JP2000512652A5 - - Google Patents

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Publication number
JP2000512652A5
JP2000512652A5 JP1998502317A JP50231798A JP2000512652A5 JP 2000512652 A5 JP2000512652 A5 JP 2000512652A5 JP 1998502317 A JP1998502317 A JP 1998502317A JP 50231798 A JP50231798 A JP 50231798A JP 2000512652 A5 JP2000512652 A5 JP 2000512652A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP1998502317A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000512652A (ja
Filing date
Publication date
Priority claimed from DE19624668A external-priority patent/DE19624668A1/de
Application filed filed Critical
Publication of JP2000512652A publication Critical patent/JP2000512652A/ja
Publication of JP2000512652A5 publication Critical patent/JP2000512652A5/ja
Withdrawn legal-status Critical Current

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JP10502317A 1996-06-20 1997-06-20 腫瘍の治療または免疫抑制におけるピリジルアルカン、ピリジルアルケンおよび/またはピリジルアルキン酸アミド類の用途 Withdrawn JP2000512652A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19624668A DE19624668A1 (de) 1996-06-20 1996-06-20 Verwendung von Pyridylalkan-, Pyridylalken- bzw. Pyridylalkinsäureamiden
PCT/EP1997/003244 WO1997048397A1 (en) 1996-06-20 1997-06-20 Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
DE19624668.7 1997-06-20

Publications (2)

Publication Number Publication Date
JP2000512652A JP2000512652A (ja) 2000-09-26
JP2000512652A5 true JP2000512652A5 (enExample) 2005-02-10

Family

ID=7797502

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10502317A Withdrawn JP2000512652A (ja) 1996-06-20 1997-06-20 腫瘍の治療または免疫抑制におけるピリジルアルカン、ピリジルアルケンおよび/またはピリジルアルキン酸アミド類の用途

Country Status (10)

Country Link
EP (1) EP0912176B1 (enExample)
JP (1) JP2000512652A (enExample)
AT (1) ATE224713T1 (enExample)
AU (1) AU3262497A (enExample)
DE (2) DE19624668A1 (enExample)
DK (1) DK0912176T3 (enExample)
ES (1) ES2181006T3 (enExample)
PT (1) PT912176E (enExample)
WO (1) WO1997048397A1 (enExample)
ZA (1) ZA975443B (enExample)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19624659A1 (de) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide
US6451816B1 (en) 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
JPH10338658A (ja) * 1997-04-08 1998-12-22 Hoechst Marion Roussel Kk レチノイド作用調節剤
DE19756212A1 (de) * 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
DE19756235A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
US6903118B1 (en) 1997-12-17 2005-06-07 Klinge Pharma Gmbh Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
DE19756261A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
DE19818044A1 (de) * 1998-04-22 1999-10-28 Klinge Co Chem Pharm Fab Verwendung von Vitamin-PP-Verbindungen
CA2340068A1 (en) * 1998-08-12 2000-02-24 Smithkline Beecham Corporation Calcilytic compounds
DE19908483A1 (de) * 1999-02-26 2000-10-05 Klinge Co Chem Pharm Fab Inhibitoren der zellulären Niacinamidmononucleotid-Bildung
EP1031564A1 (en) 1999-02-26 2000-08-30 Klinge Pharma GmbH Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy
JP2004507465A (ja) * 2000-08-11 2004-03-11 ワイス エストロゲン受容体陽性癌腫の治療方法
AU2001290143A1 (en) 2000-09-29 2002-04-08 Glaxo Group Limited Morpholin-acetamide derivatives for the treatment of inflammatory diseases
EP1348434A1 (en) * 2002-03-27 2003-10-01 Fujisawa Deutschland GmbH Use of pyridyl amides as inhibitors of angiogenesis
GB0207445D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
US7977049B2 (en) 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
WO2006097817A1 (en) 2005-03-17 2006-09-21 Pfizer Japan Inc. N- (n-sulfonylaminomethyl) cyclopropanecarboxamide derivatives useful for the treatment of pain
PE20071159A1 (es) 2005-10-31 2007-11-30 Schering Corp Derivados de tropano 3-monosustituido como ligandos de receptores de nociceptina
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
US8067415B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
HUP0600809A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
EP2098231A1 (en) 2008-03-05 2009-09-09 Topotarget Switzerland SA Use of NAD formation inhibitors for the treatment of ischemia-reperfusion injury
WO2009156421A1 (en) 2008-06-24 2009-12-30 Topotarget A/S Squaric acid derivatives as inhibitors of the nicotinamide
EP2342181A1 (en) 2008-08-29 2011-07-13 Topo Target A/S Novel urea and thiourea derivatives
EP2453883A1 (en) 2009-07-17 2012-05-23 Topo Target A/S Method for predicting the utility of administering nicotinic acid or a precursor or prodrug thereof to reduce the severity of side-effects of cancer treatment with nicotinamide phosphoribosyltransferase inhibitors
WO2011121055A1 (en) 2010-03-31 2011-10-06 Topotarget A/S Pyridinyl derivatives comprising a cyanoguanidine or squaric acid moiety
CN106243023A (zh) 2010-09-03 2016-12-21 福马Tm有限责任公司 用于抑制nampt的胍化合物和组合物
CA2809391A1 (en) 2010-09-03 2012-03-08 Genentech, Inc. 4-{[(pyridin-3-yl-methyl)aminocarbonyl]amino}benzene-sulfone derivatives as nampt inhibitors for therapy of diseases such as cancer
SG188367A1 (en) 2010-09-03 2013-04-30 Forma Tm Llc Novel compounds and compositions for the inhibition of nampt
CN103189356B (zh) * 2010-09-29 2015-11-25 英特维特国际股份有限公司 N-杂芳基化合物
JP6117104B2 (ja) 2010-11-15 2017-04-19 アッヴィ・インコーポレイテッド Namptおよびrock阻害薬
WO2012067963A1 (en) 2010-11-15 2012-05-24 Abbott Laboratories Nampt inhibitors
AU2011367222B2 (en) 2011-05-04 2017-04-13 Forma Tm, Llc Novel compounds and compositions for the inhibition of NAMPT
BR112013028877A2 (pt) 2011-05-09 2017-01-31 Forma Tm Llc derivados de piperidina e composições para a inibição de nicotinamida fosforibosiltransferase (nampt)
CA2873097A1 (en) 2012-05-11 2013-11-14 Todd M. Hansen Pyridazine and pyridine derivatives as nampt inhibitors
CN104684906B (zh) 2012-05-11 2017-06-09 艾伯维公司 Nampt抑制剂
HK1208450A1 (en) 2012-05-11 2016-03-04 Abbvie Inc. Nampt inhibitors
US9334264B2 (en) 2012-05-11 2016-05-10 Abbvie Inc. NAMPT inhibitors
HK1215579A1 (zh) 2012-11-29 2016-09-02 Karyopharm Therapeutics, Inc. 被取代的2,3-二氫苯並呋喃基化合物和其用途
KR102325247B1 (ko) 2013-07-03 2021-11-11 카리오팜 쎄라퓨틱스, 인코포레이티드 치환된 벤조퓨라닐 및 벤즈옥사졸릴 화합물 및 이의 용도
US9994558B2 (en) 2013-09-20 2018-06-12 Karyopharm Therapeutics Inc. Multicyclic compounds and methods of using same
CN108137563A (zh) 2015-08-18 2018-06-08 卡尔约药物治疗公司 用于治疗癌症的(S,E)-3-(6-氨基吡啶-3-基)-N-((5-(4-(3-氟-3-甲基吡咯烷-l-羰基)苯基)-7-(4-氟苯基)苯并呋喃-2-基)甲基)丙烯酰胺
WO2017117447A1 (en) 2015-12-31 2017-07-06 Karyopharm Therapeutics Inc. Multicyclic compounds and uses thereof
TWI835714B (zh) 2016-10-18 2024-03-21 美商思進公司 菸鹼醯胺腺嘌呤二核苷酸補救合成(salvage pathway)抑制劑之靶向投遞
WO2018086703A1 (en) 2016-11-11 2018-05-17 Bayer Pharma Aktiengesellschaft Dihydropyridazinones substituted with phenylureas
BR112019022445A2 (pt) 2017-04-27 2020-05-12 Seattle Genetics, Inc. Composição de conjugado ligante-fármaco, formulação, método para inibir a multiplicação de uma célula tumoral ou célula cancerosa ou causar apoptose em uma célula tumoral ou cancerosa, e, composto de conector de fármaco
WO2019149637A1 (en) 2018-01-31 2019-08-08 Bayer Aktiengesellschaft Antibody drug conjugates (adcs) with nampt inhibitors
KR20250107972A (ko) 2018-05-04 2025-07-14 레미디 플랜, 인크. 암 줄기 세포를 표적화하는 암 치료
WO2021013693A1 (en) 2019-07-23 2021-01-28 Bayer Pharma Aktiengesellschaft Antibody drug conjugates (adcs) with nampt inhibitors
BR112022008753A2 (pt) 2019-11-06 2022-07-19 Remedy Plan Inc Tratamentos de câncer direcionados a células-tronco cancerosas
US20240376074A1 (en) 2021-05-13 2024-11-14 Remedy Plan, Inc. Nampt inhibitors and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4778796A (en) * 1985-07-19 1988-10-18 Dainippon Pharmaceutical Co., Ltd. ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same
JP2832979B2 (ja) * 1988-02-15 1998-12-09 武田薬品工業株式会社 不飽和カルボン酸アミド誘導体
EP0343307A1 (en) * 1988-05-26 1989-11-29 Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. 4-Piperidinealkanamine derivatives
JPH05506027A (ja) * 1990-04-10 1993-09-02 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング 新規ピリジンエステル
US5352684A (en) * 1990-04-10 1994-10-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyridines as medicaments

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