JOP20210167A1 - طريقة لإنتاج جسيم نانوي يشتمل على جسيم معدني يحتوي على أكسيد حديد يرتبط به واحد أو أكثر من المركبات الترابطية الآلفة للماء تناسقيًا - Google Patents
طريقة لإنتاج جسيم نانوي يشتمل على جسيم معدني يحتوي على أكسيد حديد يرتبط به واحد أو أكثر من المركبات الترابطية الآلفة للماء تناسقيًاInfo
- Publication number
- JOP20210167A1 JOP20210167A1 JOP/2021/0167A JOP20210167A JOP20210167A1 JO P20210167 A1 JOP20210167 A1 JO P20210167A1 JO P20210167 A JOP20210167 A JO P20210167A JO P20210167 A1 JOP20210167 A1 JO P20210167A1
- Authority
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- Prior art keywords
- iron oxide
- nanoparticle
- metal particle
- coordination bonded
- producing
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
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- C01G49/00—Compounds of iron
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
- A61K49/1839—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a lipid, a fatty acid having 8 or more carbon atoms in the main chain, or a phospholipid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
- A61K49/1842—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a phosphate or a phosphonate, not being a phospholipid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G49/00—Compounds of iron
- C01G49/02—Oxides; Hydroxides
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G49/00—Compounds of iron
- C01G49/02—Oxides; Hydroxides
- C01G49/06—Ferric oxide (Fe2O3)
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G49/00—Compounds of iron
- C01G49/02—Oxides; Hydroxides
- C01G49/08—Ferroso-ferric oxide (Fe3O4)
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
- H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
- H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
- H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/60—Particles characterised by their size
- C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
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- C—CHEMISTRY; METALLURGY
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- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/80—Compositional purity
- C01P2006/82—Compositional purity water content
Abstract
[المشكلة] يتعلق الاختراع الحالي بتوفير طريقة جديدة لإنتاج جسيم نانوي يشتمل على جسيم معدنين يحتوي على أكسيد حديد يرتبط به واحد أو أكثر من المركبات الترابطية الآلفة للماء تناسقيًا، حيث يكون الجسيم النانوي مفيدًا كعامل تباين للتصوير بالرنين المغناطيسي. [وسيلة للحل] كالطريقة الجديدة لإنتاج جسيم نانوي يشتمل على جسيم معدني يحتوي على أكسيد حديد يرتبط به واحد أو أكثر من المركبات الترابطية الآلفة للماء تناسقيًا، بإجراء تبادل مركب ترابطي بمركب ترابطي آلف للماء من جسيم أكسيد حديد نانوي له سطح يرتبط به مركب ترابطي غير آلف للماء تناسقيًا في خطوة واحدة باستخدام محفز انتقال طور، يمكن توقع تقصير عمليات الإنتاج وتقليل المركبات الترابطية الآلفة للماء المستخدمة. علاوة على ذلك، بإنتاج جسيم أكسيد حديد نانوي له سطح يرتبط به مركب ترابطي غير آلف للماء تناسقيًا باستخدام طريقة إضافة قطرة قطرة، يمكن تجنب ارتفاع درجة الحرارة السريع والتفاعل عند درجة حرارة عالية تبلغ 200 ْم أو أعلى، وهو أكثر فائدة للإنتاج الصناعي. (الشكل المختار) لا يوجد
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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JP2018243906 | 2018-12-27 | ||
JP2018243905 | 2018-12-27 | ||
PCT/JP2019/051386 WO2020138404A1 (ja) | 2018-12-27 | 2019-12-27 | 親水性リガンドが1つ以上配位結合した酸化鉄を含有する金属粒子を含む、ナノ粒子の製造方法 |
Publications (1)
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JOP20210167A1 true JOP20210167A1 (ar) | 2023-01-30 |
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ID=71128779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JOP/2021/0167A JOP20210167A1 (ar) | 2018-12-27 | 2019-12-27 | طريقة لإنتاج جسيم نانوي يشتمل على جسيم معدني يحتوي على أكسيد حديد يرتبط به واحد أو أكثر من المركبات الترابطية الآلفة للماء تناسقيًا |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220089455A1 (ar) |
EP (1) | EP3904294A4 (ar) |
JP (1) | JPWO2020138404A1 (ar) |
KR (1) | KR20210106455A (ar) |
CN (1) | CN113226990A (ar) |
BR (1) | BR112021012657A2 (ar) |
CA (1) | CA3124753A1 (ar) |
IL (1) | IL284339A (ar) |
JO (1) | JOP20210167A1 (ar) |
MX (1) | MX2021007832A (ar) |
WO (1) | WO2020138404A1 (ar) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN115444945B (zh) * | 2022-07-27 | 2023-09-26 | 上海市第一人民医院 | 辅助胶质母细胞瘤成像的纳米复合物及其制备方法和应用 |
WO2024080664A1 (ko) * | 2022-10-11 | 2024-04-18 | 주식회사 지티아이바이오사이언스 | 산화철 자성 입자의 제조방법 및 이로부터 형성된 산화철 자성 입자 |
CN116283670A (zh) * | 2023-03-17 | 2023-06-23 | 胜利油田凯渡石油技术开发有限公司 | 一种稠油降粘剂及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
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US7462446B2 (en) | 2005-03-18 | 2008-12-09 | University Of Washington | Magnetic nanoparticle compositions and methods |
ES2647567T3 (es) | 2008-12-29 | 2017-12-22 | General Electric Company | Agentes de contraste de nanopartículas para el diagnóstico por imágenes |
KR101805873B1 (ko) | 2011-08-03 | 2018-01-10 | 한화케미칼 주식회사 | 단당류 인산 또는 그 유도체로 표면이 개질된 친수성 나노입자, 그의 콜로이드 용액 및 그 용도 |
JP5723978B2 (ja) * | 2010-08-05 | 2015-05-27 | ハンファ ケミカル コーポレーション | 極小かつ均一な大きさの酸化鉄系常磁性ナノ粒子の製造方法及びこれを用いるmrit1造影剤 |
KR101642903B1 (ko) * | 2011-02-09 | 2016-07-27 | 한화케미칼 주식회사 | 친수성 물질이 코팅된 산화철 나노입자의 제조방법 및 이를 이용하는 자기공명영상 조영제 |
WO2013090601A2 (en) | 2011-12-16 | 2013-06-20 | Massachusetts Institute Of Technology | Compact nanoparticles for biological applications |
CA2961358C (en) | 2014-09-15 | 2023-08-01 | Massachusetts Institute Of Technology | Nanoparticles for magnetic resonance imaging applications |
RU2767430C2 (ru) | 2017-06-28 | 2022-03-17 | Рикен | Наночастица, содержащее ее контрастное вещество для магнитно-резонансной томографии и лигандное соединение |
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2019
- 2019-12-27 JO JOP/2021/0167A patent/JOP20210167A1/ar unknown
- 2019-12-27 KR KR1020217019605A patent/KR20210106455A/ko not_active Application Discontinuation
- 2019-12-27 US US17/418,704 patent/US20220089455A1/en active Pending
- 2019-12-27 CN CN201980086656.0A patent/CN113226990A/zh active Pending
- 2019-12-27 MX MX2021007832A patent/MX2021007832A/es unknown
- 2019-12-27 BR BR112021012657-0A patent/BR112021012657A2/pt not_active Application Discontinuation
- 2019-12-27 CA CA3124753A patent/CA3124753A1/en active Pending
- 2019-12-27 EP EP19902655.0A patent/EP3904294A4/en not_active Withdrawn
- 2019-12-27 JP JP2020562484A patent/JPWO2020138404A1/ja active Pending
- 2019-12-27 WO PCT/JP2019/051386 patent/WO2020138404A1/ja unknown
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2021
- 2021-06-23 IL IL284339A patent/IL284339A/en unknown
Also Published As
Publication number | Publication date |
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JPWO2020138404A1 (ja) | 2021-11-18 |
EP3904294A1 (en) | 2021-11-03 |
BR112021012657A2 (pt) | 2021-09-08 |
IL284339A (en) | 2021-08-31 |
WO2020138404A1 (ja) | 2020-07-02 |
EP3904294A4 (en) | 2023-02-08 |
MX2021007832A (es) | 2021-08-11 |
KR20210106455A (ko) | 2021-08-30 |
US20220089455A1 (en) | 2022-03-24 |
CN113226990A (zh) | 2021-08-06 |
CA3124753A1 (en) | 2020-07-02 |
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