JP2001515581A - 安定化標準物質および検定物質 - Google Patents
安定化標準物質および検定物質Info
- Publication number
- JP2001515581A JP2001515581A JP50070597A JP50070597A JP2001515581A JP 2001515581 A JP2001515581 A JP 2001515581A JP 50070597 A JP50070597 A JP 50070597A JP 50070597 A JP50070597 A JP 50070597A JP 2001515581 A JP2001515581 A JP 2001515581A
- Authority
- JP
- Japan
- Prior art keywords
- tacrolimus
- drug
- composition
- rapamycin
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9493—Immunosupressants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/102499—Blood gas standard or control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/106664—Blood serum or blood plasma standard or control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 水性条件下で通常不安定な薬物および効果的な量の結合性蛋白質を含んで 成る安定化水性組成物。 2. 薬物がタクロリムスである、請求項1の組成物。 3. 薬物がラパマイシンである、請求項1の組成物。 4. 結合性蛋白質が、FKBP類および抗−タクロリムス抗体から成る群から 選ばれる、請求項2の組成物。 5. 結合性蛋白質が、FKBP類および抗−ラパマイシン抗体から成る群から 選ばれる、請求項3の組成物。 6. pHが7.4である、請求項4の組成物。 7. 結合性蛋白質がFKBP12である、請求項6の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/474,589 | 1995-06-07 | ||
US08/474,589 US5635406A (en) | 1995-06-07 | 1995-06-07 | Stabilized standards and calibrators containing rapamycin and tacrolimus bound to anti-rapamycin and anti-tacrolimus antibodies |
PCT/US1996/007617 WO1996041184A1 (en) | 1995-06-07 | 1996-05-24 | Stabilized standards and calibrators |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001515581A true JP2001515581A (ja) | 2001-09-18 |
JP3863564B2 JP3863564B2 (ja) | 2006-12-27 |
Family
ID=23884190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50070597A Expired - Lifetime JP3863564B2 (ja) | 1995-06-07 | 1996-05-24 | 安定化標準物質および検定物質 |
Country Status (8)
Country | Link |
---|---|
US (2) | US5635406A (ja) |
EP (1) | EP0832433B1 (ja) |
JP (1) | JP3863564B2 (ja) |
AT (1) | ATE214803T1 (ja) |
CA (1) | CA2219931C (ja) |
DE (1) | DE69619982T2 (ja) |
ES (1) | ES2176459T3 (ja) |
WO (1) | WO1996041184A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009541744A (ja) * | 2006-06-20 | 2009-11-26 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | タクロリムス標準物質及びそれを使用する方法 |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6709873B1 (en) * | 1997-04-09 | 2004-03-23 | Isodiagnostika Inc. | Method for production of antibodies to specific sites of rapamycin |
US7078495B1 (en) * | 1999-08-03 | 2006-07-18 | Dade Behring Inc. | Monoclonal antibodies to tacrolimus and immunoassay methods for tacrolimus |
US6613083B2 (en) * | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
US20030054042A1 (en) * | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
US7186518B2 (en) * | 2003-11-21 | 2007-03-06 | Dade Behring Inc. | Method and composition useful for determining FK 506 |
US8022188B2 (en) * | 2006-04-24 | 2011-09-20 | Abbott Laboratories | Immunosuppressant binding antibodies and methods of obtaining and using same |
US8329424B2 (en) | 2010-06-25 | 2012-12-11 | Siemens Healthcare Diagnostics | Reduction in false results in assay measurements |
US8809003B2 (en) | 2010-06-25 | 2014-08-19 | Siemens Healthcare Diagnostics Inc. | Reduction in false results in assay measurements |
US8563298B2 (en) | 2010-10-22 | 2013-10-22 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
CN103384724B (zh) | 2010-10-22 | 2017-11-17 | T2生物系统公司 | 用于检测分析物的核磁共振系统和方法 |
US9562271B2 (en) | 2012-04-20 | 2017-02-07 | T2 Biosystems, Inc. | Compositions and methods for detection of Candida species |
GB201309376D0 (en) * | 2013-05-24 | 2013-07-10 | Chronos Therapeutics Ltd | Medical methods and compounds for medical use |
CA3011901A1 (en) | 2016-01-21 | 2017-07-27 | T2 Biosystems, Inc. | Nmr methods and systems for the rapid detection of bacteria |
CN110849694B (zh) * | 2019-12-02 | 2022-03-18 | 北京丹大生物技术有限公司 | 一种他克莫司全血样本前处理液及其使用方法和应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3886265T2 (de) * | 1987-06-05 | 1994-04-28 | Fujisawa Pharmaceutical Co | Anti-FR-900506-Stoffe-Antikörper und höchstempfindliches Enzym-Immunoassay-Verfahren. |
US5322772A (en) * | 1991-04-09 | 1994-06-21 | Children's Research Institute | Rapamycin assay |
WO1994024568A1 (en) * | 1993-04-20 | 1994-10-27 | Abbott Laboratories | Stable aqueous fk506 standards |
WO1993025533A1 (en) * | 1992-06-05 | 1993-12-23 | Abbott Laboratories | Methods and reagents for the determination of immunosuppressive agents |
GB9307491D0 (en) * | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
GB9313163D0 (en) * | 1993-06-25 | 1993-08-11 | Health Lab Service Board | Storage of antibodies |
-
1995
- 1995-06-07 US US08/474,589 patent/US5635406A/en not_active Expired - Lifetime
-
1996
- 1996-05-24 EP EP96916602A patent/EP0832433B1/en not_active Expired - Lifetime
- 1996-05-24 AT AT96916602T patent/ATE214803T1/de not_active IP Right Cessation
- 1996-05-24 ES ES96916602T patent/ES2176459T3/es not_active Expired - Lifetime
- 1996-05-24 JP JP50070597A patent/JP3863564B2/ja not_active Expired - Lifetime
- 1996-05-24 CA CA2219931A patent/CA2219931C/en not_active Expired - Lifetime
- 1996-05-24 DE DE69619982T patent/DE69619982T2/de not_active Expired - Lifetime
- 1996-05-24 WO PCT/US1996/007617 patent/WO1996041184A1/en active IP Right Grant
- 1996-09-27 US US08/723,203 patent/US5736401A/en not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009541744A (ja) * | 2006-06-20 | 2009-11-26 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | タクロリムス標準物質及びそれを使用する方法 |
US8153594B2 (en) | 2006-06-20 | 2012-04-10 | Siemens Healthcare Diagnostics Inc. | Tacrolimus standard and methods of using same |
Also Published As
Publication number | Publication date |
---|---|
EP0832433B1 (en) | 2002-03-20 |
DE69619982T2 (de) | 2002-11-21 |
DE69619982D1 (de) | 2002-04-25 |
US5635406A (en) | 1997-06-03 |
US5736401A (en) | 1998-04-07 |
EP0832433A1 (en) | 1998-04-01 |
ATE214803T1 (de) | 2002-04-15 |
ES2176459T3 (es) | 2002-12-01 |
JP3863564B2 (ja) | 2006-12-27 |
CA2219931C (en) | 2012-05-15 |
WO1996041184A1 (en) | 1996-12-19 |
CA2219931A1 (en) | 1996-12-19 |
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