JP2001288042A - Composition for scalp and hair - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for scalp and hair, excellent in hair-growing effects, having synergistically improved effects for preventing scurf and itching, and further having excellent safety. SOLUTION: This composition for the scalp and the hair contains an antiinflammatory agent such as glycyrrhizinic acid, and adenosines such as adenosine.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for external use, particularly to a composition for scalp and hair used on the scalp and hair.

[0002]

2. Description of the Related Art There are various types of compositions for scalp and hair, and products corresponding to various scalp and hair conditions are hair compositions,
It has been developed as a hair restorer and the like. For example, products have been developed that prevent hair loss by preventing dandruff and Kayumi on the scalp.

[0003] Various troubles on the scalp are increasing with the increase in social stress in the aging society, and the demand for scalp hair compositions corresponding to troubles on the scalp is rapidly increasing.

In general, baldness and alopecia of the head, thinning of hair, dandruff and kayumi of the scalp are caused by activation of androgens in organs such as sebaceous glands of hair root, excessive sebum secretion, and production of lipid peroxide. And a decrease in blood flow to the hair follicle and stress. In addition, when sufficient hair follicles cannot be supplied with nutrients for growing durable and beautiful hair, fine hair and thin hair may be caused. Also, a decrease in blood flow to the hair follicle results in nutritional deficiency and a reduced function of excreting waste products. From this point of view, improving the stratum corneum turnover and excessive sebum secretion in the scalp is indispensable in at least improving the blood flow function in the scalp and solving problems of the scalp and hair. It is a point that can not be done.

[0005] Conventional scalp hair compositions generally contain a substance having an action of removing or reducing the factors considered to be the cause of baldness and hair loss. For example,
Vitamins such as vitamin B and vitamin E; amino acids such as serine and methionine; assembly extracts; vasodilators such as acetylcholine derivatives; anti-inflammatory agents such as purple root extract;
Hormonal preparations for women such as estradiol, skin function enhancers such as cepharanthin, etc. are blended and used for prevention and treatment of baldness, hair loss and hair thinning.

[0006]

However, it is difficult to obtain a sufficient effect even if only a small amount of these components is incorporated in the composition for scalp hair. Since the tendency to accompany irritation and redness is increased, the amount of the compound is limited, and the desired effect cannot always be sufficiently obtained.

[0007]

Means for Solving the Problems The present inventors have conducted intensive studies in view of the above-mentioned viewpoints. As a result, when a combination of an anti-inflammatory agent and adenosine is combined, not only is the hair-growth effect excellent, but also the anti-inflammatory agent is improved. The anti-inflammatory effect of the scalp,
The present inventors have found that a dandruff / kayumi prevention effect and a hair loss prevention / improvement effect are synergistically enhanced, and that a composition for scalp hair which is excellent in safety can be obtained, thereby completing the present invention.

That is, the present invention is a composition for scalp hair containing an anti-inflammatory agent and adenosine (hereinafter, also referred to as the present composition for scalp hair). In the present invention,
The “scalp hair composition” is an external composition used for the scalp and hair, and its dosage form and form are “scalp hair”
There is no direct restriction on the use of the composition, and it does not matter whether the category of the composition for external use, such as cosmetics, quasi-drugs, and pharmaceuticals, falls under the Pharmaceutical Affairs Law.

[0009]

Embodiments of the present invention will be described below. Adenosines that can be included in the present scalp hair composition are adenosine, adenosine 5'-phosphate and / or salts of adenosine 5'-phosphate.

Adenosine is one of the ribonucleosides and contains adenine which is a purine derivative in the base portion. Adenosine 5'-phosphate is also called 5'-adenylic acid, and is a nucleotide in which one molecule of phosphate binds to the 5'-hydroxyl group of ribose of adenosine.

In the salt of adenosine 5'-phosphate, the counter ion that forms the salt may be any substance as long as it forms a counter ion with an acid, such as sodium, potassium and calcium. be able to. As the salt of adenosine 5'-phosphate, its hydrate can also be used.

[0012] In the present composition for scalp hair, adenosine, adenosine 5'-phosphate and / or adenosine 5 'are used.
-As the salt of phosphoric acid, a commercially available reagent can also be used.

The amount of adenosine in the present scalp hair composition is usually 0.0001 to 10.0% by mass, preferably 0.1% by mass, as a dry solid based on the total amount of the scalp hair composition. 001 to 5.0% by mass. 0.0001 as a dry solid content relative to the total amount of the scalp hair composition
If the amount is less than 10% by mass, a sufficient hair-growth effect and the effect of preventing dandruff and swelling cannot be obtained, and if the amount exceeds 10.0% by mass, a problem in the preparation tends to occur.

On the other hand, the anti-inflammatory agent contained in the present composition for scalp hair includes glycyrrhetinic acid and its derivatives, glycyrrhizic acid and its derivatives, salicylic acid and its derivatives, octopirox, zinc oxide, allantoin and its derivatives, benzalco chloride Ium, isopropylmethylphenol, menthols, camphors, allantoin, itctamol, guaiazulene and its derivatives,
What has been conventionally compounded as an anti-inflammatory agent in the composition for external use, such as epsilon aminocaproic acid, lysozyme chloride, diphenhydramine hydrochloride, etc., can be appropriately selected.

Glycyrrhetinic acid (β-glycyrrhetinic acid) is an aglycone of glycyrrhizin extracted from licorice and is a triterpenoid compound belonging to the β-amyrin family and known as an anti-inflammatory agent. Methods for producing glycyrrhetinic acid are known and commercially available.

Examples of the derivatives of glycyrrhetinic acid include glyceryl glyceryl retinate, stearyl glycyrrhetinate, pyridoxine glycyrrhetinate, and glycyrrhetinyl stearate. These production methods are known and are all commercially available.

Glycyrrhizic acid is extracted from licorice,
It is a glycoside composed of 1 mol of glycyrrhetinic acid and 2 mol of glucuronic acid, and is known as an anti-inflammatory agent. Methods for producing glycyrrhizic acid are known and commercially available.

Examples of the derivatives of glycyrrhizic acid include trisodium glycyrrhizinate, dipotassium glycyrrhizinate, methyl glycyrrhizinate, monoammonium glycyrrhizinate, and disodium 3-succinyloxydiglycyrrhizinate. These production methods are known and are all commercially available.

Allantoin, whose chemical name is 5-ureidohydantoin, was originally found in bovine amniotic membrane, and has been found to have anti-inflammatory and astringent effects. The production method is known and commercially available.

The derivatives of allantoin include, for example,
Allantoin acetyl-DL-methionine, allantoin β-glycyrrhetinic acid, allantoin hydroxyhydroxyaluminum, allantoin dihydroxyaluminum, allantoin DL-pantothenyl alcohol, allantoin polygalacturonic acid and the like can be mentioned.
These production methods are known and commercially available menthols include, for example, 1-menthol and d-menthol.
l-menthol and the like. These menthols can be extracted from western mint and the like by an ordinary method, and are of course commercially available.

Examples of the camphors include d-camphor and dl-camphor. These camphors can be extracted from camphor tree, mayonnaise and the like by a conventional method, and are of course commercially available.

Ikutamol is generally known as Ichithiol, and its anti-inflammatory action, antiseptic action and the like are recognized. The production method is known and is commercially available. Guaiazulene has the chemical name 7-isopropyl-
It is called 1,4-dimethylazulene, which is obtained by dehydrogenating guaiol, and has been found to have an anti-inflammatory effect, an anti-allergic effect and the like. The production method is known and is commercially available.

Examples of the guaiazulene derivative include guaiazulene derivatives having an anti-inflammatory action, such as sodium guaiazulene sulfonate. These production methods are known and commercially available.

Epsilon aminocaproic acid, whose chemical name is 6-aminohexanoic acid, has a structure in which the amino group at the α-position is removed from L-lysine, and is known as a drug having a strong plasmin inhibitory action. The production method follows a generally known method such as hydrolysis of caprolactam, and is also commercially available.

Lysozyme chloride has a chemical name of N-acetylmuramidoglycanohydrase, is a basic polypeptide obtained from egg white, is an enzyme having a mucopolysaccharide degrading action, and has an anti-inflammatory action and the like. It has been known. The production method is known and commercially available.

Diphenhydramine hydrochloride is known as an antihistamine. The production method is known and commercially available. These anti-inflammatory agents can be used alone or in combination of two or more in the present scalp hair composition.

The amount of the anti-inflammatory agent used in the present invention is usually 0.001 to 5.0 based on the total amount of the scalp hair composition.
%, Preferably 0.01 to 3.0% by mass. If the amount is less than 0.001% by mass relative to the total amount of the scalp hair composition, a sufficient antidandruff / kayumi prevention effect cannot be obtained, and if the amount exceeds 5.0% by mass, it is difficult to formulate the scalp or scalp. May give an unpleasant stimulus.

As described above, the present composition for scalp hair containing an anti-inflammatory agent and adenosines can sufficiently prevent dandruff and kayumi on the scalp and has an excellent hair-growing effect. A composition.

The composition for scalp hair includes, in addition to the essential components described above, other components usually used in the composition for external use, such as an oil component, as long as the effects of the present invention are not impaired.
Surfactants, thickeners, ultraviolet absorbers, antioxidants, preservatives, fragrances, dyes, solvents such as water, alcohols, etc. can be appropriately compounded as necessary.

The scalp hair composition can be produced by a conventional method according to the intended dosage form. The dosage form of the present composition for scalp hair is arbitrary, and may be any liquid form, emulsion, ointment, cream, gel, aerosol, or any other externally applicable dosage form. Further, the product form is also arbitrary, and for example, can be used in the form of tonic, scalp treatment, shampoo, rinse and the like.

[0031]

EXAMPLES Next, the present invention will be described more specifically with reference to examples, but the technical scope of the present invention is not limited to only these examples. In addition, in the following Examples, the compounding amount is mass% with respect to a compounding object, and adenosine is shown as a solid content.

[Examples 1 to 8, Comparative Examples 1 to 10] Lotions for scalp hair were prepared according to the formulations shown in Tables 1 and 2 according to the following production method. The effect of hair lotion for scalp hair and the effect of preventing dandruff and Kayumi were examined. The test results are shown in Tables 1 and 2.

(1) Production Method Adenosine, an anti-inflammatory agent, glycerin, polyoxyethylene (100 mol) hydrogenated castor oil, silicone derivative, preservative, and fragrance were dissolved in 95% ethanol (ethanol part). Next, malic acid and a pigment were dissolved in purified water, added to the ethanol part, and stirred to obtain a transparent liquid lotion.

(2) Hair-growth effect test In order to examine the hair-growth effect of the present composition for scalp hair, a tricogram test was performed. The subject was a male, and in the comparative example, 5
In this example, four persons were used. The sample application period was 4 months, and the sample was applied to the scalp twice a day twice a day. Immediately before the start of the test and 4 months after the start of the test, 50 hairs were randomly removed from the crown of each subject, and the roots of the removed hairs were observed under a microscope. (%) Was calculated. With respect to the hair root telogen rate immediately before the start of the test, the degree of decrease in the hair root telogen rate four months after the start of the test was calculated, and the average value was calculated and determined according to the following criteria.

<Judgment Criteria> Remarkable effect (+): The ratio of hair root telogen after 4 months from the start of test to the ratio of hair root telogen immediately before the start of test was 30.
% Or more (average value). Weak effect (±): The ratio of hair root telogen after 4 months from the start of the test was 10%
% Or more and less than 30% (average value). No effect (-): The ratio of the root quiescent period 4 months after the start of the test to the ratio of the root quiescent period immediately before the start of the test was 10
% (Average value).

(3) Dandruff / Kayumi Prevention Effect Test In particular, men and women complaining of dandruff / kayumi were
Ten samples of each of the samples of Comparative Examples and Examples were examined for Kayumi on the scalp after the test and changes in the amount of dandruff before and at the end of the test, and the samples were evaluated for their dandruff and Kayumi prevention effects. The sample application period was 3 months. During this period, the hair was washed once a day with a shampoo containing no drug, and the sample was washed for 1 day.
Twice a day, 2 to 4 mL was applied to the scalp at a time.

The degree of Kayumi on the scalp was determined for each tester according to the following criteria, and the average value was evaluated. Regarding the amount of dandruff before and at the end of the test, the head dandruff was collected from the test subject with a suction device before washing the hair, the amount of protein in the dandruff (the amount of dandruff) was measured, and the amount of dandruff before the test was tested. The ratio of the amount of dandruff at the end was determined, the average value was calculated, and evaluated according to the following criteria.

<Judgment Criteria> Kayumi prevention effect 3: There is strong Kayumi. 2: There is Kayumi. 1: There is a little Kayumi. 0: There is no Kayumi.

Anti-dandruff effect A: The average value of the ratio of the dandruff amount at the end of the test to the dandruff amount before the start of the test was 70% or less. ：: The average value of the ratio of the dandruff amount at the end of the test to the dandruff amount before the start of the test was 71% or more and 80% or less. Δ: The average value of the ratio of the dandruff amount at the end of the test to the dandruff amount before the start of the test was 81% or more and 90% or less. X: The average value of the ratio of the dandruff amount at the end of the test to the dandruff amount before the start of the test was 91% or more.

[0040]

[Table 1]

[0041]

[Table 2]

From Tables 1 and 2, it can be seen that the composition for scalp hair is excellent in hair nourishing effect and also excellent in dandruff and Kayumi prevention effect by synergistic effect of anti-inflammatory agent and adenosine. It was revealed. Therefore, by using the present scalp hair composition on the scalp or hair, it is possible to sufficiently prevent dandruff and Kayumi on the scalp,
It was also found that hair growth could be promoted.

The following is an example of the formulation of the composition for scalp hair.
This is shown as an example. In addition, the compositions for scalp and hair of any of the examples were found to have an excellent hair-growing effect and an excellent dandruff-and-kaumi prevention effect in the above-mentioned tests (hair-growth effect test and dandruff / kaumi prevention effect test). . These scalp hair compositions were also excellent in safety and stability.

Example 9 Lotion Compounding Component Mixing Amount (% by mass) 95% Ethanol 55.0 Adenosine 0.1 Glycyrrhetinic acid 0.001 Octopirox 0.2 1,3-butylene glycol 2.0 Polyoxyethylene (60 mol) hydrogenated castor oil 1.0 succinic acid qs perfume and dye qs Purified water balance <Production method> Adenosine is dissolved in 95% ethanol, and glycyrrhetinic acid, octopirox, 1,
3-butylene glycol, polyoxyethylene (60 mol)
The hydrogenated castor oil and flavor were dissolved (ethanol part). Next, succinic acid and a dye were dissolved in purified water, added to the ethanol part, and stirred to obtain a transparent liquid lotion.

Example 10 Lotion Compounding Component Mixing Amount (% by mass) 95% Ethanol 75.0 Adenosine 5′-phosphate 0.0001 Dipotassium glycyrrhizinate 5.0 Allantoin 0.2 Salicylic acid 0.01 Dipropylene glycol 1 0.0 Polyoxyethylene (24 mol) ・ Polyoxypropylene (13 mol) Decyltetradecyl ether 0.5 Lactic acid Suitable amount Sodium lactate Appropriate amount Fragrance and dyes Appropriate amount Purified water balance <Production method> 95% ethanol, adenosine 5 '-Phosphoric acid, and further dipotassium glycyrrhizinate,
Allantoin, salicylic acid, dipropylene glycol,
Polyoxyethylene (24 mol) • Polyoxypropylene (13 mol) Decyl tetradecyl ether and perfume were dissolved (ethanol part). Next, lactic acid, sodium lactate and a dye were dissolved in purified water, and added to the ethanol part, followed by stirring to obtain a clear liquid lotion.

Example 11 Lotion Compounding Component Mixing Amount (% by mass) 95% ethanol 60.0 Adenosine 5′-disodium phosphate 0.01 Zinc oxide 0.1 Benzalkonium chloride 0.2 Menthol 0.5 Serine 0.05 Polyethylene glycol 400 1.0 Polyoxyethylene (20 mol) hydrogenated castor oil 1.0 Phosphoric acid Appropriate amount Perfume and pigment Appropriate amount Purified water balance <Production method> Adenosine 5'-phosphorus in 95% ethanol Disodium acid was dissolved, and menthol, serine, polyethylene glycol 400, polyoxyethylene (20 mol) hydrogenated castor oil and a fragrance were further dissolved (ethanol part). Next, zinc oxide was dispersed in purified water, and further, benzalkonium chloride, phosphoric acid, and a dye were dissolved. After adding this to the ethanol part, stirring was performed to obtain a two-layer lotion. .

[0047]

Industrial Applicability According to the present invention, there is provided a highly safe composition for scalp and hair, which has an excellent hair-growth effect and an excellent dandruff / kayumi prevention effect.

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Masahiro Tajima 1050 Nippa-cho, Kohoku-ku, Yokohama-shi, Kanagawa Prefecture F-term in Shiseido Daiichi Research Center (reference) 4C083 AA122 AB211 AB212 AB282 AC031 AC032 AC102 AC122 AC232 AC471 AC472 AC551 AC552 AC621 AC622 AC681 AC682 AC691 AC692 AC761 AC762 AD152 AD391 AD392 AD471 AD472 AD531 AD532 AD601 AD602 CC31 CC37 DD23 EE22 EE23

Claims (4)

[Claims] 1. A scalp hair composition comprising an anti-inflammatory agent and one or more adenosines selected from the group consisting of adenosine, adenosine 5'-phosphate and salts of adenosine 5'-phosphate. . 2. An anti-inflammatory agent comprising glycyrrhetinic acid and its derivatives, glycyrrhizic acid and its derivatives, salicylic acid and its derivatives, octopirox, zinc oxide, allantoin and its derivatives, benzalkonium chloride,
2. The anti-inflammatory agent selected from the group consisting of isopropyl methylphenol, menthols, camphors, allantoin, ictamole, guaiazulene and derivatives thereof, epsilon aminocaproic acid, lysozyme chloride and diphenhydramine hydrochloride. Scalp hair composition. 3. The content of the anti-inflammatory agent is 0.001 to 5.0% by mass based on the total amount of the composition for scalp hair.
Or the composition for scalp hair according to 2. 4. The content of adenosines is 0.0001 to 1 as a dry solid based on the total amount of the scalp hair composition.
The composition for scalp hair according to any one of claims 1 to 3, which is 0.0% by mass.