|
US6924128B2
(en)
*
|
1994-12-06 |
2005-08-02 |
Targeted Genetics Corporation |
Packaging cell lines for generation of high titers of recombinant AAV vectors
|
|
JP2001514845A
(ja)
|
1997-09-05 |
2001-09-18 |
ターゲティッド ジェネティクス コーポレイション |
組換えａａｖベクターの高力価ヘルパーなし調製物を生成するための方法
|
|
US6566118B1
(en)
|
1997-09-05 |
2003-05-20 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
US6995006B2
(en)
*
|
1997-09-05 |
2006-02-07 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
US6346415B1
(en)
*
|
1997-10-21 |
2002-02-12 |
Targeted Genetics Corporation |
Transcriptionally-activated AAV inverted terminal repeats (ITRS) for use with recombinant AAV vectors
|
|
US6642051B1
(en)
|
1997-10-21 |
2003-11-04 |
Targeted Genetics Corporation |
Amplifiable adeno-associated virus(AAV) packaging cassettes for the production of recombinant AAV vectors
|
|
US6953690B1
(en)
|
1998-03-20 |
2005-10-11 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
DK1930418T3
(da)
|
1998-09-04 |
2015-07-13 |
Genzyme Corp |
Fremgangsmåder til frembringelse af hjælperfri præparater med høj titer af frigjorte rekombinante AAV-vektorer
|
|
DE19905501B4
(de)
|
1999-02-10 |
2005-05-19 |
MediGene AG, Gesellschaft für molekularbiologische Kardiologie und Onkologie |
Verfahren zur Herstellung eines rekombinanten Adeno-assoziierten Virus, geeignete Mittel hierzu sowie Verwendung zur Herstellung eines Arzneimittels
|
|
US6893865B1
(en)
|
1999-04-28 |
2005-05-17 |
Targeted Genetics Corporation |
Methods, compositions, and cells for encapsidating recombinant vectors in AAV particles
|
|
DE60040147D1
(de)
*
|
1999-05-28 |
2008-10-16 |
Targeted Genetics Corp |
Methoden und zusammensetzungen zur reduktion des tumor-nekrosis-faktor-spiegels (tnf) bei tnf-assoziierten erkrankungen
|
|
PT1916258E
(pt)
|
1999-08-09 |
2014-07-29 |
Genzyme Corp |
Aumento da expressão de uma sequência nucleotídica heteróloga de cadeia simples a partir de vectores virais recombinantes por concepção da sequência de maneira que esta forme pares de bases intracadeia
|
|
EP1916258B1
(en)
|
1999-08-09 |
2014-04-23 |
Targeted Genetics Corporation |
Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms intrastrand base pairs
|
|
US7115391B1
(en)
|
1999-10-01 |
2006-10-03 |
Genovo, Inc. |
Production of recombinant AAV using adenovirus comprising AAV rep/cap genes
|
|
US7208315B2
(en)
|
2000-01-05 |
2007-04-24 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for efficient AAV vector production
|
|
DE10044384A1
(de)
*
|
2000-09-08 |
2002-04-18 |
Medigene Ag |
Wirtszellen zur Verpackung von rekombinantem Adeno-assoziiertem Virus (rAAV), Verfahren zu ihrer Herstellung und deren Verwendung
|
|
US6723551B2
(en)
|
2001-11-09 |
2004-04-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Production of adeno-associated virus in insect cells
|
|
WO2003042361A2
(en)
*
|
2001-11-09 |
2003-05-22 |
Government Of The United States Of America, Department Of Health And Human Services |
Production of adeno-associated virus in insect cells
|
|
US7332276B2
(en)
*
|
2002-03-01 |
2008-02-19 |
Celltech R&D, Inc. |
Methods to increase or decrease bone density
|
|
US6845929B2
(en)
*
|
2002-03-22 |
2005-01-25 |
Ali Dolatabadi |
High efficiency nozzle for thermal spray of high quality, low oxide content coatings
|
|
WO2004075861A2
(en)
*
|
2003-02-26 |
2004-09-10 |
Children's Hospital, Inc. |
Recombinant adeno-associated virus production
|
|
US20050281786A1
(en)
*
|
2004-06-18 |
2005-12-22 |
David Poulsen |
AAV mediated gene delivery to cochlear cells
|
|
EP2311967B1
(en)
|
2005-10-20 |
2017-09-20 |
UniQure IP B.V. |
Improved AAV vectors produced in insect cells
|
|
KR101589259B1
(ko)
|
2006-06-21 |
2016-02-01 |
유니큐어 아이피 비.브이. |
곤충세포 내 ａａｖ의 생산에 유용한 ａａｖ-ｒｅｐ78의 번역을 위한 변형된 개시 코돈을 갖는 벡터
|
|
ES2385679T3
(es)
|
2006-08-24 |
2012-07-30 |
Virovek, Inc. |
Expresión de células de insecto de genes con marcos de lectura abiertos superpuestos, métodos y composiciones de éstos
|
|
JP5879256B2
(ja)
|
2009-05-02 |
2016-03-08 |
ジェンザイム・コーポレーション |
神経変性障害のための遺伝子治療
|
|
US10415056B2
(en)
|
2010-11-10 |
2019-09-17 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for generating adeno-associated viral vectors with undetectable capsid gene contamination
|
|
AU2014251099B2
(en)
|
2013-04-08 |
2019-01-17 |
The University Of Kansas |
Chimeric adeno-associated virus/ bocavirus parvovirus vector
|
|
CN105377039A
(zh)
|
2013-05-15 |
2016-03-02 |
明尼苏达大学董事会 |
腺相关病毒介导的基因向中枢神经系统转移
|
|
WO2015191508A1
(en)
|
2014-06-09 |
2015-12-17 |
Voyager Therapeutics, Inc. |
Chimeric capsids
|
|
SG11201703148TA
(en)
|
2014-11-05 |
2017-05-30 |
Voyager Therapeutics Inc |
Aadc polynucleotides for the treatment of parkinson's disease
|
|
CN119876138A
(zh)
|
2014-11-14 |
2025-04-25 |
沃雅戈治疗公司 |
调节性多核苷酸
|
|
CA3193811A1
(en)
|
2014-11-14 |
2016-05-19 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating amyotrophic lateral sclerosis (als)
|
|
HK1245326A1
(zh)
|
2014-12-12 |
2018-08-24 |
Voyager Therapeutics, Inc. |
用於生产scaav的组合物和方法
|
|
HK1256341A1
(zh)
|
2015-05-15 |
2019-09-20 |
明尼苏达大学董事会 |
用於治疗性递送到中枢神经系统的腺相关物
|
|
CA2994160C
(en)
|
2015-07-30 |
2021-08-10 |
Massachusetts Eye And Ear Infirmary |
Ancestral virus sequences and uses thereof
|
|
US20180230489A1
(en)
|
2015-10-28 |
2018-08-16 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
WO2017139381A1
(en)
|
2016-02-08 |
2017-08-17 |
University Of Iowa Research Foundation |
Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
|
|
PL3436593T3
(pl)
|
2016-03-28 |
2023-03-27 |
Ultragenyx Pharmaceutical Inc. |
Sposoby inaktywacji termicznej adenowirusów
|
|
EP3448874A4
(en)
|
2016-04-29 |
2020-04-22 |
Voyager Therapeutics, Inc. |
COMPOSITIONS FOR TREATING A DISEASE
|
|
EP3448987A4
(en)
|
2016-04-29 |
2020-05-27 |
Voyager Therapeutics, Inc. |
COMPOSITIONS FOR TREATING A DISEASE
|
|
CA3024448C
(en)
|
2016-05-18 |
2025-09-09 |
Voyager Therapeutics, Inc. |
MODULATING POLYNUCLEOTIDES
|
|
CA3024449A1
(en)
|
2016-05-18 |
2017-11-23 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating huntington's disease
|
|
WO2018044933A1
(en)
|
2016-08-30 |
2018-03-08 |
The Regents Of The University Of California |
Methods for biomedical targeting and delivery and devices and systems for practicing the same
|
|
ES3012649T3
(en)
|
2016-10-14 |
2025-04-09 |
Ultragenyx Pharmaceutical Inc |
Use of tonicifying agents to enhance recombinant adeno-associated virus yield
|
|
EP3541946A1
(en)
|
2016-11-15 |
2019-09-25 |
Regents Of The University Of Minnesota |
Method for improving neurological function in mpsi and mpsii and other neurological disorders
|
|
US11142775B2
(en)
|
2017-01-13 |
2021-10-12 |
University Of Iowa Research Foundation |
Bocaparvovirus small noncoding RNA and uses thereof
|
|
JP7142643B2
(ja)
|
2017-03-22 |
2022-09-27 |
ウルトラジェニックス ファーマシューティカル インコーポレイテッド |
Ｈｄａｃ阻害剤またはｒｅｐタンパク質を伴う細胞培養方法
|
|
EP3618839A4
(en)
|
2017-05-05 |
2021-06-09 |
Voyager Therapeutics, Inc. |
COMPOSITIONS AND METHODS OF TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
|
|
JP2020518259A
(ja)
|
2017-05-05 |
2020-06-25 |
ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． |
ハンチントン病治療組成物および方法
|
|
JP7218303B2
(ja)
|
2017-05-09 |
2023-02-06 |
ウルトラジェニックス ファーマシューティカル インコーポレイテッド |
トランスフェクション試薬を生成するための拡大可能な方法
|
|
JOP20190269A1
(ar)
|
2017-06-15 |
2019-11-20 |
Voyager Therapeutics Inc |
بولي نوكليوتيدات aadc لعلاج مرض باركنسون
|
|
JP7229989B2
(ja)
|
2017-07-17 |
2023-02-28 |
ボイジャー セラピューティクス インコーポレイテッド |
軌道アレイガイドシステム
|
|
JP7221275B2
(ja)
|
2017-08-03 |
2023-02-13 |
ボイジャー セラピューティクス インコーポレイテッド |
Ａａｖを送達するための組成物および方法
|
|
US20200263199A1
(en)
|
2017-09-29 |
2020-08-20 |
Voyager Therapeutics, Inc. |
Rescue of central and peripheral neurological phenotype of friedreich's ataxia by intravenous delivery
|
|
US20200231986A1
(en)
|
2017-09-29 |
2020-07-23 |
Massachusetts Eye And Ear Infirmary |
Production of adeno-associated viruses in insect cells
|
|
WO2019079242A1
(en)
|
2017-10-16 |
2019-04-25 |
Voyager Therapeutics, Inc. |
TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)
|
|
TW202413649A
(zh)
|
2017-10-16 |
2024-04-01 |
美商航海家醫療公司 |
肌萎縮性脊髓側索硬化症(als)之治療
|
|
US12252527B2
(en)
|
2018-03-21 |
2025-03-18 |
University Of Florida Research Foundation, Incorporated |
CD4 muteins and methods of using the same
|
|
EP3775266A4
(en)
|
2018-04-05 |
2021-06-30 |
Massachusetts Eye and Ear Infirmary |
METHOD OF MANUFACTURING AND USING COMBINATIONAL BAR-CODED NUCLEIC ACID LIBRARIES WITH DEFINED VARIATION
|
|
CN112313331A
(zh)
|
2018-04-27 |
2021-02-02 |
沃雅戈治疗公司 |
用于测量aadc病毒载体效力的方法
|
|
SG11202011296VA
(en)
|
2018-05-15 |
2020-12-30 |
Voyager Therapeutics Inc |
Compositions and methods for the treatment of parkinson's disease
|
|
TW202015742A
(zh)
|
2018-05-15 |
2020-05-01 |
美商航海家醫療公司 |
投遞腺相關病毒（ａａｖ）之組成物和方法
|
|
US20210207167A1
(en)
|
2018-05-16 |
2021-07-08 |
Voyager Therapeutics, Inc. |
Aav serotypes for brain specific payload delivery
|
|
EP3793615A2
(en)
|
2018-05-16 |
2021-03-24 |
Voyager Therapeutics, Inc. |
Directed evolution of aav to improve tropism for cns
|
|
US20210254103A1
(en)
|
2018-07-02 |
2021-08-19 |
Voyager Therapeutics, Inc. |
Treatment of amyotrophic lateral sclerosis and disorders associated with the spinal cord
|
|
AU2019310459A1
(en)
|
2018-07-24 |
2021-02-18 |
Voyager Therapeutics, Inc. |
Systems and methods for producing gene therapy formulations
|
|
CN111315407B
(zh)
|
2018-09-11 |
2023-05-02 |
上海市公共卫生临床中心 |
一种广谱抗流感疫苗免疫原及其应用
|
|
US12281321B2
(en)
|
2018-09-28 |
2025-04-22 |
Voyager Therapeutics, Inc. |
Frataxin expression constructs having engineered promoters and methods of use thereof
|
|
WO2020072849A1
(en)
|
2018-10-04 |
2020-04-09 |
Voyager Therapeutics, Inc. |
Methods for measuring the titer and potency of viral vector particles
|
|
WO2020072844A1
(en)
|
2018-10-05 |
2020-04-09 |
Voyager Therapeutics, Inc. |
Engineered nucleic acid constructs encoding aav production proteins
|
|
WO2020077165A1
(en)
|
2018-10-12 |
2020-04-16 |
Voyager Therapeutics, Inc. |
Compositions and methods for delivery of aav
|
|
CA3116701A1
(en)
|
2018-10-15 |
2020-04-23 |
Voyager Therapeutics, Inc. |
Expression vectors for large-scale production of raav in the baculovirus/sf9 system
|
|
JP2022522995A
(ja)
|
2019-01-18 |
2022-04-21 |
ボイジャー セラピューティクス インコーポレイテッド |
Ａａｖ粒子を生成するための方法及びシステム
|
|
AU2020270960B2
(en)
|
2019-04-12 |
2026-01-29 |
Ultragenyx Pharmaceutical Inc. |
Engineered producer cell lines and methods of making and using the same
|
|
EP3955970A1
(en)
|
2019-04-15 |
2022-02-23 |
University Of Iowa Research Foundation |
Methods and compositions for transgene expression
|
|
US20220241436A1
(en)
|
2019-04-15 |
2022-08-04 |
University Of Iowa Research Foundation |
Compositions and methods for treatment of cystic fibrosis
|
|
EP3962536A1
(en)
|
2019-04-29 |
2022-03-09 |
Voyager Therapeutics, Inc. |
Systems and methods for producing baculoviral infected insect cells (biics) in bioreactors
|
|
WO2020227515A1
(en)
|
2019-05-07 |
2020-11-12 |
Voyager Therapeutics, Inc. |
Compositions and methods for the vectored augmentation of protein destruction, expression and/or regulation
|
|
WO2021030125A1
(en)
|
2019-08-09 |
2021-02-18 |
Voyager Therapeutics, Inc. |
Cell culture medium for use in producing gene therapy products in bioreactors
|
|
TW202122582A
(zh)
|
2019-08-26 |
2021-06-16 |
美商航海家醫療公司 |
病毒蛋白之控制表現
|
|
US20220333133A1
(en)
|
2019-09-03 |
2022-10-20 |
Voyager Therapeutics, Inc. |
Vectorized editing of nucleic acids to correct overt mutations
|
|
AU2020361533A1
(en)
|
2019-10-08 |
2022-04-28 |
Trustees Of Boston College |
Proteins containing multiple, different unnatural amino acids and methods of making and using such proteins
|
|
WO2021072115A1
(en)
|
2019-10-08 |
2021-04-15 |
Regents Of The University Of Minnesota |
Crispr-mediated human genome editing with vectors
|
|
IL296103A
(en)
|
2020-03-05 |
2022-11-01 |
Neotx Therapeutics Ltd |
Methods and compositions for treating cancer with immune cells
|
|
BR112022018658A2
(pt)
|
2020-03-16 |
2022-12-20 |
Ultragenyx Pharmaceutical Inc |
Métodos para potencializar o rendimento de vírus adenoassociado recombinante
|
|
MX2022012752A
(es)
|
2020-04-15 |
2023-01-16 |
Voyager Therapeutics Inc |
Compuestos de union a tau.
|
|
WO2021247995A2
(en)
|
2020-06-04 |
2021-12-09 |
Voyager Therapeutics, Inc. |
Compositions and methods of treating neuropathic pain
|
|
US20230242941A1
(en)
|
2020-06-30 |
2023-08-03 |
Eric Yuen |
Methods and compositions for administering recombinant viral vectors
|
|
US20230374483A1
(en)
|
2020-07-08 |
2023-11-23 |
Regents Of The University Of Minnesota |
Modified hexosaminidase and uses thereof
|
|
US20230285596A1
(en)
|
2020-07-27 |
2023-09-14 |
Voyager Therapeutics, Inc |
Compositions and methods for the treatment of niemann-pick type c1 disease
|
|
BR112023001456A2
(pt)
|
2020-07-27 |
2023-04-11 |
Voyager Therapeutics Inc |
Composições e métodos para o tratamento de distúrbios neurológicos relacionados à deficiência de beta glicosilceramidase
|
|
WO2022032153A1
(en)
|
2020-08-06 |
2022-02-10 |
Voyager Therapeutics, Inc. |
Cell culture medium for use in producing gene therapy products in bioreactors
|
|
WO2022047201A1
(en)
|
2020-08-27 |
2022-03-03 |
University Of Iowa Research Foundation |
Gene knock-out for treatment of glaucoma
|
|
US20230407328A1
(en)
|
2020-11-02 |
2023-12-21 |
Biomarin Pharmaceutical Inc. |
Process for enriching adeno-associated virus
|
|
EP4015637A1
(en)
*
|
2020-12-21 |
2022-06-22 |
CEVEC Pharmaceuticals GmbH |
Producer cell line having low levels of va rna
|
|
WO2022170082A1
(en)
|
2021-02-05 |
2022-08-11 |
Regents Of The University Of Minnesota |
Methods for preventing cardiac or skeletal defects in diseases including mucopolysaccharidoses
|
|
US20240115738A1
(en)
|
2021-04-15 |
2024-04-11 |
Spirovant Sciences, Inc. |
Methods and compositions for treatment of cystic fibrosis
|
|
JP2024515626A
(ja)
|
2021-04-16 |
2024-04-10 |
アスクレピオス バイオファーマシューティカル， インコーポレイテッド |
血液脳関門を横断し低減された液性応答を惹起する合理的ポリプロイドａａｖビリオン
|
|
EP4396203A1
(en)
|
2021-09-03 |
2024-07-10 |
BioMarin Pharmaceutical Inc. |
Aav capsid compositions and methods for delivery
|
|
WO2023034980A1
(en)
|
2021-09-03 |
2023-03-09 |
Bomarin Pharmaceutical Inc. |
Aav capsid compositions and methods for delivery
|
|
WO2023034994A1
(en)
|
2021-09-03 |
2023-03-09 |
Biomarin Pharmaceutical Inc. |
Aav capsid compositions and methods for delivery
|
|
WO2023034990A1
(en)
|
2021-09-03 |
2023-03-09 |
Biomarin Pharmaceutical Inc. |
Aav capsid compositions and methods for delivery
|
|
US20240376496A1
(en)
|
2021-09-03 |
2024-11-14 |
Biomarin Pharmaceutical Inc. |
Aav capsid compositions and methods for delivery
|
|
US20240384242A1
(en)
|
2021-09-03 |
2024-11-21 |
Biomarin Pharmaceutical Inc. |
Aav capsid compositions and methods for delivery
|
|
EP4405396A2
(en)
|
2021-09-20 |
2024-07-31 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of her2 positive cancer
|
|
US20250019668A1
(en)
|
2021-10-29 |
2025-01-16 |
Ultragenyx Pharmaceutical Inc. |
Engineered cell lines for increased production of recombinant adeno-associated virus (raav)
|
|
EP4433490A2
(en)
|
2021-11-17 |
2024-09-25 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of neurological disorders related to glucosylceramidase beta deficiency
|
|
US20250197887A1
(en)
*
|
2022-03-25 |
2025-06-19 |
Jichi Medical University |
Efficient system for producing adeno-associated virus (aav) vector
|
|
WO2023240236A1
(en)
|
2022-06-10 |
2023-12-14 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of spinal muscular atrophy related disorders
|
|
CA3266790A1
(en)
|
2022-09-15 |
2024-03-21 |
Voyager Therapeutics, Inc. |
TAU PROTEIN BINDING COMPOUNDS
|
|
WO2024086747A1
(en)
|
2022-10-19 |
2024-04-25 |
Affinia Therapeutics Inc. |
Recombinant aavs with improved tropism and specificity
|
|
WO2024092171A1
(en)
|
2022-10-26 |
2024-05-02 |
University Of Iowa Research Foundation |
Method to deliver large genes using virus and a dna recombination system
|
|
WO2024129853A2
(en)
*
|
2022-12-14 |
2024-06-20 |
Baylor College Of Medicine |
Improvement of recombinant adeno-associated virus gene therapy for human gene therapy
|
|
KR20250129743A
(ko)
|
2022-12-29 |
2025-08-29 |
보이저 테라퓨틱스, 인크. |
Mapt를 조절하기 위한 조성물 및 방법
|
|
AU2023427408A1
(en)
|
2023-02-02 |
2025-09-04 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of neurological disorders related to glucosylceramidase beta deficiency
|
|
WO2024226761A2
(en)
|
2023-04-26 |
2024-10-31 |
Voyager Therapeutics, Inc. |
Compositions and methods for treating amyotrophic lateral sclerosis
|
|
WO2024238807A2
(en)
|
2023-05-16 |
2024-11-21 |
Affinia Therapeutics Inc. |
Recombinant aavs with improved tropism and specificity
|
|
TW202525832A
(zh)
|
2023-08-31 |
2025-07-01 |
美商戴諾治療公司 |
衣殼多肽及其使用方法(二)
|
|
TW202545971A
(zh)
|
2024-02-08 |
2025-12-01 |
美商戴諾治療公司 |
殼體多肽及其使用方法
|
|
TW202548023A
(zh)
|
2024-03-14 |
2025-12-16 |
美商雅菲納治療公司 |
用於生產重組腺相關病毒的質體系統
|
|
WO2025227063A1
(en)
|
2024-04-26 |
2025-10-30 |
Affinia Therapeutics Inc. |
Recombinant aavs with improved tropism and specificity
|
|
WO2025235491A1
(en)
|
2024-05-07 |
2025-11-13 |
Affinia Therapeutics Inc. |
Recombinant aav for treatment of cardiac diseases
|
|
WO2026064444A1
(en)
|
2024-09-18 |
2026-03-26 |
Dyno Therapeutics, Inc. |
Capsid polypeptides and methods of use thereof
|
|
WO2026064442A2
(en)
|
2024-09-18 |
2026-03-26 |
Dyno Therapeutics, Inc. |
Capsid polypeptides and methods of use thereof
|
|
WO2026064428A2
(en)
|
2024-09-18 |
2026-03-26 |
Dyno Therapeutics, Inc. |
Capsid polypeptides and methods of use thereof
|