JP2008179576A - Medicated hair grower - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medicated hair grower capable of actually growing the hair with no side effect. <P>SOLUTION: The medical hair grower is obtained by compounding together isopropyl methylphenol, tocopherol acetate, D-pantothenyl alcohol, menthol and additional ingredients (e.g. peony extract, carrot extract, Japanese green gentian extract, adenosine disodium triphosphate, glycine, serine, methionine, Isodon japonicus extract-1, Tilia japonica extract, scutellaria root extract, soybean extract, arnica extract, Lamium album extract, watercress extract, burdock extract, Hedera helix extract, garlic extract, pine tree extract, rosemary extract, Anthemis nobilis extract, ethanol, water, BG, POP diglyceryl ether, POE hydrogenated castor oil). Thus, this medical hair grower is ensured to actually grow the hair and is free from any side effects by using phytoextracts. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a medicinal hair restorer.

    Mainly contains ingredients that stimulate the scalp with conventional medicinal hair growth agents (for example, pepper), and consumers feel that the scalp feels irritated, so it feels like it is growing I did not come.

  Make a medicinal hair restorer that actually grows and has no side effects.

  Active ingredients for hair growth approved by the Ministry of Health, Labor and Welfare Isopropylmethylphenol, tocopherol acetate, D-pantothenyl alcohol, menthol and accompanying ingredients Button extract, carrot extract, assembly extract, adenosine triphosphate 2Na, glycine, serine, methionine, cassava extract -1, Linden extract, Ogon extract, Soybean extract, Arnica extract, Odori extract, Dutch mustard extract, Burdock extract, Horseshoe extract, Garlic extract, Pine extract, Rosemary extract, Roman chamomile extract, Ethanol, Water, BG, POP Diglyceryl Add ether, POE hydrogenated castor oil, etc.

    Until now, there is no medicinal hair restorer that actually grows hair, and since the present invention has repeated medical experiments and is centered on ingredients that the Ministry of Health, Labor and Welfare has identified as effective, it helps people who are worried about hair growth, It is a groundbreaking invention with no side effects or allergies because it is botanical.

    Active ingredients for hair growth approved by the Ministry of Health, Labor and Welfare Isopropylmethylphenol, tocopherol acetate, D-pantothenyl alcohol, menthol and accompanying ingredients Button extract, carrot extract, assembly extract, adenosine triphosphate 2Na, glycine, serine, methionine, cassava extract -1, Linden extract, Ogon extract, Soybean extract, Arnica extract, Odori extract, Dutch mustard extract, Burdock extract, Horseshoe extract, Garlic extract, Pine extract, Rosemary extract, Roman chamomile extract, Ethanol, Water, BG, POP Diglyceryl Add ether, POE hydrogenated castor oil, etc.

According to the latest hair growth theory, the mechanism of hair loss is a constant hair cycle: “hair growth → growth → regression → pause → hair loss → hair growth”. However, when hair that has not grown sufficiently enters the rest period, the cycle is disturbed, the balance between hair growth and hair loss is lost, hair loss increases, and the hair becomes thin.
In the rest period, a hormone substance (cytokine) acting on the hair root regulates the hair cycle. It has been found that cytokines that lead to the resting phase cause inflammation such as IL-1α and TNFα.
Anti-inflammatory peony skin, life-prolonging grass, and bodhi machine block cytokines that lead to the resting phase and restore the balance of the hair cycle. In the present invention, these herbal medicines are blended in a balanced manner.
Hair growth is considered to be the division of hair matrix cells by cytokines secreted from the hair papilla. Normally, in the growing hair, a cytokine called IGF-1 (Insulin-like Growth Factor-1) is secreted from the hair papilla to the hair matrix cells to maintain hair growth and growth phase. We are. The hair papilla comprises vascular endothelial cells, macrophages, and a matrix in addition to dermal papilla cells. IL-1α and TNFα (Rumour Necrosis Factor α) secreted by macrophages are typical inflammatory cytokines that induce functional damage such as condensation of the entire hair papilla to the hair papilla itself, and metalloproteinases ( Decomposes matrix by activation of metalloproteinase and secretes TGBβ (Transforming Growth Factor). TGFβ is thought to induce regression and resting periods. That is, as shown in FIG. 1, it is considered that the hair cycle moves toward the regression phase and the resting phase due to the inflammatory cytokine.

Capillary function is said to decrease in the alopecia scalp, but tocopherol acetate, menthol and assembly extract stimulate peripheral blood vessel expansion and hair roots and promote blood supply to the hair follicle. Amino acids, ATP, D hemp pentenol, and carrot extract act as nutrients for hair follicle cells or as hair growth promoters by activating enzyme activity of hair matrix cells. Soybean extract containing a female hormone-like active ingredient (isoflavone) adjusts the hormone balance of the hair follicle as a kind of anti-androgen (inhibition of anti-5α reductase activity and inhibition of androgen receptor binding). Bactericidal isopropylmethylphenol suppresses dandruff and keeps the scalp in good condition. Shinano extract, toad extract, and button extract with anti-inflammatory action block hormonal substances (cytokines) that induce dysfunction such as condensation of the whole hair that leads to the rest period of the hair cycle, and balance the hair cycle .
The present invention is realized by blending the following components.
Hair growth active ingredients (these have been tested and verified, and have been confirmed by the Ministry of Health, Labor and Welfare)
Isopropylmethylphenol Tocopherol acetate
D-pantothenyl alcohol menthol Accompanying ingredients Button extract Carrot extract Assembly extract Adenosine triphosphate 2Na
Glycine Serine Methionine Toad extract 1
Linden extract Ogon extract Soybean extract Arnica extract Odorikosou extract Dutch mustard extract Burdock extract Pepper extract Garlic extract Pine extract Rosemary extract Roman chamomile extract Ethanol
water
BG
POP diglyceryl ether
Among over 29 POE hydrogenated castor oils, 16 kinds of plant extracts are blended.
By blending the above components into each, a medicinal hair restorer completely different from the conventional one is obtained. The above is an example of the implementation of the present invention, and modifications such as adding 95 synthetic unmodified alcohol, SY-DP9, Nikkor HCO-40 (medicine), Falcolex HGL, Phytylene EGX-232 (BG) to this It is included in the invention.

The effects of these components are as follows.
-Tocopherol acetate: blood circulation promotion
-Isopropylmethylphenol: fungicide (removal of scalp bacteria)
-Menthol JP: Blood circulation promoter
-Assembly extract: Blood circulation promoting and anti-inflammatory agent
-Carrot extract: blood circulation promoting / anti-inflammatory agent In addition, the present invention includes the following components.
-95 Synthetic unmodified alcohol: Base, freshener
-SY-DP9: Moisturizer
-Nikkor HCO-40 (medicine): Surfactant
-Falco Rex HGL: See separate document
-Phythelen EGX-232 (BG): Moisturizer

The beauty of the button is always contrasted with the shakushak, and the effect of the peony skin (button plant) is said to be “powder if standing, peony if sitting”, and has been awarded as Kao in China. Anti-inflammatory action has been reported to paeonol, the main component of buttonpi, which uses the root bark.
There is a legend that Kobo Daishi has been called "life-prolonging grass" because Koho Daishi saved the traveler's stomach pain with this juice of grass. Enmein has been reported to have antitumor effects.
Tea made with Bodaiju flowers (Linaceae) is called linden tea and is popular with many people. Flowers are said to be good for fever chills, respiratory catarrh, indigestion, etc., and bark is good for liver disease.
The present invention is a hair restorer containing these three kinds of adult drugs.

The results of the hair growth test of the present invention are as follows.
Experiment 1
FIG. 2 shows that in the hair growth test using C3H mice, the present invention showed a hair growth effect similar to that of minoxidil. FIG. 2 is a graph of the hair regeneration rate when the present invention is applied, and FIG. 3 is a graph of the hair regeneration rate when minoxidil is applied.
The test method was to remove the animal's back 8cm ² with an electric clipper and shaver. Next, the test drug was applied once a day, 5 days a week, 21 days to the back of the hair removed. For the determination, the ratio of the area where hair regeneration was recognized with respect to the hair removal area (body hair regeneration rate) was measured with an image analyzer from the 12th day to the 21st day after application. FIG. 4 is a photograph of an animal applied with the present invention, and FIG. 5 is a photograph of a control animal.

Experiment 2
The hair-growth effect of the present invention was also observed in human clinical trials.
The test method is to use 3 times a day for the subject and the appropriate amount of the test drug on the scalp. For the determination, the scalp before and after use was observed with a video microscope. FIG. 6 is a photograph of the scalp before use of the present invention, and FIG. 7 is a photograph of the scalp after 6 months of use of the present invention.

The present invention was confirmed to be completely safe by conducting the following safety test.
1: Acute toxicity test (single dose toxicity test)
Test to evaluate toxicity qualitatively and quantitatively: Skin primary irritation test Test to evaluate the presence or absence of skin irritation after single use 3: Continuous skin irritation test Skin irritation after continuous use Test 4 to evaluate the presence or absence: Phototoxicity test Test to evaluate the possibility of causing skin irritation by interaction with light 5: Skin sensitization test Possible to cause allergic contact dermatitis Test 6 for evaluating the presence or absence of sex: Photosensitization test Test for evaluating the possibility of causing skin allergy by interaction with light 7: Eye irritation test Test 8 for evaluating eye irritation Mutagenicity test Test 9 to evaluate whether it has the property of acting on genes and changing genetic information: human patch test

  Until now, the existence of a medicinal hair restorer that actually grows hair has not been confirmed. The present invention is an epoch-making invention that saves people suffering from hair growth without side effects.

Enlarged view of hair matrix and diagram of growth and regression phases of hair cycle by inflammatory cytokines Graph of hair regeneration rate when applying the present invention Graph of hair regeneration rate when minoxidil is applied Photographs of animals applied with the present invention Control animal pictures Scalp before use of the present invention Scalp 6 months after use of the present invention

Claims (1)

Active ingredients for hair growth approved by the Ministry of Health, Labor and Welfare Isopropylmethylphenol, tocopherol acetate, D-pantothenyl alcohol, menthol and accompanying ingredients Button extract, carrot extract, assembly extract, adenosine triphosphate 2Na, glycine, serine, methionine, cassava extract -1, Linden extract, Ogon extract, Soybean extract, Arnica extract, Odori extract, Dutch mustard extract, Burdock extract, Horseshoe extract, Garlic extract, Pine extract, Rosemary extract, Roman chamomile extract, Ethanol, Water, BG, POP Diglyceryl A medicinal hair restorer that contains ether, POE hydrogenated castor oil, etc.