|
US6924128B2
(en)
*
|
1994-12-06 |
2005-08-02 |
Targeted Genetics Corporation |
Packaging cell lines for generation of high titers of recombinant AAV vectors
|
|
US6989264B2
(en)
|
1997-09-05 |
2006-01-24 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
DK1009808T3
(da)
|
1997-09-05 |
2013-01-21 |
Genzyme Corp |
Fremgangsmåder til generering af hjælper-frie præparater af rekombinante aav-vektorer med høj titer
|
|
US6566118B1
(en)
|
1997-09-05 |
2003-05-20 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
US6346415B1
(en)
*
|
1997-10-21 |
2002-02-12 |
Targeted Genetics Corporation |
Transcriptionally-activated AAV inverted terminal repeats (ITRS) for use with recombinant AAV vectors
|
|
US6642051B1
(en)
|
1997-10-21 |
2003-11-04 |
Targeted Genetics Corporation |
Amplifiable adeno-associated virus(AAV) packaging cassettes for the production of recombinant AAV vectors
|
|
US6953690B1
(en)
|
1998-03-20 |
2005-10-11 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
EP1930418B1
(en)
|
1998-09-04 |
2015-04-08 |
Genzyme Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
DE19905501B4
(de)
|
1999-02-10 |
2005-05-19 |
MediGene AG, Gesellschaft für molekularbiologische Kardiologie und Onkologie |
Verfahren zur Herstellung eines rekombinanten Adeno-assoziierten Virus, geeignete Mittel hierzu sowie Verwendung zur Herstellung eines Arzneimittels
|
|
US6893865B1
(en)
|
1999-04-28 |
2005-05-17 |
Targeted Genetics Corporation |
Methods, compositions, and cells for encapsidating recombinant vectors in AAV particles
|
|
DK1180159T3
(da)
|
1999-05-28 |
2008-11-17 |
Targeted Genetics Corp |
Fremgangsmåder og sammensætninger til at sænke niveauet af Tumor-Nekrose-Faktor (TNF) i TNF-associerede lidelser
|
|
EP1916258B1
(en)
|
1999-08-09 |
2014-04-23 |
Targeted Genetics Corporation |
Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms intrastrand base pairs
|
|
CA2379166C
(en)
|
1999-08-09 |
2013-03-26 |
Targeted Genetics Corporation |
Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms instrastrand base pairs
|
|
US7115391B1
(en)
*
|
1999-10-01 |
2006-10-03 |
Genovo, Inc. |
Production of recombinant AAV using adenovirus comprising AAV rep/cap genes
|
|
US7208315B2
(en)
|
2000-01-05 |
2007-04-24 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for efficient AAV vector production
|
|
DE10044384A1
(de)
*
|
2000-09-08 |
2002-04-18 |
Medigene Ag |
Wirtszellen zur Verpackung von rekombinantem Adeno-assoziiertem Virus (rAAV), Verfahren zu ihrer Herstellung und deren Verwendung
|
|
US6723551B2
(en)
|
2001-11-09 |
2004-04-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Production of adeno-associated virus in insect cells
|
|
WO2003042361A2
(en)
*
|
2001-11-09 |
2003-05-22 |
Government Of The United States Of America, Department Of Health And Human Services |
Production of adeno-associated virus in insect cells
|
|
AU2003223214B2
(en)
*
|
2002-03-01 |
2008-09-18 |
Celltech R & D, Inc. |
Methods to increase or decrease bone density
|
|
US6845929B2
(en)
*
|
2002-03-22 |
2005-01-25 |
Ali Dolatabadi |
High efficiency nozzle for thermal spray of high quality, low oxide content coatings
|
|
US7510872B2
(en)
*
|
2003-02-26 |
2009-03-31 |
Nationwide Children's Hospital |
Recombinant adeno-associated virus production
|
|
EP1755400A2
(en)
*
|
2004-06-18 |
2007-02-28 |
The University Of Montana |
Aav mediated gene delivery to cochlear cells
|
|
EP2311966A3
(en)
|
2005-10-20 |
2012-09-05 |
Amsterdam Molecular Therapeutics (AMT) B.V. |
Improved AAV vectors produced in insect cells
|
|
CN103849629B
(zh)
|
2006-06-21 |
2017-06-09 |
尤尼克尔Ip股份有限公司 |
具有经修饰的用于在昆虫细胞中产生aav的aav‑rep78翻译起始密码子的载体
|
|
WO2008024998A2
(en)
|
2006-08-24 |
2008-02-28 |
Virovek, Inc. |
Expression in insect cells of genes with overlapping open reading frames, methods and compositions therefor
|
|
HRP20250897T1
(hr)
|
2009-05-02 |
2025-09-26 |
Genzyme Corporation |
Genska terapija za neurodegenerativne poremećaje
|
|
US10415056B2
(en)
|
2010-11-10 |
2019-09-17 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for generating adeno-associated viral vectors with undetectable capsid gene contamination
|
|
WO2014168953A1
(en)
|
2013-04-08 |
2014-10-16 |
University Of Iowa Research Foundation |
Chimeric adeno-associated virus/ bocavirus parvovirus vector
|
|
CN115120746A
(zh)
|
2013-05-15 |
2022-09-30 |
明尼苏达大学董事会 |
腺相关病毒介导的基因向中枢神经系统转移
|
|
EP3151866B1
(en)
|
2014-06-09 |
2023-03-08 |
Voyager Therapeutics, Inc. |
Chimeric capsids
|
|
RU2716991C2
(ru)
|
2014-11-05 |
2020-03-17 |
Вояджер Терапьютикс, Инк. |
Полинуклеотиды aadc для лечения болезни паркинсона
|
|
KR20230145206A
(ko)
|
2014-11-14 |
2023-10-17 |
보이저 테라퓨틱스, 인크. |
조절성 폴리뉴클레오티드
|
|
WO2016077687A1
(en)
|
2014-11-14 |
2016-05-19 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating amyotrophic lateral sclerosis (als)
|
|
US11697825B2
(en)
|
2014-12-12 |
2023-07-11 |
Voyager Therapeutics, Inc. |
Compositions and methods for the production of scAAV
|
|
HK1256341A1
(zh)
|
2015-05-15 |
2019-09-20 |
明尼苏达大学董事会 |
用於治疗性递送到中枢神经系统的腺相关物
|
|
CN108603235A
(zh)
|
2015-07-30 |
2018-09-28 |
马萨诸塞眼科耳科诊所 |
祖先病毒序列及其用途
|
|
WO2017075335A1
(en)
|
2015-10-28 |
2017-05-04 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
WO2017139381A1
(en)
|
2016-02-08 |
2017-08-17 |
University Of Iowa Research Foundation |
Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
|
|
FI3436593T3
(fi)
|
2016-03-28 |
2023-03-16 |
Ultragenyx Pharmaceutical Inc |
Adenoviruksen lämpöinaktivointimenetelmiä
|
|
EP3448874A4
(en)
|
2016-04-29 |
2020-04-22 |
Voyager Therapeutics, Inc. |
COMPOSITIONS FOR TREATING A DISEASE
|
|
US11299751B2
(en)
|
2016-04-29 |
2022-04-12 |
Voyager Therapeutics, Inc. |
Compositions for the treatment of disease
|
|
KR20240056729A
(ko)
|
2016-05-18 |
2024-04-30 |
보이저 테라퓨틱스, 인크. |
조절성 폴리뉴클레오티드
|
|
KR102427379B1
(ko)
|
2016-05-18 |
2022-08-02 |
보이저 테라퓨틱스, 인크. |
헌팅톤 질환을 치료하기 위한 조성물 및 방법
|
|
WO2018044933A1
(en)
|
2016-08-30 |
2018-03-08 |
The Regents Of The University Of California |
Methods for biomedical targeting and delivery and devices and systems for practicing the same
|
|
PL3526321T3
(pl)
|
2016-10-14 |
2025-04-28 |
Ultragenyx Pharmaceutical Inc. |
Zastosowanie środków regulujących ciśnienie osmotyczne w celu zwiększenia wydajności rekombinacyjnego wirusa związanego z adenowirusami
|
|
JP2020500928A
(ja)
|
2016-11-15 |
2020-01-16 |
リジェネクスバイオ インコーポレイテッド |
Ｍｐｓｉおよびｍｐｓｉｉならびに他の神経障害において神経機能を改善するための方法
|
|
US11142775B2
(en)
|
2017-01-13 |
2021-10-12 |
University Of Iowa Research Foundation |
Bocaparvovirus small noncoding RNA and uses thereof
|
|
WO2018175775A1
(en)
|
2017-03-22 |
2018-09-27 |
Dimension Therapeutics |
Cell culture methods involving hdac inhibitors or rep proteins
|
|
JP2020518259A
(ja)
|
2017-05-05 |
2020-06-25 |
ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． |
ハンチントン病治療組成物および方法
|
|
JP2020518258A
(ja)
|
2017-05-05 |
2020-06-25 |
ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． |
筋萎縮性側索硬化症（ａｌｓ）治療組成物および方法
|
|
WO2018208960A1
(en)
|
2017-05-09 |
2018-11-15 |
Dimension Therapeutics, Inc. |
Scalable method for producing transfection reagents
|
|
JOP20190269A1
(ar)
|
2017-06-15 |
2019-11-20 |
Voyager Therapeutics Inc |
بولي نوكليوتيدات aadc لعلاج مرض باركنسون
|
|
CA3070087A1
(en)
|
2017-07-17 |
2019-01-24 |
Voyager Therapeutics, Inc. |
Trajectory array guide system
|
|
EP3808849A1
(en)
|
2017-08-03 |
2021-04-21 |
Voyager Therapeutics, Inc. |
Compositions and methods for delivery of aav
|
|
AU2018338728B2
(en)
|
2017-09-29 |
2025-01-02 |
Centre National De La Recherche Scientifique (Cnrs) |
Rescue of central and peripheral neurological phenotype of Friedreich's Ataxia by intravenous delivery
|
|
US20200231986A1
(en)
|
2017-09-29 |
2020-07-23 |
Massachusetts Eye And Ear Infirmary |
Production of adeno-associated viruses in insect cells
|
|
EP3697908A1
(en)
|
2017-10-16 |
2020-08-26 |
Voyager Therapeutics, Inc. |
Treatment of amyotrophic lateral sclerosis (als)
|
|
TW202413649A
(zh)
|
2017-10-16 |
2024-04-01 |
美商航海家醫療公司 |
肌萎縮性脊髓側索硬化症(als)之治療
|
|
WO2019183387A1
(en)
|
2018-03-21 |
2019-09-26 |
The Scripps Research Institute |
Cd4 muteins and methods of using the same
|
|
US12037707B2
(en)
|
2018-04-05 |
2024-07-16 |
Massachusetts Eye And Ear Infirmary |
Methods of making and using combinatorial barcoded nucleic acid libraries having defined variation
|
|
CA3097192A1
(en)
|
2018-04-27 |
2019-10-31 |
Voyager Therapeutics, Inc. |
Methods for measuring the potency of aadc viral vectors
|
|
WO2019222329A1
(en)
|
2018-05-15 |
2019-11-21 |
Voyager Therapeutics, Inc. |
Compositions and methods for delivery of aav
|
|
KR20210019996A
(ko)
|
2018-05-15 |
2021-02-23 |
보이저 테라퓨틱스, 인크. |
파킨슨병의 치료를 위한 조성물 및 방법
|
|
US20210214749A1
(en)
|
2018-05-16 |
2021-07-15 |
Voyager Therapeutics, Inc. |
Directed evolution
|
|
US20210207167A1
(en)
|
2018-05-16 |
2021-07-08 |
Voyager Therapeutics, Inc. |
Aav serotypes for brain specific payload delivery
|
|
US20210254103A1
(en)
|
2018-07-02 |
2021-08-19 |
Voyager Therapeutics, Inc. |
Treatment of amyotrophic lateral sclerosis and disorders associated with the spinal cord
|
|
CN112770812A
(zh)
|
2018-07-24 |
2021-05-07 |
沃雅戈治疗公司 |
产生基因治疗制剂的系统和方法
|
|
CN111315407B
(zh)
|
2018-09-11 |
2023-05-02 |
上海市公共卫生临床中心 |
一种广谱抗流感疫苗免疫原及其应用
|
|
EP3856762A1
(en)
|
2018-09-28 |
2021-08-04 |
Voyager Therapeutics, Inc. |
Frataxin expression constructs having engineered promoters and methods of use thereof
|
|
WO2020072849A1
(en)
|
2018-10-04 |
2020-04-09 |
Voyager Therapeutics, Inc. |
Methods for measuring the titer and potency of viral vector particles
|
|
WO2020072844A1
(en)
|
2018-10-05 |
2020-04-09 |
Voyager Therapeutics, Inc. |
Engineered nucleic acid constructs encoding aav production proteins
|
|
US20210371470A1
(en)
|
2018-10-12 |
2021-12-02 |
Voyager Therapeutics, Inc. |
Compositions and methods for delivery of aav
|
|
CN113166781A
(zh)
|
2018-10-15 |
2021-07-23 |
沃雅戈治疗公司 |
在杆状病毒/Sf9系统中大规模生产rAAV的表达载体
|
|
SG11202107645RA
(en)
|
2019-01-18 |
2021-08-30 |
Voyager Therapeutics Inc |
Methods and systems for producing aav particles
|
|
SG11202110904PA
(en)
|
2019-04-12 |
2021-10-28 |
Ultragenyx Pharmaceutical Inc |
Engineered producer cell lines and methods of making and using the same
|
|
CN114641318A
(zh)
|
2019-04-15 |
2022-06-17 |
衣阿华大学研究基金会 |
用于治疗囊性纤维化的组合物和方法
|
|
BR112021020706A2
(pt)
|
2019-04-15 |
2022-03-15 |
Spirovant Sciences Inc |
Métodos e composições para expressão de transgene
|
|
EP3962536A1
(en)
|
2019-04-29 |
2022-03-09 |
Voyager Therapeutics, Inc. |
Systems and methods for producing baculoviral infected insect cells (biics) in bioreactors
|
|
US20240124889A1
(en)
|
2019-05-07 |
2024-04-18 |
Voyager Therapeutics, Inc. |
Compositions and methods for the vectored augmentation of protein destruction, expression and/or regulation
|
|
EP4010465A1
(en)
|
2019-08-09 |
2022-06-15 |
Voyager Therapeutics, Inc. |
Cell culture medium for use in producing gene therapy products in bioreactors
|
|
EP4022070A1
(en)
|
2019-08-26 |
2022-07-06 |
Voyager Therapeutics, Inc. |
Controlled expression of viral proteins
|
|
WO2021046155A1
(en)
|
2019-09-03 |
2021-03-11 |
Voyager Therapeutics, Inc. |
Vectorized editing of nucleic acids to correct overt mutations
|
|
KR20220076510A
(ko)
|
2019-10-08 |
2022-06-08 |
트러스티스 오브 보스톤 칼리지 |
다수의 서로 다른 비천연 아미노산을 함유하는 단백질 및 이러한 단백질의 제조 및 사용 방법
|
|
US20230416776A1
(en)
|
2019-10-08 |
2023-12-28 |
Regents Of The University Of Minnesota |
Crispr-mediated human genome editing with vectors
|
|
CN115484978A
(zh)
|
2020-03-05 |
2022-12-16 |
尼奥克斯医疗有限公司 |
使用免疫细胞治疗癌症的方法和组合物
|
|
AU2021239973A1
(en)
|
2020-03-16 |
2022-10-06 |
Ultragenyx Pharmaceutical Inc. |
Methods for enhancing recombinant adeno-associated virus yield
|
|
JP7713956B2
(ja)
|
2020-04-15 |
2025-07-28 |
ボイジャー セラピューティクス インコーポレイテッド |
タウ結合化合物
|
|
WO2021247995A2
(en)
|
2020-06-04 |
2021-12-09 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating neuropathic pain
|
|
WO2022006253A2
(en)
|
2020-06-30 |
2022-01-06 |
University Of Iowa Research Foundation |
Methods and compositions for administering recombinant viral vectors
|
|
WO2022011099A1
(en)
|
2020-07-08 |
2022-01-13 |
Regents Of The University Of Minnesota |
Modified hexosaminidase and uses thereof
|
|
WO2022026410A2
(en)
|
2020-07-27 |
2022-02-03 |
Voyager Therapeutics, Inc |
Compositions and methods for the treatment of niemann-pick type c1 disease
|
|
BR112023001456A2
(pt)
|
2020-07-27 |
2023-04-11 |
Voyager Therapeutics Inc |
Composições e métodos para o tratamento de distúrbios neurológicos relacionados à deficiência de beta glicosilceramidase
|
|
WO2022032153A1
(en)
|
2020-08-06 |
2022-02-10 |
Voyager Therapeutics, Inc. |
Cell culture medium for use in producing gene therapy products in bioreactors
|
|
WO2022047201A1
(en)
|
2020-08-27 |
2022-03-03 |
University Of Iowa Research Foundation |
Gene knock-out for treatment of glaucoma
|
|
US20230407328A1
(en)
|
2020-11-02 |
2023-12-21 |
Biomarin Pharmaceutical Inc. |
Process for enriching adeno-associated virus
|
|
EP4015637A1
(en)
*
|
2020-12-21 |
2022-06-22 |
CEVEC Pharmaceuticals GmbH |
Producer cell line having low levels of va rna
|
|
WO2022170082A1
(en)
|
2021-02-05 |
2022-08-11 |
Regents Of The University Of Minnesota |
Methods for preventing cardiac or skeletal defects in diseases including mucopolysaccharidoses
|
|
WO2022221684A1
(en)
|
2021-04-15 |
2022-10-20 |
Spirovant Sciences, Inc. |
Methods and compositions for treatment of cystic fibrosis
|
|
WO2022221529A1
(en)
|
2021-04-16 |
2022-10-20 |
Asklepios Biopharmaceutical, Inc. |
Rational polyploid aav virions that cross the blood brain barrier and elicit reduced humoral response
|
|
EP4396203A1
(en)
|
2021-09-03 |
2024-07-10 |
BioMarin Pharmaceutical Inc. |
Aav capsid compositions and methods for delivery
|
|
JP2024533174A
(ja)
|
2021-09-03 |
2024-09-12 |
ビオマリン プハルマセウトイカル インコーポレイテッド |
Ａａｖカプシド組成物及び送達方法
|
|
WO2023034990A1
(en)
|
2021-09-03 |
2023-03-09 |
Biomarin Pharmaceutical Inc. |
Aav capsid compositions and methods for delivery
|
|
WO2023034996A1
(en)
|
2021-09-03 |
2023-03-09 |
Biomarin Pharmaceutical Inc. |
Aav capsid compositions and methods for delivery
|
|
JP2024534888A
(ja)
|
2021-09-03 |
2024-09-26 |
ビオマリン プハルマセウトイカル インコーポレイテッド |
Ａａｖカプシド組成物及び送達方法
|
|
WO2023034980A1
(en)
|
2021-09-03 |
2023-03-09 |
Bomarin Pharmaceutical Inc. |
Aav capsid compositions and methods for delivery
|
|
WO2023044483A2
(en)
|
2021-09-20 |
2023-03-23 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of her2 positive cancer
|
|
US20250019668A1
(en)
|
2021-10-29 |
2025-01-16 |
Ultragenyx Pharmaceutical Inc. |
Engineered cell lines for increased production of recombinant adeno-associated virus (raav)
|
|
US20250049955A1
(en)
|
2021-11-17 |
2025-02-13 |
Voyager Therapeutics, Inc. |
Compositons and methods for the treatment of neurological disorders related to glucosylceramidase beta deficiency
|
|
WO2023182476A1
(ja)
*
|
2022-03-25 |
2023-09-28 |
学校法人自治医科大学 |
アデノ随伴ウイルス（ａａｖ）ベクターの効率の良い産生システム
|
|
WO2023240236A1
(en)
|
2022-06-10 |
2023-12-14 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of spinal muscular atrophy related disorders
|
|
KR20250069606A
(ko)
|
2022-09-15 |
2025-05-19 |
보이저 테라퓨틱스, 인크. |
타우 결합 화합물
|
|
WO2024086747A1
(en)
|
2022-10-19 |
2024-04-25 |
Affinia Therapeutics Inc. |
Recombinant aavs with improved tropism and specificity
|
|
WO2024092171A1
(en)
|
2022-10-26 |
2024-05-02 |
University Of Iowa Research Foundation |
Method to deliver large genes using virus and a dna recombination system
|
|
WO2024129853A2
(en)
*
|
2022-12-14 |
2024-06-20 |
Baylor College Of Medicine |
Improvement of recombinant adeno-associated virus gene therapy for human gene therapy
|
|
KR20250129743A
(ko)
|
2022-12-29 |
2025-08-29 |
보이저 테라퓨틱스, 인크. |
Mapt를 조절하기 위한 조성물 및 방법
|
|
AU2023427408A1
(en)
|
2023-02-02 |
2025-09-04 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of neurological disorders related to glucosylceramidase beta deficiency
|
|
WO2024226761A2
(en)
|
2023-04-26 |
2024-10-31 |
Voyager Therapeutics, Inc. |
Compositions and methods for treating amyotrophic lateral sclerosis
|
|
WO2024238807A2
(en)
|
2023-05-16 |
2024-11-21 |
Affinia Therapeutics Inc. |
Recombinant aavs with improved tropism and specificity
|
|
AU2024332181A1
(en)
|
2023-08-31 |
2026-02-12 |
Dyno Therapeutics, Inc. |
Capsid polypeptides and methods of use thereof
|
|
TW202545971A
(zh)
|
2024-02-08 |
2025-12-01 |
美商戴諾治療公司 |
殼體多肽及其使用方法
|
|
WO2025194042A1
(en)
|
2024-03-14 |
2025-09-18 |
Affinia Therapeutics Inc. |
Plasmid system for production of recombinant adenoassociated virus
|
|
WO2025227063A1
(en)
|
2024-04-26 |
2025-10-30 |
Affinia Therapeutics Inc. |
Recombinant aavs with improved tropism and specificity
|
|
WO2025235491A1
(en)
|
2024-05-07 |
2025-11-13 |
Affinia Therapeutics Inc. |
Recombinant aav for treatment of cardiac diseases
|
|
WO2026064428A2
(en)
|
2024-09-18 |
2026-03-26 |
Dyno Therapeutics, Inc. |
Capsid polypeptides and methods of use thereof
|
|
WO2026064444A1
(en)
|
2024-09-18 |
2026-03-26 |
Dyno Therapeutics, Inc. |
Capsid polypeptides and methods of use thereof
|
|
WO2026064442A2
(en)
|
2024-09-18 |
2026-03-26 |
Dyno Therapeutics, Inc. |
Capsid polypeptides and methods of use thereof
|