JP2001505204A5 - - Google Patents

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Publication number
JP2001505204A5
JP2001505204A5 JP1998523699A JP52369998A JP2001505204A5 JP 2001505204 A5 JP2001505204 A5 JP 2001505204A5 JP 1998523699 A JP1998523699 A JP 1998523699A JP 52369998 A JP52369998 A JP 52369998A JP 2001505204 A5 JP2001505204 A5 JP 2001505204A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1998523699A
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English (en)
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JP2001505204A (ja
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Priority claimed from PCT/US1997/020355 external-priority patent/WO1998022430A1/en
Publication of JP2001505204A publication Critical patent/JP2001505204A/ja
Publication of JP2001505204A5 publication Critical patent/JP2001505204A5/ja
Ceased legal-status Critical Current

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Figure 2001505204
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Figure 2001505204
JP52369998A 1996-11-22 1997-11-20 N―(アリール/ヘテロアリールアセチル)アミノ酸エステル、それを含有する医薬組成物および該化合物を用いてβ―アミロイドペプチドの放出および/または合成を阻害する方法 Ceased JP2001505204A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75489596A 1996-11-22 1996-11-22
US08/754,895 1996-11-22
PCT/US1997/020355 WO1998022430A1 (en) 1996-11-22 1997-11-20 N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING b-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS

Publications (2)

Publication Number Publication Date
JP2001505204A JP2001505204A (ja) 2001-04-17
JP2001505204A5 true JP2001505204A5 (ja) 2005-07-14

Family

ID=25036849

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52369998A Ceased JP2001505204A (ja) 1996-11-22 1997-11-20 N―(アリール/ヘテロアリールアセチル)アミノ酸エステル、それを含有する医薬組成物および該化合物を用いてβ―アミロイドペプチドの放出および/または合成を阻害する方法

Country Status (16)

Country Link
EP (1) EP0951464B1 (ja)
JP (1) JP2001505204A (ja)
KR (1) KR20000069074A (ja)
CN (1) CN1237960A (ja)
AT (1) ATE295346T1 (ja)
AU (1) AU739035B2 (ja)
BR (1) BR9713404A (ja)
CA (1) CA2267065A1 (ja)
DE (1) DE69733272T2 (ja)
HU (1) HUP0000492A3 (ja)
ID (1) ID21956A (ja)
IL (1) IL129238A0 (ja)
NO (1) NO992463L (ja)
NZ (1) NZ334950A (ja)
TR (1) TR199901128T2 (ja)
WO (1) WO1998022430A1 (ja)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
AU4707999A (en) * 1998-06-22 2000-01-10 Elan Pharmaceuticals, Inc. Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
JP2002518451A (ja) * 1998-06-22 2002-06-25 エラン ファーマシューティカルズ,インコーポレイテッド 環状アミノ酸化合物およびその医薬組成物、並びにそれら化合物を用いたβ−アミロイドペプチドの放出および/またはその合成を阻害する方法
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
WO1999067220A1 (en) * 1998-06-22 1999-12-29 Elan Pharmaceuticals, Inc. Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
NZ509241A (en) 1998-08-07 2003-08-29 Du Pont Pharm Co Succinoylamino lactams as inhibitors of alpha-beta protein production
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
US6486350B1 (en) 1998-09-30 2002-11-26 Elan Pharmaceuticals Inc. Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide
IL142816A0 (en) 1998-12-24 2002-03-10 Du Pont Pharm Co SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
AU773538B2 (en) 1999-01-22 2004-05-27 Elan Pharmaceuticals, Inc. Acyl derivatives which treat VLA-4 related disorders
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
US6503901B1 (en) 1999-10-08 2003-01-07 Bristol Myers Squibb Pharma Company Amino lactam sulfonamides as inhibitors of Aβ protein production
CN1434706A (zh) 1999-12-23 2003-08-06 神经化学公司 用于调节脑淀粉状蛋白性血管病的化合物和方法
JP2003523345A (ja) 2000-02-17 2003-08-05 ブリストル−マイヤーズ スクイブ ファーマ カンパニー Aβタンパク質産生の阻害剤としてのスクシノイルアミノ炭素環および複素環
BR0110051A (pt) 2000-04-03 2004-12-07 Bristol Myers Squibb Pharma Co Composto, uso do composto, composição farmacêutica e método de tratamento do mal de alzheimer
US6759404B2 (en) 2000-04-03 2004-07-06 Richard E. Olson Cyclic malonamides as inhibitors of aβ protein production
AU2001257006A1 (en) 2000-04-11 2001-10-23 Du Pont Pharmaceuticals Company Substituted lactams as inhibitors of abeta protein production
US6878363B2 (en) 2000-05-17 2005-04-12 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
MXPA02000862A (es) 2000-06-01 2003-07-14 Bristol Myers Squibb Pharma Co Lactamas substituidas por succinatos ciclicos como inhibidores de la produccion de proteina abeta.
US6432944B1 (en) 2000-07-06 2002-08-13 Bristol-Myers Squibb Company Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
CN100471838C (zh) * 2000-12-28 2009-03-25 第一制药株式会社 Vla-4抑制剂
ZA200304059B (en) * 2000-12-28 2004-07-06 Daiichi Seiyaku Co VLA-4 inhibitors.
AU2002357232A1 (en) * 2001-12-04 2003-06-17 Elan Pharmaceuticals, Inc. Peptide isosteres containing a heterocycle useful in the treatment of alzheimer's disease
TW200307671A (en) 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
TWI281470B (en) 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
WO2004002478A1 (en) * 2002-06-27 2004-01-08 Elan Pharmaceuticals, Inc. Methods for treating alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere
FR2842523A1 (fr) 2002-07-17 2004-01-23 Sanofi Synthelabo Derives d'acylaminothiazole, leur preparation et leur application en therapeutique
CN1826336B (zh) 2003-07-24 2010-06-02 第一制药株式会社 环己烷羧酸类
ATE502031T1 (de) 2005-09-29 2011-04-15 Elan Pharm Inc Carbamatverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren
JP5101512B2 (ja) 2005-09-29 2012-12-19 エラン ファーマシューティカルズ,インコーポレイテッド Vla−4によって媒介される白血球接着を阻害するピリミジニルアミド化合物
NZ570679A (en) 2006-02-27 2011-01-28 Elan Pharm Inc Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated By VLA-4

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE33790B1 (en) * 1968-06-04 1974-10-30 Beecham Group Ltd Derivatives of n-acylaminoacid amides
ZA945719B (en) * 1993-08-09 1996-02-01 Lilly Co Eli Identification and use of protease inhibitors

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