JP2001500365A - Ｐ５３とｍｄｍ２の間の相互作用の阻害剤 - Google Patents
Ｐ５３とｍｄｍ２の間の相互作用の阻害剤Info
- Publication number
- JP2001500365A JP2001500365A JP10504775A JP50477598A JP2001500365A JP 2001500365 A JP2001500365 A JP 2001500365A JP 10504775 A JP10504775 A JP 10504775A JP 50477598 A JP50477598 A JP 50477598A JP 2001500365 A JP2001500365 A JP 2001500365A
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- mdm2
- derivative
- acid
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 239000007160 ty medium Substances 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 150000003672 ureas Chemical group 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Amplifiers (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9614197.3A GB9614197D0 (https=) | 1996-07-05 | 1996-07-05 | |
| GB9614197.3 | 1996-07-05 | ||
| GBGB9707041.1A GB9707041D0 (en) | 1997-04-07 | 1997-04-07 | Inhibitors of the interaction between p53 and mdm2 |
| GB9707041.1 | 1997-04-07 | ||
| PCT/EP1997/003549 WO1998001467A2 (en) | 1996-07-05 | 1997-07-04 | Inhibitors of the interaction between p53 and mdm2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001500365A true JP2001500365A (ja) | 2001-01-16 |
| JP2001500365A5 JP2001500365A5 (https=) | 2005-03-10 |
Family
ID=26309649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10504775A Withdrawn JP2001500365A (ja) | 1996-07-05 | 1997-07-04 | Ｐ５３とｍｄｍ２の間の相互作用の阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0958305B1 (https=) |
| JP (1) | JP2001500365A (https=) |
| AT (1) | ATE397621T1 (https=) |
| AU (1) | AU3847997A (https=) |
| CA (1) | CA2259149A1 (https=) |
| DE (1) | DE69738754D1 (https=) |
| NZ (1) | NZ333609A (https=) |
| WO (1) | WO1998001467A2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008501315A (ja) * | 2004-04-22 | 2008-01-24 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | Ｈｄｍ２阻害剤複合体およびそれらの使用 |
| JPWO2010147145A1 (ja) * | 2009-06-16 | 2012-12-06 | 学校法人東海大学 | 抗グラム陰性菌剤 |
| JP2024518022A (ja) * | 2021-03-31 | 2024-04-24 | ゼテオ テック、 インク． | 充填ベッドシステムおよび方法を使用したエアロゾル化生体材料粒子の捕捉による呼吸器疾患の診断 |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7083983B2 (en) | 1996-07-05 | 2006-08-01 | Cancer Research Campaign Technology Limited | Inhibitors of the interaction between P53 and MDM2 |
| GB9708092D0 (en) * | 1997-04-22 | 1997-06-11 | Univ Dundee | Materials and methods relating to inhibiting the interaction of p53 and mdm2 |
| EP0989136A4 (en) * | 1997-05-15 | 2002-10-09 | Kyowa Hakko Kogyo Kk | PEPTIDES WITH CYCLIC STRUCTURES THAT CAN RECOVER THE ACTIVITY OF MUTED P53 PROTEINS. |
| US6238921B1 (en) * | 1998-03-26 | 2001-05-29 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of human mdm2 expression |
| EP0947494A1 (en) * | 1998-03-30 | 1999-10-06 | F. Hoffmann-La Roche Ag | Derivatives of phenoxy acetic acid and phenoxymethyltetrazole having antitumor activity |
| WO1999061608A2 (en) * | 1998-05-26 | 1999-12-02 | Institute Of Molecular And Cell Biology | Polypeptides from creb binding protein and related protein p300 for use in transcriptional regulation |
| GB9819860D0 (en) * | 1998-09-12 | 1998-11-04 | Zeneca Ltd | Chemical compounds |
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| US20040038902A1 (en) | 2000-04-05 | 2004-02-26 | Pincus Matthew R. | Peptides selectively lethal to malignant and transformed mammalian cells |
| AU2004212928A1 (en) | 2003-02-13 | 2004-09-02 | Bioveris Corporation | Deazaflavin compounds and methods of use thereof |
| ES2586387T3 (es) | 2003-11-05 | 2016-10-14 | Dana-Farber Cancer Institute, Inc. | Péptidos alfa helicoidales adecuados para activar o inhibir la muerte celular |
| WO2005097820A1 (en) * | 2004-04-06 | 2005-10-20 | Korea Research Institute Of Bioscience And Biotechnology | Peptides for inhibiting mdm2 function |
| DK2118123T3 (en) | 2007-01-31 | 2016-01-25 | Dana Farber Cancer Inst Inc | Stabilized p53 peptides and uses thereof |
| US8592377B2 (en) | 2007-03-28 | 2013-11-26 | President And Fellows Of Harvard College | Stitched polypeptides |
| US9175047B2 (en) | 2009-01-14 | 2015-11-03 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2011005219A1 (en) * | 2009-07-07 | 2011-01-13 | Agency For Science, Technology And Research | Novel mdm2 binding peptides and uses thereof |
| IN2012DN01693A (https=) | 2009-08-26 | 2015-06-05 | Novartis Ag | |
| CN102712675A (zh) | 2009-09-22 | 2012-10-03 | 爱勒让治疗公司 | 拟肽大环化合物 |
| CU24130B1 (es) | 2009-12-22 | 2015-09-29 | Novartis Ag | Isoquinolinonas y quinazolinonas sustituidas |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| ES2711526T3 (es) | 2010-08-13 | 2019-05-06 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
| US8859586B2 (en) | 2011-06-20 | 2014-10-14 | Novartis Ag | Cyclohexyl isoquinolinone compounds |
| WO2012175520A1 (en) | 2011-06-20 | 2012-12-27 | Novartis Ag | Hydroxy substituted isoquinolinone derivatives |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| BR112014011137A2 (pt) * | 2011-11-09 | 2018-06-12 | Merz Pharma Gmbh & Co Kgaa | polinucleotídeo, vetor, célula hospedeira, polipeptídeo, anticorpo, método para a produção de um polipeptídeo, método para a produção de um medicamento |
| US9408885B2 (en) * | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
| BR112014020103A2 (pt) | 2012-02-15 | 2018-10-09 | Aileron Therapeutics, Inc. | macrociclos peptidomiméticos |
| EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES |
| EP2855483B1 (en) | 2012-05-24 | 2017-10-25 | Novartis AG | Pyrrolopyrrolidinone compounds |
| WO2014071241A1 (en) | 2012-11-01 | 2014-05-08 | Aileron Therapeutics, Inc. | Disubstituted amino acids and methods of preparation and use thereof |
| US9556180B2 (en) | 2013-01-22 | 2017-01-31 | Novartis Ag | Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction |
| WO2014115077A1 (en) | 2013-01-22 | 2014-07-31 | Novartis Ag | Substituted purinone compounds |
| EP3412675A1 (en) | 2013-05-27 | 2018-12-12 | Novartis AG | Imidazopyrrolidinone derivatives and their use in the treatment of disease |
| AU2014272700B2 (en) | 2013-05-28 | 2016-12-01 | Novartis Ag | Pyrazolo-pyrrolidin-4-one derivatives and their use in the treatment of disease |
| MX2015016421A (es) | 2013-05-28 | 2016-03-03 | Novartis Ag | Derivados de pirazolo-pirrolidin-4-ona como inhibidores de bet y su uso en el tratamiento de enfermedades. |
| EA029269B1 (ru) | 2013-11-21 | 2018-02-28 | Новартис Аг | Производные пирролопирролона и их применение для лечения заболеваний |
| AU2015320545C1 (en) | 2014-09-24 | 2020-05-14 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
| EP3197478A4 (en) | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2017044633A1 (en) | 2015-09-10 | 2017-03-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of mcl-1 |
| CN118436801A (zh) | 2016-05-20 | 2024-08-06 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| EP3724216A1 (en) | 2017-12-15 | 2020-10-21 | Dana Farber Cancer Institute, Inc. | Stabilized peptide-mediated targeted protein degradation |
| US11091522B2 (en) | 2018-07-23 | 2021-08-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN109206474A (zh) * | 2018-11-27 | 2019-01-15 | 青岛海洋生物医药研究院 | 一种线性肽合成方法 |
| WO2020172115A1 (en) * | 2019-02-20 | 2020-08-27 | Oncolyze, Inc. | Hdm2 antibody for use in treating cancer |
| CN112266407B (zh) * | 2020-09-28 | 2023-05-12 | 宁夏医科大学总医院 | 特异结合p53蛋白的七肽、编码基因、制备方法及用途 |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
-
1997
- 1997-07-04 EP EP97935511A patent/EP0958305B1/en not_active Expired - Lifetime
- 1997-07-04 JP JP10504775A patent/JP2001500365A/ja not_active Withdrawn
- 1997-07-04 DE DE69738754T patent/DE69738754D1/de not_active Expired - Fee Related
- 1997-07-04 AU AU38479/97A patent/AU3847997A/en not_active Abandoned
- 1997-07-04 NZ NZ333609A patent/NZ333609A/xx unknown
- 1997-07-04 WO PCT/EP1997/003549 patent/WO1998001467A2/en not_active Ceased
- 1997-07-04 AT AT97935511T patent/ATE397621T1/de not_active IP Right Cessation
- 1997-07-04 CA CA002259149A patent/CA2259149A1/en not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008501315A (ja) * | 2004-04-22 | 2008-01-24 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | Ｈｄｍ２阻害剤複合体およびそれらの使用 |
| JPWO2010147145A1 (ja) * | 2009-06-16 | 2012-12-06 | 学校法人東海大学 | 抗グラム陰性菌剤 |
| JP2024518022A (ja) * | 2021-03-31 | 2024-04-24 | ゼテオ テック、 インク． | 充填ベッドシステムおよび方法を使用したエアロゾル化生体材料粒子の捕捉による呼吸器疾患の診断 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2259149A1 (en) | 1998-01-15 |
| EP0958305B1 (en) | 2008-06-04 |
| AU3847997A (en) | 1998-02-02 |
| DE69738754D1 (de) | 2008-07-17 |
| ATE397621T1 (de) | 2008-06-15 |
| WO1998001467A2 (en) | 1998-01-15 |
| NZ333609A (en) | 2000-08-25 |
| EP0958305A2 (en) | 1999-11-24 |
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