JP2009215274A - Powdery hair growth agent applied to various spots of body except head - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To bring formulation of an effective hair growth agent which is usually liquid to be a powdery agent and to be applicable to spots except head, and absorption of active ingredients and continuous daily use to be easy. <P>SOLUTION: The powdery agent is prepared by blending a carrot foliage extract and a Schisandra chinensis extract which activate and promote adrenocortical function into the hair growth agent instead of blending adrenocortical hormone which improves protection of the hair from being thinning. The agent is brought to be applied to spots except head having high rate of percutaneous absorption to obtain simplicity in use and higher effect. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

The present invention relates to a hair-growth effect powder applied to a body part other than the head.

Thinning of the hair is seen in about 40-50% of adult males, and signs appear in the late 20s and progress with age. The cause is considered to be inheritance and male hormones (Reference 1), which is difficult to take countermeasures and has long been a source of stress for many men. For this reason, the use of hair restorer, which is currently the only countermeasure, has not been able to produce a certain effect in any of a large number of products on the market. This is because the current hair-growth compounding ingredients (scalp tension relief and blood circulation promoting ingredients) are not necessarily linked to the cause of hair degradation.

Under such circumstances, in 1979, the US FDA approved piperidinopyrimidine derivative vasodilator Minoxidil brings about about 80% of the users to have hairy, soft hair, and hair diameter increase. Was found and applied to hair restorer (reference document 2). However, since this is an approval as a pharmaceutical product, there are restrictions on its use, and the effect has also been reduced to a modest improvement of 27.3% (15.7% with placebo) after 6 months of use (Reference 3). This is thought to be due to the difference between external application to the head and internal use.

Incidentally, according to the above-mentioned Reference Document 2, an adrenal cortex hormone is cited as one that causes iatrogenic hirsutism similar to minoxidil. However, this is not allowed except for medicinal use.

All of the current market hair growth agents for hair thinning are liquids with the application site as the head of scalp, hair, etc., but when the minoxidil applied to the head is applied to the head, the effect onset is slow due to slow absorption of ingredients. It is thought that it depends on. In addition, the slow speed of absorption varies depending on the application site. For example, in the case of corticosteroid, the transdermal absorption rate is 3.5 times for the head when the forearm flexion side is 1, and 3 for the armpit. .6 times, shadow area is 42 times (Reference 4).

Application of a liquid hair restorer to the head is usually recommended in large quantities. However, in general, 1 ml at a time is standard twice a day (Reference 3). There is also a need to prevent clothes from getting dirty and hairstyling.

Reference 1

"Science of hair" Iwanami Chemical Library 61, P ... 81

Reference 2

"This side effect of this medicine" Medical Life, P ... 144

Reference 3

"RiUP / Reup Manual"-Taisho Pharmaceutical Co., Ltd.

Reference 4

“Standard use of steroid ointment” Journal of the Japanese Pharmacists Association Vol. 59, No. 6, P… 103

Conventionally, liquids for scalp and scalp hair that have been used to improve thinning of men's hair have the same balance with components for relaxing scalp tension and blood circulation. However, the results of hair growth are almost unclear, so the period of use as a product did not last long. Regarding the relaxation of scalp tension, it is clear that thinning hair is not due to scalp tension, because the thinning of the scalp is not observed when the unsheared temporal scalp is transferred to the thinning frontal region. (Reference 1, P ... 89). Regarding blood circulation promotion, it is difficult to obtain a substantial effect by the blood circulation promoting component that should contribute to hair growth, because even when the amount of percutaneously absorbed drug is decomposed or barely reaches the blood vessel, it is fogged in the bloodstream. (Reference 5).

Adrenocortical hormones are the only drugs that have the same action as minoxidil, a medicinal product, in improving thinning hair, but they have not been added to hair-restoring agents. Therefore, the component which can replace it becomes a problem in terms of adjustment in a dosage form which is convenient for use, that is, it does not have to worry about “dirt of clothing” and “shampooing work each time of application”.
The present invention is intended to solve this problem with a hair-growth effect powder that can be applied to a body part other than the head to increase the absorption rate.

Reference 5

"Promoting transdermal delivery and absorption of drugs" Pharmaceutical Journal Vol120 (2000) P ... 328

Means for solving the problem

Regarding the present invention, the expectation of the hair growth effect that has been placed on the scalp tension relieving component, the blood circulation promoting component, etc., in the sorghum ginseng leaf stem extract or the magnoliaceae ginseng extract that activates and promotes the adrenal cortex function. The problem is solved by putting it in an external powder and applying it to the lower part of the heel and the genital area where the percutaneous absorption rate is high to prevent sweat odor.

The ginseng leaf stem is effective in reducing blood levels of adrenocortical hormones (due to chronic adrenocortical function decline) ... Addison's disease ... (reference 6) It is said that the organic solvent extract has a function of promoting adrenocortical function (Reference Document 7).

References

“Chinese medicine immunity”, Pingtung University Technology Publishing, P… 123

References

“Clinical application of Chinese medicine”, medical and dental publishing, P… 381

The invention's effect

The application of the hair-growth effect agent does not necessarily require external application to the head in order to obtain the results of hirsutism, vellus hair thickening, and hair diameter increase as in the case of minoxidil (Reference Document 2). Moreover, since most conventional hair-growth effect agents were liquids, there were inconveniences such as dirt on clothes and hair styling after use, and hindered continuous use and expression of effects along with the low percutaneous absorption rate of the ingredients. .
In the present invention, a plant-derived component that activates and promotes adrenocortical hormone function is adsorbed to a powder, and it is applied externally to a body part other than the head to prevent sweat odor. Therefore, the time of application can be freely selected as compared with the prior art products. In addition, since it is not a liquid agent, there is no dirt on clothes after use, no need for hair styling, and above all, the percutaneous absorption rate is improved, which helps to improve the hair-growth effect.

Ginseng leaves and stems are roasted to about 10 times the weight of water, and the magnoliaceae ginseng fruit is thinly burnt to an extent that is about 10 times the weight in an organic solvent such as ether or ethanol for 24 hours. Immerse and filter, evaporate to dryness by each known method, and pulverize and atomize separately. Using these extracts, a powder is prepared according to the formulation of the example. If this is kept on waking up, before going to bed, or at any time on the armpit, genital area, wearing underwear, etc. Can be obtained. In addition, each extract compounding amount in the present invention is preferably 0.5 to 2.5% by weight for one kind of compounding, and 1.0 to 4.0% by weight in the case of two kinds of compounding.

Hereinafter, the effects of the present invention will be described in accordance with each example formulation. However, the present invention is not limited to the following examples.

Powder aerosol ... Made with 30% LPG and 70% LPG.

Powder sheet agent: A non-woven fabric is impregnated with a lotion having the following formulation, and water is removed to cut it into an appropriate size (eg, 1 cm 4), and the parts other than the head are wiped off.

Control: A powder aerosol or powder sheet excluding ginseng leaf stem extract and ginseng extract from the formulation of powder aerosol and powder sheet is prepared separately and used as a control.

In the hair-growth effect powder agent according to the present invention, various known raw materials, additives, fragrances and the like which are usually used in quasi-drugs, cosmetics, foods, etc. in addition to the respective ingredients of the examples may be used as appropriate. Absent.

(Test example)
A third party counts the number of hairs in a circle with a radius of 0.8 mm defined in the top of the head for three groups of four men each with a view of thinning (thinning hair) of the parietal head between 26-39 years old The results were compared before and after the test for 3 months. (Attach a patch sheet with a circle centered at the intersection of the line connecting the left and right ears and the line extending from the nose bridge back to the top of the head to a radius of 0.8 mm. The results are shown in the table.

“Effective” indicates that the number of hairs increased by 5 times or more before and after the test, “slightly effective” indicates that the number of hair increased by 2 to 4 times, and “invalid” indicates that no increase was observed.

As seen in the table of test example results, the hair growth effect powder of the present invention can select the application site other than the head compared to the conventional hair growth effect solution. In addition, there is no risk of soiling clothes or the like, and there is no need for hair styling after use, and it can be used conveniently at any time, and the effect of hair growth is obvious.

Claims (2)

Hair growth effect powder applied to body parts other than the head 2. The powder preparation according to claim 1, wherein the hair-growth effect is obtained by blending one or more extracts selected from the group consisting of a leaf stem portion of a carrot family ginseng and a fruit part of a magnoliaceae plant ginseng.