JP2001510793A5 - - Google Patents
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- Publication number
- JP2001510793A5 JP2001510793A5 JP2000503829A JP2000503829A JP2001510793A5 JP 2001510793 A5 JP2001510793 A5 JP 2001510793A5 JP 2000503829 A JP2000503829 A JP 2000503829A JP 2000503829 A JP2000503829 A JP 2000503829A JP 2001510793 A5 JP2001510793 A5 JP 2001510793A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- methyl
- carbon atoms
- transplantation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000004432 carbon atoms Chemical group C* 0.000 description 2
- -1 methyl Chemical group 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 102100008428 CCL2 Human genes 0.000 description 1
- 101700006000 CCL2 Proteins 0.000 description 1
- 208000004852 Lung Injury Diseases 0.000 description 1
- 101710043203 P23p89 Proteins 0.000 description 1
- 206010058046 Post procedural complication Diseases 0.000 description 1
- 206010069363 Traumatic lung injury Diseases 0.000 description 1
- 206010047115 Vasculitis Diseases 0.000 description 1
- 201000001320 atherosclerosis Diseases 0.000 description 1
- 230000000271 cardiovascular Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 231100000515 lung injury Toxicity 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 210000000056 organs Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
Description
【特許請求の範囲】
【請求項１】 心臓血管手術、移植や器官又は組織の置換、及び人工装具移植における、アテローマ性動脈硬化症、脈管炎、間質肺障害、術後合併症からなる群から選択され、かつ、ＭＣＰ-1タンパク質の生産によって特徴付けられる、疾患の治療用の薬剤組成物であって、前記組成物が、式(1)、
(但し、Ｒ及びＲ’が、同一あるいは互いに異なり、Ｈあるいは1〜５つの炭素原子を有するアルキルであり、Ｒ’’’が、Ｈあるいは1〜4つの炭素原子を有するアルキルであり、かつ、Ｒ’’’がＨの場合には、同化合物と薬学上許容できる有機塩基又は無機塩基の塩である。)の化合物からなる薬剤組成物。
【請求項２】
Ｒ’’’がＨである請求項１記載の方法。
【請求項３】
Ｒがメチルである請求項１記載の方法。
【請求項４】
Ｒ’がメチルである請求項１記載の方法。
【請求項１】 心臓血管手術、移植や器官又は組織の置換、及び人工装具移植における、アテローマ性動脈硬化症、脈管炎、間質肺障害、術後合併症からなる群から選択され、かつ、ＭＣＰ-1タンパク質の生産によって特徴付けられる、疾患の治療用の薬剤組成物であって、前記組成物が、式(1)、
【請求項２】
Ｒ’’’がＨである請求項１記載の方法。
【請求項３】
Ｒがメチルである請求項１記載の方法。
【請求項４】
Ｒ’がメチルである請求項１記載の方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97A01789 | 1997-07-28 | ||
| IT97MI001789A IT1293795B1 (it) | 1997-07-28 | 1997-07-28 | Farmaco attivo nel ridurre la produzione di proteina mcp-1 |
| PCT/EP1998/004924 WO1999004770A2 (en) | 1997-07-28 | 1998-07-22 | A pharmaceutical composition active in reducing production of mcp-1 protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009270715A Division JP5086322B2 (ja) | 1997-07-28 | 2009-11-09 | Ｍｃｐ−１プロテインの増加生産によって特徴付けられる障害の処置のための薬剤組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001510793A JP2001510793A (ja) | 2001-08-07 |
| JP2001510793A5 true JP2001510793A5 (ja) | 2006-01-05 |
| JP4651191B2 JP4651191B2 (ja) | 2011-03-16 |
Family
ID=11377642
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000503829A Expired - Fee Related JP4651191B2 (ja) | 1997-07-28 | 1998-07-22 | Ｍｃｐ−１タンパク質の生成を減らす際に活性がある薬剤組成物 |
| JP2009270715A Expired - Fee Related JP5086322B2 (ja) | 1997-07-28 | 2009-11-09 | Ｍｃｐ−１プロテインの増加生産によって特徴付けられる障害の処置のための薬剤組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009270715A Expired - Fee Related JP5086322B2 (ja) | 1997-07-28 | 2009-11-09 | Ｍｃｐ−１プロテインの増加生産によって特徴付けられる障害の処置のための薬剤組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6534534B1 (ja) |
| EP (1) | EP1005332B1 (ja) |
| JP (2) | JP4651191B2 (ja) |
| AR (1) | AR016382A1 (ja) |
| AT (1) | ATE251902T1 (ja) |
| AU (1) | AU744492B2 (ja) |
| CA (1) | CA2300289C (ja) |
| DE (1) | DE69819012T2 (ja) |
| DK (1) | DK1005332T3 (ja) |
| ES (1) | ES2207858T3 (ja) |
| HK (1) | HK1028561A1 (ja) |
| IT (1) | IT1293795B1 (ja) |
| PT (1) | PT1005332E (ja) |
| SI (1) | SI1005332T1 (ja) |
| WO (1) | WO1999004770A2 (ja) |
| ZA (1) | ZA986636B (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1293795B1 (it) * | 1997-07-28 | 1999-03-10 | Angelini Ricerche Spa | Farmaco attivo nel ridurre la produzione di proteina mcp-1 |
| ITMI20062254A1 (it) * | 2006-11-24 | 2008-05-25 | Acraf | Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca |
| JP5509099B2 (ja) * | 2008-03-07 | 2014-06-04 | アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニ | 新規な１−ベンジル−３−ヒドロキシメチルインダゾール誘導体並びにそのＭＣＰ−１、ＣＸ３ＣＲ１およびｐ４０の発現に基づく疾患の治療への使用 |
| US8461194B2 (en) * | 2008-03-07 | 2013-06-11 | Aziende Chimiche Riunite Angelini Francesco A. C. R. A. F. S. P. A. | 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and P40 |
| BRPI0908883A2 (pt) * | 2008-03-07 | 2015-09-15 | Acraf | composto, composição farmacêutica, uso de um composto, e, método para tratar ou prevenir doenças |
| EP2462119B1 (en) | 2009-08-03 | 2014-06-11 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. | Process for the preparation of 1-benzyl-3-hydroxymethyl-1H-indazole and its derivatives and required Magnesium intermediates |
| UA108742C2 (uk) * | 2009-09-23 | 2015-06-10 | Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1 | |
| EP2539710A4 (en) | 2010-02-25 | 2016-07-06 | Prairie Ventures Llc | SYSTEM AND METHOD FOR THE HANDLING, STORAGE AND ANALYSIS OF ANATOMICAL ILLICITATION SAMPLES |
| US8999292B2 (en) | 2012-05-01 | 2015-04-07 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
| JP6944442B2 (ja) | 2015-06-12 | 2021-10-06 | ベットーレ リミテッド ライアビリティー カンパニーＶｅｔｔｏｒｅ， Ｌｌｃ | 疾患を治療するためのｍｃｔ４阻害剤 |
| WO2018111904A1 (en) | 2016-12-12 | 2018-06-21 | Vettore, LLC | Heterocyclic inhibitors of mct4 |
| EP3990433A4 (en) | 2019-06-25 | 2023-07-26 | Translatum Medicus Inc. | METHODS FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1230441B (it) * | 1989-02-07 | 1991-10-23 | Acraf | Eteri della serie dell'indazolo |
| US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
| IT1253703B (it) * | 1991-04-22 | 1995-08-23 | Angelini Francesco Ist Ricerca | Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie |
| AU5537994A (en) * | 1992-10-22 | 1994-05-09 | Mallinckrodt Medical, Inc. | Therapeutic treatment for inhibiting vascular restenosis |
| US5563145A (en) * | 1994-12-07 | 1996-10-08 | American Home Products Corporation | Rapamycin 42-oximes and hydroxylamines |
| JPH08333262A (ja) * | 1995-04-07 | 1996-12-17 | Chugai Pharmaceut Co Ltd | 免疫抑制剤 |
| US6113898A (en) * | 1995-06-07 | 2000-09-05 | Idec Pharmaceuticals Corporation | Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies |
| DE19538402A1 (de) * | 1995-10-14 | 1997-04-17 | Boehringer Mannheim Gmbh | Lipidalkohole als neue immunsuppressive und antivirale Arzneimittel |
| JPH09165339A (ja) * | 1995-10-27 | 1997-06-24 | American Home Prod Corp | ラパマイシンを付与したドナー脾細胞を用いる臓器移植の延長 |
| IT1276031B1 (it) | 1995-10-31 | 1997-10-24 | Angelini Ricerche Spa | Composizione farmaceutica per il trattamento delle malattie autoimmuni |
| US5780462A (en) * | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
| IT1293795B1 (it) * | 1997-07-28 | 1999-03-10 | Angelini Ricerche Spa | Farmaco attivo nel ridurre la produzione di proteina mcp-1 |
-
1997
- 1997-07-28 IT IT97MI001789A patent/IT1293795B1/it active IP Right Grant
-
1998
- 1998-07-22 SI SI9830573T patent/SI1005332T1/xx unknown
- 1998-07-22 DK DK98943862T patent/DK1005332T3/da active
- 1998-07-22 ES ES98943862T patent/ES2207858T3/es not_active Expired - Lifetime
- 1998-07-22 PT PT98943862T patent/PT1005332E/pt unknown
- 1998-07-22 AT AT98943862T patent/ATE251902T1/de active
- 1998-07-22 CA CA002300289A patent/CA2300289C/en not_active Expired - Fee Related
- 1998-07-22 EP EP98943862A patent/EP1005332B1/en not_active Expired - Lifetime
- 1998-07-22 AU AU91601/98A patent/AU744492B2/en not_active Ceased
- 1998-07-22 DE DE69819012T patent/DE69819012T2/de not_active Expired - Lifetime
- 1998-07-22 JP JP2000503829A patent/JP4651191B2/ja not_active Expired - Fee Related
- 1998-07-22 US US09/463,666 patent/US6534534B1/en not_active Expired - Lifetime
- 1998-07-22 WO PCT/EP1998/004924 patent/WO1999004770A2/en active IP Right Grant
- 1998-07-24 ZA ZA986636A patent/ZA986636B/xx unknown
- 1998-07-28 AR ARP980103695A patent/AR016382A1/es unknown
-
2000
- 2000-12-07 HK HK00107851A patent/HK1028561A1/xx not_active IP Right Cessation
-
2009
- 2009-11-09 JP JP2009270715A patent/JP5086322B2/ja not_active Expired - Fee Related
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