CN100382804C - N-取代的-1,5-二脱氧-1,5-亚氨基-d-山梨醇化合物在制备治疗肝炎病毒感染的药物中的用途 - Google Patents

N-取代的-1,5-二脱氧-1,5-亚氨基-d-山梨醇化合物在制备治疗肝炎病毒感染的药物中的用途 Download PDF

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Publication number
CN100382804C
CN100382804C CNB988039427A CN98803942A CN100382804C CN 100382804 C CN100382804 C CN 100382804C CN B988039427 A CNB988039427 A CN B988039427A CN 98803942 A CN98803942 A CN 98803942A CN 100382804 C CN100382804 C CN 100382804C
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CN
China
Prior art keywords
dideoxy
sorbitol
imino group
imino
nonyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB988039427A
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English (en)
Chinese (zh)
Other versions
CN1251993A (zh
Inventor
G·S·雅各布
T·M·布洛克
R·A·德维克
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GD Searle LLC
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GD Searle LLC
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Publication date
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Publication of CN1251993A publication Critical patent/CN1251993A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB988039427A 1997-02-14 1998-02-12 N-取代的-1,5-二脱氧-1,5-亚氨基-d-山梨醇化合物在制备治疗肝炎病毒感染的药物中的用途 Expired - Fee Related CN100382804C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4122197P 1997-02-14 1997-02-14
US60/041,221 1997-02-14

Publications (2)

Publication Number Publication Date
CN1251993A CN1251993A (zh) 2000-05-03
CN100382804C true CN100382804C (zh) 2008-04-23

Family

ID=21915395

Family Applications (1)

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CNB988039427A Expired - Fee Related CN100382804C (zh) 1997-02-14 1998-02-12 N-取代的-1,5-二脱氧-1,5-亚氨基-d-山梨醇化合物在制备治疗肝炎病毒感染的药物中的用途

Country Status (8)

Country Link
EP (1) EP1007058B1 (https=)
JP (1) JP2001512462A (https=)
CN (1) CN100382804C (https=)
AT (1) ATE295732T1 (https=)
AU (1) AU6169298A (https=)
DE (1) DE69830241T2 (https=)
ES (1) ES2244048T3 (https=)
WO (1) WO1998035685A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
DK1030839T3 (da) 1997-11-10 2004-05-03 Searle & Co Anvendelse af alkylerede iminosukkere til behandling af multidrugresistens
BR9813508A (pt) * 1997-12-11 2000-10-03 Univ Oxford Inibição de replicação viral associada com membrana
US6465488B1 (en) 1997-12-11 2002-10-15 Chancellor, Masters & Scholars Of The University Of Oxford Inhibition of glycolipid biosynthesis
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
EP1714676A3 (en) * 1998-02-12 2006-11-15 G.D. Searle LLC. Use of N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
US6809083B1 (en) * 1998-02-12 2004-10-26 Richard A. Mueller Use of N-substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections
WO2001008672A2 (en) * 1999-02-12 2001-02-08 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
JP2002536407A (ja) 1999-02-12 2002-10-29 ジー・ディー・サール・アンド・カンパニー 肝炎ウィルス感染の治療のための置換−１，５−ジデオキシ−１，５−イミノ−ｄ−グルシトール化合物の使用
EP1658846B1 (en) * 1999-02-12 2008-07-30 United Therapeutics Corporation N-(8,8,8-trifluorooctyl)-1,5-dideoxy-1,5-imino-D-glucitol for treating hepatitis virus infections
AU1840101A (en) 1999-08-10 2001-03-05 Chancellor, Masters And Scholars Of The University Of Oxford, The Long chain n-alkyl compounds and oxo-derivatives thereof
US7256005B2 (en) 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
WO2001060366A1 (en) * 2000-02-14 2001-08-23 Pharmacia Corporation Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
CN1694696A (zh) * 2002-09-23 2005-11-09 牛津大学校委会 亚氨基糖衍生物在抑制离子通道活性中的应用
AU2019339777B2 (en) 2018-09-12 2022-09-01 Novartis Ag Antiviral pyridopyrazinedione compounds
AU2020353055B2 (en) 2019-09-26 2024-03-07 Gilead Sciences, Inc. Antiviral pyrazolopyridinone compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006061A1 (en) * 1993-08-20 1995-03-02 G.D. Searle & Co. Retroviral protease inhibitors and combinations thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006061A1 (en) * 1993-08-20 1995-03-02 G.D. Searle & Co. Retroviral protease inhibitors and combinations thereof

Also Published As

Publication number Publication date
ES2244048T3 (es) 2005-12-01
DE69830241D1 (de) 2005-06-23
HK1027509A1 (en) 2001-01-19
EP1007058A1 (en) 2000-06-14
JP2001512462A (ja) 2001-08-21
EP1007058B1 (en) 2005-05-18
ATE295732T1 (de) 2005-06-15
CN1251993A (zh) 2000-05-03
AU6169298A (en) 1998-09-08
WO1998035685A1 (en) 1998-08-20
DE69830241T2 (de) 2006-01-26

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