JP2001505766A - アポトーシスと生長を調節するアデノウイルスベクターを有する、有糸分裂後のニューロン - Google Patents

アポトーシスと生長を調節するアデノウイルスベクターを有する、有糸分裂後のニューロン

Info

Publication number
JP2001505766A
JP2001505766A JP52340898A JP52340898A JP2001505766A JP 2001505766 A JP2001505766 A JP 2001505766A JP 52340898 A JP52340898 A JP 52340898A JP 52340898 A JP52340898 A JP 52340898A JP 2001505766 A JP2001505766 A JP 2001505766A
Authority
JP
Japan
Prior art keywords
neurons
neuron
apoptosis
infected
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP52340898A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001505766A5 (https=
Inventor
フレダ ディー. ミラー
ルース エス. スラック
Original Assignee
マクギル ユニバーシティー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by マクギル ユニバーシティー filed Critical マクギル ユニバーシティー
Publication of JP2001505766A publication Critical patent/JP2001505766A/ja
Publication of JP2001505766A5 publication Critical patent/JP2001505766A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10311Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
JP52340898A 1996-11-18 1997-11-18 アポトーシスと生長を調節するアデノウイルスベクターを有する、有糸分裂後のニューロン Ceased JP2001505766A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3105796P 1996-11-18 1996-11-18
US60/031,057 1996-11-18
PCT/IB1997/001619 WO1998022608A2 (en) 1996-11-18 1997-11-18 Post-mitotic neurons containing adenovirus vectors that modulate apoptosis and growth

Publications (2)

Publication Number Publication Date
JP2001505766A true JP2001505766A (ja) 2001-05-08
JP2001505766A5 JP2001505766A5 (https=) 2005-07-14

Family

ID=21857441

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52340898A Ceased JP2001505766A (ja) 1996-11-18 1997-11-18 アポトーシスと生長を調節するアデノウイルスベクターを有する、有糸分裂後のニューロン

Country Status (7)

Country Link
US (1) US6060247A (https=)
EP (1) EP0943004A2 (https=)
JP (1) JP2001505766A (https=)
AU (1) AU742696B2 (https=)
CA (1) CA2272578A1 (https=)
IL (1) IL130009A0 (https=)
WO (1) WO1998022608A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007509091A (ja) * 2003-10-21 2007-04-12 エイジーエイ、アクティエボラーグ プログラム細胞死の防止のためのキセノンの使用

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6551618B2 (en) * 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
US20020009747A1 (en) * 1997-08-25 2002-01-24 Freda Diane Miller Methods and reagents for identifying modulators of neuronal apoptosis
JP2002519648A (ja) * 1997-08-25 2002-07-02 マクギル ユニバーシティ ニューロンの生存に関与する化合物を検出するためのshp−1およびshp−2の使用
US6811992B1 (en) * 1998-05-14 2004-11-02 Ya Fang Liu Method for identifying MLK inhibitors for the treatment of neurological conditions
EP1173254A2 (en) * 1999-04-27 2002-01-23 Smithkline Beecham Plc Novel treatment of neurotraumatic conditions with a raf inhibitor
AU5599500A (en) * 1999-06-07 2000-12-28 J. David Gladstone Institutes, The Methods and compositions for preventing p53 mediated apoptosis
JP2003506711A (ja) * 1999-08-05 2003-02-18 セロミックス インコーポレイテッド 光学システムによる細胞の解析
EP1107003A1 (en) * 1999-12-09 2001-06-13 Trophos Methods for screening compounds active on neurons
AU2001282986A1 (en) 2000-07-26 2002-02-05 University Of Maryland, Baltimore The protein kinase domain of the large subunit of herpes simplex type 2 ribonucleotide reductase (icp10pk) has anti-apoptopic activity
US20040049024A1 (en) * 2001-12-07 2004-03-11 Geoff Clark Compositions and methods related to the minn1 tumor suppressor gene and protein
US20040001808A1 (en) * 2002-06-07 2004-01-01 Kenneth Haglid Compositions and methods for the use of Bcl-2 transfected neurons
DK1534819T3 (da) 2002-08-21 2010-04-19 Revivicor Inc Griselignende dyr, som mangler enhver ekspression af funktionel alfa-1,3-galactosyltransferase
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
US8603824B2 (en) 2004-07-26 2013-12-10 Pfenex, Inc. Process for improved protein expression by strain engineering
CA2909775A1 (en) 2005-08-09 2007-03-29 Revivicor, Inc. Transgenic ungulates expressing ctla4-ig and uses thereof
AU2008229648A1 (en) * 2007-03-20 2008-09-25 The Walter And Eliza Hall Institute Of Medical Research Method of screening
JP5444553B2 (ja) 2007-04-27 2014-03-19 フェネックス インコーポレイテッド 微生物宿主を迅速にスクリーニングして、異種タンパク質発現の収率および/または質が改善されている特定の株を同定する方法
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992013091A1 (en) * 1991-01-18 1992-08-06 Oncogene Science, Inc. Methods of transcriptionally modulating expression of oncogenes and tumor suppressor genes
US5747469A (en) * 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
US6410010B1 (en) * 1992-10-13 2002-06-25 Board Of Regents, The University Of Texas System Recombinant P53 adenovirus compositions
ATE199568T1 (de) * 1993-02-16 2001-03-15 Onyx Pharma Inc Cytopatische viren zur therapie und prophylaxe der neoplasie
WO1995005738A1 (en) * 1993-08-20 1995-03-02 Massachusetts Institute Of Technology Anticancer agents and apoptosis
EP1637608B1 (en) * 1993-10-25 2009-07-22 CANJI, Inc. Recombinant adenoviral vector and methods of use
PT728214E (pt) * 1993-11-09 2004-11-30 Ohio Med College Linhas celulares estaveis capazes de expressar o gene de replicacao do virus adeno-associado
AU2283895A (en) * 1994-04-11 1995-10-30 Sloan-Kettering Institute For Cancer Research Defective herpes and defective adeno-associated virus vectors with p53 for the treatment of cancer
US5723333A (en) * 1995-02-10 1998-03-03 Regents Of The University Of California Human pancreatic cell lines: developments and uses

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007509091A (ja) * 2003-10-21 2007-04-12 エイジーエイ、アクティエボラーグ プログラム細胞死の防止のためのキセノンの使用

Also Published As

Publication number Publication date
WO1998022608A3 (en) 1998-09-03
IL130009A0 (en) 2000-02-29
US6060247A (en) 2000-05-09
AU742696B2 (en) 2002-01-10
WO1998022608A2 (en) 1998-05-28
AU5406498A (en) 1998-06-10
CA2272578A1 (en) 1998-05-28
EP0943004A2 (en) 1999-09-22

Similar Documents

Publication Publication Date Title
JP2001505766A (ja) アポトーシスと生長を調節するアデノウイルスベクターを有する、有糸分裂後のニューロン
Wilms et al. Suppression of map kinases inhibits microglial activation and attenuates neuronal cell death induced by α-synuclein protofibrils
US9539307B2 (en) Compositions and methods for treating amyotrophic lateral sclerosis
Floriddia et al. p53 Regulates the neuronal intrinsic and extrinsic responses affecting the recovery of motor function following spinal cord injury
Tai et al. Gene transfer of glial cell line-derived neurotrophic factor promotes functional recovery following spinal cord contusion
Hannila et al. Secretory leukocyte protease inhibitor reverses inhibition by CNS myelin, promotes regeneration in the optic nerve, and suppresses expression of the transforming growth factor-β signaling protein Smad2
US7465582B1 (en) Nurr-1 induction of a dopaminergic neuronal fate in a neural stem cell or neural progenitor cell in vitro
EP0674716B1 (fr) Vecteurs retroviraux pour le traitement des tumeurs, et lignees cellulaires les contenant
WO2018148071A1 (en) Combination therapy for treating disorders of the ear
JP2000516207A (ja) P53媒介抑制への感受性を増強させるためのdna修復のダウンレギュレーション
KR101986366B1 (ko) Nurr1과 Foxa2의 교질세포 기능 조절에 의한 염증성 신경질환 치료
Meng et al. The biphasic role of Hspb1 on ferroptotic cell death in Parkinson's disease
US20220213030A1 (en) Aminoguanidine hydrazones as retromer stabilizers useful for treating neurological diseases
US8404442B2 (en) Methods for identification of bone anabolic agents
WO2022010263A1 (ko) 펩타이드가 결합된 재조합 엑소좀을 포함하는 rage 과발현에 의한 염증 매개 질환의 예방 또는 치료용 약학적 조성물
EP1556410B1 (fr) Fragments peptidiques du facteur harp inhibant l'angiogenese
FI117707B (fi) Menetelmiä terapeuttisesti käyttökelpoisen yhdistelmä-DNA-vektorin valmistamiseksi
CZ250499A3 (cs) Použití nukleové kyseliny k indukci inervace svalů a růstu axonů motorických neuronů
KR101785155B1 (ko) Tim-3을 표적으로 하는 뇌손상 질환 치료용 조성물 및 이의 스크리닝 방법
MXPA99004578A (es) Neuronas post-mitóticas que contienen vectores de adenovirus que modulan la apóptosis y el crecimiento
WO2012039578A2 (ko) 사이클로필린 b를 포함하는 아밀로이드원성 질환 예방 및 치료용 조성물
JP2008543319A (ja) 羊膜細胞およびその使用方法
EP1255559B1 (de) Verwendung von inhibitoren von caspase-3 oder der caspase-aktivierten desoxyribonuclease (cad) zur behandlung von herzerkrankungen
WO1999036559A1 (en) Viral vectors expressing self-polymerizing neuronal intermediate filaments and their use
Jiang et al. Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20041118

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20041118

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070925

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20080214

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20080325