JP2001506634A - 粘膜下組織抽出物 - Google Patents
粘膜下組織抽出物Info
- Publication number
- JP2001506634A JP2001506634A JP52694598A JP52694598A JP2001506634A JP 2001506634 A JP2001506634 A JP 2001506634A JP 52694598 A JP52694598 A JP 52694598A JP 52694598 A JP52694598 A JP 52694598A JP 2001506634 A JP2001506634 A JP 2001506634A
- Authority
- JP
- Japan
- Prior art keywords
- biologically active
- extract
- extraction
- submucosa
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factors [FGF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/80—Undefined extracts from animals
- C12N2500/84—Undefined extracts from animals from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.細胞増殖を促進するのに有用な生物学的活性組成物の調製方法であって、 粘膜下組織を抽出賦形剤(補助剤;excipients)の水溶液で抽出して、抽出され た生物学的活性成分類と抽出賦形剤との水溶液を形成し、前記抽出された生物学 的活性成分類を前記抽出賦形剤から分離して、生物学的活性組成物を形成する諸 段階を含んでなる方法。 2.少なくとも1種類の生物学的活性成分を前記生物学的活性組成物の他の生 物学的成分類から分離する段階をさらに含む請求項1記載の方法。 3.前記粘膜下組織が腸粘膜下組織、胃粘膜下組織、膀胱粘膜下組織および子 宮粘膜下組織からなる群から選択される請求項1または請求項2記載の方法。 4.前記抽出賦形剤がカオトロピック試薬類、酵素類および酵素阻止物質類か らなる群から選択される請求項1または請求項2記載の方法。 5.前記抽出賦形剤がカオトロピック試薬を含む請求項1または請求項2記載 の方法。 6.前記カオトロピック試薬が尿素、グアニジン、塩化ナトリウム、塩化マグ ネシウム、イオン性または非イオン性表面活性剤から選択される請求項5記載の 方法。 7.前記抽出賦形剤溶液が少なくとも1種類のプロテアーゼ阻止剤をさらに含 む請求項5記載の方法。 8.前記抽出された生物学的活性成分類を、前記のその他の抽出賦形剤から分 離する段階が、前記抽出された生物学的活性成分類と前記抽出賦形剤との水溶液 を透析する段階を含む請求項1または請求項2記載の方法。 9.前記透析ずみ溶液を凍結乾燥する段階をさらに含む請求項8記載の方法。 10.天然脊椎動物粘膜下組織に存在する少なくとも1種類の生物学的活性成 分に富む(enriched)脊椎動物粘膜下組織の分離抽出物であって、前記富化(enr iched)生物学的活性成分が生物学的に活性のままである前記分離抽出物。 11.前記富化生物学的活性成分が増殖因子である請求項10記載の分離抽出 物。 12.前記富化生物学的活性成分がTGFβ関連タンパク質または線維芽細胞 増殖因子である請求項11記載の分離抽出物。 13.前記富化生物学的活性成分がフィブロネクチンである請求項10記載の 分離抽出物。 14.前記富化生物学的活性成分がグリコサミノグリカンである請求項10記 載の分離抽出物。 15.前記富化生物学的活性成分がコンドロイチン硫酸Aまたはコンドロイチ ン硫酸Bである請求項10記載の分離抽出物。 16.前記富化生物学的活性成分がヘパリン、ヘパラン硫酸またはヒアルロン 酸である請求項10記載の分離抽出物。 17.前記抽出物が乾燥粉末形態または凍結乾燥形態である請求項10記載の 分離抽出物。 18.前記抽出物がクリームの形態である請求項10記載の分離抽出物。 19.天然腸粘膜下組織に存在する生物学的活性成分に富む脊椎動物腸粘膜下 組織の分離抽出物であって、前記富化生物学的活性成分が生物学的に活性のまま である前記分離抽出物。 20.粘膜下組織の生物学的活性成分に富む抽出物を調製するための温血脊椎 動物の粘膜下組織の使用であって、前記調製方法は、粘膜下組織を抽出賦形剤の 水溶液で抽出し、抽出された生物学的活性成分と賦形剤との水溶液を形成し、前 記抽出された生物学的活性成分類を前記抽出賦形剤から分離して生物学的活性抽 出物を形成する諸段階を含んでなる前記使用。 21.請求項2記載の方法によって調製された組成物。 22.細胞増殖培地のための添加物としての請求項10記載の組成物の使用。 24.創傷治癒を促進するのに有効な量の請求項10記載の組成物の創傷包帯 への使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3268596P | 1996-12-10 | 1996-12-10 | |
US60/032,685 | 1996-12-10 | ||
PCT/US1997/022721 WO1998025964A1 (en) | 1996-12-10 | 1997-12-10 | Submucosa extracts |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001506634A true JP2001506634A (ja) | 2001-05-22 |
JP4046358B2 JP4046358B2 (ja) | 2008-02-13 |
Family
ID=21866283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52694598A Expired - Fee Related JP4046358B2 (ja) | 1996-12-10 | 1997-12-10 | 粘膜下組織抽出物 |
Country Status (6)
Country | Link |
---|---|
US (1) | US6375989B1 (ja) |
EP (1) | EP0944647B1 (ja) |
JP (1) | JP4046358B2 (ja) |
AU (1) | AU728949C (ja) |
CA (1) | CA2274902C (ja) |
WO (1) | WO1998025964A1 (ja) |
Cited By (2)
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---|---|---|---|---|
US8647677B2 (en) | 1996-12-10 | 2014-02-11 | Purdue Research Foundation | Gastric submucosal tissue as a novel diagnostic tool |
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US11826490B1 (en) | 2020-12-29 | 2023-11-28 | Acell, Inc. | Extracellular matrix sheet devices with improved mechanical properties and method of making |
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US4801299A (en) | 1983-06-10 | 1989-01-31 | University Patents, Inc. | Body implants of extracellular matrix and means and methods of making and using such implants |
US4743552A (en) | 1984-09-26 | 1988-05-10 | Sloan-Kettering Institute For Cancer Research | Method for growth in tissue culture of normal colonic epithelial cells and method for determination of preneoplastic color cells |
US4829000A (en) | 1985-08-30 | 1989-05-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Reconstituted basement membrane complex with biological activity |
US5266480A (en) | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
US4902508A (en) | 1988-07-11 | 1990-02-20 | Purdue Research Foundation | Tissue graft composition |
US5217954A (en) * | 1990-04-04 | 1993-06-08 | Scios Nova Inc. | Formulations for stabilizing fibroblast growth factor |
US5714458A (en) * | 1990-07-18 | 1998-02-03 | Farmitalia Carlo Erba S.R.L. | Stable pharmaceutical compositions containing a fibroblast growth factor |
US5281422A (en) | 1991-09-24 | 1994-01-25 | Purdue Research Foundation | Graft for promoting autogenous tissue growth |
US5478739A (en) | 1992-10-23 | 1995-12-26 | Advanced Tissue Sciences, Inc. | Three-dimensional stromal cell and tissue culture system |
US5275826A (en) | 1992-11-13 | 1994-01-04 | Purdue Research Foundation | Fluidized intestinal submucosa and its use as an injectable tissue graft |
US5695998A (en) * | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
US5554389A (en) | 1995-04-07 | 1996-09-10 | Purdue Research Foundation | Urinary bladder submucosa derived tissue graft |
CA2272097C (en) | 1996-12-10 | 2007-02-20 | Purdue Research Foundation | Artificial vascular valves |
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- 1997-12-10 AU AU57956/98A patent/AU728949C/en not_active Expired
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US8647677B2 (en) | 1996-12-10 | 2014-02-11 | Purdue Research Foundation | Gastric submucosal tissue as a novel diagnostic tool |
WO2021206055A1 (ja) * | 2020-04-08 | 2021-10-14 | 一丸ファルコス株式会社 | 血管新生促進及び/又は神経再生用ユニット |
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WO1998025964A1 (en) | 1998-06-18 |
US6375989B1 (en) | 2002-04-23 |
AU728949B2 (en) | 2001-01-18 |
AU728949C (en) | 2007-03-29 |
JP4046358B2 (ja) | 2008-02-13 |
EP0944647A1 (en) | 1999-09-29 |
EP0944647B1 (en) | 2008-11-12 |
CA2274902A1 (en) | 1998-06-18 |
CA2274902C (en) | 2011-02-01 |
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