JP2000514420A5 - - Google Patents
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- Publication number
- JP2000514420A5 JP2000514420A5 JP1998503444A JP50344498A JP2000514420A5 JP 2000514420 A5 JP2000514420 A5 JP 2000514420A5 JP 1998503444 A JP1998503444 A JP 1998503444A JP 50344498 A JP50344498 A JP 50344498A JP 2000514420 A5 JP2000514420 A5 JP 2000514420A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2040696P | 1996-06-25 | 1996-06-25 | |
| US60/020,406 | 1996-06-25 | ||
| PCT/US1997/010898 WO1997049406A1 (en) | 1996-06-25 | 1997-06-24 | Use of k-252a derivative for the treatment of peripheral or central nerve disorders, and cytokine overproduction |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008053174A Division JP4767982B2 (ja) | 1996-06-25 | 2008-03-04 | 末梢または中枢神経障害およびサイトカイン過剰産生の治療のためのｋ−２５２ａ誘導体の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000514420A JP2000514420A (ja) | 2000-10-31 |
| JP2000514420A5 true JP2000514420A5 (enExample) | 2005-02-10 |
Family
ID=21798468
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10503444A Pending JP2000514420A (ja) | 1996-06-25 | 1997-06-24 | 末梢または中枢神経障害およびサイトカイン過剰産生の治療のためのｋ―２５２ａ誘導体の使用 |
| JP2008053174A Expired - Lifetime JP4767982B2 (ja) | 1996-06-25 | 2008-03-04 | 末梢または中枢神経障害およびサイトカイン過剰産生の治療のためのｋ−２５２ａ誘導体の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008053174A Expired - Lifetime JP4767982B2 (ja) | 1996-06-25 | 2008-03-04 | 末梢または中枢神経障害およびサイトカイン過剰産生の治療のためのｋ−２５２ａ誘導体の使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6184217B1 (enExample) |
| EP (1) | EP0912184B1 (enExample) |
| JP (2) | JP2000514420A (enExample) |
| CN (1) | CN1108799C (enExample) |
| AT (1) | ATE224718T1 (enExample) |
| AU (1) | AU721942B2 (enExample) |
| BR (1) | BR9710693A (enExample) |
| DE (1) | DE69715862T2 (enExample) |
| DK (1) | DK0912184T3 (enExample) |
| ES (1) | ES2184106T3 (enExample) |
| NO (1) | NO317335B1 (enExample) |
| NZ (1) | NZ333441A (enExample) |
| PT (1) | PT912184E (enExample) |
| RU (1) | RU2183959C2 (enExample) |
| UA (1) | UA65542C2 (enExample) |
| WO (1) | WO1997049406A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8932821B2 (en) | 2003-03-19 | 2015-01-13 | Biogen Idec Ma Inc. | NOGO receptor binding protein |
| US9068992B2 (en) | 2004-06-24 | 2015-06-30 | Biogen Ma Inc. | Screening methods for identifying Sp35 antagonists |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6127401A (en) * | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
| US6200968B1 (en) * | 1998-08-06 | 2001-03-13 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| HK1040053B (en) | 1998-09-25 | 2007-09-21 | Cephalon, Inc. | Use of fused pyrrolocarbazoles for preventing/treating damage to sensory hair cells and cochlear neurons |
| CN1323208A (zh) | 1998-10-13 | 2001-11-21 | 协和发酵工业株式会社 | 眼病治疗剂 |
| JP2000290184A (ja) * | 1999-04-01 | 2000-10-17 | Kyowa Hakko Kogyo Co Ltd | 経鼻投与製剤 |
| US6930125B2 (en) * | 2000-01-14 | 2005-08-16 | John F. Hunt | Airway alkalinization as a therapy for airway diseases |
| AU2001261324A1 (en) * | 2000-05-08 | 2001-11-20 | Psoriasis Research Institute | Psoriasis treatment |
| US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| US7018999B2 (en) | 2001-05-16 | 2006-03-28 | Cephalon, Inc. | Methods for the treatment and prevention of pain |
| ATE431157T1 (de) * | 2002-12-23 | 2009-05-15 | Rinat Neuroscience Corp | Verfahren zur behandlung von durch taxol induzierter sensorischer neuropathie |
| WO2004084836A2 (en) * | 2003-03-20 | 2004-10-07 | Rinat Neuroscience Corp. | Methods for treating taxol-induced gut disorder |
| TWI324604B (en) * | 2003-06-18 | 2010-05-11 | Novartis Ag | New use of staurosporine derivatives |
| AU2004257748B2 (en) * | 2003-07-14 | 2008-10-30 | Decode Genetics Ehf. | Method of diagnosis and treatment for asthma based on haplotype association |
| US20060014165A1 (en) * | 2003-07-14 | 2006-01-19 | Decode Genetics Ehf. | Methods of diagnosis and treatment for asthma and other respiratory diseases based on haplotype association |
| US20060210553A1 (en) * | 2003-07-23 | 2006-09-21 | Creabilis Therapeutics S.R.L. | Topical use of tyrosine kinase inhibitors of microbial origin to prevent and treat skin disorders characterised by excesssive cell proliferation |
| NZ548857A (en) | 2004-02-27 | 2010-05-28 | Lundbeck & Co As H | Crystalline forms of a diazocine pharmaceutical compound for Parkinson's and similar conditions |
| MX2007001155A (es) * | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
| AR054260A1 (es) * | 2005-04-26 | 2007-06-13 | Rinat Neuroscience Corp | Metodos de tratamiento de enfermedades de la neurona motora inferior y composiciones utilizadas en los mismos |
| SI1904104T1 (sl) | 2005-07-08 | 2013-12-31 | Biogen Idec Ma Inc. | Protitelesa SP35 in njihova uporaba |
| EP2068866A4 (en) | 2006-07-24 | 2010-04-07 | Biogen Idec Inc | METHODS FOR PROMOTING MYELINIZATION, NEURONAL SURVIVAL AND DIFFERENTIATION OF OLIGODENDROCYTES BY ADMINISTERING SP35 OR TRKA ANTAGONISTS |
| EP2315779A2 (en) | 2008-07-09 | 2011-05-04 | Biogen Idec MA Inc. | Compositions comprising antibodies to lingo or fragments thereof |
| US9796780B2 (en) | 2012-05-14 | 2017-10-24 | Biogen Ma Inc. | LINGO-2 antagonists for treatment of conditions involving motor neurons |
| WO2016112270A1 (en) | 2015-01-08 | 2016-07-14 | Biogen Ma Inc. | Lingo-1 antagonists and uses for treatment of demyelinating disorders |
| CN121987655A (zh) * | 2026-02-12 | 2026-05-08 | 贵州省人民医院 | k-252a在制备抑制肺纤维化药物中的应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6041489A (ja) * | 1983-08-12 | 1985-03-05 | Kyowa Hakko Kogyo Co Ltd | 新規生理活性物質ｋ―２５２ |
| US4554402A (en) | 1983-12-23 | 1985-11-19 | Aluminum Company Of America | Vibration damper for overhead conductor |
| JPS62120388A (ja) | 1985-11-19 | 1987-06-01 | Meiji Seika Kaisha Ltd | Ｓｆ−２３７０物質ハロゲン化誘導体とその製造法 |
| JPS62155285A (ja) | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質ｋ−２５２の誘導体 |
| JPS62155284A (ja) | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質ｋ−２５２の誘導体 |
| JPS62220196A (ja) | 1986-03-20 | 1987-09-28 | Kyowa Hakko Kogyo Co Ltd | 新規物質ｕｃｎ―０１ |
| US4816450A (en) | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
| JPH0826036B2 (ja) | 1987-01-22 | 1996-03-13 | 協和醗酵工業株式会社 | 生理活性物質ｋ−２５２の誘導体 |
| US4735939A (en) | 1987-02-27 | 1988-04-05 | The Dow Chemical Company | Insecticidal activity of staurosporine |
| WO1988007045A1 (fr) | 1987-03-09 | 1988-09-22 | Kyowa Hakko Kogyo Co., Ltd. | Derives de la substance physiologiquement active k-252 |
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| IL86632A0 (en) | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
| JPH07113027B2 (ja) * | 1987-12-24 | 1995-12-06 | 協和醗酵工業株式会社 | Ｋ−２５２誘導体 |
| EP0383919A4 (en) | 1988-02-04 | 1992-08-05 | Kyowa Hakko Kogyo Co., Ltd. | Staurosporin derivatives |
| DE3835842A1 (de) | 1988-10-21 | 1990-04-26 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| DE3924538A1 (de) | 1989-07-25 | 1991-01-31 | Goedecke Ag | Indolocarbazol und dessen verwendung |
| WO1991009034A1 (en) | 1989-12-14 | 1991-06-27 | Schering Corporation | Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856 |
| JPH0586068A (ja) | 1991-03-04 | 1993-04-06 | Rikagaku Kenkyusho | 新規抗生物質ｒｋ−１４０９、その製造法並びに抗腫瘍剤及び抗炎症剤 |
| AU3064992A (en) | 1991-11-08 | 1993-06-07 | University Of Southern California | Compositions containing k-252 compounds for potentiation of neurotrophin activity |
| JP2593021B2 (ja) | 1991-12-13 | 1997-03-19 | 伊藤ハム株式会社 | ウシ胚の性の識別方法 |
| RU2045575C1 (ru) * | 1992-01-29 | 1995-10-10 | Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов | Рекомбинатная плазмидная днк ppr - tgatg - hil - 1 beta - tsr, обеспечивающая синтез рекомбинантного интерлейкина-1 и штамм escherichia coli - продуцент рекомбинантного интерлейкина-1 бета человека |
| US6271242B1 (en) | 1992-02-10 | 2001-08-07 | Bristol-Myers Squibb Co. | Method for treating cancer using a tyrosine protein kinase inhibitor |
| JPH05247055A (ja) | 1992-03-03 | 1993-09-24 | Meiji Seika Kaisha Ltd | スタウロスポリン誘導体及びそれを含有する抗腫瘍効果増強剤 |
| JPH0673063A (ja) | 1992-06-22 | 1994-03-15 | Kyowa Hakko Kogyo Co Ltd | Ｕｃｎ−０１誘導体 |
| EP0575955B1 (en) | 1992-06-22 | 1999-09-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing staurosporine derivatives |
| US5461146A (en) | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
| US5621100A (en) | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
| GB9215921D0 (en) * | 1992-07-27 | 1992-09-09 | Wellcome Found | Anti-inflammatory compounds |
| WO1994027982A1 (en) | 1993-05-28 | 1994-12-08 | Cephalon, Inc. | Use of indolocarbazole derivatives to treat a pathological condition of the prostate |
| EP0703917A1 (en) | 1993-06-17 | 1996-04-03 | Novartis AG | Indolocarbazole compound useful as proteinkinase c inhibitor |
| WO1995022331A1 (en) * | 1994-02-18 | 1995-08-24 | Cephalon, Inc. | Aqueous indolocarbazole solutions |
-
1997
- 1997-06-24 AU AU34090/97A patent/AU721942B2/en not_active Expired
- 1997-06-24 BR BR9710693-3A patent/BR9710693A/pt not_active IP Right Cessation
- 1997-06-24 ES ES97930203T patent/ES2184106T3/es not_active Expired - Lifetime
- 1997-06-24 DE DE69715862T patent/DE69715862T2/de not_active Expired - Lifetime
- 1997-06-24 CN CN97197341A patent/CN1108799C/zh not_active Expired - Lifetime
- 1997-06-24 DK DK97930203T patent/DK0912184T3/da active
- 1997-06-24 US US08/881,679 patent/US6184217B1/en not_active Expired - Lifetime
- 1997-06-24 WO PCT/US1997/010898 patent/WO1997049406A1/en not_active Ceased
- 1997-06-24 PT PT97930203T patent/PT912184E/pt unknown
- 1997-06-24 UA UA99010342A patent/UA65542C2/uk unknown
- 1997-06-24 AT AT97930203T patent/ATE224718T1/de active
- 1997-06-24 RU RU99101117/14A patent/RU2183959C2/ru active
- 1997-06-24 JP JP10503444A patent/JP2000514420A/ja active Pending
- 1997-06-24 NZ NZ333441A patent/NZ333441A/xx not_active IP Right Cessation
- 1997-06-24 EP EP97930203A patent/EP0912184B1/en not_active Expired - Lifetime
-
1998
- 1998-12-23 NO NO19986111A patent/NO317335B1/no not_active IP Right Cessation
-
2008
- 2008-03-04 JP JP2008053174A patent/JP4767982B2/ja not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8932821B2 (en) | 2003-03-19 | 2015-01-13 | Biogen Idec Ma Inc. | NOGO receptor binding protein |
| US9068992B2 (en) | 2004-06-24 | 2015-06-30 | Biogen Ma Inc. | Screening methods for identifying Sp35 antagonists |