JP2000507577A - 画像診断用の生物活性造影剤 - Google Patents
画像診断用の生物活性造影剤Info
- Publication number
- JP2000507577A JP2000507577A JP9535373A JP53537397A JP2000507577A JP 2000507577 A JP2000507577 A JP 2000507577A JP 9535373 A JP9535373 A JP 9535373A JP 53537397 A JP53537397 A JP 53537397A JP 2000507577 A JP2000507577 A JP 2000507577A
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- JP
- Japan
- Prior art keywords
- use according
- prodrug
- bioactive
- group
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
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- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
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- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
Landscapes
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- Epidemiology (AREA)
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- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US1444896P | 1996-04-01 | 1996-04-01 | |
| US60/014,448 | 1996-04-01 | ||
| PCT/US1997/004804 WO1997036619A2 (en) | 1996-04-01 | 1997-03-25 | Bioactivated diagnostic imaging contrast agents |
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| JP2004055545A Division JP2004210796A (ja) | 1996-04-01 | 2004-02-27 | 画像診断用の生物活性造影剤 |
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| JP2000507577A true JP2000507577A (ja) | 2000-06-20 |
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| JP9535373A Ceased JP2000507577A (ja) | 1996-04-01 | 1997-03-25 | 画像診断用の生物活性造影剤 |
| JP2004055545A Pending JP2004210796A (ja) | 1996-04-01 | 2004-02-27 | 画像診断用の生物活性造影剤 |
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| JP2004055545A Pending JP2004210796A (ja) | 1996-04-01 | 2004-02-27 | 画像診断用の生物活性造影剤 |
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| JP (2) | JP2000507577A (Direct) |
| KR (1) | KR20060025233A (Direct) |
| CN (1) | CN1108824C (Direct) |
| AT (1) | ATE268187T1 (Direct) |
| AU (1) | AU726914B2 (Direct) |
| BR (1) | BR9708470A (Direct) |
| CA (1) | CA2247620A1 (Direct) |
| DE (1) | DE69729380T2 (Direct) |
| DK (1) | DK0907379T3 (Direct) |
| ES (1) | ES2217408T3 (Direct) |
| IL (1) | IL125895A (Direct) |
| IS (1) | IS2059B (Direct) |
| NO (1) | NO319674B1 (Direct) |
| NZ (1) | NZ331629A (Direct) |
| PT (1) | PT907379E (Direct) |
| WO (1) | WO1997036619A2 (Direct) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009054327A1 (ja) * | 2007-10-22 | 2009-04-30 | Osaka Foundation For Trade And Industry | Ｍｒｉ用プローブ |
| US8450462B2 (en) | 2009-06-26 | 2013-05-28 | Canon Kabushiki Kaisha | Compound |
| JP2020517584A (ja) * | 2017-04-27 | 2020-06-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 修飾ｍｒｉ造影剤およびその使用 |
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| IT1297035B1 (it) * | 1997-12-30 | 1999-08-03 | Bracco Spa | Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico |
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| DE19507822B4 (de) * | 1995-02-21 | 2006-07-20 | Schering Ag | Substituierte DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel |
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-
1997
- 1997-03-25 JP JP9535373A patent/JP2000507577A/ja not_active Ceased
- 1997-03-25 CA CA002247620A patent/CA2247620A1/en not_active Abandoned
- 1997-03-25 EP EP97916974A patent/EP0907379B1/en not_active Expired - Lifetime
- 1997-03-25 AT AT97916974T patent/ATE268187T1/de not_active IP Right Cessation
- 1997-03-25 KR KR1020067003261A patent/KR20060025233A/ko not_active Withdrawn
- 1997-03-25 WO PCT/US1997/004804 patent/WO1997036619A2/en not_active Ceased
- 1997-03-25 DE DE69729380T patent/DE69729380T2/de not_active Expired - Fee Related
- 1997-03-25 PT PT97916974T patent/PT907379E/pt unknown
- 1997-03-25 DK DK97916974T patent/DK0907379T3/da active
- 1997-03-25 BR BR9708470A patent/BR9708470A/pt not_active Application Discontinuation
- 1997-03-25 CN CN97193542A patent/CN1108824C/zh not_active Expired - Fee Related
- 1997-03-25 AU AU25448/97A patent/AU726914B2/en not_active Ceased
- 1997-03-25 NZ NZ331629A patent/NZ331629A/xx unknown
- 1997-03-25 IL IL12589597A patent/IL125895A/en not_active IP Right Cessation
- 1997-03-25 ES ES97916974T patent/ES2217408T3/es not_active Expired - Lifetime
-
1998
- 1998-08-26 IS IS4833A patent/IS2059B/is unknown
- 1998-09-29 NO NO19984543A patent/NO319674B1/no unknown
-
2001
- 2001-09-14 US US09/952,971 patent/US6709646B2/en not_active Expired - Fee Related
-
2004
- 2004-01-16 US US10/758,729 patent/US7147837B2/en not_active Expired - Fee Related
- 2004-02-27 JP JP2004055545A patent/JP2004210796A/ja active Pending
-
2006
- 2006-08-16 US US11/504,851 patent/US20060275216A1/en not_active Abandoned
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009054327A1 (ja) * | 2007-10-22 | 2009-04-30 | Osaka Foundation For Trade And Industry | Ｍｒｉ用プローブ |
| US8450462B2 (en) | 2009-06-26 | 2013-05-28 | Canon Kabushiki Kaisha | Compound |
| JP2020517584A (ja) * | 2017-04-27 | 2020-06-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 修飾ｍｒｉ造影剤およびその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL125895A (en) | 2001-09-13 |
| HK1016877A1 (en) | 1999-11-12 |
| JP2004210796A (ja) | 2004-07-29 |
| AU726914B2 (en) | 2000-11-23 |
| US6709646B2 (en) | 2004-03-23 |
| DE69729380T2 (de) | 2005-07-14 |
| CN1215341A (zh) | 1999-04-28 |
| BR9708470A (pt) | 1999-04-13 |
| EP0907379A2 (en) | 1999-04-14 |
| DK0907379T3 (da) | 2004-08-16 |
| US20020034476A1 (en) | 2002-03-21 |
| IS4833A (is) | 1998-08-26 |
| NO984543L (no) | 1998-11-26 |
| WO1997036619A2 (en) | 1997-10-09 |
| ATE268187T1 (de) | 2004-06-15 |
| IL125895A0 (en) | 1999-04-11 |
| US20040156785A1 (en) | 2004-08-12 |
| NO319674B1 (no) | 2005-09-05 |
| EP0907379B1 (en) | 2004-06-02 |
| AU2544897A (en) | 1997-10-22 |
| NO984543D0 (no) | 1998-09-29 |
| US7147837B2 (en) | 2006-12-12 |
| ES2217408T3 (es) | 2004-11-01 |
| CA2247620A1 (en) | 1997-10-09 |
| NZ331629A (en) | 2000-04-28 |
| PT907379E (pt) | 2004-09-30 |
| IS2059B (is) | 2005-10-14 |
| CN1108824C (zh) | 2003-05-21 |
| KR20060025233A (ko) | 2006-03-20 |
| DE69729380D1 (de) | 2004-07-08 |
| WO1997036619A3 (en) | 1998-01-29 |
| US20060275216A1 (en) | 2006-12-07 |
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