JP2001500365A5 - - Google Patents

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Publication number
JP2001500365A5
JP2001500365A5 JP1998504775A JP50477598A JP2001500365A5 JP 2001500365 A5 JP2001500365 A5 JP 2001500365A5 JP 1998504775 A JP1998504775 A JP 1998504775A JP 50477598 A JP50477598 A JP 50477598A JP 2001500365 A5 JP2001500365 A5 JP 2001500365A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
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JP1998504775A
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English (en)
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JP2001500365A (ja
Filing date
Publication date
Priority claimed from GBGB9614197.3A external-priority patent/GB9614197D0/en
Priority claimed from GBGB9707041.1A external-priority patent/GB9707041D0/en
Application filed filed Critical
Priority claimed from PCT/EP1997/003549 external-priority patent/WO1998001467A2/en
Publication of JP2001500365A publication Critical patent/JP2001500365A/ja
Publication of JP2001500365A5 publication Critical patent/JP2001500365A5/ja
Withdrawn legal-status Critical Current

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Figure 2001500365
Figure 2001500365
Figure 2001500365
Figure 2001500365
Figure 2001500365
Figure 2001500365
JP10504775A 1996-07-05 1997-07-04 Ｐ５３とｍｄｍ２の間の相互作用の阻害剤 Withdrawn JP2001500365A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9614197.3A GB9614197D0 (ja) 1996-07-05 1996-07-05
GB9707041.1 1997-04-07
GBGB9707041.1A GB9707041D0 (en) 1997-04-07 1997-04-07 Inhibitors of the interaction between p53 and mdm2
GB9614197.3 1997-04-07
PCT/EP1997/003549 WO1998001467A2 (en) 1996-07-05 1997-07-04 Inhibitors of the interaction between p53 and mdm2

Publications (2)

Publication Number Publication Date
JP2001500365A JP2001500365A (ja) 2001-01-16
JP2001500365A5 true JP2001500365A5 (ja) 2005-03-10

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ID=26309649

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10504775A Withdrawn JP2001500365A (ja) 1996-07-05 1997-07-04 Ｐ５３とｍｄｍ２の間の相互作用の阻害剤

Country Status (8)

Country Link
EP (1) EP0958305B1 (ja)
JP (1) JP2001500365A (ja)
AT (1) ATE397621T1 (ja)
AU (1) AU3847997A (ja)
CA (1) CA2259149A1 (ja)
DE (1) DE69738754D1 (ja)
NZ (1) NZ333609A (ja)
WO (1) WO1998001467A2 (ja)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7083983B2 (en) 1996-07-05 2006-08-01 Cancer Research Campaign Technology Limited Inhibitors of the interaction between P53 and MDM2
GB9708092D0 (en) * 1997-04-22 1997-06-11 Univ Dundee Materials and methods relating to inhibiting the interaction of p53 and mdm2
CA2289960A1 (en) * 1997-05-15 1998-11-19 Kyowa Hakko Kogyo Co., Ltd. Peptides having a cyclic structure and restoring the activities of p53 protein to mutant p53 protein
US6238921B1 (en) * 1998-03-26 2001-05-29 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of human mdm2 expression
EP0947494A1 (en) * 1998-03-30 1999-10-06 F. Hoffmann-La Roche Ag Derivatives of phenoxy acetic acid and phenoxymethyltetrazole having antitumor activity
AU4052399A (en) * 1998-05-26 1999-12-13 Institute Of Molecular And Cell Biology Polypeptides from creb binding protein and related protein p300 for use in transcriptional regulation
GB9819860D0 (en) * 1998-09-12 1998-11-04 Zeneca Ltd Chemical compounds
US7192713B1 (en) * 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US20040038902A1 (en) 2000-04-05 2004-02-26 Pincus Matthew R. Peptides selectively lethal to malignant and transformed mammalian cells
CA2514374A1 (en) 2003-02-13 2004-09-02 Government Of The United States Of America, As Represented By The Secret Ary, Department Of Health And Human Services Deazaflavin compounds and methods of use thereof
ES2586387T3 (es) 2003-11-05 2016-10-14 Dana-Farber Cancer Institute, Inc. Péptidos alfa helicoidales adecuados para activar o inhibir la muerte celular
WO2005097820A1 (en) * 2004-04-06 2005-10-20 Korea Research Institute Of Bioscience And Biotechnology Peptides for inhibiting mdm2 function
JP2008501315A (ja) * 2004-04-22 2008-01-24 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Ｈｄｍ２阻害剤複合体およびそれらの使用
PT2118123E (pt) 2007-01-31 2016-02-10 Harvard College Péptidos de p53 estabilizados e suas utilizações
WO2008121767A2 (en) 2007-03-28 2008-10-09 President And Fellows Of Harvard College Stitched polypeptides
JP2012515172A (ja) 2009-01-14 2012-07-05 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
EP2444105A4 (en) * 2009-06-16 2013-08-21 Univ Tokai GRAM NEGATIVE ANTI-BACTERIAL AGENT
WO2011005219A1 (en) * 2009-07-07 2011-01-13 Agency For Science, Technology And Research Novel mdm2 binding peptides and uses thereof
US20120149661A1 (en) 2009-08-26 2012-06-14 Novartis Ag Tetra-substituted heteroaryl compounds and their use as mdm2 and/or mdm4 modulators
JP2013505300A (ja) 2009-09-22 2013-02-14 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
CU24130B1 (es) 2009-12-22 2015-09-29 Novartis Ag Isoquinolinonas y quinazolinonas sustituidas
US8440693B2 (en) 2009-12-22 2013-05-14 Novartis Ag Substituted isoquinolinones and quinazolinones
RU2582678C2 (ru) 2010-08-13 2016-04-27 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы
WO2012175487A1 (en) 2011-06-20 2012-12-27 Novartis Ag Cyclohexyl isoquinolinone compounds
WO2012175520A1 (en) 2011-06-20 2012-12-27 Novartis Ag Hydroxy substituted isoquinolinone derivatives
TWI643868B (zh) 2011-10-18 2018-12-11 艾利倫治療公司 擬肽巨環化合物
BR112014011137A2 (pt) * 2011-11-09 2018-06-12 Merz Pharma Gmbh & Co Kgaa polinucleotídeo, vetor, célula hospedeira, polipeptídeo, anticorpo, método para a produção de um polipeptídeo, método para a produção de um medicamento
US9408885B2 (en) * 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
EP2819688A4 (en) 2012-02-15 2015-10-28 Aileron Therapeutics Inc TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES
JP6450191B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド ペプチドミメティック大環状化合物
US9365576B2 (en) 2012-05-24 2016-06-14 Novartis Ag Pyrrolopyrrolidinone compounds
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
WO2014115077A1 (en) 2013-01-22 2014-07-31 Novartis Ag Substituted purinone compounds
US9556180B2 (en) 2013-01-22 2017-01-31 Novartis Ag Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction
MX2015016344A (es) 2013-05-27 2016-03-01 Novartis Ag Derivados de imidazo-pirrolidinona y su uso en el tratamiento de enfermedades.
PL3004112T3 (pl) 2013-05-28 2018-02-28 Novartis Ag Pochodne pirazolo-pirolidyn-4-onu oraz ich zastosowanie w leczeniu choroby
MX2015016421A (es) 2013-05-28 2016-03-03 Novartis Ag Derivados de pirazolo-pirrolidin-4-ona como inhibidores de bet y su uso en el tratamiento de enfermedades.
EP3071571A1 (en) 2013-11-21 2016-09-28 Novartis AG Pyrrolopyrrolone derivatives and their use as bet inhibitors
KR102570210B1 (ko) 2014-09-24 2023-08-23 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 제제
KR20170058424A (ko) * 2014-09-24 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 용도
JP2018516844A (ja) 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
PL3458101T3 (pl) 2016-05-20 2021-05-31 F. Hoffmann-La Roche Ag Koniugaty PROTAC-przeciwciało i sposoby ich stosowania
CA3078682A1 (en) 2017-12-15 2019-06-20 Dana-Farber Cancer Institute, Inc. Stabilized peptide-mediated targeted protein degradation
US11091522B2 (en) 2018-07-23 2021-08-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN109206474A (zh) * 2018-11-27 2019-01-15 青岛海洋生物医药研究院 一种线性肽合成方法
AU2020225275A1 (en) * 2019-02-20 2021-09-09 Oncolyze, Inc. HDM2 antibody for use in treating cancer
CN112266407B (zh) * 2020-09-28 2023-05-12 宁夏医科大学总医院 特异结合p53蛋白的七肽、编码基因、制备方法及用途
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same

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