JP2001206836A - Skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To find an ingredient having an excellent skin-beautifying effect compared to a conventional skin-beautifying agent and provide a skin preparation for external use including this. SOLUTION: This skin preparation for external use is formulated with a seed oil of Actinidia chinensis Planch., as the skin-beautifying ingredient and the skin preparation for external use including the seed oil of Actinidia chinensis Planch., and a medicinal agent selected from a skin-beautifying agent, antioxidant, antiinflammatory agent and UV ray protective ingredient.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin containing seed oil of kiwifruit, and more particularly, to the occurrence of pigmentation by containing oil obtained by pressing kiwifruit seeds. The present invention relates to an external preparation for skin having an excellent whitening effect on the skin, for example, by preventing skin whitening.

[0002]

2. Description of the Related Art Conventionally, medicinal components have been used in skin external preparations such as emulsions, creams, lotions, packs, detergents, dispersions, ointments, and external preparations for the purpose of imparting a predetermined medicinal effect to them. Have been added. For example, whitening agents such as ascorbic acid, glutathione, and hydroquinone have been added to prevent phenomena such as darkening of the skin caused by sunburn, pigmentation, and spots and freckles caused by pigmentation.

[0003]

However, these whitening agents often have an insufficient whitening effect, or do not have the desired medicinal effect due to, for example, deterioration in the preparation. It has been desired to find a component having a whitening effect and to provide a skin external preparation containing the same.

[0004]

DISCLOSURE OF THE INVENTION The present inventors have conducted a wide search for natural ingredients that have an excellent whitening effect and can be used as medicinal ingredients in external preparations for skin, and as a result, kiwifruit (Actinidia chinensis Planch.) It was found that the seed oil had excellent melanin production inhibitory action. The present inventors have found that this seed oil can be blended with a skin external preparation as a whitening ingredient, and further excellent effects can be obtained as an external preparation by combining it with other medicinal ingredients, thereby completing the present invention.

That is, the present invention provides an external preparation for skin containing kiwifruit seed oil as a whitening component.

Further, the present invention relates to the following components (A) and (B): (A) kiwifruit seed oil; (B) a kind of medicinal agent selected from the group consisting of a whitening agent, an antioxidant, an anti-inflammatory agent, and a UV inhibitor. It is intended to provide an external preparation for skin containing two or more kinds.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, kiwifruit (Actinidia chinensis P.
lanch.) is a plant belonging to the genus Actinidiaceae, the genus Actinidiaceae, and there are no particular restrictions on the place of production and variety thereof. The kiwifruit seeds contain the essential fatty acids linoleic acid and linolenic acid,
It is also called.

[0008] Kiwifruit seed oil is obtained by pressing or solvent-extracting the seeds of the above-mentioned plants. There is no particular limitation on the method for preparing this seed oil,
In the case of preparation by squeezing, for example, after seeds are squeezed according to a conventional method to obtain seed oil, operations such as phosphoric acid treatment, alkali neutralization treatment, water washing treatment, decolorization / dehydration treatment to remove impurities as necessary are performed. Just do it. In the case of solvent extraction, it may be heated and extracted by appropriately using various solvents such as hexane, acetone, ethyl acetate, and ether, and then the solvent may be distilled off under reduced pressure. As a commercially available product, for example, a kiwifruit seed oil of Nikko Chemicals Co., Ltd. may be used.

In the external preparation for skin of the present invention, the content of the above-mentioned seed oil as a whitening component in the total composition is 0.001.
To about 100% by mass (hereinafter simply referred to as "%"), preferably about 0.01 to 50%.

The seed oil for kiwifruit of the present invention is used as an active ingredient, and is blended with various forms of bases used for ordinary skin external preparations according to a conventional method, and is formulated to prepare a skin external preparation. Although it can be obtained, by further combining it with other medicinal ingredients, a more effective skin external preparation can be obtained.

In the present invention, other medicinal components (component (B)) used in combination with kiwifruit seed oil (component (A)) include a whitening agent, an antioxidant, an anti-inflammatory agent, and a UV inhibitor. And specific examples of the medicinal agent include those shown below.

(Whitening agent) As a whitening agent, vitamin C and its derivatives and salts thereof, placenta extract, licorice extract, yokuinin extract, asparagus extract, oedum extract, raspberry extract, jinjin extract Stuff, calyx extract, kokahi extract, coffee extract, rice bran extract, wheat germ extract, saishin extract, hawthorn extract, white lily extract, peony extract, soy extract, green tea, black tea, oolong tea, etc. Tea extract, molasses extract, juniper extract, beech bud extract, grape extract, hop extract, squid extract, mocca extract,
An extract of Arhat fruit, an extract of Japanese gourd, an extract of seaweed, and the like can be given. Among these whitening agents, particularly preferable ones include vitamin C and its derivatives, salts thereof, and placental extracts.

(Antioxidants) Examples of antioxidants include mannitol, astaxanthin, rutin and its derivatives, quercetin, phospholipids, retinol and its derivatives (retinol palmitate, retinol acetate, etc.), retinal and its derivatives, dehydroretinal , Beta carotene and other carotenoids such as vitamin A, pyridoxine (pyridoxine hydrochloride, pyridoxine dioctanoate, etc.), nicotinic acids (nicotinamide, benzyl nicotinate, etc.), dibutylhydroxytoluene (BH
T), butylhydroxyanisole (BHA), vitamin E and its derivatives and their salts, carrot extract, melissa extract, yasazitsu extract and the like. Among these antioxidants, particularly preferable ones include vitamin E and its derivatives and salts thereof.

(Anti-inflammatory agent) Anti-inflammatory agents include chondroitin sulfate and its derivatives, allantoin, arnica extract, hypericum extract, oak extract, goldfish extract, watercress extract, comfrey extract, salvia extract , Sikon extract, Birch extract, Calendula extract, Elderberry extract, Asparagus extract, Mukuroji extract, Eucalyptus extract, Astragalus extract, Glycyrrhizic acid, Glycyrrhetinic acid and their derivatives and their salts, Aloe extract , Perilla extract, mugwort extract, chamomile extract and the like. Among these anti-inflammatory agents, particularly preferable ones include glycyrrhizic acid, glycyrrhetinic acid and their derivatives and salts thereof.

(Ultraviolet inhibitor) As the ultraviolet inhibitor, 2-hydroxy-4-methoxybenzophenone-5
-Sodium sulfonate, paramethoxycinnamic acid-2-
Ethylhexyl, oxybenzone, 4-tert-butyl-4′-methoxydibenzoylmethane, titanium oxide,
Fine particle titanium oxide, zinc oxide and the like. Of these UV inhibitors, particularly preferred are 2-ethylhexyl paramethoxycinnamate, titanium oxide,
Fine particle titanium oxide, zinc oxide and the like.

The compounding amount of the above-mentioned (B) component in the external preparation for skin of the present invention varies depending on the kind of the drug, but is preferably in the following range. Within this range, when combined with the kiwifruit seed oil of the component (A), it does not affect the stability over time of the formulation and the kiwifruit seed oil of the component (A) in the formulation, and provides higher whitening, A beautiful skin effect can be exhibited.

That is, the compounding amount of the whitening agent as the component (B) of the external preparation for skin of the present invention is preferably 0.000001.
-5%, more preferably in the range of 0.001-3%. Within this range, a skin external preparation exhibiting a more excellent whitening effect and having a good feeling upon use can be obtained.

The compounding amount of the antioxidant which is the component (B) of the external preparation for skin of the present invention is preferably 0.0001 to 0.0001.
5%, more preferably in the range of 0.001 to 3%. There is no problem in this range. Within this range, a more excellent antioxidant effect can be obtained, and a skin external preparation exhibiting an excellent whitening effect can be obtained.

Further, the compounding amount of the anti-inflammatory agent as the component (B) of the external preparation for skin of the present invention is 0.000001 to 5%.
Is preferably in the range of 0.001 to 3%.
Range. Within this range, an external preparation for skin which exhibits an excellent anti-inflammatory effect and an excellent whitening effect can be obtained.

Further, the compounding amount of the ultraviolet ray inhibitor as the component (B) of the external preparation for skin of the present invention is preferably 0.0001 to 20%, more preferably 0.001 to 10%.
% Range. Within this range, a skin external preparation that exhibits a more excellent ultraviolet ray preventing effect and also has an excellent whitening effect can be obtained.

These whitening agents, antioxidants, anti-inflammatory agents, and ultraviolet inhibitors can be used alone or in combination of two or more.

The external preparation for skin combining the above components (A) and (B) is also an essential component (A) according to a conventional method.
It can be prepared by mixing the component and the component (B) with various types of bases commonly used in external preparations for the skin and formulating them.

Examples of the form of formulation of the external preparation for skin of the present invention are not particularly limited. For example, cosmetics such as emulsions, creams, lotions, packs, detergents, makeup cosmetics, dispersions, ointments and the like, It can be a drug or the like.

Further, in the external preparation for skin of the present invention, depending on the form, in addition to the above essential components, components usually used for external preparation for skin such as cosmetics and pharmaceuticals, for example, purified water, lower alcohol, polyhydric alcohol, Oily components, powders, surfactants, thickeners, coloring materials, preservatives, humectants, fragrances and the like can be used.

[0025]

EXAMPLES Next, the present invention will be described in more detail with reference to Reference Examples, Test Examples and Examples, but the present invention is not limited thereto.

Reference Example 1 Production of Kiwifruit Seed Oil: Kiwifruit (Actinid
ia chinensis Planch.)
This was squeezed to obtain an oil and fat, and then neutralized to further separate impurities. After removing the treating agent, it was decolorized and deodorized to obtain a kiwifruit seed oil.

Reference Example 2 Production of yoquinin extract: 10 g of yoquinin (JP)
And ethyl alcohol 10 having a water content of 70% (v / v)
After 0 mL was added, extraction was performed at room temperature for 3 days, followed by filtration to obtain a yoquinin extract. At this time, the dry solid content of the yokunin extract was 0.8%.

Test Example 1 Inhibition of melanin production and cell viability test by cell culture:
Mouse-derived B16 melanoma cultured cells were used as test cells. M containing 10% FBS in two 6-hole petri dishes
Take an appropriate amount of EM medium, inoculate B16 melanoma cells,
The mixture was allowed to stand at 37 ° C. in a carbon dioxide concentration of 5%. On the next day, a liquid prepared by adjusting the final concentration of the kiwifruit seed oil obtained in Reference Example 1 to 0 (control), 50, 500, and 5000 μg / mL in the medium was added and mixed. On day 5 of the culture, the medium was changed, and the same solution as the first solution was added again. On the next day, remove the medium, and for one petri dish,
The cells were collected after washing with a phosphate buffer, and the whitening degree of the cultured B16 melanoma cells was evaluated according to the following criteria.
Further, as a comparative example, a similar test was performed on a yokunin extract which is already known to have a melanin production inhibitory action.

(Criteria for determining whitening degree) <Judgment> <Contents> ++: extremely white with respect to the control. +: Clearly white with respect to the control. ±: slightly white with respect to the control. -: The same black color as the control.

For the remaining one petri dish, the cells were fixed in formalin and added to a 1% crystal violet solution for staining. The viable cell ratio for each sample concentration was measured with a monocerator (Olympus). Table 1 shows the above results.

(Result)

[Table 1]

As is clear from the results in Table 1, it was confirmed that the kiwifruit seed oil had a high ability to inhibit the production of melanin and had low toxicity to cultured B16 melanoma cells. Therefore, by applying to the skin the external preparation for skin of the present invention in which this seed oil is blended as a whitening component, it exerts an extremely excellent melanin production inhibitory effect, and effectively inhibits skin blackening due to sunburn, spots, freckles, etc. To suppress.

Example 1 Cream: A cream was prepared by the composition shown in Table 2 and by the following method, and the whitening effect of the kiwifruit seed oil was examined. Table 2 shows the results.

(Composition and Results)

[Table 2]

(Production method) A. Components (1) to (7), (10), (12) and (13)
And heat to keep at 70 ° C. B. Heat a portion of component (15) to 70 ° C. C. B was added to A, (9) and (11) dissolved in the remainder of (8), (14) and (15) were mixed, and then cooled to obtain a cream.

(Test method) 2 per test cream
A panel consisting of 15 women aged 7-54 years
After washing the face for 12 weeks, an appropriate amount of the test cream was applied to the face. The whitening effect of the coating was evaluated according to the following criteria.

(Evaluation Criteria) <Evaluation> <Contents> Effective: The dullness of the skin became less noticeable. Slightly effective: Skin dullness became less noticeable. Ineffective: No change from before use.

As shown in the results in Table 2, it has been clarified that the external preparation using kiwifruit seed oil can prevent and improve the appearance of "dullness" on the skin, thereby obtaining beautiful skin.

Example 2 Cosmetic lotion: A lotion was prepared according to the following formulation and production method. (Preparation) (%) (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene (20EO) 1.2 Sorbitan monolaurate (4) Ethyl alcohol 8.0 (5) Kiwifruit seed oil ^{* 1} 1.0 (6) Preservative appropriate amount (7) Flavor appropriate amount (8) Purified water residue * 1 Produced in Reference Example 1

(Production method) A. Components (3) to (7) are mixed and dissolved. B. Mix and dissolve components (1), (2) and (8). C. A and B were mixed and made uniform to obtain a lotion.

Example 3 Emulsion: An emulsion was prepared according to the following formulation and production method. (Preparation) (%) (1) Polyoxyethylene (10EO) 1.0 Sorbitan monostearate (2) Polyoxyethylene (60EO) 0.5 Sorbit tetraoleate (3) Glyceryl mono Stearate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 1.0 (7) Kiwi fruit seed oil ^{* 1} 20.0 (8) Placenta extract ^{* 2} 5.0 (9) Preservative 0.1 (10) Carboxyvinyl polymer 10.0 (1% aqueous solution) (11) Sodium hydroxide 0.05 (12) Ethyl alcohol 5.0 (13) Remaining purified water (14) Fragrance Material * 1 Manufactured in Reference Example 1 * 2 Nichirei Co., Ltd.

(Preparation method) A. Components (11) to (13) are mixed by heating and maintained at 70 ° C. B. Components (1) to (7) and (9) are mixed by heating and heated to 70 ° C.
To keep. C. Add A to B, mix and emulsify uniformly. After cooling D.C, (8), (10) and (14) were added and mixed uniformly to obtain an emulsion.

The lotion of Example 2 and the emulsion of Example 3
All were excellent in stability over time, and when applied to the skin, prevented "dullness", spots and freckles of the skin due to sunburn, and made the skin beautiful and transparent.

Example 4 Ointment: An ointment was prepared according to the following formulation and production method. (Presence) (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) Kiwi fruit seed oil ^{* 1} 5.0 (6) dipotassium glycyrrhizinate ^{* 2} 0.5 (7) dl-α-tocopherol acetate ^{* 3} 0.2 (8) residual amount of purified water * 1 manufactured in Reference Example 1 * 2 manufactured by Maruzen Pharmaceutical Co. * 3 Eisai Company

(Preparation Method) A. A part of the components (3), (4) and (8) is mixed by heating and kept at 75 ° C. B. Heat mix components (1), (2), (5) and (7) and keep at 75 ° C. C. Add A slowly to B. While cooling D.C, (6) dissolved in the remainder of (8) was added to obtain an ointment.

The ointment of Example 4 was excellent in stability over time and, when applied to the skin, prevented the skin from "dullness", spots and freckles, and gave a clear and beautiful skin.

Example 5 Pack: A pack was prepared according to the following formulation and manufacturing method. (Preparation) (%) (1) Polyvinyl alcohol 20.0 (2) Ethyl alcohol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) Kiwi fruit seed oil ^{* 1} 1.0 ( 6) Magnesium phosphate L-ascorbyl ^{* 2} 1.0 (7) Preservatives 0.2 (8) Fragrance 0.1 (9) Residual water balance * 1 Manufactured in Reference Example 1 * 2 Nikko Chemicals Company

(Production method) A. Components (1), (3), (4) and (9) are mixed,
Heat to 70 ° C. and stir. B. Mix components (2), (5) and (7). C. The above B was added to the above A, mixed, cooled, and (6) and (8) were uniformly dispersed to obtain a pack.

The pack of Example 5 was excellent in stability over time, and was applied to the skin to prevent dullness and spots on the skin, and to make the skin transparent and beautiful.

Example 6 Liquid foundation: A liquid foundation was prepared according to the following formulation and production method. (Preparation) (%) (1) Lanolin 7.0 (2) Liquid paraffin 5.0 (3) Stearic acid 2.0 (4) Cetanol 1.0 (5) Paramethoxycinnamic acid 3.0-2 -Ethylhexyl ^{* 1} (6) Glycerin 5.0 (7) Triethanolamine 1.0 (8) Carboxymethylcellulose 0.7 (9) Remaining purified water (10) Titanium oxide 8.0 (11) Fine particle titanium oxide 2 (12) Zinc oxide 5.0 (13) Mica 15.0 (14) Talc 6.0 (15) Color pigment 6.0 (16) Kiwifruit seed oil ^{* 2} 0.01 (17) Yoquinin extract ^{* 3} 0.5 (18) Suitable amount of fragrance * 1 BASF * 2 Manufactured in Reference Example 1 * 3 Manufactured in Reference Example 2

(Production method) A. Components (1) to (5) and (16) are mixed and dissolved. B. Add components (10) to (15) to A, mix uniformly, and keep at 70 ° C. C. Components (6) to (9) are uniformly dissolved and kept at 70 ° C. D. Add C to B and emulsify uniformly. After cooling E.D, components (17) and (18) were added to obtain a liquid foundation.

The liquid foundation of Example 6 was excellent in stability over time and, when applied to the skin, prevented blackening of the skin due to sunburn, spots and freckles.

[0053]

As described above, the external preparation for skin of the present invention comprises:
Because it contains a kiwifruit seed oil that has a whitening effect such as a melanin production inhibitory effect, it exerts a high inhibitory effect on pigmentation, dull skin, darkening of the skin due to sunburn, stains, freckles It is effective for prevention and improvement.

Also, together with the kiwifruit seed oil,
The external preparation of the present invention containing other medicinal ingredients such as a whitening agent, an antioxidant, an anti-inflammatory agent, and an ultraviolet ray inhibitor shows a more excellent whitening effect than the case where the above-mentioned seed oil is used alone. . that's all

────────────────────────────────────────────────── ───

[Procedure amendment]

[Submission date] September 27, 2000 (2009.2)
7)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Claim 6

[Correction method] Change

[Correction contents]

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 M NU 7/021 7/021 35/78 35/78 CW A61P 17 / 16 A61P 17/16 (72) Inventor Taku Hoshino 48-18 Sakaemachi, Kita-ku, Tokyo Inside the Kose Research Center (72) Inventor Osamu Sakata 48-18 Sakaemachi, Kita-ku, Tokyo Kose Research In the headquarters (72) Inventor Hiroaki Tamura 1-4-8, Nihonbashi Bakurocho, Chuo-ku, Tokyo Nikko Chemicals Co., Ltd. F-term (reference) AC131 AC211 AC242 AC341 AC342 AC422 AC442 AC471 AC542 AC681 AC791 AC851 AD092 AD112 AD272 AD341 AD391 AD512 AD531 AD532 AD571 AD611 AD612 AD621 AD631 AD641 AD642 AD661 AD 662 BB46 BB47 BB51 CC02 CC04 CC05 CC07 CC12 CC19 DD23 DD27 DD31 DD41 EE06 EE07 EE16 FF01 FF05 4C088 AB12 AB14 AB15 AB16 AB19 AB25 AB26 AB29 AB32 AB34 AB38 AB40 AB45 AB51 AB53 AB56 AB57 AB59 AB60 AB61 AB62 AB71 AB74 AC BA18 CA06 CA09 MA03 MA05 MA08 MA17 MA28 MA63 NA05 NA14 ZA89 ZC20

Claims (6)

[Claims] 1. The kiwi fruit (Actinidia chinensis P)
lanch.) An external preparation for skin, comprising seed oil as a whitening ingredient. 2. The following components (A) and (B): (A) Kiwi fruit (Actinidia chinensis Planch.)
Seed oil (B) An external preparation for the skin, characterized by containing one or more kinds of medicinal agents selected from a whitening agent, an antioxidant, an anti-inflammatory agent and an ultraviolet inhibitor. 3. The whitening agent of the component (B) is vitamin C or a derivative thereof or a salt thereof, a placenta extract, a licorice extract, a yoquinin extract, an asparagus extract, an Eigetsu extract, a raspberry extract, and kujin Extracts, citrus extract, kokahi extract, coffee extract, rice bran extract, wheat germ extract, saicin extract, hawthorn extract, white lily extract, peony extract, soy extract,
Extracts of green tea, black tea, oolong tea, etc., molasses extract, juniper extract, beech bud extract, grape extract, hop extract, maikaika extract, mocca extract, arhat extract, gongon extract and seaweed extract 3. The external preparation for skin according to claim 2, wherein the external preparation is selected from the group consisting of: 4. The antioxidant of the component (B) is mannitol, astaxanthin, rutin or a derivative thereof, quercetin, phospholipid, retinol or a derivative thereof (retinol palmitate, retinol acetate, etc.), retinal or a derivative thereof, dehydroretinal Vitamin A such as carotenoids such as beta-carotene, pyridoxine (pyridoxine hydrochloride, pyridoxine dioctanoate, etc.), nicotinic acids (nicotinamide, benzyl nicotinate, etc.), dibutylhydroxytoluene (BHT),
Butylhydroxyanisole (BHA), vitamin E or a derivative thereof or a salt thereof, a carrot extract,
3. The external preparation for skin according to claim 2, which is selected from Melissa extract and Jasagetsu extract. 5. The anti-inflammatory agent of the component (B) is chondroitin sulfate or a derivative thereof, allantoin, arnica extract, hypericum extract, oak extract, goldfish extract, watercress extract, comfrey extract, salvia extract , Siconium extract, birch extract, calendula extract, elderberry extract, asparagus extract, mud mushroom extract, eucalyptus extract, astragalus extract, glycyrrhizic acid, glycyrrhetinic acid or a derivative or salt thereof, aloe The external preparation for skin according to claim 2, which is selected from an extract, a perilla extract, a mugwort extract, and a chamomile extract. 6. The component (B), wherein the ultraviolet ray preventing agent is sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 2-ethylhexyl paramethoxycinnamate, oxybenzone, 4-tert-butyl-4-acid. The skin external preparation according to claim 2, which is selected from methoxydibenzoylmethane, titanium oxide, fine particle titanium oxide, and zinc oxide.