JP2000501620A - ａｒｅＡ，ｐｅｐＣ及び／又はｐｅｐＥ遺伝子が不活性化されている菌類 - Google Patents
ａｒｅＡ，ｐｅｐＣ及び／又はｐｅｐＥ遺伝子が不活性化されている菌類Info
- Publication number
- JP2000501620A JP2000501620A JP09522430A JP52243097A JP2000501620A JP 2000501620 A JP2000501620 A JP 2000501620A JP 09522430 A JP09522430 A JP 09522430A JP 52243097 A JP52243097 A JP 52243097A JP 2000501620 A JP2000501620 A JP 2000501620A
- Authority
- JP
- Japan
- Prior art keywords
- fungus
- pepe
- pepc
- area
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/38—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK142895 | 1995-12-15 | ||
| DK1428/95 | 1995-12-15 | ||
| PCT/DK1996/000528 WO1997022705A1 (en) | 1995-12-15 | 1996-12-16 | A FUNGUNS WHEREIN THE areA, pepC AND/OR pepE GENES HAVE BEEN INACTIVATED |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007155715A Division JP2007267752A (ja) | 1995-12-15 | 2007-06-12 | ａｒｅＡ，ｐｅｐＣ及び／又はｐｅｐＥ遺伝子及びプロテアーゼ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000501620A true JP2000501620A (ja) | 2000-02-15 |
| JP2000501620A5 JP2000501620A5 (OSRAM) | 2004-11-04 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP09522430A Pending JP2000501620A (ja) | 1995-12-15 | 1996-12-16 | ａｒｅＡ，ｐｅｐＣ及び／又はｐｅｐＥ遺伝子が不活性化されている菌類 |
| JP2007155715A Pending JP2007267752A (ja) | 1995-12-15 | 2007-06-12 | ａｒｅＡ，ｐｅｐＣ及び／又はｐｅｐＥ遺伝子及びプロテアーゼ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007155715A Pending JP2007267752A (ja) | 1995-12-15 | 2007-06-12 | ａｒｅＡ，ｐｅｐＣ及び／又はｐｅｐＥ遺伝子及びプロテアーゼ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6013452A (OSRAM) |
| EP (1) | EP0866872A1 (OSRAM) |
| JP (2) | JP2000501620A (OSRAM) |
| CN (1) | CN1160465C (OSRAM) |
| AU (1) | AU1092897A (OSRAM) |
| WO (1) | WO1997022705A1 (OSRAM) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011517943A (ja) * | 2008-04-08 | 2011-06-23 | ダニスコ・ユーエス・インク | 改変されたタンパク質の生成のための不活性化されたプロテアーゼ遺伝子を持つ糸状菌 |
| JP2018038419A (ja) * | 2012-01-05 | 2018-03-15 | グリコス・フィンランド・オーワイＧｌｙｋｏｓ Ｆｉｎｌａｎｄ Ｏｙ | プロテアーゼ欠損糸状菌細胞及びその使用方法 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070111201A1 (en) * | 2001-04-30 | 2007-05-17 | Benjamin Doranz | Reverse transfection of cell arrays for structural and functional analyses of proteins |
| BRPI0409599B1 (pt) | 2003-04-28 | 2014-09-16 | Novozymes As | Sequência de ácido nucléico, construto de ácido nucléico, vetor de expressão recombinante, micro-organismo recombinante, composição de massa, métodos de produzir uma fosfolipase, de preparar uma massa ou um produto assado feito da massa, processos para reduzir o conteúdo de fósforo em um óleo vegetal e para produzir queijo |
| US20050106703A1 (en) * | 2003-11-05 | 2005-05-19 | Kyowa Hakko Kogyo Co., Ltd. | Microorganisms producing dipeptides and process for producing dipeptides using the microorganisms |
| JP4507618B2 (ja) * | 2004-02-05 | 2010-07-21 | 味の素株式会社 | 変異型微生物およびこれを用いたペプチドの製造方法 |
| EP2123746B1 (en) * | 2005-04-12 | 2016-11-16 | Danisco US Inc. | Gene inactivated mutants with altered protein production |
| ATE514770T1 (de) | 2005-10-17 | 2011-07-15 | Novozymes As | Verwendung von pilzmutanten zur expression von antikörpern |
| EP2220110A1 (en) * | 2007-12-06 | 2010-08-25 | Novozymes A/S | Fungal pepc inhibitor |
| JP5344857B2 (ja) * | 2008-06-24 | 2013-11-20 | 月桂冠株式会社 | 糸状菌プロテアーゼの生産方法 |
| WO2011075677A2 (en) | 2009-12-18 | 2011-06-23 | Novozymes, Inc. | Methods for producing polypeptides in protease-deficient mutants of trichoderma |
| WO2012048334A2 (en) * | 2010-10-08 | 2012-04-12 | Dyadic International (Usa) Inc. | Novel fungal proteases |
| EP2852610B1 (en) | 2012-05-23 | 2018-07-11 | Glykos Finland Oy | Production of fucosylated glycoproteins |
| CA2916905A1 (en) | 2013-07-10 | 2015-01-15 | Novartis Ag | Multiple proteases deficient filamentous fungal cells and methods of use thereof |
| WO2015025055A1 (en) * | 2013-08-23 | 2015-02-26 | Novozymes A/S | Regulated pepc expression |
| CN108064266A (zh) | 2014-07-21 | 2018-05-22 | 格利科斯芬兰公司 | 在丝状真菌中具有哺乳动物样n-聚糖的糖蛋白的制备 |
| WO2025157268A1 (zh) * | 2024-01-24 | 2025-07-31 | 南京百斯杰生物工程有限公司 | 一种米曲霉重组菌株的构建方法 |
| CN119823971A (zh) * | 2025-01-20 | 2025-04-15 | 江南大学 | 米曲霉来源蛋白酶及其在豆类发酵产品中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5190931A (en) * | 1983-10-20 | 1993-03-02 | The Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| US4885249A (en) * | 1984-12-05 | 1989-12-05 | Allelix, Inc. | Aspergillus niger transformation system |
| AU5912586A (en) * | 1985-06-20 | 1986-12-24 | Salk Institute Biotechnology/Industrial Associates, Inc., The | Alpha-factor leader peptide-facilitated secretion from transformed s cerevisiae |
| DK122686D0 (da) * | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| EP0327797B1 (de) * | 1988-01-05 | 2003-09-03 | Roche Diagnostics GmbH | Verfahren zur Herstellung von Proteinen oder proteinhaltigen Genprodukten |
| CA1333777C (en) * | 1988-07-01 | 1995-01-03 | Randy M. Berka | Aspartic proteinase deficient filamentous fungi |
| EP0578746B1 (en) * | 1991-04-01 | 2002-07-03 | Merck & Co., Inc. | GENES WHICH INFLUENCE $i(PICHIA) PROTEOLYTIC ACTIVITY, AND USES THEREFOR |
| ATE252156T1 (de) * | 1992-04-15 | 2003-11-15 | Novartis Pharma Gmbh | Neue schimmel-protease |
| US5674728A (en) * | 1993-11-03 | 1997-10-07 | Novartis Corporation | Aspergillus niger vacuolar aspartyl protease |
| FI965031A0 (fi) * | 1994-06-17 | 1996-12-16 | Novo Nordisk As | Sieni, jossa AreA-geeni on muunnettu, ja Aspergillus oryzaesta peräisin oleva areA-geeni |
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1996
- 1996-12-16 CN CNB961990066A patent/CN1160465C/zh not_active Expired - Fee Related
- 1996-12-16 EP EP96941590A patent/EP0866872A1/en not_active Withdrawn
- 1996-12-16 AU AU10928/97A patent/AU1092897A/en not_active Abandoned
- 1996-12-16 JP JP09522430A patent/JP2000501620A/ja active Pending
- 1996-12-16 WO PCT/DK1996/000528 patent/WO1997022705A1/en not_active Ceased
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1998
- 1998-05-14 US US09/079,415 patent/US6013452A/en not_active Expired - Fee Related
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2007
- 2007-06-12 JP JP2007155715A patent/JP2007267752A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011517943A (ja) * | 2008-04-08 | 2011-06-23 | ダニスコ・ユーエス・インク | 改変されたタンパク質の生成のための不活性化されたプロテアーゼ遺伝子を持つ糸状菌 |
| JP2018038419A (ja) * | 2012-01-05 | 2018-03-15 | グリコス・フィンランド・オーワイＧｌｙｋｏｓ Ｆｉｎｌａｎｄ Ｏｙ | プロテアーゼ欠損糸状菌細胞及びその使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1204370A (zh) | 1999-01-06 |
| US6013452A (en) | 2000-01-11 |
| WO1997022705A1 (en) | 1997-06-26 |
| CN1160465C (zh) | 2004-08-04 |
| JP2007267752A (ja) | 2007-10-18 |
| EP0866872A1 (en) | 1998-09-30 |
| AU1092897A (en) | 1997-07-14 |
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