JP2000514092A - エリトロポエチン及び鉄調製物を含む医薬的組み合わせ調製物 - Google Patents
エリトロポエチン及び鉄調製物を含む医薬的組み合わせ調製物Info
- Publication number
- JP2000514092A JP2000514092A JP10540046A JP54004698A JP2000514092A JP 2000514092 A JP2000514092 A JP 2000514092A JP 10540046 A JP10540046 A JP 10540046A JP 54004698 A JP54004698 A JP 54004698A JP 2000514092 A JP2000514092 A JP 2000514092A
- Authority
- JP
- Japan
- Prior art keywords
- iron
- preparation
- combination
- erythropoietin
- preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- VAVPGQSSOJBZIP-UHFFFAOYSA-N sodium;iron(3+) Chemical compound [Na+].[Fe+3] VAVPGQSSOJBZIP-UHFFFAOYSA-N 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 208000008203 tachypnea Diseases 0.000 description 1
- 206010043089 tachypnoea Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- MYVIATVLJGTBFV-UHFFFAOYSA-M thiamine(1+) chloride Chemical compound [Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N MYVIATVLJGTBFV-UHFFFAOYSA-M 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- GZXOHHPYODFEGO-UHFFFAOYSA-N triglycine sulfate Chemical compound NCC(O)=O.NCC(O)=O.NCC(O)=O.OS(O)(=O)=O GZXOHHPYODFEGO-UHFFFAOYSA-N 0.000 description 1
- 238000004879 turbidimetry Methods 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- FUTVBRXUIKZACV-UHFFFAOYSA-J zinc;3-[18-(2-carboxylatoethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoate Chemical compound [Zn+2].[N-]1C2=C(C)C(CCC([O-])=O)=C1C=C([N-]1)C(CCC([O-])=O)=C(C)C1=CC(C(C)=C1C=C)=NC1=CC(C(C)=C1C=C)=NC1=C2 FUTVBRXUIKZACV-UHFFFAOYSA-J 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Clamps And Clips (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. a)250〜20,000Uの量の活性物質の個々の投与に適した個々の投与の形 態のエリトロポエチン調製物と、 b)1〜40mgの鉄イオンと等量に相当する生理的に適合する鉄調製物と、 を含む医薬用組合せ調製物。 2. 2,000U超、7,000U未満の個々の投与に適したエリトロポエチン調製物を 含む請求項1に記載の組合せ調製物。 3. 500〜2,000Uのエリトロポエチン調製物を含む請求項2に記載の組合せ調 製物。 4. 1〜30mgの鉄イオンと等量の鉄調製物を含む請求項1〜3のいずれかに記 載の組合せ調製物。 5. 5〜20mgの鉄イオンを含む請求項4に記載の組合せ調製物。 6. 前記鉄調製物が30,000〜100,000Dの分子量の複合体、好ましくはFe(III )サッカレートであることを特徴とする請求項1〜5のいずれか一に記載の組合 せ調製物。 7. 前記鉄調製物がFe(III)グルコネートであることを特徴とする請求項1 〜5のいずれか一に記載の組合せ調製物。 8. 血液透析患者の治療のための請求項1〜7のいずれか一に記載の組合せ調 製物。 9. 貧血症の治療のための請求項1〜7のいずれか一に記載の組合せ調製物。 10.請求項1〜9のいずれか一に記載の医薬用組合せ調製物を生産するための 方法であって、個々の投与の形態の250〜20,000Uのエリトロポエチン調製物及 び1〜40mgの鉄イオンに等量の生理的に適合する鉄調製物を一緒に又は別個に、 一般的な医薬担体又は補助 物質と一緒に製剤化し、そしてこれら調製物を組合せ調製物の形態で供すること を特徴とする方法。 11.1〜40mgの鉄イオンと等量の生理的に適合する鉄調製物と一緒に組み合わ せて投与するための個々の投与の形態の250〜20,000Uのエリトロポエチン調製 物を含む組合せ調製物を生産するためのエリトロポエチンの使用。 12.250〜20,000Uのエリトロポエチン調製物と一緒に組み合わせて投与する ための個々の投与の形態の1〜40mgの鉄イオンと等量の生理的に適合する鉄調製 物を含む組合せ調製物を生産するための鉄調製物の使用。 13.個々の投与形態の250〜20,000UのEPO調製物と、1の容器内に一様な投与 の形態として又は別個の容器内に別個の投与の形態としての1〜40mgの鉄イオン と等量の生理的に適合する鉄調製物と、を含む医薬パッケージングユニット。 14.前記エリトロポエチン調製物及び前記鉄調製物が、注射又は注入目的のた めの溶液の形態で別個の投与の形態で各々存在することを特徴とする請求項13に 記載のパッケージングユニット。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP1997/001343 WO1998041226A1 (de) | 1997-03-18 | 1997-03-18 | Pharmazeutische kombinationspräparate enthaltend erythropoietin und eisenpräparate |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2000514092A true JP2000514092A (ja) | 2000-10-24 |
Family
ID=8166555
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10540046A Pending JP2000514092A (ja) | 1997-03-18 | 1997-03-18 | エリトロポエチン及び鉄調製物を含む医薬的組み合わせ調製物 |
Country Status (19)
Country | Link |
---|---|
US (1) | US6710028B2 (ja) |
EP (1) | EP0977582B1 (ja) |
JP (1) | JP2000514092A (ja) |
AT (1) | ATE222118T1 (ja) |
AU (1) | AU726801B2 (ja) |
BR (1) | BR9714632A (ja) |
CA (1) | CA2284910C (ja) |
CZ (1) | CZ296960B6 (ja) |
DE (1) | DE59707988D1 (ja) |
DK (1) | DK0977582T3 (ja) |
ES (1) | ES2180958T3 (ja) |
HU (1) | HU226204B1 (ja) |
IL (2) | IL131959A0 (ja) |
NO (1) | NO324661B1 (ja) |
NZ (1) | NZ337465A (ja) |
PL (1) | PL187479B1 (ja) |
PT (1) | PT977582E (ja) |
SI (1) | SI0977582T1 (ja) |
WO (1) | WO1998041226A1 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7304150B1 (en) | 1998-10-23 | 2007-12-04 | Amgen Inc. | Methods and compositions for the prevention and treatment of anemia |
US7459435B2 (en) | 2002-08-29 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
US7459436B2 (en) | 2002-11-22 | 2008-12-02 | Hoffmann-La Roche Inc. | Treatment of disturbances of iron distribution |
US20040198663A1 (en) * | 2003-04-04 | 2004-10-07 | Baker John E. | Method of treating cardiac ischemia by using erythropoietin |
WO2005000340A1 (en) * | 2003-06-27 | 2005-01-06 | Pomytkin Igor A | Synergistic compositions comprising erythropoietin and succinic acid (salt) |
SI1696947T1 (sl) * | 2003-12-19 | 2014-05-30 | F. Hoffmann-La Roche Ag | Uporaba eritropoetina pri zdravljenju motenj porazdelitve železa pri kroničnih vnetnih črevesnih boleznih |
US20080090765A1 (en) * | 2006-05-25 | 2008-04-17 | The Trustees Of Columbia University In The City Of New York | Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage |
EP2219602A1 (en) | 2007-11-15 | 2010-08-25 | Amgen, Inc | Aqueous formulation of erythropoiesis stimulating protein stablised by antioxidants for parenteral administration |
EP2067752A1 (en) * | 2007-12-06 | 2009-06-10 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Construction material |
US8536106B2 (en) | 2010-04-14 | 2013-09-17 | Ecolab Usa Inc. | Ferric hydroxycarboxylate as a builder |
WO2011149962A1 (en) | 2010-05-24 | 2011-12-01 | The Trustees Of Columbia University In The City Of New York | Mutant ngal proteins and uses thereof |
EP2925337B1 (en) | 2012-11-21 | 2019-07-03 | The Trustees of Columbia University in the City of New York | Mutant ngal proteins and uses thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL77081A (en) | 1984-12-04 | 1999-10-28 | Genetics Inst | AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin |
US4745099A (en) | 1985-02-06 | 1988-05-17 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for the treatment of the anemia of malignant tumors |
JP2858752B2 (ja) * | 1987-04-10 | 1999-02-17 | オーソ・フアーマシユーチカル・コーポレーシヨン | 正常な哺乳動物のヘマトクリツト値の増大方法 |
GB9001987D0 (en) * | 1990-01-29 | 1990-03-28 | Janssen Pharmaceutica Nv | Improved cyclodextrin based erythropietin formulation |
DE19535571A1 (de) * | 1995-09-14 | 1997-03-20 | Boehringer Mannheim Gmbh | Pharmazeutische Kombinationspräparate und deren Verwendung zur Behandlung von Hämodialysepatienten |
EP0885613A1 (de) * | 1997-06-21 | 1998-12-23 | Roche Diagnostics GmbH | Verwendung von modifizierten Hämoglobinen zur Behandlung von Anämien und Kombinationspräparate umfassend Erythropoietin und modifiziertes Hämoglobin |
DE19734293A1 (de) * | 1997-08-08 | 1999-02-11 | Boehringer Mannheim Gmbh | Verwendung von pharmazeutischen Kombinationspräparaten enthaltend Erythropoietin und Eisenpräparate zur Behandlung von rheumatischen Erkrankungen |
US20020065214A1 (en) * | 2000-11-29 | 2002-05-30 | Adrian Iaina | Method of treating congestive heart failure |
MXPA03005406A (es) * | 2000-12-20 | 2003-09-25 | Hoffmann La Roche | Conjugados de eritropoyetina. |
-
1997
- 1997-03-18 DE DE59707988T patent/DE59707988D1/de not_active Expired - Lifetime
- 1997-03-18 WO PCT/EP1997/001343 patent/WO1998041226A1/de active IP Right Grant
- 1997-03-18 CZ CZ0330099A patent/CZ296960B6/cs not_active IP Right Cessation
- 1997-03-18 BR BR9714632-3A patent/BR9714632A/pt not_active Application Discontinuation
- 1997-03-18 AU AU21572/97A patent/AU726801B2/en not_active Expired
- 1997-03-18 JP JP10540046A patent/JP2000514092A/ja active Pending
- 1997-03-18 EP EP97914258A patent/EP0977582B1/de not_active Expired - Lifetime
- 1997-03-18 PL PL97335858A patent/PL187479B1/pl unknown
- 1997-03-18 HU HU0001409A patent/HU226204B1/hu unknown
- 1997-03-18 DK DK97914258T patent/DK0977582T3/da active
- 1997-03-18 NZ NZ337465A patent/NZ337465A/en not_active IP Right Cessation
- 1997-03-18 PT PT97914258T patent/PT977582E/pt unknown
- 1997-03-18 ES ES97914258T patent/ES2180958T3/es not_active Expired - Lifetime
- 1997-03-18 IL IL13195997A patent/IL131959A0/xx active IP Right Grant
- 1997-03-18 CA CA002284910A patent/CA2284910C/en not_active Expired - Lifetime
- 1997-03-18 AT AT97914258T patent/ATE222118T1/de active
- 1997-03-18 SI SI9730390T patent/SI0977582T1/xx unknown
-
1999
- 1999-09-16 IL IL131959A patent/IL131959A/en not_active IP Right Cessation
- 1999-09-17 NO NO19994511A patent/NO324661B1/no not_active IP Right Cessation
-
2001
- 2001-10-23 US US10/047,749 patent/US6710028B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
NO994511L (no) | 1999-09-17 |
CA2284910C (en) | 2003-01-28 |
NO324661B1 (no) | 2007-11-26 |
CA2284910A1 (en) | 1998-09-24 |
WO1998041226A1 (de) | 1998-09-24 |
ES2180958T3 (es) | 2003-02-16 |
HUP0001409A3 (en) | 2003-08-28 |
IL131959A0 (en) | 2001-03-19 |
EP0977582A1 (de) | 2000-02-09 |
DE59707988D1 (de) | 2002-09-19 |
HU226204B1 (en) | 2008-06-30 |
PL335858A1 (en) | 2000-05-22 |
CZ296960B6 (cs) | 2006-08-16 |
NZ337465A (en) | 2002-04-26 |
IL131959A (en) | 2006-12-31 |
SI0977582T1 (en) | 2002-12-31 |
NO994511D0 (no) | 1999-09-17 |
PT977582E (pt) | 2002-12-31 |
US6710028B2 (en) | 2004-03-23 |
AU2157297A (en) | 1998-10-12 |
ATE222118T1 (de) | 2002-08-15 |
WO1998041226A9 (de) | 1999-11-25 |
HUP0001409A2 (en) | 2001-03-28 |
PL187479B1 (pl) | 2004-07-30 |
US20020094948A1 (en) | 2002-07-18 |
CZ9903300A3 (cs) | 2001-03-14 |
DK0977582T3 (da) | 2002-12-16 |
BR9714632A (pt) | 2000-05-23 |
EP0977582B1 (de) | 2002-08-14 |
AU726801B2 (en) | 2000-11-23 |
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