|
ZA981936B
(en)
*
|
1997-03-07 |
1999-09-06 |
Metabasis Therapeutics Inc |
Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.
|
|
WO1998039344A1
(en)
|
1997-03-07 |
1998-09-11 |
Metabasis Therapeutics, Inc. |
Novel purine inhibitors of fructose-1,6-bisphosphatase
|
|
US6312662B1
(en)
|
1998-03-06 |
2001-11-06 |
Metabasis Therapeutics, Inc. |
Prodrugs phosphorus-containing compounds
|
|
EP1060182B1
(en)
|
1998-03-06 |
2012-12-19 |
Metabasis Therapeutics, Inc. |
Novel prodrugs for phosphorus-containing compounds
|
|
WO2000014095A1
(en)
|
1998-09-09 |
2000-03-16 |
Metabasis Therapeutics, Inc. |
Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
|
|
EP1391457B1
(de)
|
1998-11-03 |
2013-12-25 |
AbbVie Deutschland GmbH & Co KG |
Substituierte 2-Phenylbenzimidazole und deren Verwendung als PARP Inhibitoren
|
|
US6756360B1
(en)
*
|
1998-12-24 |
2004-06-29 |
Metabasis Therapeutics, Inc. |
Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
|
|
RU2227749C2
(ru)
*
|
1998-12-24 |
2004-04-27 |
Метабэйсис Терапьютикс, Инк. |
Комбинация ингибиторов fbpазы и сенсибилизаторов инсулина для лечения диабета
|
|
IL145052A0
(en)
*
|
1999-03-05 |
2002-06-30 |
Metabasis Therapeutics Inc |
Novel phosphorus-containing prodrugs
|
|
US7205404B1
(en)
*
|
1999-03-05 |
2007-04-17 |
Metabasis Therapeutics, Inc. |
Phosphorus-containing prodrugs
|
|
US6831069B2
(en)
|
1999-08-27 |
2004-12-14 |
Ribapharm Inc. |
Pyrrolo[2,3-d]pyrimidine nucleoside analogs
|
|
EP1210354A1
(en)
*
|
1999-09-08 |
2002-06-05 |
Metabasis Therapeutics, Inc. |
Prodrugs for liver specific drug delivery
|
|
AU2006202624B2
(en)
*
|
1999-12-22 |
2008-08-14 |
Metabasis Therapeutics, Inc. |
Novel bisamidate phosphonate prodrugs
|
|
EP1240174A2
(en)
*
|
1999-12-22 |
2002-09-18 |
Metabasis Therapeutics, Inc. |
Novel bisamidate phosphonate prodrugs
|
|
DK1248604T4
(da)
|
2000-01-21 |
2012-05-21 |
Novartis Ag |
Kombinationer indeholdende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler
|
|
KR20020079988A
(ko)
*
|
2000-03-08 |
2002-10-21 |
메타베이시스 테라퓨틱스, 인크. |
신규한 아릴 프럭토스-1,6-비스포스파타제 억제제
|
|
US7563774B2
(en)
*
|
2000-06-29 |
2009-07-21 |
Metabasis Therapeutics, Inc. |
Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
|
|
HUP0301830A3
(en)
*
|
2000-07-06 |
2007-10-29 |
Metabasis Therapeutics Inc |
Pharmaceutical composition containing a combination of fbpase inhibitors and antidiabetic agents useful for the treatment of diabetes
|
|
AU2003235501A1
(en)
*
|
2002-05-13 |
2003-11-11 |
Metabasis Therapeutics, Inc. |
PMEA and PMPA cyclic producing synthesis
|
|
NZ536328A
(en)
|
2002-05-13 |
2007-11-30 |
Metabasis Therapeutics Inc |
Novel phosphonic acid based prodrugs of PMEA and its analogues
|
|
EP1556398B1
(en)
*
|
2002-10-31 |
2009-09-09 |
Metabasis Therapeutics, Inc. |
Novel cytarabine monophosphate prodrugs
|
|
EP1689383B1
(en)
|
2003-11-19 |
2012-10-31 |
Metabasis Therapeutics, Inc. |
Novel phosphorus-containing thyromimetics
|
|
US7129049B2
(en)
*
|
2003-12-22 |
2006-10-31 |
Regents Of The University Of Minnesota |
Method of detecting equine glycogen storage disease IV
|
|
MXPA06014013A
(es)
*
|
2004-06-08 |
2007-03-15 |
Metabasis Therapeutics Inc |
Sintesis mediada por acidos de lewis de esteres ciclicos.
|
|
WO2006023515A2
(en)
*
|
2004-08-18 |
2006-03-02 |
Metabasis Therapeutics, Inc. |
Novel thiazole inhibitors of fructose 1,6-bisphosphatase
|
|
WO2006110683A1
(en)
|
2005-04-11 |
2006-10-19 |
Abbott Laboratories |
2-substituted-1h-benzimidazole-4-carboxamides are parp inhibitors
|
|
TWI375673B
(en)
|
2005-04-11 |
2012-11-01 |
Abbott Lab |
1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors
|
|
TW200720255A
(en)
|
2005-07-13 |
2007-06-01 |
Taiho Pharmaceutical Co Ltd |
Benzoimidazole compound capable of inhibiting prostaglandin d synthetase
|
|
EP1752450A1
(en)
|
2005-08-01 |
2007-02-14 |
Merck Sante |
Imidazole derivatives as fructose-1,6-bisphosphatase inhibitors and pharmaceutical compositions containing them
|
|
PL1931350T5
(pl)
|
2005-09-14 |
2021-11-15 |
Takeda Pharmaceutical Company Limited |
Podanie inhibitorów dipeptydylo-peptydazy
|
|
WO2007059230A2
(en)
|
2005-11-15 |
2007-05-24 |
Abbott Laboratories |
Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
|
|
US20070259937A1
(en)
|
2006-05-02 |
2007-11-08 |
Giranda Vincent L |
Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
|
|
US8466096B2
(en)
*
|
2007-04-26 |
2013-06-18 |
Afton Chemical Corporation |
1,3,2-dioxaphosphorinane, 2-sulfide derivatives for use as anti-wear additives in lubricant compositions
|
|
US8067613B2
(en)
|
2007-07-16 |
2011-11-29 |
Abbott Laboratories |
Benzimidazole poly(ADP ribose)polymerase inhibitors
|
|
EP2058308A1
(fr)
|
2007-11-12 |
2009-05-13 |
Merck Sante |
Dérivés de benzimidazoledihydrothiadiazinone comme inhibiteurs de fructose-1,6-biphosphatase et compositions pharmaceutiques les contenant.
|
|
US8759345B2
(en)
|
2008-04-28 |
2014-06-24 |
Janssen Pharmaceutica Nv |
Benzoimidazoles as prolyl hydroxylase inhibitors
|
|
CN102361857B
(zh)
|
2008-09-26 |
2015-09-16 |
默沙东公司 |
可用作抗糖尿病剂的环状苯并咪唑衍生物
|
|
EP2348857B1
(en)
*
|
2008-10-22 |
2016-02-24 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
JP5557845B2
(ja)
*
|
2008-10-31 |
2014-07-23 |
メルク・シャープ・アンド・ドーム・コーポレーション |
糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体
|
|
JO2870B1
(en)
|
2008-11-13 |
2015-03-15 |
ميرك شارب اند دوهم كورب |
Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes
|
|
US8759539B2
(en)
|
2008-11-17 |
2014-06-24 |
Merck Sharp & Dohme Corp. |
Substituted bicyclic amines for the treatment of diabetes
|
|
WO2010083199A1
(en)
|
2009-01-19 |
2010-07-22 |
Abbott Laboratories |
Benzthiazole inhibitors of poly(adp-ribose)polymerase
|
|
US20120046364A1
(en)
|
2009-02-10 |
2012-02-23 |
Metabasis Therapeutics, Inc. |
Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
|
|
EP2805951B1
(en)
|
2009-03-20 |
2018-03-14 |
Metabasis Therapeutics, Inc. |
Inhibitors of diacylglycerol o-acyltransferase 1 (DGAT-1) and uses thereof
|
|
US20120220567A1
(en)
|
2009-07-23 |
2012-08-30 |
Shipps Jr Gerald W |
Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
|
|
WO2011011506A1
(en)
|
2009-07-23 |
2011-01-27 |
Schering Corporation |
Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
|
|
EP2464228B1
(en)
|
2009-08-13 |
2017-12-06 |
Merck Sharp & Dohme Corp. |
Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
|
|
BR112012004335A8
(pt)
|
2009-09-02 |
2016-06-21 |
Merck Sharp & Dohme |
Composto, composição farmacêutica, e, uso do composto.
|
|
WO2011041293A1
(en)
|
2009-09-30 |
2011-04-07 |
Takeda Pharmaceutical Company Limited |
Pyrazolo [1, 5-a] pyrimidine derivatives as apoptosis signal-regulating kinase 1 inhibitors
|
|
WO2011097079A1
(en)
|
2010-02-03 |
2011-08-11 |
Takeda Pharmaceutical Company Limited |
Apoptosis signal-regulating kinase 1 inhibitors
|
|
EP2538783B1
(en)
|
2010-02-22 |
2016-06-01 |
Merck Sharp & Dohme Corp. |
Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
|
|
AU2011218830B2
(en)
|
2010-02-25 |
2014-07-24 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
US8980929B2
(en)
|
2010-05-21 |
2015-03-17 |
Merck Sharp & Dohme Corp. |
Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
|
|
US8742110B2
(en)
|
2010-08-18 |
2014-06-03 |
Merck Sharp & Dohme Corp. |
Spiroxazolidinone compounds
|
|
ES2616238T3
(es)
|
2010-10-06 |
2017-06-12 |
Glaxosmithkline Llc, Corporation Service Company |
Derivados de bencimidazol como inhibidores de PI3 quinasa
|
|
MX348131B
(es)
|
2011-02-25 |
2017-05-26 |
Merck Sharp & Dohme |
Novedosos derivados de azabencimidazol ciclico utiles como agentes antidiabeticos.
|
|
EP2693882B1
(en)
|
2011-04-08 |
2017-06-28 |
Merck Sharp & Dohme Corp. |
Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
|
|
CN103687855A
(zh)
|
2011-06-02 |
2014-03-26 |
英特维特国际股份有限公司 |
咪唑衍生物
|
|
CA2838079A1
(en)
|
2011-06-16 |
2012-12-20 |
Merck Sharp & Dohme Corp. |
Substituted cyclopropyl compounds, compositions containing such compounds, and methods of treatment
|
|
EP2760855B1
(en)
|
2011-09-30 |
2017-03-15 |
Merck Sharp & Dohme Corp. |
Substituted cyclopropyl compounds, compositions containing such compounds as well as their use in treating type-2 diabetes
|
|
US9018200B2
(en)
|
2011-10-24 |
2015-04-28 |
Merck Sharp & Dohme Corp. |
Substituted piperidinyl compounds useful as GPR119 agonists
|
|
ES2818977T3
(es)
|
2011-10-25 |
2021-04-14 |
Janssen Pharmaceutica Nv |
Método para obtener cristales de sal de meglumina de ácido 1-(5,6-dicloro-1H-benzo[d]imidazol-2-il)-1H-pirazol-4-carboxílico
|
|
WO2013068328A1
(en)
|
2011-11-07 |
2013-05-16 |
Intervet International B.V. |
Bicyclo [2.2.2] octan-1-ylcarboxylic acid compounds as dgat-1 inhibitors
|
|
WO2013068439A1
(en)
|
2011-11-09 |
2013-05-16 |
Intervet International B.V. |
4-amino-5-oxo-7,8-dihydropyrimido[5, 4 -f] [1, 4] oxazepine compounds as dgat1 inhibitors
|
|
US9018224B2
(en)
|
2011-11-15 |
2015-04-28 |
Merck Sharp & Dohme Corp. |
Substituted cyclopropyl compounds useful as GPR119 agonists
|
|
US9073930B2
(en)
|
2012-02-17 |
2015-07-07 |
Merck Sharp & Dohme |
Dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
|
|
US20150057220A1
(en)
|
2012-04-16 |
2015-02-26 |
Kaneq Pharma Inc. |
Fused aromatic phosphonate derivatives as precursors to ptp-1b inhibitors
|
|
US9315508B2
(en)
|
2012-07-23 |
2016-04-19 |
Merck Sharp & Dohme Corp. |
Treating diabetes with dipeptidyl peptidase-IV inhibitors
|
|
WO2014022528A1
(en)
|
2012-08-02 |
2014-02-06 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
WO2014031441A1
(en)
|
2012-08-22 |
2014-02-27 |
Merck Sharp & Dohme Corp. |
Novel benzimidazole tetrahydrofuran derivatives
|
|
US9382243B2
(en)
|
2012-08-22 |
2016-07-05 |
Merck Sharp & Dohme Corp. |
Azabenzimidazole tetrahydropyran derivatives
|
|
EP2888008B1
(en)
|
2012-08-22 |
2018-12-26 |
Merck Sharp & Dohme Corp. |
Novel azabenzimidazole tetrahydrofuran derivatives
|
|
JP2015526468A
(ja)
|
2012-08-22 |
2015-09-10 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
新規なアザベンズイミダゾールヘキサヒドロフロ[3,2−b]フラン誘導体
|
|
WO2014031445A1
(en)
|
2012-08-22 |
2014-02-27 |
Merck Sharp & Dohme Corp. |
Novel benzimidazole tetrahydropyran derivatives
|
|
ES2755087T3
(es)
|
2012-08-22 |
2020-04-21 |
Merck Sharp & Dohme |
Derivados de benzimidazol hexahidrofuro[3,2-b]furano útiles como activadores de proteína cinasa activada por AMP
|
|
WO2014099578A1
(en)
|
2012-12-17 |
2014-06-26 |
Merck Sharp & Dohme Corp. |
Novel glucokinase activator compounds, compositions containing such compounds, and methods of treatment
|
|
WO2014139388A1
(en)
|
2013-03-14 |
2014-09-18 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
US10519115B2
(en)
|
2013-11-15 |
2019-12-31 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
WO2015089809A1
(en)
|
2013-12-19 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Antidiabetic substituted heteroaryl compounds
|
|
WO2015112465A1
(en)
|
2014-01-24 |
2015-07-30 |
Merck Sharp & Dohme Corp. |
Isoquinoline derivatives as mgat2 inhibitors
|
|
US10449210B2
(en)
|
2014-02-13 |
2019-10-22 |
Ligand Pharmaceuticals Inc. |
Prodrug compounds and their uses
|
|
WO2015176267A1
(en)
|
2014-05-22 |
2015-11-26 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
CN106687118A
(zh)
|
2014-07-02 |
2017-05-17 |
配体药物公司 |
前药化合物及其用途
|
|
EP3177287B1
(en)
|
2014-08-08 |
2022-02-23 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
WO2016022446A1
(en)
|
2014-08-08 |
2016-02-11 |
Merck Sharp & Dohme Corp. |
[5,6]-fused bicyclic antidiabetic compounds
|
|
EP3177282B1
(en)
|
2014-08-08 |
2021-10-06 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
CA3093383A1
(en)
|
2014-10-24 |
2016-04-28 |
Merck Sharp & Dohme Corp. |
Co-agonists of the glucagon and glp-1 receptors
|
|
EP3212226B1
(en)
|
2014-10-31 |
2020-03-18 |
NGM Biopharmaceuticals, Inc. |
Compositions and methods of use for treating metabolic disorders
|
|
TW201625635A
(zh)
|
2014-11-21 |
2016-07-16 |
默沙東藥廠 |
作為可溶性鳥苷酸環化酶活化劑之三唑并吡基衍生物
|
|
EP3078378B1
(en)
|
2015-04-08 |
2020-06-24 |
Vaiomer |
Use of factor xa inhibitors for regulating glycemia
|
|
EP3303342B1
(en)
|
2015-05-27 |
2021-03-17 |
Merck Sharp & Dohme Corp. |
Imidazo-pyrazinyl derivatives useful as soluble guanylate cyclase activators
|
|
EP3310782B1
(en)
|
2015-05-28 |
2021-12-01 |
Merck Sharp & Dohme Corp. |
Imidazo-pyrazinyl derivatives useful as soluble guanylate cyclase activators
|
|
EP3359191A4
(en)
|
2015-10-05 |
2019-05-29 |
Merck Sharp & Dohme Corp. |
ANTIBODY PEPTIDE CONJUGATES WITH AGONISTEACTIVITY ON GLUCAGON RECEPTORS AND GLUCAGON-LIKE PEPTIDE-1
|
|
US20190382363A1
(en)
|
2015-11-30 |
2019-12-19 |
Merck Sharp & Dohme Corp. |
Aryl sulfonamides as blt1 antagonists
|
|
WO2017107052A1
(en)
|
2015-12-22 |
2017-06-29 |
Merck Sharp & Dohme Corp. |
Soluble guanylate cyclase stimulators
|
|
WO2017197555A1
(en)
|
2016-05-16 |
2017-11-23 |
Merck Sharp & Dohme Corp. |
Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators
|
|
WO2017201683A1
(en)
|
2016-05-25 |
2017-11-30 |
Merck Sharp & Dohme Corp. |
Substituted tetrahydroisoquinoline compounds useful as gpr120 agonists
|
|
WO2018034918A1
(en)
|
2016-08-15 |
2018-02-22 |
Merck Sharp & Dohme Corp. |
Compounds useful for altering the levels of bile acids for the treatment of diabetes and cardiometabolic disease
|
|
US10414775B2
(en)
|
2016-08-15 |
2019-09-17 |
Merck Sharp & Dohme Corp. |
Compounds useful for altering the levels of bile acids for the treatment of diabetes and cardiometabolic disease
|
|
US11008313B2
(en)
|
2016-09-20 |
2021-05-18 |
Merck Sharp & Dohme Corp. |
Substituted 1-methyl-1,2,3,4-tetrahydroisoquinoline molecules as PCSK9 allosteric binders
|
|
KR20190078646A
(ko)
|
2016-11-18 |
2019-07-04 |
머크 샤프 앤드 돔 코포레이션 |
디아실글리세리드 o-아실트랜스퍼라제 2의 억제제로서 유용한 인다졸 유도체
|
|
CA3043206A1
(en)
|
2016-11-18 |
2018-05-24 |
Merck Sharp & Dohme Corp. |
Indole derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
|
|
WO2018107415A1
(en)
|
2016-12-15 |
2018-06-21 |
Merck Sharp & Dohme Corp. |
Hydroxy isoxazole compounds useful as gpr120 agonists
|
|
CN111788196A
(zh)
|
2018-01-09 |
2020-10-16 |
配体药物公司 |
缩醛化合物及其治疗用途
|
|
IL321719A
(en)
|
2018-06-21 |
2025-08-01 |
Merck Sharp ַ& Dohme Llc |
Pcsk9 antagonist compounds
|
|
EP3946324B1
(en)
|
2019-04-04 |
2025-07-30 |
Merck Sharp & Dohme LLC |
Inhibitors of histone deacetylase-3 useful for the treatment of cancer, inflammation, neurodegeneration diseases and diabetes
|
|
WO2021041770A1
(en)
|
2019-08-30 |
2021-03-04 |
Merck Sharp & Dohme Corp. |
Pcsk9 antagonist compounds
|
|
EP3842061A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled triazole co-agonists of the glucagon and glp-1 receptors
|
|
EP3842060A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled lactam co-agonists of the glucagon and glp-1 receptors
|
|
EP3842449A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled olefin co-agonists of the glucagon and glp-1 receptors
|
|
US11787810B2
(en)
|
2020-05-18 |
2023-10-17 |
Merck Sharp & Dohme Llc |
Diacylglyceride O-acyltransferase 2 inhibitors
|
|
PT4225739T
(pt)
|
2020-10-08 |
2026-04-07 |
Merck Sharp & Dohme Llc |
Preparação de derivados de benzimidazolona como novos inibidores da diacilglicerol o-aciltransferase 2
|
|
TW202229232A
(zh)
|
2020-10-08 |
2022-08-01 |
美商默沙東藥廠 |
作為新穎二醯基甘油酯o-醯基轉移酶2抑制劑之吲哚酮衍生物的製備
|
|
MX2024002146A
(es)
|
2021-08-19 |
2024-03-08 |
Merck Sharp & Dohme Llc |
Compuestos para el tratamiento de afecciones relacionadas con la actividad de pcsk9.
|
|
EP4540267B1
(en)
|
2022-06-15 |
2026-04-15 |
Merck Sharp & Dohme LLC |
Cyclic peptides for trapping interleukin-1 beta
|
|
IL321166A
(en)
|
2022-12-02 |
2025-07-01 |
Merck Sharp & Dohme Llc |
Preparation of fused azole derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors
|
|
US20250152658A1
(en)
|
2023-11-14 |
2025-05-15 |
Merck Sharp & Dohme Llc |
Cyclic peptide for trapping interleukin-1 beta
|
|
WO2025128805A1
(en)
|
2023-12-15 |
2025-06-19 |
Merck Sharp & Dohme Llc |
A cyclic peptide il-1beta trap for the treatment of atherosclerosis and inflammatory disorders
|
|
US20260022125A1
(en)
|
2024-07-19 |
2026-01-22 |
Merck Sharp & Dohme Llc |
Pyrrolopyridazine vegfr inhibitors
|
|
WO2026096330A1
(en)
|
2024-10-28 |
2026-05-07 |
Merck Sharp & Dohme Llc |
Glp-1 receptor agonists and methods of use
|