JP2000512434A - 磁 石 - Google Patents
磁 石Info
- Publication number
- JP2000512434A JP2000512434A JP09517509A JP51750997A JP2000512434A JP 2000512434 A JP2000512434 A JP 2000512434A JP 09517509 A JP09517509 A JP 09517509A JP 51750997 A JP51750997 A JP 51750997A JP 2000512434 A JP2000512434 A JP 2000512434A
- Authority
- JP
- Japan
- Prior art keywords
- magnet
- beads
- magnetic
- cell
- magnetic field
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 title 1
- 239000011324 bead Substances 0.000 claims abstract description 93
- 230000005291 magnetic effect Effects 0.000 claims abstract description 90
- 238000000034 method Methods 0.000 claims abstract description 5
- 230000014759 maintenance of location Effects 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000010409 thin film Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 17
- 239000003153 chemical reaction reagent Substances 0.000 description 15
- 230000005298 paramagnetic effect Effects 0.000 description 8
- 239000000203 mixture Substances 0.000 description 5
- 238000003556 assay Methods 0.000 description 4
- 238000005842 biochemical reaction Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000376 reactant Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 239000004593 Epoxy Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000696 magnetic material Substances 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 239000002907 paramagnetic material Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000013019 agitation Methods 0.000 description 1
- 238000010256 biochemical assay Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920005597 polymer membrane Polymers 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F7/00—Magnets
- H01F7/02—Permanent magnets [PM]
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F7/00—Magnets
- H01F7/02—Permanent magnets [PM]
- H01F7/0273—Magnetic circuits with PM for magnetic field generation
- H01F7/0278—Magnetic circuits with PM for magnetic field generation for generating uniform fields, focusing, deflecting electrically charged particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/025—High gradient magnetic separators
- B03C1/031—Component parts; Auxiliary operations
- B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
- B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00459—Beads
- B01J2219/00468—Beads by manipulation of individual beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/22—Details of magnetic or electrostatic separation characterised by the magnetic field, e.g. its shape or generation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
Landscapes
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Engineering & Computer Science (AREA)
- Power Engineering (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US620295P | 1995-11-03 | 1995-11-03 | |
| US60/006,202 | 1995-11-03 | ||
| PCT/US1996/017398 WO1997016835A1 (en) | 1995-11-03 | 1996-11-01 | Magnet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2000512434A true JP2000512434A (ja) | 2000-09-19 |
Family
ID=21719777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP09517509A Pending JP2000512434A (ja) | 1995-11-03 | 1996-11-01 | 磁 石 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0876668A1 (enrdf_load_stackoverflow) |
| JP (1) | JP2000512434A (enrdf_load_stackoverflow) |
| KR (1) | KR19990067263A (enrdf_load_stackoverflow) |
| AU (1) | AU7483596A (enrdf_load_stackoverflow) |
| WO (1) | WO1997016835A1 (enrdf_load_stackoverflow) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5935401A (en) * | 1996-09-18 | 1999-08-10 | Aclara Biosciences | Surface modified electrophoretic chambers |
| US5770029A (en) * | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
| US6074827A (en) | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
| US6241894B1 (en) * | 1997-10-10 | 2001-06-05 | Systemix | High gradient magnetic device and method for cell separation or purification |
| US6942771B1 (en) | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
| US8481268B2 (en) | 1999-05-21 | 2013-07-09 | Illumina, Inc. | Use of microfluidic systems in the detection of target analytes using microsphere arrays |
| US6875619B2 (en) | 1999-11-12 | 2005-04-05 | Motorola, Inc. | Microfluidic devices comprising biochannels |
| US6361958B1 (en) | 1999-11-12 | 2002-03-26 | Motorola, Inc. | Biochannel assay for hybridization with biomaterial |
| FR2826882B1 (fr) | 2001-07-09 | 2003-09-12 | Bio Merieux | Procede de traitement de particules magnetiques et configurations d'aimants permettant la mise en oeuvre de ce procede |
| EP3718635A1 (en) | 2003-07-31 | 2020-10-07 | Handylab, Inc. | Processing particle-containing samples |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| WO2005114166A1 (en) | 2004-05-21 | 2005-12-01 | Atonomics A/S | Surface acoustic wave sensor comprising a hydrogel |
| NL1030761C2 (nl) * | 2005-12-23 | 2007-06-29 | Bakker Holding Son Bv | Werkwijze en inrichting voor het scheiden van vaste deeltjes op basis van dichtheidsverschil. |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| ES2692380T3 (es) | 2006-03-24 | 2018-12-03 | Handylab, Inc. | Método para realizar PCR con un cartucho con varias pistas |
| US20070247968A1 (en) * | 2006-04-21 | 2007-10-25 | V & P Scientific, Inc. | Sandwich magnetic stir elements for stirring the contents of vessels |
| AU2007274748A1 (en) * | 2006-06-21 | 2008-01-24 | Spinomix S.A. | A device and method for manipulating and mixing magnetic particles in a liquid medium |
| US8709787B2 (en) | 2006-11-14 | 2014-04-29 | Handylab, Inc. | Microfluidic cartridge and method of using same |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| ES2877602T3 (es) | 2007-07-13 | 2021-11-17 | Handylab Inc | Materiales de captura de polinucleótidos y procedimientos de uso de los mismos |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| BR112013026451B1 (pt) | 2011-04-15 | 2021-02-09 | Becton, Dickinson And Company | sistema e método para realizar ensaios de diagnóstico molecular em várias amostras em paralelo e simultaneamente amplificação em tempo real em pluralidade de câmaras de reação de amplificação |
| CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
| US10091594B2 (en) | 2014-07-29 | 2018-10-02 | Cochlear Limited | Bone conduction magnetic retention system |
| US10130807B2 (en) | 2015-06-12 | 2018-11-20 | Cochlear Limited | Magnet management MRI compatibility |
| US20160381473A1 (en) | 2015-06-26 | 2016-12-29 | Johan Gustafsson | Magnetic retention device |
| US10917730B2 (en) | 2015-09-14 | 2021-02-09 | Cochlear Limited | Retention magnet system for medical device |
| US11595768B2 (en) | 2016-12-02 | 2023-02-28 | Cochlear Limited | Retention force increasing components |
| CN114340725A (zh) | 2019-09-27 | 2022-04-12 | 科利耳有限公司 | 用于医用植入物系统的多极磁体 |
| US11701668B1 (en) * | 2020-05-08 | 2023-07-18 | 10X Genomics, Inc. | Methods and devices for magnetic separation |
| US11946038B1 (en) | 2020-05-29 | 2024-04-02 | 10X Genomics, Inc. | Methods and systems including flow and magnetic modules |
| US12263482B1 (en) | 2020-06-03 | 2025-04-01 | 10X Genomics, Inc. | Methods and devices for magnetic separation in a flow path |
| KR102643820B1 (ko) * | 2022-01-28 | 2024-03-06 | 한국기계연구원 | 자기장 제어를 이용한 입자 이동 제어장치 및 이를 이용한 입자 이동 제어방법 |
| CN116020656B (zh) * | 2022-12-30 | 2024-02-02 | 辽宁润兴新材料有限公司 | 一种包覆沥青材料加工用除杂装置 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB236808A (en) * | 1924-12-02 | 1925-07-16 | Krupp Fried Grusonwerk Ag | Improvements in or relating to zone poles for magnetic separators |
| JPS6253714A (ja) * | 1985-08-30 | 1987-03-09 | Kamata Bio Eng Kk | 流体の磁化浄化装置 |
| US4998083A (en) * | 1989-11-02 | 1991-03-05 | New York University | Yokeless permanent magnet structure and method of construction |
| DE4032616A1 (de) * | 1990-09-29 | 1992-04-02 | Kloeckner Humboldt Deutz Ag | Magnetsystem |
| JP3065781B2 (ja) * | 1992-03-09 | 2000-07-17 | ティーディーケイ株式会社 | 永久磁石磁気回路 |
| EP0589636B1 (en) * | 1992-09-24 | 2000-08-02 | Amersham Pharmacia Biotech UK Limited | Magnetic separation method and apparatus therefor |
| WO1995007126A1 (en) * | 1993-09-07 | 1995-03-16 | Brunsting William J | Magnetic filter assembly |
-
1996
- 1996-11-01 KR KR1019980703228A patent/KR19990067263A/ko not_active Withdrawn
- 1996-11-01 AU AU74835/96A patent/AU7483596A/en not_active Abandoned
- 1996-11-01 JP JP09517509A patent/JP2000512434A/ja active Pending
- 1996-11-01 EP EP96937082A patent/EP0876668A1/en not_active Withdrawn
- 1996-11-01 WO PCT/US1996/017398 patent/WO1997016835A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0876668A1 (en) | 1998-11-11 |
| EP0876668A4 (enrdf_load_stackoverflow) | 1998-11-18 |
| KR19990067263A (ko) | 1999-08-16 |
| WO1997016835A1 (en) | 1997-05-09 |
| AU7483596A (en) | 1997-05-22 |
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