JP2001509782A5 - - Google Patents
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- Publication number
- JP2001509782A5 JP2001509782A5 JP1997538862A JP53886297A JP2001509782A5 JP 2001509782 A5 JP2001509782 A5 JP 2001509782A5 JP 1997538862 A JP1997538862 A JP 1997538862A JP 53886297 A JP53886297 A JP 53886297A JP 2001509782 A5 JP2001509782 A5 JP 2001509782A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/637,968 | 1996-04-30 | ||
| US08/637,968 US5608095A (en) | 1996-04-30 | 1996-04-30 | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
| PCT/US1997/003335 WO1997041129A1 (en) | 1996-04-30 | 1997-03-03 | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001509782A JP2001509782A (ja) | 2001-07-24 |
| JP2001509782A5 true JP2001509782A5 (cg-RX-API-DMAC10.html) | 2004-12-02 |
| JP4309473B2 JP4309473B2 (ja) | 2009-08-05 |
Family
ID=24558107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53886297A Expired - Fee Related JP4309473B2 (ja) | 1996-04-30 | 1997-03-03 | 抗アテローム性動脈硬化剤としてのアルキル―４―シリル―フェノールおよびそのエステル |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5608095A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0900225B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP4309473B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR100503181B1 (cg-RX-API-DMAC10.html) |
| CN (1) | CN1216993A (cg-RX-API-DMAC10.html) |
| AR (1) | AR006890A1 (cg-RX-API-DMAC10.html) |
| AT (1) | ATE212639T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU711322B2 (cg-RX-API-DMAC10.html) |
| BR (1) | BR9709190A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2251991C (cg-RX-API-DMAC10.html) |
| DE (1) | DE69710191T2 (cg-RX-API-DMAC10.html) |
| DK (1) | DK0900225T3 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2167716T3 (cg-RX-API-DMAC10.html) |
| IL (1) | IL126758A0 (cg-RX-API-DMAC10.html) |
| NO (1) | NO985039L (cg-RX-API-DMAC10.html) |
| PT (1) | PT900225E (cg-RX-API-DMAC10.html) |
| TW (1) | TW474940B (cg-RX-API-DMAC10.html) |
| WO (1) | WO1997041129A1 (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA973503B (cg-RX-API-DMAC10.html) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2252869A1 (en) * | 1996-04-30 | 1997-11-06 | Hoechst Marion Roussel, Inc. | Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-di-alkyl-4-silyl-phenols |
| US5795876A (en) * | 1996-04-30 | 1998-08-18 | Hoechst Marion Rousssel, Inc. | Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols |
| US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
| TR199902802T2 (xx) | 1997-05-14 | 2000-04-21 | Atherogenics, Inc. | Kardiyovask�ler hastal�klar ve enflamatuar hastal�klar�n tedavisi i�in probukol monoesterleri. |
| US6121463A (en) * | 1997-06-24 | 2000-09-19 | Hoechst Marion Roussel, Inc. | Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents |
| US6133467A (en) * | 1997-06-25 | 2000-10-17 | Hoechst Marion Roussel, Inc. | 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol |
| JP2002506443A (ja) * | 1997-06-25 | 2002-02-26 | アベンティス・ファーマスーティカルズ・インコーポレイテッド | ２，６−ジ−ｔ−ブチル−４−［（ジメチル−４−メトキシフェニルシリル）メチルオキシ］フェノール及び２，６−ジ−ｔ−ブチル−４−［（ジメチル−２−メトキシフェニルシリル）メチルオキシ］フェノール |
| KR20010020611A (ko) * | 1997-07-01 | 2001-03-15 | 아테로제닉스, 인코포레이티드 | 항산화제에 의한 과증식질병 치료의 향상 |
| WO2000028332A1 (en) * | 1998-11-09 | 2000-05-18 | Atherogenics, Inc. | Methods and compositions to lower plasma cholesterol levels |
| US6887712B1 (en) | 1998-11-09 | 2005-05-03 | Atherogenics, Inc. | Methods and compositions to lower plasma cholesterol levels |
| US6020383A (en) * | 1999-01-11 | 2000-02-01 | Eastman Chemicals Company | Method for reducing blood cholesterol and/or blood triglycerides |
| WO2002040021A2 (en) | 2000-11-17 | 2002-05-23 | Idenix (Cayman) Limited | Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines |
| WO2002087556A2 (en) * | 2001-04-11 | 2002-11-07 | Atherogenics, Inc. | Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality |
| WO2003039231A2 (en) * | 2001-10-25 | 2003-05-15 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
| JP2006506314A (ja) * | 2001-11-09 | 2006-02-23 | アセロジエニクス・インコーポレイテツド | 心血管疾患の逆転及び予防方法 |
| RU2004121898A (ru) * | 2001-12-19 | 2006-01-20 | Атеродженикс, Инк. (Us) | Производные халкона и их применение для лечения заболеваний |
| US6960683B2 (en) * | 2002-07-12 | 2005-11-01 | Atherogenics, Inc. | Salt forms of poorly soluble probucol esters and ethers |
| AU2003266165A1 (en) * | 2002-09-13 | 2004-04-30 | Hossein Dovlatabadi | Methods and compositons for the use of d-malic acid to decrease serum triglyceride, cholesterol, and lipoprotein levels |
| US20040181075A1 (en) * | 2002-12-19 | 2004-09-16 | Weingarten M. David | Process of making chalcone derivatives |
| CA2512980A1 (en) * | 2003-01-13 | 2004-07-29 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
| US7173129B2 (en) * | 2003-06-06 | 2007-02-06 | Athero Genics, Inc. | Sulfonamide-substituted chalcone derivatives and their use to treat diseases |
| JP2007509054A (ja) * | 2003-10-17 | 2007-04-12 | アミリン・ファーマシューティカルズ，インコーポレイテッド | 血管健康を促進するシリルフェノール |
| WO2005102323A2 (en) | 2004-04-20 | 2005-11-03 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
| WO2005112914A2 (en) | 2004-04-20 | 2005-12-01 | Atherogenics, Inc. | Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease |
| US20060063828A1 (en) * | 2004-06-28 | 2006-03-23 | Weingarten M D | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof |
| US20060058268A1 (en) * | 2004-07-01 | 2006-03-16 | Sundell Cynthia L | Compounds and methods for treating diabetic vascular diseases |
| BRPI0809423A2 (pt) * | 2007-03-26 | 2014-09-09 | Salutria Pharmaceuticals Llc | Usos e composições de derivados de probucol para o tratamento de diabetes |
| WO2008118946A1 (en) * | 2007-03-27 | 2008-10-02 | Atherogenics, Inc. | Methods and compositions using certain phenolic derivatives for the treatment of diabetes |
| BR112012025343A2 (pt) * | 2010-04-15 | 2016-06-28 | Merck Patent Gmbh | processo para a preparação de hidroquinonas |
| CN109641004A (zh) * | 2016-07-08 | 2019-04-16 | 燕财成有限公司 | 实体癌治疗剂 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3129262A (en) * | 1962-10-08 | 1964-04-14 | Consolidation Coal Co | Reduction of organic thiocyanates |
| US3862332A (en) * | 1967-05-11 | 1975-01-21 | Dow Chemical Co | Method of lowering serum cholesterol |
| US3576883A (en) * | 1969-06-30 | 1971-04-27 | Consolidation Coal Co | Alkylidenedithiobisphenols |
| US3786100A (en) * | 1971-12-10 | 1974-01-15 | Continental Oil Co | Keto substituted alkylidenedithiobisphenols |
| US3897500A (en) * | 1971-12-10 | 1975-07-29 | Continental Oil Co | Alkylidenedithiobisphenols |
| JPS61263988A (ja) * | 1985-05-16 | 1986-11-21 | Shionogi & Co Ltd | シリル置換エ−テル類および殺虫・殺ダニ剤 |
| US5356917A (en) * | 1985-08-09 | 1994-10-18 | Eli Lilly And Company | Aryl-substituted rhodanine derivatives |
| US4719237A (en) * | 1986-01-28 | 1988-01-12 | Merrell Dow Pharmaceuticals Inc. | Cardiac antiarrythmic method employing probucol |
| US4734527A (en) * | 1986-10-17 | 1988-03-29 | Merrell Dow Pharmaceuticals Inc. | Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol |
| US4772363A (en) * | 1987-01-14 | 1988-09-20 | Merrell Dow Pharmaceuticals Inc. | Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol by electrocatalysis |
| US4861443A (en) * | 1987-01-14 | 1989-08-29 | Merrell Dow Pharmaceuticals Inc. | Process for preparing 4,4'-isopropylidenedithio-bis-(2,6-di-tertiarybutylphenol) by electrocatalysis |
| US5401883A (en) * | 1987-01-20 | 1995-03-28 | Merrell Dow Pharmaceuticals Inc. | Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol and 4,4'-isopropylidenedithio-bis-(2,6-di-tertiarybutylphenol) |
| US4975467A (en) * | 1987-03-17 | 1990-12-04 | Merrell Dow Pharmaceuticals Inc. | Method of inhibiting interleukin-1 release and alleviating interleukin-1 mediated conditions |
| JPH0813824B2 (ja) * | 1988-10-27 | 1996-02-14 | 北興化学工業株式会社 | 有機ケイ素化合物 |
| US4900757A (en) * | 1988-12-08 | 1990-02-13 | Merrell Dow Pharmaceuticals Inc. | Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane |
| US5047555A (en) * | 1988-12-13 | 1991-09-10 | Tanabe Seiyaku Co., Ltd. | 4-aminophenol derivatives and processes for preparing the same |
| US5217870A (en) * | 1989-04-28 | 1993-06-08 | Biogen, Inc. | Monoclonal antibodies against CDX |
| US5272263A (en) * | 1989-04-28 | 1993-12-21 | Biogen, Inc. | DNA sequences encoding vascular cell adhesion molecules (VCAMS) |
| US5008421A (en) * | 1989-07-05 | 1991-04-16 | Aristech Chemical Corporation | Silyl derivatives of 2,6-dimethyl-4-allyl phenol |
| DE3935638A1 (de) * | 1989-10-26 | 1991-05-02 | Consortium Elektrochem Ind | Organosilylalkylaromaten |
| US5061734A (en) * | 1990-05-09 | 1991-10-29 | Merrell Dow Pharmaceuticals Inc. | Bis(alkyl-substituted-4-hydroxyphenylthio)alkane analogs as inhibitors of cataractogenesis |
| US5112870A (en) * | 1990-05-09 | 1992-05-12 | Merrell Dow Pharmaceuticals Inc. | Bis(alkyl-substituted-4-hydroxyphenylthio)alkane analogs as inhibitors of cataractogenesis |
| JP2899064B2 (ja) * | 1990-05-23 | 1999-06-02 | キヤノン株式会社 | 液晶性化合物、これを含む液晶組成物およびこれを使用した液晶素子 |
| US5155250A (en) * | 1990-07-05 | 1992-10-13 | Merrell Dow Pharmaceuticals Inc. | 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents |
| US5304668A (en) * | 1990-07-05 | 1994-04-19 | Merrell Dow Pharmaceuticals | Bis-[4-(2,6-di-alkyl)phenolisilane derivatives as antiatherosclerotic agents |
| NZ238807A (en) * | 1990-07-05 | 1994-03-25 | Merrell Dow Pharma | Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions |
| US5254549A (en) * | 1991-12-19 | 1993-10-19 | Merz & Co. Gmbh & Co. | New BHT ether compounds and their use as hypolipidemic and antiatherosclerotic drugs |
| US5262439A (en) * | 1992-04-30 | 1993-11-16 | The Regents Of The University Of California | Soluble analogs of probucol |
| ATE231915T1 (de) * | 1992-09-02 | 2003-02-15 | Isis Pharmaceuticals Inc | Beeinflussing der zelladhäsie durch oligonukleotide |
| US5380747A (en) * | 1992-10-30 | 1995-01-10 | Emory University | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases |
| EP0670735B1 (en) * | 1992-11-13 | 1997-04-02 | Board Of Regents Of The University Of Washington | Peripheralization of hematopoietic stem cells |
| EP0675883A1 (en) * | 1992-12-22 | 1995-10-11 | Smithkline Beecham Plc | Piperidine derivatives as calcium channel antagonists |
| ATE182625T1 (de) * | 1993-01-12 | 1999-08-15 | Biogen Inc | Rekombinante anti-vla4 antikörpermoleküle |
| JP3593343B2 (ja) * | 1993-02-09 | 2004-11-24 | バイオジェン インコーポレイテッド | インシュリン依存型糖尿病の治療 |
| WO1995004749A1 (en) * | 1993-08-05 | 1995-02-16 | Isis Pharmaceuticals, Inc. | Oligomers for modulating metabolic function |
| JP3650144B2 (ja) * | 1994-06-08 | 2005-05-18 | 花王株式会社 | 細胞接着抑制剤 |
-
1996
- 1996-04-30 US US08/637,968 patent/US5608095A/en not_active Expired - Fee Related
-
1997
- 1997-03-03 DK DK97907998T patent/DK0900225T3/da active
- 1997-03-03 WO PCT/US1997/003335 patent/WO1997041129A1/en not_active Ceased
- 1997-03-03 AU AU19854/97A patent/AU711322B2/en not_active Ceased
- 1997-03-03 BR BR9709190A patent/BR9709190A/pt active Search and Examination
- 1997-03-03 KR KR1019980708692A patent/KR100503181B1/ko not_active Expired - Fee Related
- 1997-03-03 AT AT97907998T patent/ATE212639T1/de not_active IP Right Cessation
- 1997-03-03 CA CA002251991A patent/CA2251991C/en not_active Expired - Fee Related
- 1997-03-03 PT PT97907998T patent/PT900225E/pt unknown
- 1997-03-03 CN CN97194267A patent/CN1216993A/zh active Pending
- 1997-03-03 IL IL12675897A patent/IL126758A0/xx unknown
- 1997-03-03 DE DE69710191T patent/DE69710191T2/de not_active Expired - Fee Related
- 1997-03-03 EP EP97907998A patent/EP0900225B1/en not_active Expired - Lifetime
- 1997-03-03 JP JP53886297A patent/JP4309473B2/ja not_active Expired - Fee Related
- 1997-03-03 ES ES97907998T patent/ES2167716T3/es not_active Expired - Lifetime
- 1997-04-23 TW TW086105269A patent/TW474940B/zh active
- 1997-04-23 ZA ZA9703503A patent/ZA973503B/xx unknown
- 1997-04-29 AR ARP970101749A patent/AR006890A1/es unknown
-
1998
- 1998-10-29 NO NO985039A patent/NO985039L/no unknown