RU2183959C2 - Применение производных к-252а для лечения расстройств периферической или центральной нервной системы и избыточной выработки цитокина - Google Patents
Применение производных к-252а для лечения расстройств периферической или центральной нервной системы и избыточной выработки цитокина Download PDFInfo
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- RU2183959C2 RU2183959C2 RU99101117/14A RU99101117A RU2183959C2 RU 2183959 C2 RU2183959 C2 RU 2183959C2 RU 99101117/14 A RU99101117/14 A RU 99101117/14A RU 99101117 A RU99101117 A RU 99101117A RU 2183959 C2 RU2183959 C2 RU 2183959C2
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- VCDAQRLRXBTPOZ-RSWBELOFSA-N CC([C@](C1)(C(O)=O)O)([n](c2ccc(C)cc2c2c3CCCN4)c2c2N)OC1Cc(ccc(C)c1)c1-c2c3C4=C Chemical compound CC([C@](C1)(C(O)=O)O)([n](c2ccc(C)cc2c2c3CCCN4)c2c2N)OC1Cc(ccc(C)c1)c1-c2c3C4=C VCDAQRLRXBTPOZ-RSWBELOFSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2040696P | 1996-06-25 | 1996-06-25 | |
| US60/020,406 | 1996-06-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU99101117A RU99101117A (ru) | 2000-12-10 |
| RU2183959C2 true RU2183959C2 (ru) | 2002-06-27 |
Family
ID=21798468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU99101117/14A RU2183959C2 (ru) | 1996-06-25 | 1997-06-24 | Применение производных к-252а для лечения расстройств периферической или центральной нервной системы и избыточной выработки цитокина |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6184217B1 (enExample) |
| EP (1) | EP0912184B1 (enExample) |
| JP (2) | JP2000514420A (enExample) |
| CN (1) | CN1108799C (enExample) |
| AT (1) | ATE224718T1 (enExample) |
| AU (1) | AU721942B2 (enExample) |
| BR (1) | BR9710693A (enExample) |
| DE (1) | DE69715862T2 (enExample) |
| DK (1) | DK0912184T3 (enExample) |
| ES (1) | ES2184106T3 (enExample) |
| NO (1) | NO317335B1 (enExample) |
| NZ (1) | NZ333441A (enExample) |
| PT (1) | PT912184E (enExample) |
| RU (1) | RU2183959C2 (enExample) |
| UA (1) | UA65542C2 (enExample) |
| WO (1) | WO1997049406A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6127401A (en) * | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
| US6200968B1 (en) * | 1998-08-06 | 2001-03-13 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| CN1329034C (zh) | 1998-09-25 | 2007-08-01 | 赛福伦公司 | 预防/治疗感觉毛细胞和耳蜗神经元损伤的药物 |
| NZ511084A (en) | 1998-10-13 | 2004-01-30 | Kyowa Hakko Kogyo Kk | An agent for treating ophthalmopathy |
| JP2000290184A (ja) * | 1999-04-01 | 2000-10-17 | Kyowa Hakko Kogyo Co Ltd | 経鼻投与製剤 |
| US6930125B2 (en) * | 2000-01-14 | 2005-08-16 | John F. Hunt | Airway alkalinization as a therapy for airway diseases |
| AU2001261324A1 (en) * | 2000-05-08 | 2001-11-20 | Psoriasis Research Institute | Psoriasis treatment |
| US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| AR035971A1 (es) * | 2001-05-16 | 2004-07-28 | Cephalon Inc | Metodos para el tratamiento y la prevencion del dolor |
| JP2006513187A (ja) * | 2002-12-23 | 2006-04-20 | ライナット ニューロサイエンス コーポレイション | タキソール誘発性感覚性ニューロパシーを処置するための方法 |
| PL2248899T3 (pl) | 2003-03-19 | 2015-10-30 | Biogen Ma Inc | Białko wiążące receptor nogo |
| US20070014786A1 (en) * | 2003-03-20 | 2007-01-18 | Rinat Neuroscience Corp. | Methods for treating taxol-induced gut disorder |
| TWI324604B (en) | 2003-06-18 | 2010-05-11 | Novartis Ag | New use of staurosporine derivatives |
| EP1646372A2 (en) * | 2003-07-14 | 2006-04-19 | Decode Genetics EHF. | Methods of diagnosis and treatment for asthma based on haplotype association |
| US20060014165A1 (en) * | 2003-07-14 | 2006-01-19 | Decode Genetics Ehf. | Methods of diagnosis and treatment for asthma and other respiratory diseases based on haplotype association |
| US20060210553A1 (en) * | 2003-07-23 | 2006-09-21 | Creabilis Therapeutics S.R.L. | Topical use of tyrosine kinase inhibitors of microbial origin to prevent and treat skin disorders characterised by excesssive cell proliferation |
| NZ548857A (en) | 2004-02-27 | 2010-05-28 | Lundbeck & Co As H | Crystalline forms of a diazocine pharmaceutical compound for Parkinson's and similar conditions |
| KR101239542B1 (ko) | 2004-06-24 | 2013-03-07 | 바이오겐 아이덱 엠에이 인코포레이티드 | 탈수초화를 수반하는 병의 치료 |
| MX2007001155A (es) * | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
| AR054260A1 (es) * | 2005-04-26 | 2007-06-13 | Rinat Neuroscience Corp | Metodos de tratamiento de enfermedades de la neurona motora inferior y composiciones utilizadas en los mismos |
| CA2902070A1 (en) | 2005-07-08 | 2007-01-18 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
| WO2008013782A2 (en) | 2006-07-24 | 2008-01-31 | Biogen Idec Ma Inc. | Methods for promoting myelination, neuronal survival and oligodendrocyte differentiation via administration of sp35 or trka antagonists |
| JP2011527572A (ja) | 2008-07-09 | 2011-11-04 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Lingo抗体または断片を含む組成物 |
| MX381731B (es) | 2012-05-14 | 2025-03-13 | Biogen Ma Inc | Antagonistas de proteina que interactua con el receptor nogo 2 que contiene repeticion rica en leucina y dominio de inmunoglobulina (lingo-2) para el tratamiento de afecciones que involucran neuronas motoras. |
| JP2018504400A (ja) | 2015-01-08 | 2018-02-15 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | Lingo‐1拮抗薬及び脱髄障害の治療のための使用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4877776A (en) * | 1987-12-24 | 1989-10-31 | Kyowa Hakko Kogyo Co., Ltd. | K-252 compounds |
| RU2045575C1 (ru) * | 1992-01-29 | 1995-10-10 | Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов | Рекомбинатная плазмидная днк ppr - tgatg - hil - 1 beta - tsr, обеспечивающая синтез рекомбинантного интерлейкина-1 и штамм escherichia coli - продуцент рекомбинантного интерлейкина-1 бета человека |
| US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6041489A (ja) * | 1983-08-12 | 1985-03-05 | Kyowa Hakko Kogyo Co Ltd | 新規生理活性物質k―252 |
| US4554402A (en) | 1983-12-23 | 1985-11-19 | Aluminum Company Of America | Vibration damper for overhead conductor |
| JPS62120388A (ja) | 1985-11-19 | 1987-06-01 | Meiji Seika Kaisha Ltd | Sf−2370物質ハロゲン化誘導体とその製造法 |
| JPS62155285A (ja) | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質k−252の誘導体 |
| JPS62155284A (ja) | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質k−252の誘導体 |
| JPS62220196A (ja) | 1986-03-20 | 1987-09-28 | Kyowa Hakko Kogyo Co Ltd | 新規物質ucn―01 |
| US4816450A (en) | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
| JPH0826036B2 (ja) | 1987-01-22 | 1996-03-13 | 協和醗酵工業株式会社 | 生理活性物質k−252の誘導体 |
| US4735939A (en) | 1987-02-27 | 1988-04-05 | The Dow Chemical Company | Insecticidal activity of staurosporine |
| US4923986A (en) | 1987-03-09 | 1990-05-08 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of physiologically active substance K-252 |
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| IL86632A0 (en) | 1987-06-15 | 1988-11-30 | Ciba Geigy Ag | Derivatives substituted at methyl-amino nitrogen |
| JP2766360B2 (ja) | 1988-02-04 | 1998-06-18 | 協和醗酵工業株式会社 | スタウロスポリン誘導体 |
| DE3835842A1 (de) | 1988-10-21 | 1990-04-26 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| DE3924538A1 (de) | 1989-07-25 | 1991-01-31 | Goedecke Ag | Indolocarbazol und dessen verwendung |
| WO1991009034A1 (en) | 1989-12-14 | 1991-06-27 | Schering Corporation | Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856 |
| JPH0586068A (ja) | 1991-03-04 | 1993-04-06 | Rikagaku Kenkyusho | 新規抗生物質rk−1409、その製造法並びに抗腫瘍剤及び抗炎症剤 |
| WO1993008809A1 (en) | 1991-11-08 | 1993-05-13 | The University Of Southern California | Compositions containing k-252 compounds for potentiation of neurotrophin activity |
| JP2593021B2 (ja) | 1991-12-13 | 1997-03-19 | 伊藤ハム株式会社 | ウシ胚の性の識別方法 |
| US6271242B1 (en) | 1992-02-10 | 2001-08-07 | Bristol-Myers Squibb Co. | Method for treating cancer using a tyrosine protein kinase inhibitor |
| JPH05247055A (ja) | 1992-03-03 | 1993-09-24 | Meiji Seika Kaisha Ltd | スタウロスポリン誘導体及びそれを含有する抗腫瘍効果増強剤 |
| ES2136103T3 (es) | 1992-06-22 | 1999-11-16 | Kyowa Hakko Kogyo Kk | Procedimiento para la preparacion de derivados de estaurosporina. |
| JPH0673063A (ja) | 1992-06-22 | 1994-03-15 | Kyowa Hakko Kogyo Co Ltd | Ucn−01誘導体 |
| US5621100A (en) | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
| GB9215921D0 (en) * | 1992-07-27 | 1992-09-09 | Wellcome Found | Anti-inflammatory compounds |
| EP0699204B1 (en) | 1993-05-28 | 1998-04-15 | Cephalon, Inc. | Use of indolocarbazole derivatives to treat a pathological condition of the prostate |
| AU7000094A (en) | 1993-06-17 | 1995-01-17 | Ciba-Geigy Ag | Indolocarbazole compound useful as proteinkinase c inhibitor |
| AU1911095A (en) * | 1994-02-18 | 1995-09-04 | Cephalon, Inc. | Aqueous indolocarbazole solutions |
-
1997
- 1997-06-24 BR BR9710693-3A patent/BR9710693A/pt not_active IP Right Cessation
- 1997-06-24 ES ES97930203T patent/ES2184106T3/es not_active Expired - Lifetime
- 1997-06-24 PT PT97930203T patent/PT912184E/pt unknown
- 1997-06-24 AU AU34090/97A patent/AU721942B2/en not_active Expired
- 1997-06-24 CN CN97197341A patent/CN1108799C/zh not_active Expired - Lifetime
- 1997-06-24 UA UA99010342A patent/UA65542C2/uk unknown
- 1997-06-24 DE DE69715862T patent/DE69715862T2/de not_active Expired - Lifetime
- 1997-06-24 DK DK97930203T patent/DK0912184T3/da active
- 1997-06-24 EP EP97930203A patent/EP0912184B1/en not_active Expired - Lifetime
- 1997-06-24 AT AT97930203T patent/ATE224718T1/de active
- 1997-06-24 JP JP10503444A patent/JP2000514420A/ja active Pending
- 1997-06-24 RU RU99101117/14A patent/RU2183959C2/ru active
- 1997-06-24 US US08/881,679 patent/US6184217B1/en not_active Expired - Lifetime
- 1997-06-24 NZ NZ333441A patent/NZ333441A/xx not_active IP Right Cessation
- 1997-06-24 WO PCT/US1997/010898 patent/WO1997049406A1/en not_active Ceased
-
1998
- 1998-12-23 NO NO19986111A patent/NO317335B1/no not_active IP Right Cessation
-
2008
- 2008-03-04 JP JP2008053174A patent/JP4767982B2/ja not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4877776A (en) * | 1987-12-24 | 1989-10-31 | Kyowa Hakko Kogyo Co., Ltd. | K-252 compounds |
| RU2045575C1 (ru) * | 1992-01-29 | 1995-10-10 | Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов | Рекомбинатная плазмидная днк ppr - tgatg - hil - 1 beta - tsr, обеспечивающая синтез рекомбинантного интерлейкина-1 и штамм escherichia coli - продуцент рекомбинантного интерлейкина-1 бета человека |
| US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997049406A1 (en) | 1997-12-31 |
| UA65542C2 (uk) | 2004-04-15 |
| JP4767982B2 (ja) | 2011-09-07 |
| DK0912184T3 (da) | 2002-11-25 |
| DE69715862T2 (de) | 2003-04-10 |
| ATE224718T1 (de) | 2002-10-15 |
| US6184217B1 (en) | 2001-02-06 |
| AU721942B2 (en) | 2000-07-20 |
| NO986111D0 (no) | 1998-12-23 |
| JP2008189676A (ja) | 2008-08-21 |
| PT912184E (pt) | 2002-12-31 |
| NO317335B1 (no) | 2004-10-11 |
| HK1018745A1 (en) | 2000-01-07 |
| DE69715862D1 (de) | 2002-10-31 |
| AU3409097A (en) | 1998-01-14 |
| CN1228024A (zh) | 1999-09-08 |
| NZ333441A (en) | 1999-05-28 |
| BR9710693A (pt) | 2000-01-11 |
| CN1108799C (zh) | 2003-05-21 |
| NO986111L (no) | 1999-02-23 |
| EP0912184A1 (en) | 1999-05-06 |
| JP2000514420A (ja) | 2000-10-31 |
| ES2184106T3 (es) | 2003-04-01 |
| EP0912184B1 (en) | 2002-09-25 |
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