JP2001511814A - ＮＦ−κＢの阻害を介する梗塞の治療 - Google Patents
ＮＦ−κＢの阻害を介する梗塞の治療Info
- Publication number
- JP2001511814A JP2001511814A JP53600398A JP53600398A JP2001511814A JP 2001511814 A JP2001511814 A JP 2001511814A JP 53600398 A JP53600398 A JP 53600398A JP 53600398 A JP53600398 A JP 53600398A JP 2001511814 A JP2001511814 A JP 2001511814A
- Authority
- JP
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- Prior art keywords
- inhibitor
- activation
- proteasome
- mammal
- ischemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Organic Insulating Materials (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Artificial Filaments (AREA)
- Transplanting Machines (AREA)
- Investigation Of Foundation Soil And Reinforcement Of Foundation Soil By Compacting Or Drainage (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US80193697A | 1997-02-15 | 1997-02-15 | |
| US98833997A | 1997-12-03 | 1997-12-03 | |
| US08/988,339 | 1997-12-03 | ||
| US08/801,936 | 1997-12-03 | ||
| PCT/US1998/003077 WO1998035691A1 (en) | 1997-02-15 | 1998-02-17 | Treatment of infarcts through inhibition of nf-kappab |
Publications (2)
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| JP2001511814A true JP2001511814A (ja) | 2001-08-14 |
| JP2001511814A5 JP2001511814A5 (https=) | 2005-08-11 |
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| US (3) | US6271199B2 (https=) |
| EP (1) | EP0979096B1 (https=) |
| JP (1) | JP2001511814A (https=) |
| CN (1) | CN1159061C (https=) |
| AT (1) | ATE240113T1 (https=) |
| AU (1) | AU741802B2 (https=) |
| CA (1) | CA2281224A1 (https=) |
| DE (1) | DE69814618T2 (https=) |
| ES (1) | ES2196547T3 (https=) |
| IL (1) | IL131410A0 (https=) |
| NO (1) | NO321203B1 (https=) |
| NZ (1) | NZ337364A (https=) |
| PT (1) | PT979096E (https=) |
| WO (1) | WO1998035691A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007523862A (ja) * | 2003-06-20 | 2007-08-23 | ネレアス ファーマシューティカルズ インコーポレイテッド | 癌、炎症及び感染性疾患の治療のための、［３．２．０］複素環式化合物およびそれらの類縁体の使用 |
| WO2011090159A1 (ja) | 2010-01-22 | 2011-07-28 | 独立行政法人科学技術振興機構 | 蛋白質の分解活性を測定するためのプローブ試薬 |
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| US5942494A (en) | 1995-10-06 | 1999-08-24 | The Trustees Of Columbia University In The City Of New York | Stimulation of gene expression and synthesis of heat shock protein 72/73 (HSP 70) |
| JP2000510328A (ja) | 1996-03-19 | 2000-08-15 | プロスクリプト・インコーポレイテッド | ＩкＢαを部位特異的にリン酸化し得るキナーゼ |
| US6133308A (en) | 1997-08-15 | 2000-10-17 | Millennium Pharmaceuticals, Inc. | Synthesis of clasto-lactacystin beta-lactone and analogs thereof |
-
1998
- 1998-02-17 US US09/285,170 patent/US6271199B2/en not_active Expired - Lifetime
- 1998-02-17 AU AU61719/98A patent/AU741802B2/en not_active Ceased
- 1998-02-17 NZ NZ337364A patent/NZ337364A/en unknown
- 1998-02-17 PT PT98906511T patent/PT979096E/pt unknown
- 1998-02-17 DE DE69814618T patent/DE69814618T2/de not_active Expired - Lifetime
- 1998-02-17 WO PCT/US1998/003077 patent/WO1998035691A1/en not_active Ceased
- 1998-02-17 CN CNB988033968A patent/CN1159061C/zh not_active Expired - Fee Related
- 1998-02-17 AT AT98906511T patent/ATE240113T1/de not_active IP Right Cessation
- 1998-02-17 EP EP98906511A patent/EP0979096B1/en not_active Expired - Lifetime
- 1998-02-17 JP JP53600398A patent/JP2001511814A/ja not_active Ceased
- 1998-02-17 IL IL13141098A patent/IL131410A0/xx not_active IP Right Cessation
- 1998-02-17 CA CA002281224A patent/CA2281224A1/en not_active Abandoned
- 1998-02-17 ES ES98906511T patent/ES2196547T3/es not_active Expired - Lifetime
-
1999
- 1999-08-16 NO NO19993935A patent/NO321203B1/no unknown
-
2001
- 2001-07-30 US US09/919,116 patent/US20010053760A1/en not_active Abandoned
-
2002
- 2002-04-08 US US10/118,526 patent/US20030069189A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007523862A (ja) * | 2003-06-20 | 2007-08-23 | ネレアス ファーマシューティカルズ インコーポレイテッド | 癌、炎症及び感染性疾患の治療のための、［３．２．０］複素環式化合物およびそれらの類縁体の使用 |
| WO2011090159A1 (ja) | 2010-01-22 | 2011-07-28 | 独立行政法人科学技術振興機構 | 蛋白質の分解活性を測定するためのプローブ試薬 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2281224A1 (en) | 1998-08-20 |
| US20030069189A1 (en) | 2003-04-10 |
| AU741802B2 (en) | 2001-12-13 |
| ES2196547T3 (es) | 2003-12-16 |
| US20010053760A1 (en) | 2001-12-20 |
| PT979096E (pt) | 2003-09-30 |
| NO993935L (no) | 1999-10-04 |
| EP0979096B1 (en) | 2003-05-14 |
| NO993935D0 (no) | 1999-08-16 |
| ATE240113T1 (de) | 2003-05-15 |
| US20010002391A1 (en) | 2001-05-31 |
| CN1250376A (zh) | 2000-04-12 |
| NO321203B1 (no) | 2006-04-03 |
| NZ337364A (en) | 2001-06-29 |
| HK1025266A1 (en) | 2000-11-10 |
| US6271199B2 (en) | 2001-08-07 |
| DE69814618D1 (de) | 2003-06-18 |
| WO1998035691A1 (en) | 1998-08-20 |
| AU6171998A (en) | 1998-09-08 |
| DE69814618T2 (de) | 2004-03-25 |
| IL131410A0 (en) | 2001-01-28 |
| CN1159061C (zh) | 2004-07-28 |
| EP0979096A1 (en) | 2000-02-16 |
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