JP2000143460A - Hair grower - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair grower having excellent hair loss-preventive effect and trichogenesis-promotive effect by including an extract from a plant belonging to the genus Baccharis of Compositae family as active ingredient. SOLUTION: This hair grower is obtained by including, as active ingredient, an extract from a plant belonging to the genus Baccharis of Compositae family (pref. Baccharis genistelloides mainly of Brazilian growth); wherein the extract can be obtained by subjecting a plant as mentioned above to solvent extraction either directly, or after ground following being dried as necessary. The content of the above extract in a hair grower composition is pref. 0.005-20.0 (more pref. 0.01-10.0) wt.% on a dry basis.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a hair restorer containing a specific plant extract as an active ingredient. The hair restoration of the present invention,
Used in the pharmaceutical, quasi-drug, and cosmetic fields.

[0002]

2. Description of the Related Art Conventionally, causes of baldness and hair loss include activation of male hormones in organs such as hair roots and sebaceous glands, a decrease in blood flow to hair follicles, excessive secretion of sebum, and generation of peroxide. Abnormalities of the scalp are considered. For this reason, a compound having an action of removing or reducing the above-mentioned causes is generally added to the conventional hair restoration. For example, vitamins such as vitamin B and vitamin E, serine,
Amino acids such as methionine, assembly extract, vasodilators such as acetylcholine derivatives, purple root extract, anti-inflammatory agents such as hinokitiol, female hormones such as estradiol, skin function enhancers such as cepharanthin, etc.
It is used for the prevention and treatment of alopecia.

[0003] In addition to the above, sebum suppressants (specials) containing extracts derived from medicinal plants such as pepper (pepper), Shimatsuurishi (purple mariko), and leopard (buoying) are also used as natural substances. Japanese Unexamined Patent Publication (Kokai) No. 3-220129) and a hair restorer prepared by mixing 15 kinds of medicinal natural products such as pepper and ground yellow at a specific ratio and immersing the mixture in an aqueous solution containing ethanol and acetic acid.
No. 2) has also been proposed.

[0004]

However, in spite of various attempts as described above, the conventional hair restorer can always sufficiently satisfy the hair restoration effects such as the prevention of hair loss and the hair growth effect. It was not something. This is probably due to a variety of causes of hair loss and the very complex mechanism of hair growth. Given the variety of causes of such hair loss, it has been desired to provide further novel hair restorations.

[0005] An object of the present invention is to provide a hair nourishing material having an excellent hair loss preventing effect and a hair growth promoting effect in order to cope with the various causes of hair loss described above.

[0006]

Means for Solving the Problems From the above viewpoints, the present inventors have sought to search for effective substances widely overseas and have studied them. As a result, they have found that an extract of a plant belonging to the genus Baccharis of the Compositae family (Compositae) has an excellent hair loss preventing effect and a hair growth promoting effect, and have completed the present invention.

[0007] That is, the present invention relates to asteraceae (Compositae).
The present invention relates to a hair restorer comprising an extract of a plant belonging to the genus Baccharis as an active ingredient.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail.

Asteraceae (Compositae) used in the present invention
Plants belonging to the genus Baccharis have aromatic roots, yellowish white flowers on the inflorescence head, and are high in resin. Shrubs are produced mainly in South America, such as Brazil and Peru.
In the present invention, any plants belonging to the genus Baccharis can be used without any particular limitation. Among them, Baccharis genisteroides (Bacci) mainly produced in Brazil
haris genistelloides) is particularly preferably used.

[0010] Each plant belonging to the genus Baccharis can be used either raw or dried.
It is preferably used as a dry powder or a solvent extract from the viewpoints of usability, formulation and the like.

[0011] The sites of use of plants belonging to the genus Baccharis are:
As long as it does not adversely affect the purpose of the present invention and contains an active ingredient that exerts the effects of the present invention, whole plants or those derived from any component thereof can be used. It is preferably used.

An extract of a plant belonging to the genus Baccharis can be obtained by a conventional method. That is, it can be obtained by subjecting a plant belonging to the genus to a raw or, if necessary, drying, and then subjecting it to solvent extraction as it is or pulverized.

As the above-mentioned extraction solvent, any solvent can be used as long as it is a solvent usually used for plant extraction or the like. For example, hot water, methanol, ethanol, isopropanol,
Lower alcohols such as n-butanol, polyhydric alcohols such as propylene glycol and 1,3-butylene glycol, and hydrates of these alcohols, hydrocarbon solvents such as n-hexane and toluene, etc. They can be used in combination. Among them, lower alcohols such as methanol and ethanol are preferably used. When these lower alcohols are used, the resulting extract can be directly contained in the dermal papilla activator of the present invention, but may be contained after the extraction solvent is distilled off and, if necessary, dried.

The plant extract thus obtained is highly safe and has excellent hair-growing action (prevention of hair loss and promotion of hair growth,
And dandruff, itching prevention, etc.).

Therefore, the hair restoration of the present invention containing the above extract as an active ingredient can be used as an active ingredient of a composition for external use on the skin, including a cosmeceutical for hair growth of hair.

As mentioned above, the term "hair growth" as used in the present invention is used in a concept that includes the effects of promoting hair growth, preventing hair loss, and further inhibiting dandruff and itch.

The amount of the extract of the genus Baccharis in the hair restorer of the present invention can be appropriately selected according to the dosage form of the hair restorer, the method of application, etc., but the extract (dry weight) is contained in the total amount of the hair restorer. ) Is preferably about 0.005 to 20.0% by weight, more preferably about 0.01 to 10.0% by weight. If the amount is less than 0.005% by weight, it is difficult to sufficiently achieve the desired effects of the present invention, such as the promotion of hair growth and the prevention of hair loss. The effect cannot be expected to increase in proportion to the increase in volume,
It is also not preferable from the viewpoint of formulation.

The dosage form of the hair restorer of the present invention is not particularly limited as long as it can be applied to the scalp. For example, a liquid form, an emulsion, an ointment and the like can be appropriately selected. Specifically, for example, it can be in the form of a tonic, a hair cream, a mousse, a shampoo, a rinse, and the like, but is not limited to these.

The hair restorer of the present invention comprises, in addition to the above essential components,
Various components generally used in cosmetics, quasi-drugs, pharmaceuticals, and the like can be arbitrarily added according to the purpose of use, as long as the effects of the present invention are not impaired. In particular, as an auxiliary component of the composition for hair growth, specifically, for example, higher fatty acids, solid paraffin, liquid paraffin, silicone oil,
Oils such as squalane; humectants such as hyaluronic acid, propylene glycol, maltitol, atelocollagen, and sodium lactate; thickeners such as quince, carboxyvinyl polymer, and xanthan gum. Other active ingredients other than these include oils such as glyceryl monooleate; vasodilators such as nicotinamide, benzyl nicotinate, vitamin E acetate, assembly extract, carpronium chloride, assembly extract, and acetylcholine derivatives; Amino acids such as methionine; vitamins B ₆ and vitamin E and derivatives thereof; vitamins such as biotin; pantothenic acid and derivatives thereof;
Glycyrrhetinic acid and its derivatives, nicotinic acid esters such as nicotinic acid, methyl nicotinate, and tocopherol nicotinate; skin function enhancers such as cepharanthin; and female hormones such as estradiol.
Furthermore, additives usually used for hair restorer, for example, antibacterial agents such as hinokitiol, hexachlorophen, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide and bitionol; refreshing agents such as menthol; salicylic acid , Drugs such as zinc and derivatives thereof, lactic acid and alkyl esters thereof; organic acids such as citric acid; amino acids such as arginine; oils such as olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids and higher alcohols; Polyhydric alcohols such as propylene glycol; fragrances; antioxidants; ultraviolet absorbers; pigments; ethanol; water; humectants;

[0020]

Next, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples. In addition, the compounding amount is shown by weight% unless otherwise specified.

I. Hair growth effect test of Baccharis plant extract [Preparation of extract] (Preparation Example 1) Baccharis genistellos
ides) 500 g of the dried product was immersed in 7.5 liters of methanol at room temperature for 5 days to carry out extraction to obtain an extract. The solvent was distilled off from this extract, and then dried to obtain 38.0 g of a methanol extract (dry product) of B. genistelloides.

[Hair Growth Test] C3H / HeNCrj mice in the telogen phase of the hair cycle were used as experimental animals, and the method of Ogawa et al. ("Normal and Abnormal Epidermal Differentia") was used.
Option ", edited by M. Seiji and IA Bernstein, pp. 159-1
70, 1982, The University of Tokyo Press).

That is, each group consisted of 10 mice, and each of the test substances [70% ethanol solution containing 1% of the dry extract obtained in the above preparation example (sample 1), 2
% 70% ethanol solution (sample 2), 4% 70% ethanol solution (sample 3)], control sample (70% ethanol solution), and comparison control (0.1% croton oil 75% ethanol solution) )). The back of the mouse was shaved with a hair clipper and a shaver, and the sample of each group was applied to the back (shaved portion) at a rate of 0.1 ml once a day for 30 days. 17 days after application, 30
After the day, the hair regeneration area was measured to evaluate the hair growth effect. Table 1 shows the results.

[0024]

[Table 1]

As is clear from the results in Table 1, it is found that the extract of the plant belonging to the genus Baccharis shows an excellent hair growth effect in a hair growth test in mice.

II. Tricogram test In order to investigate the hair growth effects such as the hair loss prevention and the hair growth effect of the hair growth preparation of the present invention, the following Examples 1 to 4, Comparative Example 1, and 70% ethanol as a control were used. Was performed by the method described in the above.

(Example 1) Liquid hair restorer (composition component) (% by weight) (1) Baccharis genistelloides methanol extract dried product (obtained in Preparation Example 1) 0.1 (2) 70% ethanol 90.0 (3) Sodium oleate 0.01 (4) Dodecylbenzenesulfonic acid 0.49 (5) Hardened castor oil ethylene oxide (40 mol) adduct 0.5 (6) Ion-exchange water residue (Production method) (1) , (2) to (5) and some (6)
With stirring to dissolve. The remaining (6) (10
%) Was added and mixed to obtain a liquid hair restorative.

(Example 2) Oil-in-water emulsion type hair nourishing agent (Blend component) (% by weight) (A phase) Baccharis genistelloides ethanol extract dried product 1.0 Polyoxyethylene (60 mol) addition-hardened castor oil 0 glycerin 10.0 dipropylene glycol 10.0 1,3-butylene glycol 5.0 polyethylene glycol (1500) 5.0 (phase B) cetyl isooctanoate 10.0 squalane 5.0 petrolatum 2.0 propyl parapen 2 0.0 (C phase) 1% aqueous solution of carboxyvinyl polymer 30.0 Sodium hexametaphosphate 0.03 Ion exchange water 8.35 (D phase) Ion exchange water 4.5 (E phase) Potassium hydroxide 0.12 Ion exchange water 5.0 (Preparation method) Phase A “Ethanol-extracted dried product of Baccharis genistelloides” was used in the production process of Preparation Example 1. Used was prepared by immersing B. Genistelloides with ethanol in place of methanol.

The phases A and B were each dissolved by heating at 60 ° C., mixed, and treated with a homomixer to prepare a gel. Phase D was gradually added to this gel, and further dispersed with a homomixer. The dissolved C phase was added thereto, and finally the dissolved E phase was added and emulsified with a homomixer to obtain an oil-in-water emulsion type hair restorer.

(Example 3) Creamy hair restorer (Blending ingredients) (% by weight) (A phase) Liquid paraffin 5.0 Cetostearyl alcohol 5.5 Glyceryl monostearate 3.0 EO (20 mol) -2- Octyldodecyl ether 8.0 Propyl parapen 3.0 Fragrance 0.1 (Phase B) 70% ethanol extract dried product of Baccharis genistelloides 5.0 Glycerin 8.0 Cypropylene glycol 20.0 Polyethylene glycol (4000) 5.0 Dodecyl Sodium sulfate 0.1 Sodium hexametaphosphate 0.005 Ion-exchanged water 45.095 (Preparation method) In Phase A, “70% ethanol-extracted dried product of Baccharis genistelloides” was prepared by replacing 70% with methanol in the production process of Preparation Example 1. B. geniste with ethanol
What was prepared by immersing lloides was used.

The phases A and B were each dissolved by heating, mixed, and emulsified by a homomixer to obtain a creamy hair restorer.

(Example 4) Liquid hair restorer (compounding component) (% by weight) (1) Baccharis genistelloides methanol extract dried product (obtained in Preparation Example 1) 0.5 (2) 70% ethanol 90.0 (3) Sodium oleate 0.01 (4) Dodecylbenzenesulfonic acid 0.49 (5) Hardened castor oil ethylene oxide (40 mol) adduct 0.5 (6) Ion-exchange water residue (Production method) (1) , (2) to (5) and some (6)
With stirring to dissolve. The remaining (6) (10
%) Was added and mixed to obtain a liquid hair restorative.

(Comparative Example 1) Liquid Hair Restoration In Example 1, pepper (Piper) was used instead of the methanol extract dried Baccharis genistelloides (Preparation Example 1).
nigrum) was obtained in the same manner as in Example 1 except that 0.1% of a methanol extract dried product was used. The dried methanol extract of pepper is pepper (dried).
500 g was immersed in 7.5 liters of methanol at room temperature for 5 days, and after extraction, the solvent was distilled off and dried.

[Trichogram test method] Using the hair nourishes of Examples 1 to 4 and Comparative example 1 obtained above, the roots of the extracted hair before and after use were observed under a microscope, and the roots were examined. The number of telogens in the telogen was counted from the form of the above, and the hair-growing effect of the hair-growing agent was compared by changing the ratio.

That is, the test sample and the control sample were applied to the scalp of 10 male subjects twice a day, 2 ml at a time, for 6 consecutive months, immediately before the application and immediately after the completion of the application for 6 months. 100 hairs were removed from each subject, and the roots of each hair were examined, and an actual use test was performed.
Table 2 shows the results.

The telogen hair root is a hair root in the telogen of the hair cycle, and is a hair root that has stopped growing.
It has been observed that those who report hair loss have a higher percentage of this telogen root than those who do not. That is, in this test, the higher the proportion of the telogen roots, the more the degree of hair loss is progressing.

[0037]

[Table 2]

As is evident from the results in Table 2, the hair restorer of the present invention containing the Baccharis plant extract was compared with Comparative Example 1 in which a large amount of a pepper extract having a hair-growth effect was added. It was also recognized that the hair growth effect was excellent.

[0039]

As described above, according to the present invention, there is provided a hair restorer having an excellent effect of preventing hair loss, promoting hair growth, promoting hair growth such as hair growth, and suppressing dandruff and itch.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Jun Suzuki 1050 Nippa-cho, Kohoku-ku, Yokohama, Kanagawa Prefecture Inside Shiseido Daiichi Research Center (72) Inventor Masahiro Tajima 1050 Nippa-cho, Kohoku-ku, Yokohama, Kanagawa, Japan Inside Shiseido Daiichi Research Center (72) Inventor Masahiro Ota 1050 Nippa-cho, Kohoku-ku, Yokohama-shi, Kanagawa F-term in Shiseido Daiichi Research Center (reference) AC482 AC792 AD042 AD092 CC37 DD23 DD31 DD33 EE22 FF05 4C088 AB26 AC01 AC04 AC11 BA08 CA03 MA01 MA63 NA14 ZA92

Claims (2)

[Claims] [Claim 1] The genus Baccharis (Compositae)
A hair restorer comprising an extract of a plant belonging to ccharis) as an active ingredient. 2. The plant belonging to the genus Baccharis of the Compositae family is Baccharis genistelloide.
The hair restorer according to claim 1, which is s).