JP2000512137A - レプチン（ｏｂタンパク質）のフラグメント - Google Patents

レプチン（ｏｂタンパク質）のフラグメント

Info

Publication number
JP2000512137A
JP2000512137A JP10500240A JP50024098A JP2000512137A JP 2000512137 A JP2000512137 A JP 2000512137A JP 10500240 A JP10500240 A JP 10500240A JP 50024098 A JP50024098 A JP 50024098A JP 2000512137 A JP2000512137 A JP 2000512137A
Authority
JP
Japan
Prior art keywords
peptide
dna
peptides
compound
functional derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10500240A
Other languages
English (en)
Japanese (ja)
Inventor
アル―バラザンジ，カマル・エイ
アーチ，ジョナサン・ロバート・サンダース
カミレリ，パトリック
ネビル，ウィリアム・アーサー
Original Assignee
スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9611775.9A external-priority patent/GB9611775D0/en
Priority claimed from GBGB9618540.0A external-priority patent/GB9618540D0/en
Priority claimed from GBGB9703493.8A external-priority patent/GB9703493D0/en
Application filed by スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー filed Critical スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー
Publication of JP2000512137A publication Critical patent/JP2000512137A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP10500240A 1996-06-06 1997-06-04 レプチン（ｏｂタンパク質）のフラグメント Pending JP2000512137A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9611775.9 1996-06-06
GBGB9611775.9A GB9611775D0 (en) 1996-06-06 1996-06-06 Novel compounds
GB9618540.0 1996-09-05
GBGB9618540.0A GB9618540D0 (en) 1996-09-05 1996-09-05 Novel compounds
GBGB9703493.8A GB9703493D0 (en) 1997-02-20 1997-02-20 Novel compounds
GB9703493.8 1997-02-20
PCT/EP1997/002968 WO1997046585A2 (en) 1996-06-06 1997-06-04 Fragments of leptin (ob protein)

Publications (1)

Publication Number Publication Date
JP2000512137A true JP2000512137A (ja) 2000-09-19

Family

ID=27268305

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10500240A Pending JP2000512137A (ja) 1996-06-06 1997-06-04 レプチン（ｏｂタンパク質）のフラグメント

Country Status (15)

Country Link
EP (1) EP0912609A2 (no)
JP (1) JP2000512137A (no)
KR (1) KR20000016402A (no)
CN (1) CN1221426A (no)
AR (1) AR008765A1 (no)
AU (1) AU3337297A (no)
BR (1) BR9709529A (no)
CA (1) CA2257240A1 (no)
CZ (1) CZ397898A3 (no)
IL (1) IL127153A0 (no)
NO (1) NO985683L (no)
NZ (1) NZ332879A (no)
PL (1) PL330361A1 (no)
TR (1) TR199802534T2 (no)
WO (1) WO1997046585A2 (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018504913A (ja) * 2015-05-06 2018-02-22 広東省生物資源応用研究所Ｇｕａｎｇｄｏｎｇ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ａｐｐｌｉｅｄ Ｂｉｏｌｏｇｉｃａｌ Ｒｅｓｏｕｒｃｅｓ Ｃｄループとｅへリックス領域とでの突然変異を有するレプチン活性ペプチド、そのコード遺伝子およびその応用

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000007014A2 (en) 1998-07-28 2000-02-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Leptin-mediated gene-induction
US6777388B1 (en) 1998-08-21 2004-08-17 Clf Medical Technology Acceleration Program, Inc. Leptin-related peptides
US7208572B2 (en) * 1998-08-21 2007-04-24 Albany Medical College Leptin-related peptides
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
CA2388417A1 (en) 1999-09-22 2001-03-29 Genset Methods of screening for compounds that modulate the lsr-leptin interaction and their use in the prevention and treatment of obesity-related diseases
CA2407872C (en) 2000-05-22 2013-11-12 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Receptor-based interaction trap
WO2003034996A2 (en) 2001-10-22 2003-05-01 Amgen, Inc. Use of leptin for treating human lipoatrophy and method of determining predisposition to said treatment
ES2300817T3 (es) 2003-09-08 2008-06-16 Laboratoires Serono Sa Tratamiento de enfermedades fibroticas.
CN103897066A (zh) 2004-02-11 2014-07-02 安米林药品有限责任公司 具有可选择特性的杂合多肽
EP1812038A1 (en) 2004-11-18 2007-08-01 VIB vzw Fibronectin iii domain as leptin receptor antagonists
EA011653B1 (ru) 2005-02-11 2009-04-28 Амилин Фармасьютикалз, Инк. Аналоги и гибридные полипептиды gip с избираемыми свойствами
US7629315B2 (en) 2005-03-09 2009-12-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Compositions for blocking the inhibitory effect of human CRP on human leptin
AU2006279680B2 (en) 2005-08-11 2012-12-06 Amylin Pharmaceuticals, Llc Hybrid polypeptides with selectable properties
EP2330125A3 (en) 2005-08-11 2012-12-12 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
ES2319048B1 (es) * 2007-06-20 2010-02-10 Universitat De Les Illes Balears Uso de leptina en el tratamiento de alteraciones en los habitos alimentarios.
US8889622B2 (en) 2007-07-25 2014-11-18 Washington University Methods of inhibiting seizure in a subject
GB2451858A (en) * 2007-08-15 2009-02-18 Sergiy Konovchuk Methods of reducing body fat and treating obesity
US20110059969A1 (en) 2007-12-05 2011-03-10 Astrazeneca Ab Piperazines as anti-obesity agents
WO2009071668A2 (en) 2007-12-05 2009-06-11 Biovitrum Ab (Publ) Piperazine derivatives and their use as leptin receptor modulators
BRPI0913448A2 (pt) * 2008-06-04 2015-12-01 Astrazeneca Ab composto, formulação farmacêutica, uso de um composto, e, método para o tratamento ou prevenção das condições ou doenças que são prevenidas, tratadas, ou melhoradas pela ação seletiva por intermédio do receptor de leptina0.
MX2010013355A (es) * 2008-06-04 2010-12-21 Astrazeneca Ab Nuevos compuestos v.
JP2012523434A (ja) 2009-04-10 2012-10-04 アミリン・ファーマシューティカルズ，インコーポレイテッド エストロゲン欠乏哺乳類のためのアミリンアゴニスト化合物
ES2602436T3 (es) * 2010-05-11 2017-02-21 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Inhibidor basado en péptido de la activación de interleucina 10 o STAT-3
EA032917B1 (ru) 2010-09-28 2019-08-30 Амилин Фармасьютикалс, Ллк Сконструированные полипептиды, характеризующиеся увеличенной продолжительностью действия
CN110183530A (zh) * 2019-06-21 2019-08-30 深圳市亚辉龙生物科技股份有限公司 瘦素免疫原、杂交瘤细胞、单克隆抗体、多克隆抗体及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309853B1 (en) * 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
AU4766096A (en) * 1995-01-31 1996-08-21 Eli Lilly And Company Anti-obesity proteins
WO1996023815A1 (en) * 1995-01-31 1996-08-08 Eli Lilly And Company Ob gene product antibodies
US5552523A (en) * 1995-01-31 1996-09-03 Eli Lilly And Company Anti-obesity proteins
AU5539596A (en) * 1995-04-06 1996-10-23 Amylin Pharmaceuticals, Inc. Anti-obesity agents
GB9509164D0 (en) * 1995-05-05 1995-06-28 Smithkline Beecham Plc Novel compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018504913A (ja) * 2015-05-06 2018-02-22 広東省生物資源応用研究所Ｇｕａｎｇｄｏｎｇ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ａｐｐｌｉｅｄ Ｂｉｏｌｏｇｉｃａｌ Ｒｅｓｏｕｒｃｅｓ Ｃｄループとｅへリックス領域とでの突然変異を有するレプチン活性ペプチド、そのコード遺伝子およびその応用

Also Published As

Publication number Publication date
CN1221426A (zh) 1999-06-30
AU3337297A (en) 1998-01-05
WO1997046585A2 (en) 1997-12-11
KR20000016402A (ko) 2000-03-25
EP0912609A2 (en) 1999-05-06
WO1997046585A3 (en) 1998-04-23
AR008765A1 (es) 2000-02-23
CA2257240A1 (en) 1997-12-11
BR9709529A (pt) 1999-08-10
NO985683D0 (no) 1998-12-04
IL127153A0 (en) 1999-09-22
TR199802534T2 (xx) 1999-03-22
NO985683L (no) 1998-12-04
PL330361A1 (en) 1999-05-10
CZ397898A3 (cs) 1999-04-14
NZ332879A (en) 2000-09-29

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