-05 |
| WO1999013907A9 (en) | 1999-09-10 |
| US6455047B1 (en) | 2002-09-24 |
| WO1999013907A3 (en) | 1999-06-03 |
| US7147858B2 (en) | 2006-12-12 |
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Legal Events
| Date | Code | Title | Description |
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| FGA | Letters patent sealed or granted (standard patent) |