KR101472466B1 - A pharmaceutical composition and a hair make-up composition for prompt hair-increasing and for treating hair loss - Google Patents

Abstract

The present invention relates to a liquid preparation comprising a therapeutic agent for depilation; And
An activated carbon having a carboxyl group of not less than 0.25 mmol / g, a total pore size of not more than 50 angstroms, not more than 0.4 mL / g, an average particle size of 20 nm to 500 μm, and a surface area of 100 to 1,500 m ² / Including,
A weight ratio of the liquid preparation to activated carbon is 1: 1 to 3: 1; And a pharmaceutical composition for prevention, treatment or hair growth of hair loss.

Description

TECHNICAL FIELD The present invention relates to a pharmaceutical composition and a hair make-up composition,

The present invention relates to a cosmetic composition for an instant boosting agent and a pharmaceutical composition for prevention, treatment, or hair growth of hair loss, more specifically, it can be used safely and safely, And also to prevent, treat, and hair growth of hair loss.

Testosterone is involved in the normal aspects of male physical characteristics such as skeletal muscle growth, genital development, sperm formation, and sexual desire. Acne, sebum enlargement, hair loss, and prostate hypertrophy, which are negative aspects, are caused by dihydrotestosterone It is known to occur in association with the organization. Among them, long-term studies have been conducted on hair loss, which is common in men. However, the mechanism of hair loss and hair growth has not yet been clarified. However, in modern society where appearance is important, the necessity of prevention and treatment is increasingly needed.

Hair is a creature that regularly repeats the periodic changes of growth, regressor, and resting period. Each hair keeps a constant number of hair because each hair repeats generation and disappearance independently. Although the number of hairs is determined from birth, it is often mistaken for an increase in the number of steps of sexual maturation of hair due to sexual hormone effects after puberty. During the growing season, hair follicle activity and cell division are active and the hair grows for about 2-6 years, about 85% of total hair. In the growing stage, the mollusk cells are surrounded by the papillae, which are stromal cells, and have a circular shape, and the cell division is active for the generation of new hair. The regressive period is when the growth of the hair follicles stops and rapidly shrinks, and the shape of the hair is similar to that of the club. It takes about 2-3 weeks and about 5% of the total hair. The resting period is the period when the hair cell activity is completely extinguished. During the period of 2-3 months, the hair is naturally pulled out by the growing hair that grows from the base of the resting hair, or by mechanical action such as combing or winding the hair . In general, alopecia refers to an increase in the number of abnormal hair loss due to shortening of hair growth rate during the growing period and increased number of hair in the retrogressive or resting period during this period.

The cause of such hair loss, which falls from the scalp, is diverse and largely divided into male hormone action, mental stress, lipid peroxidation accumulation in the scalp, drug side effects, chronic diseases such as leukemia or tuberculosis, side effects due to radiation therapy, And deficiency. In recent years, hair loss, which has been known to be a male anxiety, is increasingly demanded for prevention and treatment of female hair loss and hair loss of a young person.

Currently, drugs used as hair growth and hair-dressing agents include vasodilators to circulate enough blood to the scalp, female hormones to inhibit the action of male hormones, 5α-tocopherol (5-DHT) There is a male hormone activity inhibitor that inhibits reductase. Examples of the vasodilators include caproium chloride, minoxidil, and various plant extracts. Examples of female hormones include estrogen, estradiol, and progesterone. Examples of male hormone activity inhibitors include pinasteride and pentadecanoic acid.

However, there is a need for more effective and safe hair loss treatment or development of drugs for hair growth due to insufficient effects or side effects. Minoxidil, administered topically or orally, is irritating to the skin such as scalp erythema, inflammation, infection, irritation or pain, and has a lowering effect on blood pressure. Therefore, patients with hypertension, including patients with hypotensive agents, And the like. In addition, finasteride has a disadvantage of impaired erectile dysfunction due to the inhibitory effect of male hormone activity, and a decrease in sexual desire.

The present inventors have found that a compound of the following formula 1, which is a specific derivative of phytosphingosine, which has been used as a moisturizer and acne remedy, has an effect equal to or higher than that of minoxidil in prevention, treatment or hair growth of hair loss, And that there is no adverse effect such as careful administration to the patient, and has been filed under a patent application (Patent Document 1).

[Chemical Formula 1]

Wherein R is hydrogen or -COR ¹ , wherein R ¹ is C ₁ -C ₆ alkyl, preferably R is hydrogen or C ₁ -C ₃ alkyl.

However, since these hair loss remedies do not show immediate effects on hair loss patients, the appearance complex due to hair loss can not be immediately resolved. Therefore, in recent years, a product called an instantaneous thickening agent (also referred to as "hair application agent" or "black dye") has become popular. Instantaneous boosting agent refers to a product group that covers the part where hair thinning or thinning becomes thin by using a technique similar to makeup to cover the part where the scalp is exposed, and currently powder type product called "Super Million Hair" of RUAN of Japan is imported and sold , And similar products are also being sold.

This powder type Super Million Hair of Japan RUAN Co., Ltd. is a powder form of rayon dyed powder. Due to the nature of the powder product, some of it is blown in the process of roughening the hair loss portion and sucked into the respiratory system of the user or its neighbor . Therefore, the user inevitably sucks in the artificial fiber powder in the course of using the instantaneous thickening agent in the form of rayon powder, and because of its frequent use due to the characteristics of the product, the possibility of causing harm to the human body It is very high. In addition, there is a disadvantage that such an instant warming-up agent of a powder type has to be fixed by using a hair spray in order to prevent the powder from being blown out due to the influence of wind after being sprayed on the unhairing portion.

In order to overcome the harmful possibility of rayon powder, a black dye composition using natural pulp has been developed (Patent Document 2). These black pulp compositions using natural pulp are characterized by containing natural pulp as a main component and containing charcoal, pine needles, rosin, and loess, and they are completely natural components and are harmless to the human body even if consumed by the user. However, since the composition is still in the form of powder, there is inconvenience in use.

In addition, these instantaneous thickening agents are sure to have a cosmetic effect, but they also prevent the hair from interrupting the respiration of the scalp by blocking hair follicles and hair follicles, which in turn may weaken the hair follicle and eventually lead to hair loss There is a problem.

1. Korean Patent Registration 1003532 2. Korean Patent Publication No. 2010-0036685

Accordingly, the inventors of the present invention have studied a composition that can be used safely and safely and has a natural increase effect as well as prolonged hair loss prevention, treatment, and hair growth effect as compared with the conventional instant warming- It was completed.

Accordingly, it is an object of the present invention to provide a cosmetic composition for a temporary depressant which is effective not only in the use of the instantaneous depressant, but also a safe and effective instantaneous depressing effect as well as prevention, treatment or hair growth in the long term .

Another object of the present invention is to provide a pharmaceutical composition for prevention, treatment, or hair growth, which is effective in prevention, treatment, or hair growth of hair loss, and which is easy to use and can exhibit safe and effective instantaneous hair growth.

In order to achieve the above object, one aspect of the present invention is

A liquid preparation containing a depilatory remedy; And

An activated carbon having a carboxyl group of not less than 0.25 mmol / g, a total pore size of not more than 50 angstroms, not more than 0.4 mL / g, an average particle size of 20 nm to 500 μm, and a surface area of 100 to 1,500 m ² / Including,

Wherein the weight ratio of the liquid preparation to the activated carbon is 1: 1 to 3: 1.

In another aspect of the present invention,

A liquid preparation containing a therapeutic agent for depilation; And

An activated carbon having a carboxyl group of not less than 0.25 mmol / g, a total pore size of not more than 50 angstroms, not more than 0.4 mL / g, an average particle size of 20 nm to 500 μm, and a surface area of 100 to 1,500 m ² / Including,

Wherein the ratio of the liquid preparation to the activated carbon is 1: 1 to 3: 1.

Hereinafter, the present invention will be described in more detail.

All technical terms used in the present invention are used in the sense that they are generally understood by those of ordinary skill in the relevant field of the present invention unless otherwise defined. In addition, preferred methods or samples are described in this specification, but similar or equivalent ones are also included in the scope of the present invention. The contents of all publications cited herein are hereby incorporated by reference in their entirety.

The present inventors have studied to develop a composition which can be used as an instant boosting agent but is effective not only for immediate boosting effect but also for treatment, prevention and hair loss of hair loss. In addition, the present inventors have studied an ideal composition which simultaneously solves the problems such as the inconvenience of use, the itching caused by the scalp stimulation, and the promotion of hair loss.

As a result, when activated carbon having a specific condition, which is a substance disclosed in Japanese Patent Registration No. 4650268, is used as a new material which has not been used at all as a conventional instant warming-up agent, a natural sudden increase effect is obtained without symptoms such as hair loss, scalp rash or itching . In addition, it has been found that when the activated carbon is administered in combination with a conventional hair loss treatment agent in a specific mass ratio, not only the above effect is obtained, but also long-term hair loss treatment, prevention and hair growth effect can be obtained by the hair loss treatment agent, The ideal moment was made to become a bonus.

Accordingly, the present invention provides, in one aspect,

A liquid preparation containing a depilatory remedy; And

An activated carbon having a carboxyl group of not less than 0.25 mmol / g, a total pore size of not more than 50 angstroms, not more than 0.4 mL / g, an average particle size of 20 nm to 500 μm, and a surface area of 100 to 1,500 m ² / Including,

Wherein the weight ratio of the liquid preparation to the activated carbon is 1: 1 to 3: 1.

In another aspect of the present invention,

A liquid preparation containing a depilatory remedy; And

An activated carbon having a carboxyl group of not less than 0.25 mmol / g, a total pore size of not more than 50 angstroms, not more than 0.4 mL / g, an average particle size of 20 nm to 500 μm, and a surface area of 100 to 1,500 m ² / Including,

Wherein the ratio of the liquid preparation to the activated carbon is 1: 1 to 3: 1.

Hereinafter, the cosmetic composition and the pharmaceutical composition are collectively referred to as "composition according to the present invention ".

As used herein, the term "hair loss treatment" means any compound that has been found to be effective in preventing, treating, or hair loss hair loss. Examples of the compound include chloramphenic chloride, minoxidil, estrogen, estradiol, progesterone, pinasteride, , Or a combination thereof, but are not limited thereto.

The depilatory remedy may preferably be a compound of the following formula 1 or a pharmaceutically acceptable salt thereof:

[Chemical Formula 1]

In Formula 1, R is hydrogen or -COR ¹ , wherein R ¹ is C ₁ -C ₆ alkyl.

The pharmaceutically acceptable salt may exist as an acid addition salt in which the compound of formula (I) forms a salt with a free acid. The compound of formula 1 may form pharmaceutically acceptable acid addition salts according to conventional methods known in the art. As the free acid, an organic acid or an inorganic acid can be used. As the inorganic acid, hydrochloric acid, bromic acid, sulfuric acid, phosphoric acid or the like can be used. As the organic acid, citric acid, acetic acid, lactic acid, tartaric acid Maleic acid, fumaric acid, formic acid, propionic acid, oxalic acid, trifluoroacetic acid, benzoic acid, gluconic acid, methanesulfonic acid, glycolic acid, succinic acid, 4-toluenesulfonic acid, galacturonic acid, Glutamic acid or aspartic acid can be used. The compounds of formula (I) according to the present invention may include pharmaceutically acceptable salts as well as solvates including all salts and hydrates which can be prepared by conventional methods.

The compound of Formula 1 may be prepared using conventional knowledge known in the art of organic chemistry, for example, S. Li, W. K. et al. Wilson, G.J. Schroepfer, Chemical synthesis of D-ribo-phytosphingosine-1-phosphate, a potential modulator of cellular processes. J. Lipid Res. 40: 117-125, 1999.

The compound of formula (1) has been proved effective in the treatment of hair loss, prevention, and hair growth. Experiments demonstrating this are described in Korean Patent Registration No. 1003532, which patent application is incorporated herein by reference in its entirety. Specifically, the compound of Formula 1 was subjected to a hair growth test using a balb / c mouse. As a result, the compound of the present invention showed a hair growth effect equal to or higher than that of 5% logine (minoxidil 5% solution, Johnson & Johnson) that is currently approved by the FDA as a hair loss therapeutic agent. In addition, for the compounds of the present invention, the neovascularization activity was measured by a chorioallantoic membrane (CAM) assay, and a phosphate buffer solution as a negative control, sphingosine-1-phosphate as a positive control and a neovascular inhibitor TMP (Trimethyl phytosphingosine). As a result, the compound of Formula 1 showed a remarkably excellent effect in promoting the generation of angiogenesis. Therefore, it is expected that the compound of formula (1) is effective for treatment of alopecia, prevention, and hair growth by promotion of angiogenesis.

The liquid preparation containing the hair loss therapeutic agent may further include nutritional ingredients or adjuvants which are useful for prevention, treatment, or hair growth of other hair loss. Other nutritional ingredients or adjuvants include, but are not limited to, biotin, genistein, centrum extract, mulberry extract, mulberry root extract, onion extract, pumpkin seed oil, emu oil, green tea extract, willow bark extract .

The liquid preparation may be a liquid, a liposome, an emulsion, or a nano emulsion, but is not limited thereto. It is preferable to formulate it as a liposome or a nano emulsion so as to promote the effect, preferably by increasing transdermal absorption. The formulations of the compositions may be prepared using pharmaceutically acceptable carriers, diluents, or additives suitable for the manufacture of each preparation known in the art of pharmacy.

The compound of formula (1) or a pharmaceutically acceptable salt thereof is excellent in the effect of treating hair loss, prevention or hair growth, and is easy to manufacture by simple synthesis due to its simple chemical structure, Can be easily delivered to the hair follicle when formulated with a lipid microparticle preparation such as an emulsion. In addition, compared to minoxidil and finasteride which are conventionally used as hair loss treatment agents, there is no skin irritation and there is no side effect and it is highly desirable.

The liquid preparation containing the hair loss treatment agent may contain the hair loss treatment agent in an amount of about 0.001 wt% to 5 wt%, preferably 0.05 wt% to 1 wt%, based on the total amount of the composition, . The liquid preparation containing the compound of Formula 1 or a pharmaceutically acceptable salt thereof may contain about 0.001% by weight to 5% by weight, preferably 0.05% by weight to 1% by weight, And can be increased or decreased depending on the kind of the compound of the formula (1).

The activated carbon contained in the composition according to the present invention has a carboxyl group content of 0.25 mmol / g or more, a total volume of pores having a pore diameter of 50 angstrom or less of 0.4 mL / g or less, an average particle diameter of 20 nm to 500 μm, Is 100 to 1,500 m ² / g, which is a substance disclosed in Japanese Patent No. 4650268. In terms of the use of the instant boosting agent, the average particle size of the activated carbon is preferably 500 nm - 200 μm, and the surface area of the activated carbon is preferably 80 nm - 1500 m ² / g. The material can be prepared by oxidizing activated carbon with agaric acid. By adjusting specific production conditions, the amount of carboxyl groups, pore volume, average particle size, surface area, etc. of the activated carbon can be controlled. Such a specific production method can be produced by a person skilled in the art using the technique described in Japanese Patent Registration No. 4650268 and a technique known in the art, and is commercially available (H-1-C , SIZE Tech, Japan).

The activated carbon may act as an instantaneous thickening agent, and when mixed with a conventional liquid formulation containing a compound of formula (1) in a weight ratio of 1: 1 to 1: 3, it exhibits a cream-like or an isomeric form of an isomeric form. Applying the composition in the form of a semi-solid formulation to the scalp to cover it may provide a natural instantaneous growth effect. The composition according to the present invention may be a form in which the liquid preparation containing the hair loss therapeutic agent is homogeneously mixed with the activated carbon, and the liquid preparation and the activated carbon are present in a state in which they are separated from each other.

The composition according to the present invention can be used not only as a hair loss treatment agent effective for hair loss treatment, prevention or hair growth but also as a cosmetic composition showing an instantaneous hair growth effect because it contains activated carbon which can act as an instantaneous hair growth agent, Or as a pharmaceutical composition effective for hair growth.

The activated carbon contains very small air holes, so there is no risk of clogging the pores, so there is no harmful effect on the scalp. Therefore, it is highly desirable to avoid the problem that hair powder, which had been conventionally instantaneous thickening agent, blocks hair root and hair follicles and hinders respiration and nutritional supply of scalp, thereby promoting hair loss.

In addition, since the activated carbon has a high adsorption effect, it absorbs excess sebum and adsorbs contaminants such as heavy metals, so that the scalp can be kept clean. In addition, the effect of blocking the scalp from ultraviolet rays can also be obtained by forming an ultraviolet shielding film on the activated carbon.

Therefore, by containing the activated carbon, the composition of the present invention can prevent hair loss due to the use of a hair increasing agent itself, and prevent alopecia due to sebum, heavy metals, ultraviolet rays, etc., in addition to an instantaneous hair growth effect. In addition, there is also an effect of stabilizing the scalp due to anions generated from activated carbon, and an effect of eliminating hair odor due to the adsorption of waste materials can also be obtained incidentally.

Further, in terms of the instantaneous increase effect, the activated carbon is not caused by an artificial dyeing, and since the particles of the activated carbon are very small, it is possible to exhibit a more natural instantaneous increase effect and the degree of black color is very high, The effect is excellent. In addition, since the activated carbon has a carboxyl group, it has an anion. Due to the existence of such anions, each of the activated carbon particles has a repulsive force with respect to each other, so that the activated carbon particles are dispersed without agglomeration, . Therefore, the composition according to the present invention can have a more natural and excellent instantaneous growth effect.

In addition, since the composition according to the present invention is not a natural powder type but a cream type, it can be easily applied only to a desired scalp area, and since there is no danger of blowing powder during use, there is no fear of inhalation, And there is no need to clean the surroundings.

The composition according to the present invention can be used in a proper amount to exhibit a desired instantaneous growth effect by applying to the hair loss site. When the composition is used in such an amount, the composition of the hair loss treatment agent, , Hair loss prevention, treatment, or hair growth effect can also be obtained at the same time.

As described above, the composition according to the present invention is useful as an active carbon which can exhibit an instantaneous growth effect; And the hair loss treatment agent, it is possible to obtain both instantaneous hair loss and hair loss prevention, treatment or hair growth effect.

Therefore, the cosmetic composition for an instant boosting agent according to the present invention is advantageous not only in the instantaneous growth effect but also in preventing hair loss, treating or hair growth effect at the same time.

The cosmetic composition for an instant boosting agent according to the present invention can reduce an appropriate amount of the cosmetic composition necessary for attaining the hair increasing effect, and a natural hair increasing effect can be obtained when the composition is applied to a desired site. The application method may be carried out by, for example, applying a small amount of the composition to the scalp and massaging the scalp, or may be performed by any method capable of uniformly applying the composition.

The pharmaceutical composition for prevention, treatment, or hair loss of hair loss according to the present invention can provide not only hair loss preventing effect, hair treatment effect, but also immediate hair growth effect, have.

As described above, the composition according to the present invention is useful as an active carbon which can exhibit an instantaneous growth effect; And the hair loss treatment agent, it is possible to obtain both instantaneous hair loss and hair loss prevention, treatment or hair growth effect. In addition, due to the inherent characteristics of the activated carbon used for the instant boosting effect, the composition according to the present invention can exhibit a very natural growth effect even in a small amount. In addition, since it is a cream type, it can be easily applied only to a desired scalp area, and there is no danger of flour spraying at the time of use. In addition, it is possible to avoid side effects of promoting hair loss due to blocking of the pore, which was a fatal side effect of the conventional instant boosting agent, and can be used as a safe instant boosting agent.

FIG. 1 is a picture of a crown of a head of a composition according to an embodiment of the present invention taken before and after application to a hair loss region and about 30 seconds after application. FIG.
FIG. 2 is a photograph of the crown of a patient showing the best effect before and after the application of the phytosphingosine-1-phosphate (PhS-1-P) liquid preparation for 3 weeks.
FIG. 3 is a photograph of the crown of a patient having the best effect before and after applying the composition according to an embodiment of the present invention for 3 weeks.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, these embodiments are provided to aid understanding of the present invention, and the scope of the present invention is not limited thereto in any sense.

Example 1: Production of activated carbon

According to the description of the embodiment of Japanese Patent Registration No. 4650268, graphite was subjected to oxidation treatment using agricultural chemicals to obtain a hydrophilic carbon material having the following characteristics.

Average particle size: 20 um

Surface area: 1,000 m ² / g

Total volume of small pores less than 50 angstroms: 0.52 mL / g

Amount of carboxyl group per 1 g: 0.26 mmol

Example 2-6: Liquid preparation of the compound of formula (1)

Phytosphingocosine-1-phosphate (PhS-1-P) and a solution of the following composition were prepared from the compound of formula (1).

Lecithin, tween 80, menthol, phytosphingosine-1-phosphate, and salicylic acid were dissolved in ethanol and transcutol (ethoxydiglycol), and then the extracts of Poloxamer, Centella asiatica, Green tea, Mulberry extract, Willow bark extract Dimethysulfone, niacinamide, panthenol, and glycerin were dissolved in water and slowly added to the ethanol solution. After vigorously stirring for 30 minutes, the PhS-1-P solution was prepared by ultrasonication for 30 minutes to 1 hour.

Composition (% by weight) Example 2 Example 3 Example 4 Example 5 Example 6 lecithin One 1.5 2 1.5 2 Twin 80 0.5 0.5 One 0.6 0.7 PhS-1-P 0.01 0.01 0.02 0.02 0.02 menthol 0.5 0.5 0.6 0.6 0.6 ethanol 20 20 20 20 20 Transcuttle 2 2 2 2 2 Pollock Sommer 0.5 0.5 One 0.6 0.6 Centipede extract 3 5 5 3 5 Green tea extract 2 3 5 3 3 Mulberry extract 2 2 5 3 3 Willow extract 2 2 5 0 0 Root Extract 2 2 5 3 3 Dimethysulfone 3 3 3 3 3 Panthenol One One One One One Niacinamide 0.5 0.5 0.6 0.6 0.6 glycerin 5 5 5 0 0 Salicylic acid 0 0 0 0.5 0.5 Distilled water 54.99 51.49 38.78 57.58 54.98

Example  7: The moment Increase  Manufacture of cream

The liquid preparation prepared in Example 2-6 and the activated carbon prepared in Example 1 were mixed in proper weight ratios (3: 1, 2.5: 1, 2: 1, 1.5: 1, 1: 1) Cream.

Among them, the cream prepared by mixing the liquid preparation of Example 3 and activated carbon at a ratio of 2: 1 was used for clinical use.

Test Example 1: Instantaneous Increase of Instantaneous Increase Cream

A creamy preparation (preparation of Example 7) in which the liquid preparation of Example 3 and activated carbon was mixed at 2: 1 was applied to a minute amount of fingertips, the cover was evenly applied to a desired depilation area, and the cream was rubbed with a fingertip to spread evenly. Photographs were taken about 30 seconds before and after application of the cream formulations. The photograph is shown in Fig.

According to FIG. 1, it can be seen clearly that the hair loss site is covered very naturally after application, compared to before application of the cream phase preparation.

Test Example 2: Comparative Test (1)

Ten adult male subjects with hair loss symptoms were treated with a powder type product called "Super Million Hair" manufactured by Japan RUAN, which was previously commercially available, and a cream phase After applying a small amount of about 0.5-1 g of the preparation (Example 7) to the scalp and applying it to the scalp as a massage, the hair was applied once a day for three weeks. Then, And scalp itching. The answers to the questionnaires were conducted according to the 5 - point method and the average value was expressed as a result.

The criteria for the 5-point method are as follows.

5: Very good. 4: Good. 3: Usually. 2: Poor. 1: Very bad.

The results are shown in Table 2 below.

division Super Miller Hair ^TM The formulation of Example 7 Augmentation effect 5 5 Natural feeling 4 5 Hair loss phenomenon (scalp damage) 2 5 Scalp rash 2 4 Scalp itching 2 5

Test Example  3: Comparative test (2)

(10 mg / kg) of the liquid preparation of Example 3 and the liquid preparation and the activated carbon of Example 3 in a 2: 1 ratio (the preparation of Example 7) After applying a small amount of 0.5-1 g to the scalp as if applying massage to the scalp, it was applied once a day for 3 weeks. Then, a questionnaire was conducted on the effects of augmentation, natural feeling, hair loss, scalp rash and scalp itching. The answers to the questionnaires were conducted according to the 5 - point method and the average value was expressed as a result.

The criteria for the 5-point method are as follows.

5: Very good. 4: Good. 3: Usually. 2: Poor. 1: Very bad.

The results are shown in Table 3 below.

division The liquid agent of Example 3 The formulation of Example 7 Augmentation effect 2 5 Hair growth effect 4 5 Hair loss phenomenon (scalp damage) 5 5 Scalp rash 4 4 Scalp itching 5 5

Photographs before and 3 weeks after application of the most effective one in each group are shown in Fig. 2 (liquid preparation of Example 3) and 3 (formulation of Example 7).

As can be seen from the above experimental results, the composition according to the present invention is superior to the instantaneous hair growth enhancer in that it has an instantaneous increase in hair growth effect, exhibits a natural increase in hair growth effect, and disappears such as hair loss, scalp rash, and itchy scalp, , It was found that the effect of treating hair loss was remarkably increased due to the addition of activated carbon as compared with a substance known as a conventional hair loss treatment agent alone.

Therefore, the composition according to the present invention can be used not only as a cosmetic composition for the purpose of instantaneous growth, but also as a medicament for preventing and treating hair loss more effectively.

Claims (9)

A liquid preparation containing a depilatory remedy; And
An activated carbon having a carboxyl group of not less than 0.25 mmol / g, a total pore size of not more than 50 angstroms, not more than 0.4 mL / g, an average particle size of 20 nm to 500 μm, and a surface area of 100 to 1,500 m ² / Including,
Wherein the weight ratio of the liquid preparation to activated carbon is 1: 1 to 3: 1. A liquid preparation containing a therapeutic agent for depilation; And
An activated carbon having a carboxyl group of not less than 0.25 mmol / g, a total pore size of not more than 50 angstroms, not more than 0.4 mL / g, an average particle size of 20 nm to 500 μm, and a surface area of 100 to 1,500 m ² / Including,
Wherein the ratio of the liquid preparation to the activated carbon is 1: 1 to 3: 1. 3. The composition according to claim 1 or 2, wherein the depilatory remedy is a compound represented by the following formula (1) or a pharmaceutically acceptable salt thereof:
[Chemical Formula 1]

In Formula 1, R is hydrogen or -COR ¹ , wherein R ¹ is C ₁ -C ₆ alkyl. The composition according to claim 1 or 2, wherein the hair loss therapeutic agent is a combination of chloramphenic chloride, minoxidil, estrogen, estradiol, progesterone, pinasteride, pentadecanoic acid, or a combination thereof. 3. The composition according to claim 1 or 2, wherein the activated carbon has an average particle diameter of 500 nm to 200 m. The composition according to claim 1 or 2, wherein the activated carbon has a surface area of 800 - 1500 m ² / g. The composition of claim 1 or 2, wherein the liquid formulation is a liquid, a liposome, an emulsion, or a nanoemulsion. 3. The composition according to claim 1 or 2, wherein the liquid preparation and the activated carbon are homogeneously mixed. The composition according to claim 1 or 2, wherein the liquid preparation and the activated carbon are separately present and mixed in use.

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