WO2019083323A3 - 자성 나노 구조체 및 그 제조방법 - Google Patents
자성 나노 구조체 및 그 제조방법 Download PDFInfo
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- WO2019083323A3 WO2019083323A3 PCT/KR2018/012833 KR2018012833W WO2019083323A3 WO 2019083323 A3 WO2019083323 A3 WO 2019083323A3 KR 2018012833 W KR2018012833 W KR 2018012833W WO 2019083323 A3 WO2019083323 A3 WO 2019083323A3
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- nanostructure
- magnetic
- magnetic nanostructure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/183—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an inorganic material or being composed of an inorganic material entrapping the MRI-active nucleus, e.g. silica core doped with a MRI-active nucleus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
Abstract
본 발명은 자성 나노클러스터를 포함하는 코어부; 상기 코어부를 둘러싸고 있는 쉘부; 상기 쉘부를 둘러싸고 있는 표면부; 및 상기 표면부에 로딩된 약물을 포함하는 자성 나노 구조체, 이를 포함하는 항암용 조성물 및 상기 자성 나노 구조체의 제조방법에 관한 것으로, 상기 나노 구조체는 암 주변 신생혈관에서 축척되고 높은 감도로 MRI에 의해 확인되므로, 기존보다 더 고해상도로 종양의 위치를 확인할 수 있고, 실질적인 광열/광역학 치료와 화학적 항암 치료가 동시에 가능하여 치료 효율을 높일 수 있으므로, 결과적으로 적은 양으로도 효과적인 항암 치료가 가능할 것으로 기대된다.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020170141349A KR102372367B1 (ko) | 2017-10-27 | 2017-10-27 | 자성 나노 구조체 및 그 제조방법 |
KR10-2017-0141349 | 2017-10-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2019083323A2 WO2019083323A2 (ko) | 2019-05-02 |
WO2019083323A3 true WO2019083323A3 (ko) | 2019-06-13 |
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Application Number | Title | Priority Date | Filing Date |
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PCT/KR2018/012833 WO2019083323A2 (ko) | 2017-10-27 | 2018-10-26 | 자성 나노 구조체 및 그 제조방법 |
Country Status (2)
Country | Link |
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KR (1) | KR102372367B1 (ko) |
WO (1) | WO2019083323A2 (ko) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109985248B (zh) * | 2019-05-20 | 2022-03-15 | 北京农学院 | 甲氨蝶呤经皮给药局部控释制剂及其制备方法和应用 |
US20230122688A1 (en) * | 2020-03-10 | 2023-04-20 | POSTECH Research and Business Development Foundation | Method for preparing polydopamine nanomotor using urease, and use of same |
CN111388450B (zh) * | 2020-04-29 | 2021-02-02 | 南京工业大学 | Co气体协同化学动力疗法抗肿瘤纳米递送载体、制备方法及抗肿瘤药物中的应用 |
CN112656960B (zh) * | 2020-12-31 | 2022-09-20 | 中国药科大学 | 一种线粒体调控型铁基磁性配位聚合物纳米粒及其制备方法和应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100713745B1 (ko) * | 2006-02-27 | 2007-05-07 | 연세대학교 산학협력단 | 상전이 리간드로 코팅된 수용성 자성 또는 금속 산화물나노입자 및 이의 제조방법 |
KR20080035926A (ko) * | 2006-10-20 | 2008-04-24 | 재단법인서울대학교산학협력재단 | 자성체 나노입자를 함유한 코어-외각 구조의 금 나노입자의자기공명영상의 티2 조영제, 암 진단제 및 암치료제로서의 용도 |
KR20100138848A (ko) * | 2009-06-25 | 2010-12-31 | 연세대학교 산학협력단 | 아연-함유 자성 나노 입자-기반 자성 분리시스템 |
US20160331850A1 (en) * | 2014-01-07 | 2016-11-17 | Colorobbia Italia S.P.A. | Magnetic nanoparticles functionalized with cathecol, production and use thereof |
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2017
- 2017-10-27 KR KR1020170141349A patent/KR102372367B1/ko active IP Right Grant
-
2018
- 2018-10-26 WO PCT/KR2018/012833 patent/WO2019083323A2/ko active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100713745B1 (ko) * | 2006-02-27 | 2007-05-07 | 연세대학교 산학협력단 | 상전이 리간드로 코팅된 수용성 자성 또는 금속 산화물나노입자 및 이의 제조방법 |
KR20080035926A (ko) * | 2006-10-20 | 2008-04-24 | 재단법인서울대학교산학협력재단 | 자성체 나노입자를 함유한 코어-외각 구조의 금 나노입자의자기공명영상의 티2 조영제, 암 진단제 및 암치료제로서의 용도 |
KR20100138848A (ko) * | 2009-06-25 | 2010-12-31 | 연세대학교 산학협력단 | 아연-함유 자성 나노 입자-기반 자성 분리시스템 |
US20160331850A1 (en) * | 2014-01-07 | 2016-11-17 | Colorobbia Italia S.P.A. | Magnetic nanoparticles functionalized with cathecol, production and use thereof |
Non-Patent Citations (1)
Title |
---|
AN, PENG: "A bio-inspired polydopamine approach to preparation of gold- coated Fe3O4 core-shell nanoparticles: synthesis, characterization and mechanism", NANO, vol. 8, no. 6, 1350061, 29 July 2013 (2013-07-29), pages 1 - 13, XP055616387 * |
Also Published As
Publication number | Publication date |
---|---|
KR20190047448A (ko) | 2019-05-08 |
KR102372367B1 (ko) | 2022-03-11 |
WO2019083323A2 (ko) | 2019-05-02 |
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