JP2000178128A - Cosmetic for skin and mind - Google Patents

Abstract

PROBLEM TO BE SOLVED: To produce a cosmetic useful for treating skin diseases or skin troubles suddenly increasing in the present day by including a stress preventing agent and a collagen fiber bundle reconstructing agent. SOLUTION: This cosmetic is obtained by including (A) a stress preventing agent which is preferably an essence of a plant of the family Polyporaceae such as Hoelen and (B) a collagen fiber bundle reconstructing agent that is preferably an essence of a rosemary, ursolic acid, etc. The amounts of the ingredients are preferably 0.01-10 wt.% of the ingredient A and 0.01-10 wt.% of the ingredient B and more preferably 0.05-5 wt.% of the ingredient A and 0.05-5 wt.% of the ingredient B. Furthermore, an elastin decomposition inhibitor such as a soybean protein is preferably contained. The resultant cosmetic is useful for a cream, an emulsion, a toilet lotion, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic which is useful for conditioning skin and mind.

[0002]

2. Description of the Related Art In recent years, there has been an era of excessive stress,
Those who live today are exposed to greater or lesser stress. It is well known that such excessive stress has a large effect on the human body, for example, that people who are exposed to excessive stress have many serious diseases such as cancer and short life expectancy. It is. For this reason, means for alleviating many stresses have been devised. Examples of such means include stress reduction by aromatherapy using olfaction, relaxation massage using tactile sensation, and the like. However, such a reducing means is effective but not sufficient, and further reducing means have been desired.

On the other hand, in recent years, as the number of patients with atopic dermatitis and the number of patients with allergic dermatitis have rapidly increased,
The number of people suffering from skin diseases is increasing, including mild skin troubles that have not yet led to the disease. As described later, the present inventors have analyzed this tendency and found that the tendency is caused by excessively applied stress. That is, by reducing the transcutaneous load stress, the effect of the component having the effect of improving the skin condition is effectively exerted, and it has been found that such skin diseases and skin troubles can be reduced.
Such knowledge has not been known at all.

[0004] That is, no means of percutaneous stress relaxation was known at all, and this stress relaxation means was combined with a substance having a skin condition improving effect such as a collagen fiber bundle restructuring agent or an elastin degradation inhibitor. It was not known at all to include it in cosmetics. In addition, there was no concept of cosmetics for conditioning the skin and mind.

[0005]

SUMMARY OF THE INVENTION The present invention has been made under such circumstances, and it is an object of the present invention to provide means suitable for treating skin diseases and skin troubles which are increasing rapidly in modern times. I do.

[0006]

In view of such a situation, the present inventors have made intensive research efforts in search of suitable means for treating skin diseases and skin troubles, which have been rapidly increasing in the modern day.
Such effects were found in cosmetics containing a stress preventive agent and a collagen fiber bundle remodeling agent, and the present invention was completed. Hereinafter, a detailed description will be given focusing on the embodiment of the present invention.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION (1) Stress preventive agent as an essential component of the cosmetic of the present invention The cosmetic of the present invention contains a stress preventive as an essential component. Here, the stress preventive agent as referred to in the present invention means a general term for components that act on the living body and make the environment of the living body less susceptible to the adverse effects of stress. It can be selected by screening using animals as shown. As a stress preventive agent having such properties, the present inventors have found the essence of plants of the family Sarcophaga, such as Bakryo, Chorei, Tsukiyotake mushroom, and Sarnokoshikame. Above all, this effect is remarkable in liquorice, and the essence of liquorice is a stress preventive suitable for the cosmetic of the present invention. Here, the essence referred to in the present invention is a plant itself, a processed product obtained by drying, shredding, and pulverizing a plant, an extract obtained by adding a solvent to a plant or a processed product, and extracting a solvent from an extract. It is a generic term for the solvent-extracted product of the extract, the purified product obtained by fractionating and purifying the extract and the solvent-removed product. Among these essences, those suitable for the cosmetic of the present invention are extracts or solvent-free products thereof. The extract may be produced in accordance with a usual method. For example, 1 to 10 parts by weight of a solvent is added to 1 part by weight of a plant or a processed product thereof. It may be immersed for several hours. The solvent may be removed by vacuum concentration or steam distillation. As the solvent, water, ethanol, methanol, alcohols such as 1,3-butanediol,
Esters such as ethyl acetate and methyl formate, ethers such as diethyl ether and tetrahydrofuran, ketones such as acetone and methyl ethyl ketone, halogenated hydrocarbons such as chloroform and methylene chloride, and nitriles such as acetonitrile are preferred. Water or alcohols are particularly preferred. The preferred content of such a stress preventive agent in the cosmetic of the present invention is 0.0%
It is 1 to 10% by weight, more preferably 0.05 to 5% by weight. This is because if the amount is too small, the effect of preventing stress may not be exhibited, and if the amount is too large, the effect may reach a plateau.

<Screening Example of Stress Preventive Agent> The preventive effect of the test substance on the decrease in skin function due to stress was examined. The stress model used was an overbreeding and stripping stress model. The sample contains 50 test substances.
A solution dissolved in a 1% ethanol aqueous solution at a concentration of 1% was used. That is, after breeding at twice the normal density for 2 weeks, the back skin was stripped with cellophane tape, and the decrease in skin function was measured by measuring the amount of diffused and dissipated water (TEWL) and using this as an index. The preventive effect was obtained by administering 0.1 ml of the test substance once a day to the back site during the preliminary breeding period (two weeks). The control group was treated with 50% ethanol. Preliminary rearing was performed at normal density. The animals used were ICR hairless mice (male, 10 to 15 weeks of age), with 10 animals per group.
For evaluation, look at the state of TEWL of the whole group, and ++: remarkable TE
WL increase suppression, +: obvious TEWL increase suppression, ±:
Preventive action was determined based on the criteria that weak suppression of increase in TEWL and-: no suppression was observed. In this judgment, the 50% ethanol extract of bougainvillea was ++.
Thus, it can be seen that by treating the living body with the stress preventive agent, the in-vivo environment is prepared so that the living body is prepared for the coming stress.

(2) Collagen fiber bundle remodeling agent which is an essential component of the cosmetic of the present invention The cosmetic of the present invention is characterized by further containing a collagen fiber bundle restructuring agent. Here, the collagen fiber bundle restructuring agent has a function of reconstructing and repairing the disorder of the collagen fiber bundle of the skin caused by long-term exposure to low-intensity ultraviolet rays, that is, a collagen fiber bundle structure called wrinkles. It refers to a substance that acts on a disordered state and has an action of reconstructing and repairing the disorder and improving wrinkles. Specific examples of such a substance include, for example, essence of rosemary, ursolic acid and physiological Examples thereof include salts thereof, and esters of ursolic acid. Here, the essence means the same as that used above. Also, as ursolic acid esters,
Methyl, ethyl, tertiary butyl, octyl, cyclohexyl, hexenyl, isooctyl, cetyl, myristyl, stearyl, oleyl, decanyl, etc. And aromatic esters such as benzyl and phenylethyl. Examples of physiologically acceptable salts include alkali metal salts such as sodium and potassium, alkaline earth metal salts such as magnesium and calcium, ammonium salts, organic amine salts such as triethylamine salts and triethanolamine salts, and lysine salts. And a basic amino acid salt such as arginine salt. Of these, particularly preferred are one or more selected from the essence of ursolic acid, ursolic acid salt, benzyl ursolic acid, and rosemary.
The preferred content of these collagen fiber bundle structure remodeling agents in the cosmetic of the present invention is 0.01 to 10% by weight, and more preferably 0.05 to 5% by weight. This is because, if the amount is too small, the collagen fiber bundle remodeling effect may not be exhibited, and if the amount is too large, the effect may reach a plateau and the stability may be impaired.

(3) Elastin Decomposition Inhibitor Suitable for the Cosmetic of the Present Invention The cosmetic of the present invention preferably contains an elastin decomposition inhibitor. This is because the skin condition can be more effectively improved by combining the effects of the elastin degradation inhibitor and the collagen fiber bundle remodeling agent. A protein contained in soybean is known as an elastin decomposition inhibitor that suppresses such elastin decomposition. The preferred content of the elastin decomposition inhibitor in the cosmetic of the present invention is 0.01 to 10% by weight, more preferably 0.05 to 5% by weight. This is because if the amount is too small, the elastin degradation inhibitory effect may not exhibit the elastin degradation inhibitory effect, and if the amount is too large, the effect may plateau.

(4) Cosmetic of the Present Invention The cosmetic of the present invention is characterized by containing the above-mentioned essential components, a stress preventive agent and a collagen fiber bundle remodeling agent. In a particularly preferred form, the composition further contains an elastin decomposition inhibitor. The cosmetic of the present invention has an effect of suppressing the expression of a factor that exacerbates the skin condition due to stress by a stress preventive agent, and more effectively repairing a damaged site by a collagen fiber bundle remodeling agent. The cosmetic of the present invention can be applied without particular limitation as long as it is a cosmetic. For example, basic cosmetics such as creams, emulsions, lotions, packs, and makeup cosmetics such as under makeup and foundations. , Shampoo, rinse, treatment, washing cosmetics such as soap, hair toning lotion, hair cosmetics such as hair cream, etc.
Among them, it is particularly preferable to be used for skin care. Further, as the dosage form, any of a solubilized system, an emulsified system, and a dispersed system can be used. However, the use of a water-in-oil emulsified system in which the outermost phase is an oil phase makes it possible to store the active ingredient. It is particularly preferable from the viewpoint of providing properties and a pleasant feeling in use. In such a water-in-oil emulsified form, it is advantageous to use an organically modified bentonite for the purpose of improving the stability of both the form and the feeling upon use. Since the cosmetic of the present invention prepares an in vivo environment against stress by a stress preventive agent, by using the cosmetic of the present invention, the heart can be kept more comfortable, and this feeling of comfort is further improved by collagen. The effect of a fiber bundle remodeling agent or an elastin decomposition inhibitor can be enhanced, and beautiful skin can be effectively realized.

The cosmetic of the present invention may contain, in addition to the above-mentioned components, optional components usually used in cosmetics. Such optional components include, for example, hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, triglycerides such as tallow, olive oil, higher alcohols such as cetanol and oleyl alcohol, Fatty acids such as stearic acid and oleic acid, polyhydric alcohols such as glycerin and 1,3-butanediol, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, ethanol, carbopol, etc. Preferred examples include thickeners, preservatives, ultraviolet absorbers, antioxidants, pigments, and powders. By treating these components according to the usual method,
The cosmetic of the present invention can be manufactured.

[0013]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples, but it goes without saying that the present invention is not limited to only these Examples.

Example 1 The effect of a combination of a stress preventive agent and a collagen fiber bundle remodeling agent was examined using the above-mentioned stress model. Specimen 1 was a 1% solution of eucalyptus essence, Specimen 2 was a 1% solution of eucalyptus essence and rosemary essence (solvent removed from 50% aqueous ethanol extract), and Specimen 3 was an essence of liquorice 1% solution of rosemary essence 1% and soy protein 1%, sample 4 is a 1% solution of rosemary essence, sample 5 is a 1% solution of soy protein, sample 6 is rosemary essence 1% of soy protein and 1%
Was used. The solvent used was a 50% aqueous ethanol solution. The stress model used was an overbreeding stress model. That is, they were bred at twice the normal density for 2 weeks, and the decrease in skin function was evaluated by measuring the amount of diffused and dissipated water (TEWL) and using this as an index. The preventive effect is based on the preliminary breeding period (2
Week), the test substance was administered once daily at a dose of 0.1 ml to the back site. As a control group, a sample 1 administration group was used. Preliminary rearing was performed at normal density. The animals used were ICR hairless mice (male, 10 to 15 weeks of age), with 10 animals per group. In the evaluation, the state of TEWL in the whole group was observed, and ++: remarkable suppression of TEWL increase compared to control group, +: clear suppression of increase of TEWL compared to control group, ±: weak suppression of increase of TEWL compared to control group ,-: The effect was determined on the basis that no inhibition was observed as compared with the control group. Table 1 shows the results.
This indicates that it is preferable to use a collagenase bundle reconstructing agent in combination, and it is particularly preferable to use an elastin decomposition inhibitor in combination.

[0015]

[Table 1]

Example 2 A water-in-oil cream was prepared according to the following formulation. That is, the components (a) and (b) were each heated to 80 ° C., (b) was gradually added to (a), emulsified, and the particles were homogenized with a homogenizer. A Sucrose fatty acid ester 0.5 parts by weight Vaseline 1 part by weight Lanolin 3 parts by weight Liquid paraffin 8 parts by weight Low viscosity silicone 30 parts by weight Stearyl alcohol 0.5 parts by weight Stearic acid 0.55 parts by weight Undecylenic acid monoglyceride 2 parts by weight Organic modification Bentonite 2 parts by weight b 1,3-butanediol 5 parts by weight Glycerin 20 parts by weight Rosemary essence 1 part by weight Bokuryo essence 0.5 part by weight Potassium hydroxide 0.05 part by weight Water 25.9 parts by weight

Example 3 A water-in-oil cream was prepared according to the following formulation. That is, the components (a) and (b) were each heated to 80 ° C., (b) was gradually added to (a), emulsified, and the particles were homogenized with a homogenizer. A Sucrose fatty acid ester 0.5 parts by weight Vaseline 1 part by weight Lanolin 3 parts by weight Liquid paraffin 8 parts by weight Low viscosity silicone 30 parts by weight Stearyl alcohol 0.5 parts by weight Stearic acid 0.55 parts by weight Undecylenic acid monoglyceride 2 parts by weight Organic modification Bentonite 2 parts by weight b 1,3-butanediol 5 parts by weight Glycerin 20 parts by weight Rosemary essence 1 part by weight Bokuryo essence 0.5 part by weight Potassium hydroxide 0.05 part by weight Soy protein 0.5 part by weight Water 25 .4 parts by weight

Example 4 An oil-in-water cream was prepared according to the following formulation. That is, the components (a) and (b) were each heated to 80 ° C., (b) was gradually added to (a), emulsified, and the particles were homogenized with a homogenizer. A Sucrose fatty acid ester 0.5 parts by weight Vaseline 1 part by weight Lanolin 3 parts by weight Liquid paraffin 8 parts by weight Low viscosity silicone 10 parts by weight Stearyl alcohol 0.5 parts by weight Stearic acid 0.55 parts by weight Undecylenic acid monoglyceride 2 parts by weight Polyoxy Ethylene (20) behenyl ether 2 parts by weight b 1,3-butanediol 5 parts by weight Glycerin 5 parts by weight Rosemary essence 1 part by weight Bukuroyou essence 0.5 part by weight Potassium hydroxide 0.05 part by weight Water 60.9 Parts by weight

Example 5 An oil-in-water cream was prepared according to the following formulation. That is, the components (a) and (b) were each heated to 80 ° C., (b) was gradually added to (a), emulsified, and the particles were homogenized with a homogenizer. A Sucrose fatty acid ester 0.5 parts by weight Vaseline 1 part by weight Lanolin 3 parts by weight Liquid paraffin 8 parts by weight Low viscosity silicone 10 parts by weight Stearyl alcohol 0.5 parts by weight Stearic acid 0.55 parts by weight Undecylenic acid monoglyceride 2 parts by weight Polyoxy Ethylene (20) behenyl ether 2 parts by weight b 1,3-butanediol 5 parts by weight Glycerin 5 parts by weight Rosemary essence 1 part by weight Bukryo essence 0.5 part by weight Potassium hydroxide 0.05 part by weight Soy protein 0. 5 parts by weight water 60.4 parts by weight

<Example 6> A cream in which the essence of the cream of the above creams 1-4 and cream 1 was replaced with water (Comparative Example 1), and a cream in which the essence of the rosemary of Cream 1 was replaced with water (Comparative Example 2) A use test was conducted using 35 panelists who were worried about rough skin, in which the essence of Bokuryou and the essence of rosemary of Cream 1 were replaced with water (control example). The samples were randomly divided into seven groups of five and each group was assigned these samples. Each sample was taken twice a day, morning and evening,
We had you use every month. Blood was collected before and after the use test and the concentration of cortisol was measured. Moreover, the improvement of the state of rough skin is significantly improved compared to before use.
+: Clearly improved compared to before use, ±: slightly improved compared to before use,-: evaluated by criteria for no improvement. The results are shown in Table 2 as the average decrease rate (%) of the concentration of cortisol and the number of appearances of answers. From this table, the combination effect of a stress preventive agent and a collagen fiber bundle remodeling agent,
Further, the combination effect when an elastin decomposition inhibitor is combined is apparent. In addition, since the blood concentration of cortisol, which is an index of stress, is significantly reduced after the use of the cosmetic of the present invention, the cosmetic of the present invention prevents the expression of a factor for the deterioration of skin condition due to stress. You can see that it is. This is in good agreement with the results of animal experiments. That is, it can be seen that the cosmetic of the present invention is a cosmetic that cares for the mind. It is also clear from the comparison of the two that the improvement of the skin condition and the prevention from stress influence each other. That is, it can be estimated that one of the causes of the rapidly increasing skin diseases unique to modern times is stress in social life.

[0021]

[Table 2]

[0022]

According to the present invention, according to the present invention, it is rapidly increasing in modern times,
Suitable means for treatment of skin diseases and skin troubles can be provided.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Shigeharu Tanizawa 27-1, Takashimadai, Kanagawa-ku, Yokohama-shi, Kanagawa Prefecture Inside the Yokohama Research Laboratories of Polar Chemical Industry Co., Ltd. (72) Kenya Hirayama 27-27 Takashimadai, Kanagawa-ku, Yokohama-shi, Kanagawa Prefecture 1 Inside the Yokohama Research Laboratory of POLA CHEMICAL INDUSTRIES, LTD. (72) Inventor Takehiro Okuda 27-27 Takashimadai, Kanagawa-ku, Yokohama, Kanagawa Prefecture 1 Inside the Yokohama Research Laboratory of POLA CHEMICAL INDUSTRIES, LTD. (72) Inventor Chihoko Suga Takashima, Kanagawa-ku, Yokohama-shi Stand No. 27 1 Polar Chemical Industry Co., Ltd. Yokohama Research Laboratory F-term (reference) 4C083 AA111 AA112 AB032 AB442 AC012 AC022 AC072 AC122 AC182 AC242 AC422 AC442 AD152 AD411 AD412 AD491 AD492 AD512 BB51 CC01 CC02 CC05 DD27 DD32 EE12 EE13 FF05 4C088 AA08 AB MA63 ZA18 ZA89

Claims (7)

[Claims] 1. A cosmetic comprising a stress preventive and a collagen fiber bundle remodeling agent. 2. The cosmetic according to claim 1, wherein the stress preventive agent is an essence of a plant belonging to the family Sarcophaga. 3. The collagen fiber bundle remodeling agent is selected from essence of rosemary, ursolic acid and physiologically acceptable salts thereof, and esters of ursolic acid.
The cosmetic according to claim 1, wherein the cosmetic is at least two species. 4. The cosmetic according to claim 1, further comprising an elastin decomposition inhibitor. 5. The cosmetic according to claim 1, wherein the elastin degradation inhibitor is soy protein. 6. A skin and heart conditioner,
The cosmetic according to any one of claims 1 to 5. 7. The method according to claim 1, wherein the outermost phase is an oil phase.
The cosmetic according to any one of claims 1 to 6.