JP2001515456A - 口腔の苦痛状態を治療するための経口投与および方法 - Google Patents
口腔の苦痛状態を治療するための経口投与および方法Info
- Publication number
- JP2001515456A JP2001515456A JP50071297A JP50071297A JP2001515456A JP 2001515456 A JP2001515456 A JP 2001515456A JP 50071297 A JP50071297 A JP 50071297A JP 50071297 A JP50071297 A JP 50071297A JP 2001515456 A JP2001515456 A JP 2001515456A
- Authority
- JP
- Japan
- Prior art keywords
- active agent
- dosage form
- oral
- drug
- site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.該口腔内の苦痛状態の部位を治療するデバイスにおいて、 該苦痛状態の該部位に適用できる経口投与形態を含み、前記投与形態が、局所 性麻酔剤を速やかに放出することによって該状態の該部位を麻痺させるのに有効 であり、かつ 前記投与形態が、該麻痺部位に非麻酔性有効薬剤を連続的に適用するのに有効 である デバイス。 2.該非麻酔性有効薬剤を、該麻酔部位に1.0ないし3時間のT90以内で投 与する請求項1記載のデバイス。 3.該状態の該部位が0.1ないし10分間で痛みの軽減を生じる請求項1記 載のデバイス。 4.該局所性麻酔剤が15ないし30分以内に溶解される表面皮膜である請求 項1記載のデバイス。 5.該長期投与時間にわたり該有効薬剤を投与するのに適している有効薬剤の コアによって、該非麻酔性有効薬剤が連続的に適用される請求項1記載のデバイ ス。 6.前記コアが、有効薬剤と膨張可能な駆動部材とを包囲する半透性壁を含む 浸透投与デバイスをさらに含む請求項5記載のデバイス。 7.該有効薬剤が、投与時間中50ないし100μg/時の速度で絶えず適用 される請求項5記載のデバイス。 8.該有効薬剤が非炎症性薬剤である請求項1記載のデバイス。 9.約1ないし3時間の投与時間にわたり、動物の口腔に制御された迅速な有 効薬剤の投与によってアフタ性口内炎を治療するための経口投与形態において、 該浸透投与形態が、 非炎症性有効薬剤製剤であって、該製剤がフロックおよび治療に役立つ量のジ プロピオン酸ベクロメサゾンを含み、該フロック中に該有効薬剤が分散している 非炎症性有効薬剤製剤; 膨張可能な駆動部材であって、該製剤と該膨張可能な駆動部材とが1.27な い し1.30cmの長軸の長さおよび0.70ないし0.73cmの短軸の長さを有する ように構成されている膨張可能な駆動部材; 該薬剤製剤と該膨張可能な駆動部材とを包囲する半透性壁; 該有効薬剤層を動物の該口腔と連結する出口通路;および 該半透性壁を包囲する即時放出性麻酔剤層 を含む経口投与形態。 10.該有効薬剤製剤が100ないし250μgの非炎症性薬剤を含む請求項9 記載の経口投与形態。 11.該半透性壁が70%の酢酸セルロースと30%のポリエチレングリコール とのブレンドを24ないし30mg含む請求項10記載の経口投与形態。 12.該フロック中に有効薬剤を分散させた該フロックが親水性コポリマーおよ び脱水剤を含む請求項10記載の経口投与形態。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/475,233 US5713852A (en) | 1995-06-07 | 1995-06-07 | Oral dosage and method for treating painful conditions of the oral cavity |
US08/475,233 | 1995-06-07 | ||
PCT/US1996/007668 WO1996040050A1 (en) | 1995-06-07 | 1996-05-24 | Oral dosage and method for treating painful conditions of the oral cavity |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001515456A true JP2001515456A (ja) | 2001-09-18 |
JP3973684B2 JP3973684B2 (ja) | 2007-09-12 |
Family
ID=23886750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50071297A Expired - Lifetime JP3973684B2 (ja) | 1995-06-07 | 1996-05-24 | 口腔の苦痛状態を治療するための経口投与および方法 |
Country Status (7)
Country | Link |
---|---|
US (1) | US5713852A (ja) |
EP (1) | EP0831774B1 (ja) |
JP (1) | JP3973684B2 (ja) |
AT (1) | ATE202923T1 (ja) |
AU (1) | AU5876596A (ja) |
DE (1) | DE69613840T2 (ja) |
WO (1) | WO1996040050A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005508980A (ja) * | 2001-11-05 | 2005-04-07 | オラヘルス コーポレーション | 治癒を促進し、痛みを緩和させるパッチによる口内炎治療法 |
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US6060534A (en) | 1996-07-11 | 2000-05-09 | Scimed Life Systems, Inc. | Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties |
US6319510B1 (en) | 1999-04-20 | 2001-11-20 | Alayne Yates | Gum pad for delivery of medication to mucosal tissues |
US20020013331A1 (en) * | 2000-06-26 | 2002-01-31 | Williams Robert O. | Methods and compositions for treating pain of the mucous membrane |
US20030190360A1 (en) * | 2001-03-13 | 2003-10-09 | Baichwal Anand R. | Chronotherapeutic dosage forms containing glucocorticosteroid and methods of treatment |
US7201930B2 (en) | 2001-11-05 | 2007-04-10 | Haley Jeffrey T | Licorice root extract oral patch for treating canker sores |
US20030124178A1 (en) * | 2001-12-28 | 2003-07-03 | Haley Jeffrey T. | Soft, adherent, soluble oral patch |
US20050226915A1 (en) * | 2001-12-28 | 2005-10-13 | Oramelts Corporation, A Washington Corporation | Method for manufacturing and packaging oral patches with rounded edges |
US20050208135A1 (en) * | 2002-05-06 | 2005-09-22 | Narayanan Badri Viswanathan | Monocompartment osmotic controlled drug delivery system |
US20050118267A1 (en) * | 2003-09-19 | 2005-06-02 | Penwest Pharmaceuticals Co. | Chronotherapeutic dosage forms |
NZ545921A (en) * | 2003-09-19 | 2009-09-25 | Penwest Pharmaceuticals Co | Delayed released dosage forms |
WO2006030402A2 (en) * | 2004-09-17 | 2006-03-23 | Ranbaxy Laboratories Limited | Dual compartment osmotic delivery device |
DE102004050591A1 (de) * | 2004-09-22 | 2006-04-06 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Schleimdrogenbasierte Lutschtablette gegen entzündliche Erkrankungen des Mund- und Rachenraums |
WO2006046114A2 (en) * | 2004-10-25 | 2006-05-04 | Ranbaxy Laboratories Limited | Osmotic dosage forms providing ascending drug release, and processes for their preparation |
US20060134201A1 (en) * | 2004-12-16 | 2006-06-22 | Haley Jeffrey T | Collagen troches for treating mouth lesions |
US8349120B2 (en) * | 2006-03-07 | 2013-01-08 | Ora Health Corporation | Multi-layer patch made on a sheet and enclosed in a blister |
US20070248655A1 (en) * | 2006-04-21 | 2007-10-25 | Haley Jeffrey T | Lenticular shaped protective mouth sore discs |
US20070248654A1 (en) * | 2006-04-21 | 2007-10-25 | Haley Jeffrey T | Protective mouth sore discs made with corn starch |
US8701671B2 (en) | 2011-02-04 | 2014-04-22 | Joseph E. Kovarik | Non-surgical method and system for reducing snoring |
US9549842B2 (en) | 2011-02-04 | 2017-01-24 | Joseph E. Kovarik | Buccal bioadhesive strip and method of treating snoring and sleep apnea |
US20120083763A1 (en) * | 2010-10-04 | 2012-04-05 | Diaz Edwin A | Method for Delivering a Topical Agent to a Nasaogastric Passage |
US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
PL2701681T3 (pl) | 2011-04-29 | 2017-03-31 | Moberg Pharma Ab | Kompozycje farmaceutyczne zawierające środek miejscowo znieczulający, taki jak bupiwakaina, do podawania miejscowego do jamy ustnej lub gardła |
EP2742931A1 (de) | 2012-12-13 | 2014-06-18 | LTS LOHMANN Therapie-Systeme AG | Topisches Arzneimittel zur Behandlung von Aphten |
US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
US10758329B1 (en) | 2019-08-20 | 2020-09-01 | Raymond L. Wright, III | Hydrating mouth guard |
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-
1995
- 1995-06-07 US US08/475,233 patent/US5713852A/en not_active Expired - Lifetime
-
1996
- 1996-05-24 JP JP50071297A patent/JP3973684B2/ja not_active Expired - Lifetime
- 1996-05-24 AU AU58765/96A patent/AU5876596A/en not_active Abandoned
- 1996-05-24 WO PCT/US1996/007668 patent/WO1996040050A1/en active IP Right Grant
- 1996-05-24 EP EP96920480A patent/EP0831774B1/en not_active Expired - Lifetime
- 1996-05-24 DE DE69613840T patent/DE69613840T2/de not_active Expired - Lifetime
- 1996-05-24 AT AT96920480T patent/ATE202923T1/de not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005508980A (ja) * | 2001-11-05 | 2005-04-07 | オラヘルス コーポレーション | 治癒を促進し、痛みを緩和させるパッチによる口内炎治療法 |
Also Published As
Publication number | Publication date |
---|---|
ATE202923T1 (de) | 2001-07-15 |
EP0831774B1 (en) | 2001-07-11 |
EP0831774A1 (en) | 1998-04-01 |
DE69613840D1 (de) | 2001-08-16 |
WO1996040050A1 (en) | 1996-12-19 |
AU5876596A (en) | 1996-12-30 |
JP3973684B2 (ja) | 2007-09-12 |
DE69613840T2 (de) | 2002-04-04 |
US5713852A (en) | 1998-02-03 |
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