JOP20200068A1 - طريقة لتحضير جسيمات دقيقة بواسطة تقنية مستحلب مزدوج - Google Patents

طريقة لتحضير جسيمات دقيقة بواسطة تقنية مستحلب مزدوج

Info

Publication number
JOP20200068A1
JOP20200068A1 JOP/2020/0068A JOP20200068A JOP20200068A1 JO P20200068 A1 JOP20200068 A1 JO P20200068A1 JO P20200068 A JOP20200068 A JO P20200068A JO P20200068 A1 JOP20200068 A1 JO P20200068A1
Authority
JO
Jordan
Prior art keywords
particles
micro
preparing
phase
double emulsion
Prior art date
Application number
JOP/2020/0068A
Other languages
English (en)
Inventor
Franciscus Duwel Robertus
Janine Marie Blazejewski Emilie
Original Assignee
Nanomi B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanomi B V filed Critical Nanomi B V
Publication of JOP20200068A1 publication Critical patent/JOP20200068A1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Abstract

طريقة لتحضير جسيمات دقيقة بواسطة تقنية مستحلب مزدوج الملخص يتعلق الاختراع الحالي بتزويد طرق لتحضير جسيمات دقيقة تستخدم تقنية مستحلب مزدوج والتي تجمع بين غشاء وغربال دقيق المسام. ويتعلق الاختراع الحالي على نحو خاص بطريقة لتحضير جسيمات دقيقة، حيث تشمل: تحضير طور أول يشتمل على عامل فعّال؛ تحضير طور ثانِ يشتمل على مادة حاملة ومذيب؛ إمرار الطور الأول والطور الثاني خلال غشاء لتشكيل مستحلب أوّلي؛ إمرار المستحلب الأوّلي خلال غربال دقيق المسام في طور متواصل لتشكيل مستحلب ثانوي؛ وإزالة المذيب لتشكيل جسيمات دقيقة. [الشكل 4]
JOP/2020/0068A 2017-09-26 2018-09-26 طريقة لتحضير جسيمات دقيقة بواسطة تقنية مستحلب مزدوج JOP20200068A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2019632 2017-09-26
PCT/NL2018/050636 WO2019066649A1 (en) 2017-09-26 2018-09-26 PROCESS FOR THE PREPARATION OF MICROPARTICLES BY A DOUBLE EMULSION TECHNIQUE

Publications (1)

Publication Number Publication Date
JOP20200068A1 true JOP20200068A1 (ar) 2020-04-27

Family

ID=60628132

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2020/0068A JOP20200068A1 (ar) 2017-09-26 2018-09-26 طريقة لتحضير جسيمات دقيقة بواسطة تقنية مستحلب مزدوج

Country Status (14)

Country Link
US (1) US11052046B2 (ar)
EP (1) EP3687503A1 (ar)
JP (1) JP2020535224A (ar)
CN (1) CN111315365A (ar)
AU (1) AU2018341389A1 (ar)
BR (1) BR112020006136A2 (ar)
CA (1) CA3077011A1 (ar)
CL (1) CL2020000793A1 (ar)
CO (1) CO2020004360A2 (ar)
IL (1) IL273560B (ar)
JO (1) JOP20200068A1 (ar)
MX (1) MX2020003681A (ar)
SA (1) SA520411598B1 (ar)
WO (1) WO2019066649A1 (ar)

Family Cites Families (24)

* Cited by examiner, † Cited by third party
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US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
PH19942A (en) 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
CH660302A5 (fr) 1984-10-17 1987-04-15 Debiopharm Sa Procede de micro-encapsulation en phase heterogene de substances medicamenteuses hydrosolubles.
GB2209937B (en) 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
CH679207A5 (ar) 1989-07-28 1992-01-15 Debiopharm Sa
US5439688A (en) 1989-07-28 1995-08-08 Debio Recherche Pharmaceutique S.A. Process for preparing a pharmaceutical composition
US5225205A (en) 1989-07-28 1993-07-06 Debiopharm S.A. Pharmaceutical composition in the form of microparticles
EP0546174B1 (en) * 1991-06-29 1997-10-29 Miyazaki-Ken Monodisperse single and double emulsions and production thereof
CH683149A5 (fr) 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
JPH0558882A (ja) * 1991-09-04 1993-03-09 Yoshiaki Kawashima ナノカプセルの製造法
CH688269A5 (fr) 1992-08-21 1997-07-15 Debio Rech Pharma Sa Broyeur ultra-centrifuge et sa mise en oeuvre pour le broyage cryogénique de matériau thermosensible.
US5945126A (en) 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
NL1026261C2 (nl) 2004-05-25 2005-11-28 Nanomi B V Sproei inrichting met een nozzleplaat voorzien van structuren ter bevordering van self-breakup, een nozzleplaat, alsmede werkwijzen ter vervaardiging en toepassing van een dergelijke nozzleplaat.
WO2006123359A2 (en) * 2005-03-01 2006-11-23 Sun Pharmaceutical Industries Limited A process of making microspheres
JP4580801B2 (ja) * 2005-03-29 2010-11-17 株式会社東芝 複合型微粒子の製造方法及び複合型微粒子の製造装置
MX2009006653A (es) * 2006-12-18 2009-07-02 Takeda Pharmaceutical Composicion de liberacion prolongada y metodo para producirla.
ES2877206T3 (es) * 2008-09-18 2021-11-16 Evonik Corp Proceso de microencapsulación con disolvente y sal
WO2010085607A1 (en) 2009-01-23 2010-07-29 Surmodics Pharmaceuticals, Inc. Continuous double emulsion process for making microparticles
WO2011001780A1 (ja) * 2009-07-02 2011-01-06 コニカミノルタホールディングス株式会社 特定分散剤を含有する外水相を利用する二段階乳化法によるリポソームの製造方法、ならびに当該リポソームの製造方法を用いるリポソーム分散液またはその乾燥粉末の製造方法およびそれにより製造されるリポソーム分散液またはその乾燥粉末
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KR101558083B1 (ko) * 2014-04-07 2015-10-07 에스케이케미칼주식회사 약물함유 고분자미립구 제조방법

Also Published As

Publication number Publication date
RU2020113100A3 (ar) 2021-11-25
CO2020004360A2 (es) 2020-04-24
CA3077011A1 (en) 2019-04-04
WO2019066649A8 (en) 2019-05-31
CN111315365A (zh) 2020-06-19
US11052046B2 (en) 2021-07-06
JP2020535224A (ja) 2020-12-03
EP3687503A1 (en) 2020-08-05
US20200230061A1 (en) 2020-07-23
CL2020000793A1 (es) 2021-01-04
RU2020113100A (ru) 2021-10-08
AU2018341389A1 (en) 2020-04-23
WO2019066649A1 (en) 2019-04-04
BR112020006136A2 (pt) 2020-10-06
MX2020003681A (es) 2020-08-03
SA520411598B1 (ar) 2022-11-30
IL273560B (en) 2022-06-01
IL273560A (en) 2020-05-31

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