JP2000510858A - ６―フルオロウルソデオキシコール酸（６―ｆｕｄｃａ）による結腸直腸癌の予防および治療 - Google Patents
６―フルオロウルソデオキシコール酸（６―ｆｕｄｃａ）による結腸直腸癌の予防および治療Info
- Publication number
- JP2000510858A JP2000510858A JP09541562A JP54156297A JP2000510858A JP 2000510858 A JP2000510858 A JP 2000510858A JP 09541562 A JP09541562 A JP 09541562A JP 54156297 A JP54156297 A JP 54156297A JP 2000510858 A JP2000510858 A JP 2000510858A
- Authority
- JP
- Japan
- Prior art keywords
- fudca
- colon
- pharmaceutically acceptable
- acid
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1820296P | 1996-05-23 | 1996-05-23 | |
| US60/018,202 | 1996-05-23 | ||
| PCT/EP1997/002632 WO1997044043A1 (en) | 1996-05-23 | 1997-05-22 | Prevention and treatment of colorectal cancer by 6-fluoroursodeoxycholic acid (6-fudca) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009252071A Division JP2010059175A (ja) | 1996-05-23 | 2009-11-02 | ６−フルオロウルソデオキシコール酸（６−ｆｕｄｃａ）を含む結腸腺腫または結腸微小腺腫の処置または進行の遅延用医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000510858A true JP2000510858A (ja) | 2000-08-22 |
| JP2000510858A5 JP2000510858A5 (cg-RX-API-DMAC7.html) | 2004-12-09 |
Family
ID=21786767
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP09541562A Pending JP2000510858A (ja) | 1996-05-23 | 1997-05-22 | ６―フルオロウルソデオキシコール酸（６―ｆｕｄｃａ）による結腸直腸癌の予防および治療 |
| JP2009252071A Withdrawn JP2010059175A (ja) | 1996-05-23 | 2009-11-02 | ６−フルオロウルソデオキシコール酸（６−ｆｕｄｃａ）を含む結腸腺腫または結腸微小腺腫の処置または進行の遅延用医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009252071A Withdrawn JP2010059175A (ja) | 1996-05-23 | 2009-11-02 | ６−フルオロウルソデオキシコール酸（６−ｆｕｄｃａ）を含む結腸腺腫または結腸微小腺腫の処置または進行の遅延用医薬組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6426340B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP0906106B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2000510858A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE394107T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU3091597A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2253593C (cg-RX-API-DMAC7.html) |
| DE (1) | DE69738667D1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2306459T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT906106E (cg-RX-API-DMAC7.html) |
| WO (1) | WO1997044043A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU758679B2 (en) * | 1998-07-24 | 2003-03-27 | Seo Hong Yoo | Preparation of aqueous clear solution dosage forms with bile acids |
| JP2002522381A (ja) * | 1998-08-06 | 2002-07-23 | ストレンメル，ボルフガング | 粘膜保護用医薬としてのホスファチジルコリン |
| MXPA02003321A (es) * | 1999-09-28 | 2004-09-10 | Panacea Biotec Ltd | Composiciones de liberacion controlada que comprenden nimesulida. |
| US7053076B2 (en) | 2001-08-29 | 2006-05-30 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
| EP1558763A4 (en) * | 2002-11-01 | 2007-08-15 | James Kaput | IDENTIFICATION OF GENES ASSOCIATED WITH A DISEASE REGULATED BY A DIET |
| CA2674683A1 (en) * | 2007-01-16 | 2008-07-24 | The Burnham Institute For Medical Research | Compositions and methods for treatment of colorectal cancer |
| EP2255813A1 (en) * | 2009-05-29 | 2010-12-01 | The Royal College of Surgeons in Ireland | Derivatives of ursodeoxycholic acid for the treatment of diarrhoea |
| SMT201800453T1 (it) | 2010-11-04 | 2018-11-09 | Albireo Ab | Inibitori di ibat per il trattamento delle epatopatie |
| JP6751020B2 (ja) | 2014-06-25 | 2020-09-02 | Ｅａファーマ株式会社 | 固形製剤及びその着色防止又は着色低減方法 |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| CA3071285A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | Cholestyramine granules, oral cholestyramine formulations and use thereof |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| TW202015699A (zh) | 2018-06-05 | 2020-05-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽汁酸調節劑之用途 |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| FI3810581T3 (fi) | 2018-06-20 | 2025-02-28 | Albireo Ab | Odeviksibaatin kiteiset modifikaatiot |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| ES2937153T3 (es) | 2019-02-06 | 2023-03-24 | Albireo Ab | Compuestos de benzotiadiazepinas y su uso como moduladores de ácidos biliares |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| KR20220109450A (ko) | 2019-12-04 | 2022-08-04 | 알비레오 에이비 | 벤조티아(디)아제핀 화합물 및 담즙산 조절제로서의 이의 용도 |
| CN114761018B (zh) | 2019-12-04 | 2025-12-02 | 阿尔比里奥公司 | 苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| ES2973355T3 (es) | 2019-12-04 | 2024-06-19 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar |
| CA3158276A1 (en) | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
| CA3186857A1 (en) | 2020-08-03 | 2022-02-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
| JP2023549226A (ja) | 2020-11-12 | 2023-11-22 | アルビレオ エービー | 進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット |
| CN116583504A (zh) | 2020-12-04 | 2023-08-11 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8825526D0 (en) * | 1988-11-01 | 1988-12-07 | Enzymatix Ltd | Diagnosis |
| US5175320A (en) * | 1989-04-17 | 1992-12-29 | Giuliani S.P.A. | Fluorinated bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| US5843929A (en) | 1996-03-22 | 1998-12-01 | Mayo Foundation For Medical Education And Research | Chemoprevention of metachronous adenomatous colorectal polyps |
-
1997
- 1997-05-22 EP EP97925934A patent/EP0906106B1/en not_active Expired - Lifetime
- 1997-05-22 CA CA002253593A patent/CA2253593C/en not_active Expired - Fee Related
- 1997-05-22 ES ES97925934T patent/ES2306459T3/es not_active Expired - Lifetime
- 1997-05-22 AU AU30915/97A patent/AU3091597A/en not_active Abandoned
- 1997-05-22 WO PCT/EP1997/002632 patent/WO1997044043A1/en not_active Ceased
- 1997-05-22 DE DE69738667T patent/DE69738667D1/de not_active Expired - Lifetime
- 1997-05-22 AT AT97925934T patent/ATE394107T1/de not_active IP Right Cessation
- 1997-05-22 JP JP09541562A patent/JP2000510858A/ja active Pending
- 1997-05-22 PT PT97925934T patent/PT906106E/pt unknown
-
2000
- 2000-10-06 US US09/684,585 patent/US6426340B1/en not_active Expired - Fee Related
-
2009
- 2009-11-02 JP JP2009252071A patent/JP2010059175A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES2306459T3 (es) | 2008-11-01 |
| CA2253593A1 (en) | 1997-11-27 |
| WO1997044043A1 (en) | 1997-11-27 |
| PT906106E (pt) | 2008-08-07 |
| US6426340B1 (en) | 2002-07-30 |
| EP0906106B1 (en) | 2008-05-07 |
| JP2010059175A (ja) | 2010-03-18 |
| ATE394107T1 (de) | 2008-05-15 |
| AU3091597A (en) | 1997-12-09 |
| CA2253593C (en) | 2008-07-08 |
| DE69738667D1 (de) | 2008-06-19 |
| EP0906106A1 (en) | 1999-04-07 |
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