JOP20210040A1 - طريقة تصنيع مشتقات 4- ميثوكسي بيرول - Google Patents

طريقة تصنيع مشتقات 4- ميثوكسي بيرول

Info

Publication number
JOP20210040A1
JOP20210040A1 JOP/2021/0040A JOP20210040A JOP20210040A1 JO P20210040 A1 JOP20210040 A1 JO P20210040A1 JO P20210040 A JOP20210040 A JO P20210040A JO P20210040 A1 JOP20210040 A1 JO P20210040A1
Authority
JO
Jordan
Prior art keywords
manufacturing
methoxypyrrole derivatives
methoxypyrrole
derivatives
present disclosure
Prior art date
Application number
JOP/2021/0040A
Other languages
English (en)
Inventor
Jeong Taek Shin
Jeong Hyun Son
Deok Ki Eom
Original Assignee
Dae Woong Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dae Woong Pharma filed Critical Dae Woong Pharma
Priority claimed from PCT/KR2019/012122 external-priority patent/WO2020060213A1/ko
Publication of JOP20210040A1 publication Critical patent/JOP20210040A1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

يتعلق الكشف الحالي بطريقة تصنيع لمشتقات 4- ميثوكسي بيرول. يكون نموذج الكشف الحالي مفيد للإنتاج الصناعي بكمية كبيرة لمشتقات 4- ميثوكسي بيرول, لأنه يتم تحسين فعالية العملية وحصيلة الإنتاج, ويتم تجنب استخدام مواد تفاعل خطرة ومواد تفاعل ملوثة للبيئة.
JOP/2021/0040A 2018-09-19 2019-09-19 طريقة تصنيع مشتقات 4- ميثوكسي بيرول JOP20210040A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20180112196 2018-09-19
KR1020190110997A KR102126576B1 (ko) 2018-09-19 2019-09-06 4-메톡시 피롤 유도체의 제조 방법
PCT/KR2019/012122 WO2020060213A1 (ko) 2018-09-19 2019-09-19 4-메톡시 피롤 유도체의 제조 방법

Publications (1)

Publication Number Publication Date
JOP20210040A1 true JOP20210040A1 (ar) 2021-03-07

Family

ID=69959291

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2021/0040A JOP20210040A1 (ar) 2018-09-19 2019-09-19 طريقة تصنيع مشتقات 4- ميثوكسي بيرول

Country Status (21)

Country Link
US (1) US20210221770A1 (ar)
EP (1) EP3854784A4 (ar)
JP (1) JP7253624B2 (ar)
KR (1) KR102126576B1 (ar)
CN (1) CN112739684B (ar)
AU (1) AU2019343857B2 (ar)
BR (1) BR112021005156A2 (ar)
CA (1) CA3110830A1 (ar)
CL (1) CL2021000639A1 (ar)
CO (1) CO2021003195A2 (ar)
DO (1) DOP2021000042A (ar)
EC (1) ECSP21019076A (ar)
JO (1) JOP20210040A1 (ar)
MA (1) MA53673A (ar)
MX (1) MX2021003137A (ar)
NZ (1) NZ773997A (ar)
PE (1) PE20211736A1 (ar)
PH (1) PH12021550523A1 (ar)
RU (1) RU2763287C1 (ar)
SG (1) SG11202101919VA (ar)
TN (1) TN2021000035A1 (ar)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102081920B1 (ko) 2016-03-25 2020-02-26 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민 염의 신규한 결정형
KR102233455B1 (ko) * 2017-06-21 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
KR20220088362A (ko) 2020-12-18 2022-06-27 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민을 포함하는 신규한 경구투여용 제제
KR102556500B1 (ko) * 2021-11-19 2023-07-19 하나제약 주식회사 피롤 유도체 또는 이의 약학적 또는 식품학적으로 허용 가능한 염, 및 이를 유효성분으로 포함하는 위장 질환의 예방, 개선 또는 치료용 조성물
TW202411216A (zh) * 2022-05-23 2024-03-16 南韓商日東製藥股份有限公司 ６－甲氧基吡啶－３－基衍生物之製造方法
WO2023229322A1 (ko) * 2022-05-23 2023-11-30 일동제약(주) 6-메톡시피리딘-3-일 유도체의 제조방법
CN117820193A (zh) * 2022-09-29 2024-04-05 安徽皓元药业有限公司 一种非苏拉赞盐酸盐晶型a及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8048909B2 (en) * 2004-09-30 2011-11-01 Takeda Pharmaceutical Company Limited Proton pump inhibitors
WO2007114338A1 (ja) * 2006-03-31 2007-10-11 Takeda Pharmaceutical Company Limited 酸分泌抑制薬
US8933105B2 (en) * 2007-02-28 2015-01-13 Takeda Pharmaceutical Company Limited Pyrrole compounds
CA2891523A1 (en) * 2012-11-19 2014-05-22 Jiangsu Hansoh Pharmaceutical Co., Ltd. Pyrrole sulfonamide derivative, preparation method for same, and medical application thereof
JP2017071553A (ja) * 2014-02-25 2017-04-13 味の素株式会社 ヘテロ原子−メチレン−ヘテロ環構造を有する新規化合物
CN104447491B (zh) * 2014-11-19 2017-06-23 连云港恒运医药有限公司 含吡咯环质子泵抑制剂的半富马酸盐及其中间体和医药用途
KR101613245B1 (ko) * 2015-04-27 2016-04-18 주식회사 대웅제약 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
CN106432191A (zh) * 2015-08-10 2017-02-22 陕西合成药业股份有限公司 一种新的吡咯类衍生物、其制备方法及其在医药上的应用
KR102081920B1 (ko) * 2016-03-25 2020-02-26 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민 염의 신규한 결정형
WO2017164575A1 (en) * 2016-03-25 2017-09-28 Daewoong Pharmaceutical Co.,Ltd. Novel acid addition salt of 1-(5-(2,4-difluorophenyl)-1-((3- fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n- methylmethanamine
CN107879964B (zh) * 2016-09-29 2023-02-10 江苏柯菲平医药股份有限公司 1-(5-(2-氟苯基)-1-(3-(3-甲氧丙氧基)苯磺酰氯)-1h-吡咯-3-基)-n-甲基胺的制备方法
CN108503621B (zh) * 2017-12-25 2021-09-14 上海中拓医药科技有限公司 一种富马酸沃诺拉赞的制备方法

Also Published As

Publication number Publication date
ECSP21019076A (es) 2021-05-31
KR102126576B1 (ko) 2020-06-24
TN2021000035A1 (en) 2022-10-03
CO2021003195A2 (es) 2021-04-08
DOP2021000042A (es) 2021-05-31
RU2763287C1 (ru) 2021-12-28
MA53673A (fr) 2022-03-30
MX2021003137A (es) 2021-05-14
CA3110830A1 (en) 2020-03-26
JP7253624B2 (ja) 2023-04-06
NZ773997A (en) 2024-03-22
AU2019343857A1 (en) 2021-04-15
PH12021550523A1 (en) 2022-02-21
CL2021000639A1 (es) 2021-08-06
EP3854784A1 (en) 2021-07-28
AU2019343857B2 (en) 2021-12-02
CN112739684A (zh) 2021-04-30
CN112739684B (zh) 2024-06-04
PE20211736A1 (es) 2021-09-06
KR20200033178A (ko) 2020-03-27
US20210221770A1 (en) 2021-07-22
SG11202101919VA (en) 2021-04-29
JP2021535934A (ja) 2021-12-23
EP3854784A4 (en) 2022-03-30
BR112021005156A2 (pt) 2021-06-15

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