JP2000512614A5 - - Google Patents

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Publication number
JP2000512614A5
JP2000512614A5 JP1997520159A JP52015997A JP2000512614A5 JP 2000512614 A5 JP2000512614 A5 JP 2000512614A5 JP 1997520159 A JP1997520159 A JP 1997520159A JP 52015997 A JP52015997 A JP 52015997A JP 2000512614 A5 JP2000512614 A5 JP 2000512614A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1997520159A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000512614A (ja
Filing date
Publication date
Priority claimed from GBGB9524104.8A external-priority patent/GB9524104D0/en
Application filed filed Critical
Publication of JP2000512614A publication Critical patent/JP2000512614A/ja
Publication of JP2000512614A5 publication Critical patent/JP2000512614A5/ja
Ceased legal-status Critical Current

Links

JP09520159A 1995-11-24 1996-11-22 Nk3アンタゴニストとしてのキノリン誘導体 Ceased JP2000512614A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9524104.8A GB9524104D0 (en) 1995-11-24 1995-11-24 Novel compounds
GB9524104.8 1995-11-24
PCT/EP1996/005209 WO1997019927A1 (en) 1995-11-24 1996-11-22 Quinoline derivatives as nk3 antagonists
CA002238171A CA2238171C (en) 1995-11-24 1998-05-21 Quinoline derivatives as nk3 antagonists

Publications (2)

Publication Number Publication Date
JP2000512614A JP2000512614A (ja) 2000-09-26
JP2000512614A5 true JP2000512614A5 (enExample) 2004-10-07

Family

ID=31496493

Family Applications (1)

Application Number Title Priority Date Filing Date
JP09520159A Ceased JP2000512614A (ja) 1995-11-24 1996-11-22 Nk3アンタゴニストとしてのキノリン誘導体

Country Status (9)

Country Link
US (1) US6743804B2 (enExample)
EP (1) EP0874827B1 (enExample)
JP (1) JP2000512614A (enExample)
CA (1) CA2238171C (enExample)
CY (1) CY2505B1 (enExample)
DE (1) DE69628334T2 (enExample)
ES (1) ES2200080T3 (enExample)
GB (1) GB9524104D0 (enExample)
WO (1) WO1997019927A1 (enExample)

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US7037922B1 (en) 2000-03-10 2006-05-02 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
WO2000058313A1 (en) 1999-03-29 2000-10-05 Neurogen Corporation 4-substituted quinoline derivatives as gaba receptor ligands
US6855715B1 (en) 1999-06-14 2005-02-15 Eli Lilly And Company Serine protease inhibitors
KR100681724B1 (ko) 1999-10-19 2007-02-28 머크 앤드 캄파니 인코포레이티드 티로신 키나제 억제제 및 이를 포함하는 약제학적 조성물
US6794393B1 (en) 1999-10-19 2004-09-21 Merck & Co., Inc. Tyrosine kinase inhibitors
US6313138B1 (en) 2000-02-25 2001-11-06 Merck & Co., Inc. Tyrosine kinase inhibitors
US6420382B2 (en) 2000-02-25 2002-07-16 Merck & Co., Inc. Tyrosine kinase inhibitors
US6521618B2 (en) 2000-03-28 2003-02-18 Wyeth 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
CA2424689A1 (en) 2000-10-17 2002-04-25 Merck & Co., Inc. Orally active salts with tyrosine kinase activity
GB0028964D0 (en) * 2000-11-28 2001-01-10 Smithkline Beecham Spa Novel compounds
US7169788B2 (en) 2001-10-30 2007-01-30 Merck & Co., Inc. Tyrosine kinase inhibitors
US20060111368A1 (en) * 2002-06-26 2006-05-25 Kyowa Hakko Kogyo Co., Ltd. Phosphodiesterase inhibitor
ATE477268T1 (de) 2003-01-28 2010-08-15 Ironwood Pharmaceuticals Inc Zusammensetzungen zur behandlung von magen-darm- störungen
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
RU2229475C1 (ru) * 2003-03-06 2004-05-27 ООО "Исследовательский институт химического разнообразия 6-сульфамоилхинолин-4-карбоновые кислоты, их производные и комбинаторная библиотека
TW201018662A (en) 2005-12-12 2010-05-16 Astrazeneca Ab Alkylsulphonamide quinolines
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX2009013293A (es) 2007-06-04 2010-02-15 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
US20090118135A1 (en) * 2007-06-08 2009-05-07 The Burnham Institute Methods and compounds for regulating apoptosis
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
KR20170091783A (ko) 2008-12-31 2017-08-09 알데릭스, 인코포레이티드 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료 시에 nhe-매개된 역수송을 억제하는 화합물 및 방법
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
AU2013304812B2 (en) 2012-08-21 2016-06-09 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
SMT201900386T1 (it) 2013-04-12 2019-09-09 Ardelyx Inc Composti nhe3-leganti e metodi per l'inibizione del trasporto di fosfato
WO2014170648A1 (en) 2013-04-19 2014-10-23 Astrazeneca Ab A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos)
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
MX387903B (es) * 2014-07-08 2025-03-19 Corteva Agriscience Llc Proceso para la preparacion de acidos 3-hidroxipicolinicos.
WO2017072629A1 (en) 2015-10-29 2017-05-04 Cadila Healthcare Limited Pharmaceutical combination of nk3 receptor antagonist and biguanides
JP2020505333A (ja) 2017-01-09 2020-02-20 アルデリックス, インコーポレイテッド Nhe媒介性アンチポートの阻害薬
AU2018205400C1 (en) 2017-01-09 2026-01-15 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders
US20210401821A1 (en) * 2018-11-15 2021-12-30 Kyushu University, National University Corporation Prophylactic or therapeutic agent and medicinal composition for il-31-mediated disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
EP1082959A1 (en) * 1991-09-20 2001-03-14 Glaxo Group Limited NK1 Antagonists for the treatment of depression
ATE161530T1 (de) * 1992-09-04 1998-01-15 Takeda Chemical Industries Ltd Kondensierte heterozyklische verbindungen, deren herstellung und verwendung
TW263498B (enExample) * 1993-11-10 1995-11-21 Takeda Pharm Industry Co Ltd
RO114445B1 (ro) * 1994-05-27 1999-04-30 Smithkline Beecham S.P.A. Derivaţi de chinolină antagonişti ai receptorului nk3 tachichinină,procedeu de preparare,compoziţii farmaceutice pe baza acestora şi metodă de tratament
IT1270615B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina

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