JP2001512462A - Ｎ−置換−１，５−ジデオキシ−１，５−イミノ−ｄ−グルシトール化合物の、肝炎ウイルス感染の治療のための組み合わせ療法における使用 - Google Patents
Ｎ−置換−１，５−ジデオキシ−１，５−イミノ−ｄ−グルシトール化合物の、肝炎ウイルス感染の治療のための組み合わせ療法における使用Info
- Publication number
- JP2001512462A JP2001512462A JP53598798A JP53598798A JP2001512462A JP 2001512462 A JP2001512462 A JP 2001512462A JP 53598798 A JP53598798 A JP 53598798A JP 53598798 A JP53598798 A JP 53598798A JP 2001512462 A JP2001512462 A JP 2001512462A
- Authority
- JP
- Japan
- Prior art keywords
- dideoxy
- imino
- glucitol
- compound
- tetrabutyrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4122197P | 1997-02-14 | 1997-02-14 | |
| US60/041,221 | 1997-02-14 | ||
| PCT/US1998/003004 WO1998035685A1 (en) | 1997-02-14 | 1998-02-12 | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001512462A true JP2001512462A (ja) | 2001-08-21 |
| JP2001512462A5 JP2001512462A5 (https=) | 2006-07-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53598798A Pending JP2001512462A (ja) | 1997-02-14 | 1998-02-12 | Ｎ−置換−１，５−ジデオキシ−１，５−イミノ−ｄ−グルシトール化合物の、肝炎ウイルス感染の治療のための組み合わせ療法における使用 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1007058B1 (https=) |
| JP (1) | JP2001512462A (https=) |
| CN (1) | CN100382804C (https=) |
| AT (1) | ATE295732T1 (https=) |
| AU (1) | AU6169298A (https=) |
| DE (1) | DE69830241T2 (https=) |
| ES (1) | ES2244048T3 (https=) |
| WO (1) | WO1998035685A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030100532A1 (en) | 1997-02-14 | 2003-05-29 | Gary S. Jacob | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
| DK1030839T3 (da) | 1997-11-10 | 2004-05-03 | Searle & Co | Anvendelse af alkylerede iminosukkere til behandling af multidrugresistens |
| BR9813508A (pt) * | 1997-12-11 | 2000-10-03 | Univ Oxford | Inibição de replicação viral associada com membrana |
| US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
| US6689759B1 (en) | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
| EP1714676A3 (en) * | 1998-02-12 | 2006-11-15 | G.D. Searle LLC. | Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections |
| US6809083B1 (en) * | 1998-02-12 | 2004-10-26 | Richard A. Mueller | Use of N-substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections |
| WO2001008672A2 (en) * | 1999-02-12 | 2001-02-08 | G.D. Searle & Co. | Glucamine compounds for treating hepatitis virus infections |
| JP2002536407A (ja) | 1999-02-12 | 2002-10-29 | ジー・ディー・サール・アンド・カンパニー | 肝炎ウィルス感染の治療のための置換−１，５−ジデオキシ−１，５−イミノ−ｄ−グルシトール化合物の使用 |
| EP1658846B1 (en) * | 1999-02-12 | 2008-07-30 | United Therapeutics Corporation | N-(8,8,8-trifluorooctyl)-1,5-dideoxy-1,5-imino-D-glucitol for treating hepatitis virus infections |
| AU1840101A (en) | 1999-08-10 | 2001-03-05 | Chancellor, Masters And Scholars Of The University Of Oxford, The | Long chain n-alkyl compounds and oxo-derivatives thereof |
| US7256005B2 (en) | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
| WO2001060366A1 (en) * | 2000-02-14 | 2001-08-23 | Pharmacia Corporation | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections |
| CN1694696A (zh) * | 2002-09-23 | 2005-11-09 | 牛津大学校委会 | 亚氨基糖衍生物在抑制离子通道活性中的应用 |
| AU2019339777B2 (en) | 2018-09-12 | 2022-09-01 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
| AU2020353055B2 (en) | 2019-09-26 | 2024-03-07 | Gilead Sciences, Inc. | Antiviral pyrazolopyridinone compounds |
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| AU7518694A (en) * | 1993-08-20 | 1995-03-21 | G.D. Searle & Co. | Retroviral protease inhibitors and combinations thereof |
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1998
- 1998-02-12 AU AU61692/98A patent/AU6169298A/en not_active Abandoned
- 1998-02-12 WO PCT/US1998/003004 patent/WO1998035685A1/en not_active Ceased
- 1998-02-12 JP JP53598798A patent/JP2001512462A/ja active Pending
- 1998-02-12 CN CNB988039427A patent/CN100382804C/zh not_active Expired - Fee Related
- 1998-02-12 AT AT98906475T patent/ATE295732T1/de not_active IP Right Cessation
- 1998-02-12 DE DE69830241T patent/DE69830241T2/de not_active Expired - Lifetime
- 1998-02-12 EP EP98906475A patent/EP1007058B1/en not_active Expired - Lifetime
- 1998-02-12 ES ES98906475T patent/ES2244048T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2244048T3 (es) | 2005-12-01 |
| DE69830241D1 (de) | 2005-06-23 |
| HK1027509A1 (en) | 2001-01-19 |
| EP1007058A1 (en) | 2000-06-14 |
| EP1007058B1 (en) | 2005-05-18 |
| CN100382804C (zh) | 2008-04-23 |
| ATE295732T1 (de) | 2005-06-15 |
| CN1251993A (zh) | 2000-05-03 |
| AU6169298A (en) | 1998-09-08 |
| WO1998035685A1 (en) | 1998-08-20 |
| DE69830241T2 (de) | 2006-01-26 |
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