JP2000514789A5 - - Google Patents
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- Publication number
- JP2000514789A5 JP2000514789A5 JP1998503446A JP50344698A JP2000514789A5 JP 2000514789 A5 JP2000514789 A5 JP 2000514789A5 JP 1998503446 A JP1998503446 A JP 1998503446A JP 50344698 A JP50344698 A JP 50344698A JP 2000514789 A5 JP2000514789 A5 JP 2000514789A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2065596P | 1996-06-27 | 1996-06-27 | |
| US60/020,655 | 1996-06-27 | ||
| PCT/US1997/010900 WO1997049286A1 (en) | 1996-06-27 | 1997-06-24 | Il-8 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000514789A JP2000514789A (ja) | 2000-11-07 |
| JP2000514789A5 true JP2000514789A5 (enExample) | 2005-02-10 |
Family
ID=21799843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10503446A Ceased JP2000514789A (ja) | 1996-06-27 | 1997-06-24 | Ｉｌ―８受容体拮抗薬 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6271261B1 (enExample) |
| EP (1) | EP0915651A4 (enExample) |
| JP (1) | JP2000514789A (enExample) |
| KR (1) | KR20000022273A (enExample) |
| AU (1) | AU3499497A (enExample) |
| BR (1) | BR9709938A (enExample) |
| CO (1) | CO4890843A1 (enExample) |
| CZ (1) | CZ425698A3 (enExample) |
| HU (1) | HUP9903922A3 (enExample) |
| IL (1) | IL127667A0 (enExample) |
| NO (1) | NO986109L (enExample) |
| PL (1) | PL330849A1 (enExample) |
| TR (1) | TR199802695T2 (enExample) |
| WO (1) | WO1997049286A1 (enExample) |
| ZA (1) | ZA975671B (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0932405A4 (en) | 1996-06-27 | 2001-10-17 | Smithkline Beckman Corp | IL-8 RECEPTOR ANTAGONISTS |
| AU8673198A (en) * | 1997-07-29 | 1999-02-22 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
| US7329670B1 (en) | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
| US20080300281A1 (en) * | 1997-12-22 | 2008-12-04 | Jacques Dumas | Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas |
| WO1999036069A1 (en) * | 1998-01-16 | 1999-07-22 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| UY25842A1 (es) * | 1998-12-16 | 2001-04-30 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
| US20080269265A1 (en) * | 1998-12-22 | 2008-10-30 | Scott Miller | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas |
| CA2359244C (en) | 1999-01-13 | 2013-10-08 | Bayer Healthcare Llc | .omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| US7351834B1 (en) * | 1999-01-13 | 2008-04-01 | Bayer Pharmaceuticals Corporation | ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| EP1140840B1 (en) | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| JP2003527360A (ja) * | 2000-03-14 | 2003-09-16 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−８受容体アンタゴニスト |
| US6767922B2 (en) | 2000-03-14 | 2004-07-27 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| AR030689A1 (es) * | 2000-03-14 | 2003-09-03 | Smithkline Beecham Corp | Compuestos de 3-aminosulfonil-2-hidroxifenil urea, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la manufactura de medicamentos para tratar enfermedades mediadas por quimioquinas |
| US7235576B1 (en) | 2001-01-12 | 2007-06-26 | Bayer Pharmaceuticals Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| RU2344123C9 (ru) * | 2001-04-16 | 2009-05-20 | Шеринг Корпорейшн | 3,4-дизамещенные циклобутен-1,2-дионы как лиганды схс-хемокинового рецептора |
| US7371763B2 (en) * | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
| AU2002351196A1 (en) * | 2001-12-03 | 2003-06-17 | Bayer Pharmaceuticals Corporation | Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers |
| EP2324825A1 (en) | 2002-02-11 | 2011-05-25 | Bayer Healthcare LLC | Aryl ureas with angiogenesis inhibiting activity |
| SI1580188T1 (sl) * | 2002-02-11 | 2012-02-29 | Bayer Healthcare Llc | Aril sečnine kot kinazni inhibitorji |
| US20030216396A1 (en) | 2002-02-11 | 2003-11-20 | Bayer Corporation | Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors |
| WO2003068223A1 (en) * | 2002-02-11 | 2003-08-21 | Bayer Corporation | Aryl ureas with raf kinase and angiogenesis inhibiting activity |
| AR041834A1 (es) * | 2002-10-29 | 2005-06-01 | Smithkline Beecham Corp | Compuesto de difenilurea sustituido con sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion |
| WO2004058722A1 (en) * | 2002-12-24 | 2004-07-15 | Arena Pharmaceuticals, Inc. | Diarylamine and arylheteroarylamine pyrazole derivatives as modulators of 5ht2a |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| DE602004007382T2 (de) | 2003-05-20 | 2008-04-17 | Bayer Pharmaceuticals Corp., West Haven | Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten |
| EP1558582B1 (en) | 2003-07-22 | 2005-12-21 | Arena Pharmaceuticals, Inc. | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
| DK1663978T3 (da) | 2003-07-23 | 2008-04-07 | Bayer Pharmaceuticals Corp | Fluorsubstitueret omega-carboxyaryl-diphenylurinstof til behandling og forebyggelse af sygdomme og lidelser |
| CN1926114B (zh) * | 2004-03-23 | 2011-08-24 | 艾尼纳制药公司 | 用于制备经取代n-芳基-n′-′3-(1h-吡唑-5-基)苯基脲及其中间体的方法 |
| JP2007535565A (ja) * | 2004-04-30 | 2007-12-06 | バイエル ファーマシューティカルス コーポレーション | 癌の治療に有用な置換ピラゾリル尿素誘導体 |
| WO2005113534A2 (en) | 2004-05-12 | 2005-12-01 | Schering Corporation | Cxcr1 and cxcr2 chemokine antagonists |
| WO2006043950A1 (en) * | 2004-10-20 | 2006-04-27 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| PE20061130A1 (es) | 2004-11-19 | 2007-01-05 | Arena Pharm Inc | Derivados de 3-fenil-pirazol como moduladores del receptor de serotonina 5-ht2a |
| WO2006060762A2 (en) * | 2004-12-03 | 2006-06-08 | Arena Pharmaceuticals, Inc. | Pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| CN101160127A (zh) * | 2005-01-19 | 2008-04-09 | 艾尼纳制药公司 | 用于预防或治疗进行性多灶性白质脑病而作为5-ht2a血清素受体调节剂的二芳基和芳基杂芳基脲衍生物 |
| CA2600008A1 (en) * | 2005-02-22 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Improved process for the synthesis of enantiomeric indanylamine derivatives |
| US8097626B2 (en) | 2006-04-21 | 2012-01-17 | Glaxosmithkline Llc | IL-8 receptor antagonists |
| AU2007240365B2 (en) * | 2006-04-21 | 2011-12-15 | Glaxosmithkline Llc | IL-8 receptor antagonists |
| USRE45336E1 (en) | 2006-05-18 | 2015-01-13 | Arena Pharmaceuticals, Inc. | Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| EA016675B1 (ru) | 2006-05-18 | 2012-06-29 | Арена Фармасьютикалз, Инк. | Способы получения фенилпиразолов и кристаллическая форма производного фенилпиразола |
| WO2007136680A2 (en) | 2006-05-18 | 2007-11-29 | Arena Pharmaceuticals, Inc. | 3-pyraz0lyl-benzamide-4-ethers, secondary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| CL2007001829A1 (es) * | 2006-06-23 | 2008-01-25 | Smithkline Beecham Corp | P-toluensulfonato de n-[4-cloro-2-hidroxi-3-(piperazina-1-sulfonil)fenil]-n-(2-cloro-3-fluorofenil)urea;procedimiento de preparacion;composicion farmaceutica;combinacion farmaceutica;y uso en el tratamiento de una enfermedad mediada por la quiimioquina il-8, tales como asma y epoc. |
| TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 |
| US9567327B2 (en) | 2007-08-15 | 2017-02-14 | Arena Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| US20110021538A1 (en) * | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| WO2010062321A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto |
| TR201805216T4 (en) | 2008-10-28 | 2018-06-21 | Arena Pharm Inc | COMPOSITIONS OF A USEFUL 5-HT2A SEROTONINE RECEPTOR MODULATOR FOR THE TREATMENT OF RELATED DISORDERS |
| WO2011075596A1 (en) | 2009-12-18 | 2011-06-23 | Arena Pharmaceuticals, Inc. | Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| HK1245660A1 (zh) | 2015-06-12 | 2018-08-31 | Axovant Sciences Gmbh | 有用於预防和治疗rem睡眠行为障碍的二芳基脲和芳基脲衍生物 |
| WO2017011767A2 (en) | 2015-07-15 | 2017-01-19 | Axovant Sciences Ltd. | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2363074A (en) * | 1938-06-16 | 1944-11-21 | Geigy Ag J R | Halogen substituted acylamino sulphonic acids of the aromatic series and their manufacture |
| BE639588A (enExample) * | 1962-11-06 | |||
| US3332981A (en) * | 1964-09-14 | 1967-07-25 | Gen Aniline & Film Corp | Urea stilbene brighteners |
| US3996253A (en) * | 1966-01-11 | 1976-12-07 | Minnesota Mining And Manufacturing Company | Process for the preparation of color images |
| GB1210596A (en) | 1967-04-06 | 1970-10-28 | Armour Grocery Products Compan | Antiseptic compositions |
| CH506240A (de) | 1969-02-04 | 1971-04-30 | Ciba Geigy Ag | Verwendung von N-Hydroxyphenyl-N'-phenylharnstoffen zur Bekämpfung schädlicher Mikroorganismen ausserhalb der Textilindustrie |
| SE370866B (enExample) | 1968-03-21 | 1974-11-04 | Ciba Geigy Ag | |
| GB1281437A (en) | 1970-07-23 | 1972-07-12 | Ici Ltd | Urea derivatives |
| US3856951A (en) | 1971-06-21 | 1974-12-24 | Co Pfizer Inc | Substituted benzoic acid hypoliphemic agents |
| US3855285A (en) | 1971-06-21 | 1974-12-17 | Pfizer | Acylmethylthio-trifluoromethyl-benzoic acids |
| US4048333A (en) | 1971-08-23 | 1977-09-13 | Medizinska Akademia | Method for treating a picorna virus infection |
| FR2150834B1 (enExample) | 1971-08-23 | 1975-10-17 | Medizinska Akad | |
| US3869553A (en) | 1972-11-07 | 1975-03-04 | Pfizer | Substituted benzoic acid hypolipemic agents |
| US3882230A (en) | 1972-11-07 | 1975-05-06 | Pfizer | Substituted benzoic acid hypolipemic agents |
| DE2303761A1 (de) * | 1973-01-26 | 1974-08-01 | Henkel & Cie Gmbh | Neue n,n'-disubstituierte thioharnstoffe, deren herstellung sowie verwendung als antimikrobielle substanzen |
| GB1393854A (en) | 1973-02-26 | 1975-05-14 | Pfizer | Benzoic acid compounds and pharmaceutical compositions containing them |
| JPS5598152A (en) | 1979-01-16 | 1980-07-25 | Hokko Chem Ind Co Ltd | Phenylurea derivative |
| DE2928485A1 (de) | 1979-07-14 | 1981-01-29 | Bayer Ag | Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen |
| DE2942930A1 (de) | 1979-10-24 | 1981-05-27 | Basf Ag, 6700 Ludwigshafen | Substituierte harnstoffe, deren herstellung und verwendung als herbizide |
| DE3006671A1 (de) | 1980-02-22 | 1981-08-27 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue benzoxazole, deren herstellung und deren verwendung als arzneumittel |
| GB2079480B (en) * | 1980-07-08 | 1984-05-16 | Kodak Ltd | Heat-activated photographic and thermal recording processes employing precursor compounds |
| US4608205A (en) | 1983-03-09 | 1986-08-26 | American Cyanamid Company | Polyanionic benzene ureas |
| JPS60126256A (ja) * | 1983-12-13 | 1985-07-05 | Hokko Chem Ind Co Ltd | Ν−アシルクロルアミノフエノ−ル誘導体 |
| US4591604A (en) | 1984-03-28 | 1986-05-27 | American Cyanamid Company | Method of inhibiting the complement system by administering multisulfonated naphthalene ureas |
| JPS6135444A (ja) * | 1984-07-28 | 1986-02-19 | Konishiroku Photo Ind Co Ltd | ハロゲン化銀カラ−写真感光材料 |
| ATE98223T1 (de) * | 1988-03-30 | 1993-12-15 | Warner Lambert Co | N-(((2,6-disubstituierte)phenyl>n'- arylalkyl> harnstoffe als antihypercholesterolemische und antiatherosclerotische mittel. |
| JP2684409B2 (ja) | 1988-03-31 | 1997-12-03 | コニカ株式会社 | シアノ基および／またはハロゲン原子で置換されたアニリン類の製造方法およびその製造のために使用される化合物 |
| JP2835631B2 (ja) | 1990-01-19 | 1998-12-14 | コニカ株式会社 | 色再現性の改良されたハロゲン化銀カラー写真感光材料 |
| US5276182A (en) | 1990-07-09 | 1994-01-04 | The Dow Chemical Company | Process for preparing polyurea oligomers |
| JP2655384B2 (ja) | 1991-11-08 | 1997-09-17 | 富士写真フイルム株式会社 | ポジ型レジスト組成物 |
| DE4200259A1 (de) | 1992-01-08 | 1993-07-15 | Asta Medica Ag | Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung |
| US5424063A (en) | 1992-01-09 | 1995-06-13 | The Dow Chemical Company | Narrow poly- and mono-dispersed anionic oligomers, and their uses, formulations and process |
| EP0626945B1 (en) | 1992-02-20 | 1998-04-22 | Merrell Pharmaceuticals Inc. | Sulfonic acid derivatives in the treatment of viral diseases |
| US5275932A (en) | 1992-03-16 | 1994-01-04 | Minnesota Mining And Manufacturing Company | Thermal development accelerators for thermographic materials |
| KR950703347A (ko) | 1992-09-28 | 1995-09-20 | 스티븐 엘. 네스비트 | 이노시톨 1,4,5-트리포스페이트의 길항 방법(Method for Antagonizing Inositol 1,4,5-Triphosphate) |
| US5384319A (en) | 1993-01-06 | 1995-01-24 | Ciba-Geigy Corporation | Aminoalkylphenyl compounds |
| DK41193D0 (da) | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
| JPH06313992A (ja) | 1993-04-28 | 1994-11-08 | Canon Inc | 静電荷像現像用トナー |
| US5312831A (en) | 1993-05-12 | 1994-05-17 | American Cyanamid Company | Urethanes and ureas that induce cytokine production |
| CA2123728A1 (en) | 1993-05-21 | 1994-11-22 | Noriyoshi Sueda | Urea derivatives and their use as acat inhibitors |
| US5576335A (en) * | 1994-02-01 | 1996-11-19 | Nisshin Flour Milling Co., Ltd. | Urea derivatives and their use as ACAT inhibitors |
| DE4413265A1 (de) | 1994-04-16 | 1995-10-19 | Basf Ag | Hydroxyphenylharnstoffe |
| WO1995033458A1 (en) | 1994-06-02 | 1995-12-14 | Smithkline Beecham Corporation | Anti-inflammatory compounds |
| US5470882A (en) * | 1994-06-02 | 1995-11-28 | Smithkline Beecham Corp. | Anti-inflammatory compounds |
| US5447957A (en) * | 1994-06-02 | 1995-09-05 | Smithkline Beecham Corp. | Anti-inflammatory compounds |
| MX9702044A (es) | 1994-09-27 | 1997-06-28 | Imation Corp | Elementos termograficos direccionables con laser. |
| CA2197364A1 (en) * | 1996-02-15 | 1997-08-16 | Toshikazu Suzuki | Phenol compound and process for preparing the same |
-
1997
- 1997-06-24 PL PL97330849A patent/PL330849A1/xx unknown
- 1997-06-24 EP EP97931342A patent/EP0915651A4/en not_active Withdrawn
- 1997-06-24 KR KR1019980710693A patent/KR20000022273A/ko not_active Withdrawn
- 1997-06-24 IL IL12766797A patent/IL127667A0/xx unknown
- 1997-06-24 BR BR9709938A patent/BR9709938A/pt not_active Application Discontinuation
- 1997-06-24 WO PCT/US1997/010900 patent/WO1997049286A1/en not_active Ceased
- 1997-06-24 US US09/202,570 patent/US6271261B1/en not_active Expired - Fee Related
- 1997-06-24 TR TR1998/02695T patent/TR199802695T2/xx unknown
- 1997-06-24 AU AU34994/97A patent/AU3499497A/en not_active Abandoned
- 1997-06-24 JP JP10503446A patent/JP2000514789A/ja not_active Ceased
- 1997-06-24 HU HU9903922A patent/HUP9903922A3/hu unknown
- 1997-06-24 CZ CZ984256A patent/CZ425698A3/cs unknown
- 1997-06-26 ZA ZA9705671A patent/ZA975671B/xx unknown
- 1997-06-27 CO CO97036015A patent/CO4890843A1/es unknown
-
1998
- 1998-12-23 NO NO986109A patent/NO986109L/no not_active Application Discontinuation