JP2001505204A5 - - Google Patents

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Publication number
JP2001505204A5
JP2001505204A5 JP1998523699A JP52369998A JP2001505204A5 JP 2001505204 A5 JP2001505204 A5 JP 2001505204A5 JP 1998523699 A JP1998523699 A JP 1998523699A JP 52369998 A JP52369998 A JP 52369998A JP 2001505204 A5 JP2001505204 A5 JP 2001505204A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1998523699A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001505204A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/020355 external-priority patent/WO1998022430A1/en
Publication of JP2001505204A publication Critical patent/JP2001505204A/ja
Publication of JP2001505204A5 publication Critical patent/JP2001505204A5/ja
Ceased legal-status Critical Current

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JP52369998A 1996-11-22 1997-11-20 N―(アリール/ヘテロアリールアセチル)アミノ酸エステル、それを含有する医薬組成物および該化合物を用いてβ―アミロイドペプチドの放出および/または合成を阻害する方法 Ceased JP2001505204A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75489596A 1996-11-22 1996-11-22
US08/754,895 1997-02-28
PCT/US1997/020355 WO1998022430A1 (en) 1996-11-22 1997-11-20 N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING b-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS

Publications (2)

Publication Number Publication Date
JP2001505204A JP2001505204A (ja) 2001-04-17
JP2001505204A5 true JP2001505204A5 (https=) 2005-07-14

Family

ID=25036849

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52369998A Ceased JP2001505204A (ja) 1996-11-22 1997-11-20 N―(アリール/ヘテロアリールアセチル)アミノ酸エステル、それを含有する医薬組成物および該化合物を用いてβ―アミロイドペプチドの放出および/または合成を阻害する方法

Country Status (16)

Country Link
EP (1) EP0951464B1 (https=)
JP (1) JP2001505204A (https=)
KR (1) KR20000069074A (https=)
CN (1) CN1237960A (https=)
AT (1) ATE295346T1 (https=)
AU (1) AU739035B2 (https=)
BR (1) BR9713404A (https=)
CA (1) CA2267065A1 (https=)
DE (1) DE69733272T2 (https=)
HU (1) HUP0000492A3 (https=)
ID (1) ID21956A (https=)
IL (1) IL129238A0 (https=)
NO (1) NO992463L (https=)
NZ (1) NZ334950A (https=)
TR (1) TR199901128T2 (https=)
WO (1) WO1998022430A1 (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
AU4710499A (en) * 1998-06-22 2000-01-10 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use ofsuch compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
WO1999067219A1 (en) * 1998-06-22 1999-12-29 Elan Pharmaceuticals, Inc. Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
EP1089981A1 (en) * 1998-06-22 2001-04-11 Elan Pharmaceuticals, Inc. Compounds for inhibiting beta-amyloid peptide release and/or its synthesis.
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
US6486350B1 (en) 1998-09-30 2002-11-26 Elan Pharmaceuticals Inc. Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide
EP1313426A2 (en) 1998-12-24 2003-05-28 Bristol-Myers Squibb Pharma Company Succinoylamino benzodiazepines as inhibitors of a-beta protein production
PL350050A1 (en) 1999-01-22 2002-10-21 Elan Pharm Inc Acyl derivatives which treat vla-4 related disorders
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
WO2001027108A1 (en) 1999-10-08 2001-04-19 Bristol-Myers Squibb Pharma Company AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
IL150374A0 (en) 1999-12-23 2002-12-01 Neurochem Inc Compounds and methods for modulating cerebral amyloid angiopathy
US6525044B2 (en) 2000-02-17 2003-02-25 Bristol-Myers Squibb Company Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production
CN1436175A (zh) 2000-04-03 2003-08-13 布里斯托尔-迈尔斯斯奎布药品公司 作为Aβ-蛋白生产抑制剂的环状内酰胺
JP2004508289A (ja) 2000-04-03 2004-03-18 デュポン ファーマシューティカルズ カンパニー Aβタンパク質産生の阻害剤としての環状ラクタム
CA2404273A1 (en) 2000-04-11 2001-10-18 Bristol-Myers Squibb Pharma Company Substituted lactams as inhibitors of a.beta. protein production
US6878363B2 (en) 2000-05-17 2005-04-12 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
EP1268450A1 (en) 2000-06-01 2003-01-02 Bristol-Myers Squibb Pharma Company Lactams substituted by cyclic succinates as inhibitors of a-beta protein production
US6432944B1 (en) 2000-07-06 2002-08-13 Bristol-Myers Squibb Company Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
CN100396680C (zh) * 2000-12-28 2008-06-25 第一制药株式会社 极迟抗原-4抑制剂
US7157487B2 (en) * 2000-12-28 2007-01-02 Daiichi Pharmaceutical Co., Ltd. Vla-4 inhibitors
CA2469130A1 (en) * 2001-12-04 2003-06-12 Elan Pharmaceuticals, Inc. Peptide isosteres containing a heterocycle useful in the treatment of alzheimer's disease
TWI281470B (en) 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200307671A (en) 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
US7459476B2 (en) 2002-06-27 2008-12-02 Elan Pharmaceuticals, Inc. Methods for treating Alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere
FR2842523A1 (fr) * 2002-07-17 2004-01-23 Sanofi Synthelabo Derives d'acylaminothiazole, leur preparation et leur application en therapeutique
EP1650205B1 (en) 2003-07-24 2012-04-25 Daiichi Sankyo Company, Limited Cyclohexanecarboxylic acid compound
ATE493405T1 (de) 2005-09-29 2011-01-15 Elan Pharm Inc Pyrimidinylamidverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren
CA2624524C (en) 2005-09-29 2014-07-08 Elan Pharmaceuticals, Inc. Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4
WO2007101165A1 (en) 2006-02-27 2007-09-07 Elan Pharmaceuticals, Inc. Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE33790B1 (en) * 1968-06-04 1974-10-30 Beecham Group Ltd Derivatives of n-acylaminoacid amides
NZ264143A (en) * 1993-08-09 1996-11-26 Lilly Co Eli Use of an aspartyl protease inhibitor to inhibit beta-amyloid peptide production

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