JP2000514307A5 - - Google Patents

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Publication number
JP2000514307A5
JP2000514307A5 JP1998506265A JP50626598A JP2000514307A5 JP 2000514307 A5 JP2000514307 A5 JP 2000514307A5 JP 1998506265 A JP1998506265 A JP 1998506265A JP 50626598 A JP50626598 A JP 50626598A JP 2000514307 A5 JP2000514307 A5 JP 2000514307A5
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JP
Japan
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Ceased
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JP1998506265A
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English (en)
Japanese (ja)
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JP2000514307A (ja
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Priority claimed from PCT/US1997/012347 external-priority patent/WO1998002582A2/en
Publication of JP2000514307A publication Critical patent/JP2000514307A/ja
Publication of JP2000514307A5 publication Critical patent/JP2000514307A5/ja
Ceased legal-status Critical Current

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JP10506265A 1996-07-16 1997-07-15 増加した標的特異的ｔ▲下ｍ▼を持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法 Ceased JP2000514307A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2181896P 1996-07-16 1996-07-16
US60/021,818 1996-07-16
PCT/US1997/012347 WO1998002582A2 (en) 1996-07-16 1997-07-15 Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific t¿m?

Related Child Applications (1)

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JP2008137832A Division JP4527789B2 (ja) 1996-07-16 2008-05-27 増加した標的特異的ｔｍを持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法

Publications (2)

Publication Number Publication Date
JP2000514307A JP2000514307A (ja) 2000-10-31
JP2000514307A5 true JP2000514307A5 (cg-RX-API-DMAC7.html) 2007-08-02

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JP10506265A Ceased JP2000514307A (ja) 1996-07-16 1997-07-15 増加した標的特異的ｔ▲下ｍ▼を持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法
JP2008137832A Expired - Lifetime JP4527789B2 (ja) 1996-07-16 2008-05-27 増加した標的特異的ｔｍを持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法

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JP2008137832A Expired - Lifetime JP4527789B2 (ja) 1996-07-16 2008-05-27 増加した標的特異的ｔｍを持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法

Country Status (11)

Country Link
US (3) US6130038A (cg-RX-API-DMAC7.html)
EP (1) EP0912767B1 (cg-RX-API-DMAC7.html)
JP (2) JP2000514307A (cg-RX-API-DMAC7.html)
KR (1) KR20000023814A (cg-RX-API-DMAC7.html)
AT (1) ATE339514T1 (cg-RX-API-DMAC7.html)
AU (1) AU726821B2 (cg-RX-API-DMAC7.html)
CA (1) CA2260749A1 (cg-RX-API-DMAC7.html)
DE (1) DE69736667T2 (cg-RX-API-DMAC7.html)
DK (1) DK0912767T3 (cg-RX-API-DMAC7.html)
ES (1) ES2270467T3 (cg-RX-API-DMAC7.html)
WO (1) WO1998002582A2 (cg-RX-API-DMAC7.html)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
DE69736667T2 (de) * 1996-07-16 2007-09-06 Gen-Probe Inc., San Diego Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm)
US7070925B1 (en) 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
JP3981416B2 (ja) 1997-04-10 2007-09-26 ユニバーシティ メディカル センター ナイメーヘン Ｐｃａ３タンパク質、ｐｃａ３遺伝子、及びこれらの用途
ATE440963T1 (de) 1998-07-02 2009-09-15 Gen Probe Inc Molekulare fackeln
EP1100972B1 (en) 1998-07-31 2006-06-14 Gen-Probe Incorporated Reversible inhibiting probes
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
WO2000070093A1 (en) * 1999-05-13 2000-11-23 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US6844151B1 (en) 1999-09-29 2005-01-18 Oligos Etc. Inc. Methods for production of arrays with modified oligonucleotide and polynucleotide compositions
AU7742100A (en) * 1999-09-29 2001-04-30 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
DK1222266T3 (da) 1999-09-29 2006-07-10 Diagnocure Inc PCA3-messenger-RNA i benigne og maligne prostatavæv
GB2355791B (en) * 1999-10-28 2004-10-20 Molecular Light Tech Res Ltd Detection of mRNA expression using chemiluminescent labelled probes
US6924108B2 (en) * 1999-12-21 2005-08-02 Ingeneus Corporation Nucleic acid binding enhancement by conjugation with nucleotides, nucleosides, bases and/or their analogues
US7833715B1 (en) * 2000-01-11 2010-11-16 Nanogen Recognomics Gmbh Biomolecules having multiple attachment moieties for binding to a substrate surface
DK1294751T3 (en) 2000-03-31 2014-03-24 Merial Ltd GABA-DEPENDENT chloride FROM Dermacentor variabilis
JP4950414B2 (ja) * 2000-08-03 2012-06-13 独立行政法人産業技術総合研究所 核酸の測定方法、それに用いる核酸プローブ及びその方法によって得られるデータを解析する方法
ATE414794T1 (de) 2000-09-01 2008-12-15 Gen Probe Inc Amplifizierung von hiv-1 sequenzen zur detektion von sequenzen, die mit wirkstoff-resistenz mutationen einhergehen
US20020055116A1 (en) * 2000-09-12 2002-05-09 Cunningham Melissa M. Compositions, methods and kits for determining the presence of cryptosporidium organisms in a test sample
DE60115811T2 (de) * 2000-10-25 2006-08-03 Roche Diagnostics Gmbh Amplifizierung unter Verwendung von modifizierten Primern
EP1251183A3 (en) * 2001-04-18 2003-12-10 Exiqon A/S Improved helper probes for detection of a target sequence by a capture oligonucleotide
CA2449011A1 (en) 2001-05-31 2002-12-05 Merck & Co., Inc. Rhesus monkey, dog and ferret melanin-concentrating hormone type 2 receptor
JP2005517381A (ja) * 2001-06-12 2005-06-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｗｉｔ３．０、軟組織創傷治癒を制御する新規遺伝子
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
EP1495139A4 (en) * 2002-03-29 2006-06-28 Genentech Inc METHODS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING NUCLEIC ACID ANALYTES
US7211382B2 (en) * 2002-04-09 2007-05-01 Orchid Cellmark Inc. Primer extension using modified nucleotides
US7199107B2 (en) 2002-05-23 2007-04-03 Isis Pharmaceuticals, Inc. Antisense modulation of kinesin-like 1 expression
US20030235827A1 (en) * 2002-06-25 2003-12-25 Orchid Biosciences, Inc. Methods and compositions for monitoring primer extension and polymorphism detection reactions
EP1573037A4 (en) * 2002-06-28 2007-05-09 Orchid Cellmark Inc METHODS AND COMPOSITIONS FOR ANALYZING WEAKENED SAMPLES USING UNIQUE NUCLEOTIDE POLYMORPHISMS PANELS
JP2006517385A (ja) * 2002-08-02 2006-07-27 オーキッド セルマーク インコーポレイテッド 遺伝子型特定のための方法および組成物
US7192700B2 (en) * 2002-12-20 2007-03-20 Orchid Cellmark Inc. Methods and compositions for conducting primer extension and polymorphism detection reactions
US7319041B2 (en) * 2002-09-27 2008-01-15 Siemens Medical Solutions Diagnostic Applications of acridinium compounds and derivatives in homogeneous assays
WO2004067726A2 (en) * 2003-01-29 2004-08-12 Keck Graduate Institute Isothermal reactions for the amplification of oligonucleotides
WO2004070056A2 (en) 2003-02-07 2004-08-19 Diagnocure Inc. Method to detect prostate cancer in a sample
EP1633893B1 (en) * 2003-05-19 2012-01-25 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of trichomonas vaginalis in a test sample
US20080176220A1 (en) * 2004-02-26 2008-07-24 Thomsen Bioscience Method, Kit and System for Enhanced Nested Pcr
WO2006007567A2 (en) 2004-07-01 2006-01-19 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
US7713697B2 (en) * 2004-08-27 2010-05-11 Gen-Probe Incorporated Methods and kits for amplifying DNA
CA2980050C (en) * 2004-08-27 2018-01-23 Gen-Probe Incorporated Single-primer nucleic acid amplification methods
CA2491067A1 (en) 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
ES2381279T3 (es) 2005-05-06 2012-05-24 Gen-Probe Incorporated Métodos y productos para la captura de ácido nucleico diana
CA2609206A1 (en) 2005-06-06 2006-12-14 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of chlamydophila pneumoniae in a test sample
DE602007012045D1 (de) 2006-06-06 2011-03-03 Gen Probe Inc Markierte oligonukleotide und ihre verwendung in nukleinsäureverstärkungsverfahren
EP2765202B1 (en) 2006-08-01 2017-02-01 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
AU2007284651B2 (en) 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
US8183359B2 (en) * 2007-03-01 2012-05-22 Gen-Probe Incorporated Kits for amplifying DNA
EP1978111B1 (en) 2007-04-02 2013-03-27 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Pseudomonas aeruginosa
US9689031B2 (en) * 2007-07-14 2017-06-27 Ionian Technologies, Inc. Nicking and extension amplification reaction for the exponential amplification of nucleic acids
US8911946B2 (en) 2007-12-21 2014-12-16 Gen-Probe Incorporated Detection of antibiotic-resistant microorganisms
US20090215050A1 (en) * 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
DK2644707T3 (en) 2008-04-30 2015-06-29 Integrated Dna Tech Inc RNase-H-based assays using modified RNA monomers.
US9434988B2 (en) * 2008-04-30 2016-09-06 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
CA2723726C (en) 2008-05-13 2017-09-12 Michael M. Becker Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
AU2009262870B2 (en) 2008-05-30 2014-03-20 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Salmonella
CN102292457B (zh) 2008-11-25 2014-04-09 简·探针公司 检测小rna的组合物和方法及其用途
AU2009323766B2 (en) 2008-12-02 2016-10-06 Wave Life Sciences Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
AU2009335053B2 (en) 2008-12-30 2013-08-01 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Listeria
WO2010126913A1 (en) 2009-04-27 2010-11-04 Gen-Probe Incorporated Methods and kits for use in the selective amplification of target sequences
SG177564A1 (en) 2009-07-06 2012-02-28 Ontorii Inc Novel nucleic acid prodrugs and methods of use thereof
CA2770888C (en) 2009-08-31 2020-04-14 Gen-Probe Incorporated Dengue virus assay
WO2011091330A1 (en) 2010-01-22 2011-07-28 Gen-Probe Incorporated Probes for detecting the presence of trichomonas vaginalis in a sample
CN102985566B (zh) 2010-06-30 2015-06-17 简.探针公司 使用分析物和过程控制信号的单次读取确定而鉴定含分析物的样品的方法和设备
CA2810856C (en) 2010-08-13 2022-05-17 Envirologix Inc. Compositions and methods for quantifying a nucleic acid sequence in a sample
EP2620428B1 (en) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
AU2012312169B2 (en) 2011-09-21 2016-01-14 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
US9352312B2 (en) 2011-09-23 2016-05-31 Alere Switzerland Gmbh System and apparatus for reactions
JP5801513B2 (ja) 2012-04-09 2015-10-28 エンバイロロジックス インコーポレイテッド 試料中の核酸配列を定量するための組成物および方法
EP2839024B1 (en) * 2012-04-16 2017-09-06 Life Technologies Corporation Methods for the preparation of rna libraries
JP6268157B2 (ja) 2012-07-13 2018-01-24 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ 不斉補助基
JP6246121B2 (ja) 2012-07-13 2017-12-13 株式会社新日本科学 キラル核酸アジュバント
SG10201912895PA (en) 2012-07-13 2020-02-27 Wave Life Sciences Ltd Chiral control
AU2013202793B2 (en) 2012-07-31 2014-09-18 Gen-Probe Incorporated System, method and apparatus for automated incubation
WO2014140167A1 (en) 2013-03-14 2014-09-18 Dsm Ip Assets B.V. Cell wall deconstruction enzymes of malbranchea cinnamomea and uses thereof
WO2014140165A1 (en) 2013-03-14 2014-09-18 Dsm Ip Assets B.V. Cell wall deconstruction enzymes of paecilomyces byssochlamydoides and uses thereof
WO2014152054A1 (en) 2013-03-15 2014-09-25 Bio-Rad Laboratories, Inc. Digital assays for mutation detection
US10752940B2 (en) 2013-11-08 2020-08-25 Ionis Pharmaceuticals, Inc. Compounds and methods for detecting oligonucleotides
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
EP3095460A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
PT3094728T (pt) 2014-01-16 2022-05-19 Wave Life Sciences Ltd Desenho quiral
JP6596442B2 (ja) 2014-04-22 2019-10-23 エンバイロロジックス インコーポレイテッド Ｄｎａ増幅を増強および／または予測するための組成物および方法
MX2017005159A (es) 2014-10-20 2017-08-18 Envirologix Inc Composiciones y metodos para detectar un virus de rna.
CN107428821B (zh) 2014-12-08 2022-06-24 博格有限责任公司 包括细丝蛋白a的标志物在诊断和治疗前列腺癌中的用途
ES2961374T3 (es) 2015-04-24 2024-03-11 Atila Biosystems Incorporated Amplificación con cebadores de composición de nucleótidos limitada
US10329601B2 (en) 2015-12-28 2019-06-25 Ionian Technologies, Inc. Nicking and extension amplification reaction (NEAR) of Streptococcus species
AU2019319203B8 (en) 2018-08-08 2025-10-09 Gen-Probe Incorporated Compositions, methods and kits for detecting Mycoplasma genitalium
AU2020210753A1 (en) 2019-01-25 2021-09-02 Gen-Probe Incorporated Detection of drug-resistant mycoplasma genitalium
CA3138566A1 (en) 2019-04-30 2020-11-05 Larimar Therapeutics, Inc. Frataxin-sensitive markers for determining effectiveness of frataxin replacement therapy
EP3994284A1 (en) 2019-07-03 2022-05-11 Gen-Probe Incorporated Oligonucleotides for use in determining the presence of trichomonas vaginalis in a sample
CA3152309A1 (en) 2019-08-23 2021-03-04 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
CA3188657A1 (en) 2020-07-17 2022-01-20 Gen-Probe Incorporated Detection of macrolide-resistant mycoplasma genitalium
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
US20240230651A1 (en) 2021-04-06 2024-07-11 Bpgbio, Inc. Protein markers for the prognosis of breast cancer progression
EP4320441A1 (en) 2021-04-06 2024-02-14 BPGbio, Inc. Protein markers for estrogen receptor (er)-positive-like and estrogen receptor (er)-negative-like breast cancer
WO2022216841A1 (en) 2021-04-06 2022-10-13 Berg Llc Protein markers for estrogen receptor (er)-positive luminal a(la)-like and luminal b1 (lb1)-like breast cancer
EP4505182A1 (en) 2022-04-06 2025-02-12 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring frataxin replacement therapy
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome
WO2024220373A1 (en) 2023-04-15 2024-10-24 Accent Therapeutics, Inc. Assays for monitoring inhibition of rna helicase dhx9
WO2025155991A2 (en) 2024-01-19 2025-07-24 Bpgbio, Inc. Predictive biomarkers for response to coenzyme q10 treatment in pancreatic cancer

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087558A (en) 1981-09-25 1992-02-11 Webster John A Jr Method for identifying and characterizing organisms
US4766062A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
US4820630A (en) * 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
JPS61243182A (ja) * 1985-04-19 1986-10-29 Nitsukan Kogyo Kk 金属メツキされたチタン酸カリウム繊維およびその製造方法
US4822733A (en) * 1985-05-28 1989-04-18 Amoco Corporation Lifetime-resolved assay procedures
US4797355A (en) * 1985-06-13 1989-01-10 Amgen Inc. Methods for attaching polynucleotides to supports
US4996143A (en) * 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
ATE88761T1 (de) * 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.
US4925785A (en) * 1986-03-07 1990-05-15 Biotechnica Diagnostics, Inc. Nucleic acid hybridization assays
US5091519A (en) * 1986-05-01 1992-02-25 Amoco Corporation Nucleotide compositions with linking groups
JP2774121B2 (ja) 1987-07-31 1998-07-09 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 標的ポリヌクレオチド配列の選択的増幅
US5030557A (en) * 1987-11-24 1991-07-09 Ml Technology Venture Means and method for enhancing nucleic acid hybridization
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
ES2093633T3 (es) * 1989-01-19 1997-01-01 Behringwerke Ag Amplificacion de acidos nucleicos utilizando un unico cebador.
DE69030804T2 (de) * 1989-04-05 1997-11-06 Vysis Inc Reagenzien zur verbesserung von hybridisierung
IE81145B1 (en) 1989-04-20 2000-05-03 Thomas Gerard Barry Generation of specific probes for target nucleotide sequences
AU5966990A (en) * 1989-05-24 1990-12-18 Gene-Trak Systems Nucleic acid probes for the detection of neisseria gonorrhoeae
US5849504A (en) 1989-08-11 1998-12-15 Amoco Corporation Nucleic acid probes and methods for detecting Pneumocystis carinii
US5134066A (en) * 1989-08-29 1992-07-28 Monsanto Company Improved probes using nucleosides containing 3-dezauracil analogs
CA2025178A1 (en) * 1989-10-02 1991-04-03 William G. Weisburg Nucleic acid probes for the detection of lyme disease spirochetes
CA2069948A1 (en) * 1989-12-01 1991-06-02 Brian Wylie Pontius Promotion of high specificity molecular assembly
US5914396A (en) 1990-01-11 1999-06-22 Isis Pharmaceuticals, Inc. 2'-O-modified nucleosides and phosphoramidites
US5536638A (en) 1990-04-18 1996-07-16 N.V. Innogenetics S.A. Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of Neisseria gonorrhoeae
US5811533A (en) 1990-06-11 1998-09-22 Nexstar Pharmaceuticals, Inc. High-affinity oligonucleotide ligands to vascular endothelial growth factor (VEGF)
US5614617A (en) * 1990-07-27 1997-03-25 Isis Pharmaceuticals, Inc. Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
US5386023A (en) * 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
WO1992009581A1 (fr) * 1990-11-29 1992-06-11 Kumiai Chemical Industry Co., Ltd. Derive de benzohydroxymoylazole, production de ce derive et insecticide le contenant
US5641625A (en) * 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US5435248A (en) * 1991-07-09 1995-07-25 The Ensign-Bickford Company Extended range digital delay detonator
AU3222793A (en) * 1991-11-26 1993-06-28 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
EP0618925B2 (en) * 1991-12-24 2012-04-18 Isis Pharmaceuticals, Inc. Antisense oligonucleotides
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US5652099A (en) * 1992-02-12 1997-07-29 Conrad; Michael J. Probes comprising fluorescent nucleosides and uses thereof
EP0566751B1 (en) * 1992-03-23 1996-01-10 F. Hoffmann-La Roche Ag DNA detection method
DE69333842T2 (de) * 1992-07-23 2006-04-27 Isis Pharmaceuticals, Inc., Carlsbad Neue 2'-O-Alkyl-Nukleoside und -Phosphoramidite, Verfahren zu ihrer Herstellung und ihre Verwendungen
US5445933A (en) * 1992-09-15 1995-08-29 Boehringer Mannheim Corporation Strand displacement assay and complex useful therefor
EP0601889A2 (en) * 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nucleic acid probes
JPH08503957A (ja) * 1993-02-19 1996-04-30 アイシス・ファーマシューティカルス・インコーポレーテッド シクロブチルアンチセンスオリゴヌクレオチド、その作成および使用方法
CA2105364A1 (en) * 1993-09-01 1995-03-02 Eric T. Kool Stem-loop oligonucleotides containing parallel and antiparallel binding domains
US6156501A (en) * 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5827648A (en) * 1995-12-13 1998-10-27 Chiron Corporation Differential hybridization for relative quantification of variant populations
SE9400522D0 (sv) * 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
AU2522095A (en) * 1994-05-19 1995-12-18 Dako A/S Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis
ZA956776B (en) * 1994-08-25 1996-03-20 Akzo Nobel Nv A process for making the product of a nucleic acid amplification reaction incapable of being a target for further amplification a diagnostic assay employing said process a kit and a container suitable for carrying out said process for assay
US5656427A (en) * 1994-08-29 1997-08-12 Gen-Probe Incorporated Nucleic acid hybridization assay probes, helper probes and amplification oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid
US5681702A (en) * 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
US6001564A (en) * 1994-09-12 1999-12-14 Infectio Diagnostic, Inc. Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
DE69610304T2 (de) * 1995-05-05 2001-04-05 Perkin-Elmer Corp., Foster City Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay
US5731148A (en) 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
EP0833944B1 (en) 1995-06-07 2009-01-07 Gilead Sciences, Inc. Nucleic acid ligands that bind to and inhibit dna polymerases
US5747252A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Nucleic acid probes and amplification oligonucleotides for Neisseria species
WO1997039008A1 (en) * 1996-04-12 1997-10-23 The Public Health Research Institute Of The City Of New York, Inc. Detection probes, kits and assays
JP4241929B2 (ja) 1996-05-22 2009-03-18 ジェン―プローブ・インコーポレーテッド Ｍｙｃｏｂａｃｔｅｒｉｕｍ Ｋａｎｓａｓｉｉを検出するための組成物および方法
US5898031A (en) * 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US7070925B1 (en) * 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
DE69736667T2 (de) * 1996-07-16 2007-09-06 Gen-Probe Inc., San Diego Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm)
US6747252B2 (en) * 1996-11-15 2004-06-08 Kenneth J. Herzog Multiple head induction sealer apparatus and method
US5846726A (en) * 1997-05-13 1998-12-08 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
US6210015B1 (en) * 1999-10-04 2001-04-03 Kenneth Alan Ross Stand for cakes or pastry

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